What is buplus 150mg tablet used for?

This medicine is an extended-release tablet containing Bupropion 150 mg, used to treat major depressive disorder and aid smoking cessation. It works by increasing levels of norepinephrine and dopamine in the brain. It is not suitable for individuals with a history of seizures or eating disorders.

Generic Name: Bupropion (150mg)
Manufacturer: Volus Pharma Pvt Ltd
Form: Allopathy
Pregnancy Category: Consult doctor
Prescription Required: Yes

🇮🇳 buplus 150mg tablet के बारे में (Hindi Summary)

उपयोग: यह दवा ब्यूप्रोपियन 150 मिलीग्राम एक्सटेंडेड-रिलीज़ टैबलेट है, जिसका उपयोग अवसाद (डिप्रेशन) के इलाज और धूम्रपान छोड़ने में मदद के लिए किया जाता है। यह मस्तिष्क में नॉरएपिनेफ्रिन और डोपामाइन के स्तर को बढ़ाकर काम करती है। यह मूड को बेहतर बनाती है और निकोटीन की लत को कम करने में सहायक है।

साइड इफेक्ट्स: इस दवा के सामान्य दुष्प्रभावों में मुँह सूखना, सिरदर्द, मतली, अनिद्रा, चक्कर आना और बेचैनी शामिल हैं। गंभीर दुष्प्रभाव दुर्लभ हैं लेकिन इनमें दौरे और गंभीर एलर्जी प्रतिक्रियाएँ शामिल हो सकती हैं। यदि कोई दुष्प्रभाव लगातार बना रहे तो डॉक्टर से संपर्क करें।

सुरक्षा सलाह: इस दवा को लेने से पहले अपने डॉक्टर को अपनी सभी चिकित्सीय स्थितियों के बारे में बताएं, विशेष रूप से यदि आपको दौरे, सिर की चोट, हृदय रोग, उच्च रक्तचाप, या यकृत या गुर्दे की समस्या है। इस दवा को लेते समय शराब न पिएं, क्योंकि इससे दौरे का खतरा बढ़ सकता है। यह दवा आपकी गाड़ी चलाने या मशीनरी चलाने की क्षमता को प्रभावित कर सकती है; जब तक आपको इसका असर पता न चल जाए, इन गतिविधियों से बचें। डॉक्टर से सलाह लिए बिना इस दवा को अचानक बंद न करें।

💊 buplus 150mg tablet Uses & Benefits

[{"condition":"Major Depressive Disorder","description":"This medicine is used to treat major depressive disorder in adults.
It helps improve mood, energy, and interest in daily activities.","evidence":"Well-established"},{"condition":"Smoking Cessation","description":"This medicine is used to help people quit smoking by reducing cravings and withdrawal symptoms.","evidence":"Well-established"},{"condition":"Seasonal Affective Disorder","description":"This medicine may be prescribed to prevent depressive episodes in people with seasonal affective disorder.","evidence":"Well-established"}]

Off-label uses: [{"condition":"Attention Deficit Hyperactivity Disorder (ADHD)","description":"Sometimes prescribed off-label for ADHD when other treatments are ineffective or not tolerated.","evidence":"Limited"},{"condition":"Bipolar Depression","description":"May be used off-label for bipolar depression, but usually in combination with other medications.","evidence":"Limited"},{"condition":"Sexual Dysfunction","description":"Occasionally used off-label to treat sexual dysfunction caused by other antidepressants.","evidence":"Limited"}]

Primary treatment for: Major Depressive Disorder

Also treats: Smoking Cessation, Seasonal Affective Disorder

📋 Drug Information

Generic Name(s)	Bupropion (150mg)
Brand Name	buplus 150mg tablet
Manufacturer	Volus Pharma Pvt Ltd
Packaging / Form	Varies by brand (Allopathy)
Therapeutic Class	NEURO CNS
Action Class	Norepinephrine-dopamine reuptake inhibitor (NDRI)
Route of Administration	Oral
Storage	Store at room temperature between 20°C and 25°C (68°F to 77°F). Keep away from moisture and heat. Keep out of reach of children.
Shelf Life	24 months from the date of manufacture.
WHO Guideline	Not established from the available information.
ICMR Guideline	Not established from the available information.

👨‍⚕️ Doctor's Practical Tips

Evidence-based practical advice from experienced clinicians

1

Take this medicine in the morning to minimize insomnia.

2

Swallow the tablet whole; do not crush, chew, or split it.

3

Avoid alcohol completely while on this medicine to reduce seizure risk.

4

Monitor your blood pressure regularly, especially if you have hypertension.

5

Report any new or worsening mood changes, especially suicidal thoughts, immediately.

6

Do not stop this medicine abruptly; taper gradually under medical supervision.

🔍 Is This Medicine Right for Your Symptom?

Educational reference. Always consult a doctor for diagnosis.

✅

Persistent sadness

This medicine is commonly prescribed for depression.

Likely Use

✅

Nicotine cravings

This medicine helps reduce cravings for smoking cessation.

Likely Use

❌

Fever

This medicine is not a primary fever reducer.

Not Primary

🔬 How This Medicine Works (Pharmacology)

Pharmacokinetics

AbsorptionThis medicine is well absorbed from the gastrointestinal tract after oral administration. The extended-release formulation slows the absorption rate, providing a more sustained release of the drug.

DistributionThis medicine is widely distributed throughout the body, including the brain. It crosses the blood-brain barrier and is also excreted in breast milk.

Protein BindingThis medicine is approximately 84% bound to plasma proteins.

MetabolismThis medicine is extensively metabolized in the liver, primarily by the CYP2B6 enzyme, to several active metabolites, including hydroxybupropion, which is a potent inhibitor of norepinephrine reuptake.

Half-LifeThe elimination half-life of this medicine is approximately 20 to 21 hours. The half-life of its active metabolite, hydroxybupropion, is longer, around 20 to 37 hours.

ExcretionThis medicine and its metabolites are primarily excreted in the urine (87%) and to a lesser extent in the feces (10%).

BioavailabilityThe absolute bioavailability of this medicine is not well established, but it is estimated to be around 5% to 10% due to first-pass metabolism.

Onset of ActionThe onset of antidepressant effects typically takes 1 to 2 weeks, but full therapeutic benefits may take 4 to 6 weeks. For smoking cessation, the effect may begin within 1 to 2 weeks.

Peak Plasma TimeThe peak plasma concentration of this medicine is reached approximately 3 hours after oral administration of the extended-release tablet.

Duration of ActionThe duration of action of this medicine is approximately 24 hours, allowing for once-daily dosing.

How It Works

This medicine works by inhibiting the reuptake of the neurotransmitters norepinephrine and dopamine in the brain. This leads to increased levels of these chemicals in the synaptic cleft, which helps improve mood and reduce cravings for nicotine. Unlike selective serotonin reuptake inhibitors, it has minimal effect on serotonin reuptake.

Mechanism Steps

1

Inhibition of norepinephrine reuptake: This medicine blocks the norepinephrine transporter, leading to increased norepinephrine levels in the brain.

2

Inhibition of dopamine reuptake: This medicine blocks the dopamine transporter, leading to increased dopamine levels in the brain.

3

Increased neurotransmitter activity: The elevated levels of norepinephrine and dopamine enhance neurotransmission, which is thought to underlie its antidepressant and smoking cessation effects.

💡 How to Take buplus 150mg tablet

Strength: Extended-release tablet, 150 mg

1Take this medicine exactly as prescribed by your doctor.

2Swallow the tablet whole with a glass of water. Do not crush, chew, or split the tablet.

3Take it in the morning to reduce the risk of insomnia.

4You may take it with or without food. If it upsets your stomach, take it with food.

5Do not stop taking this medicine suddenly without consulting your doctor.

Dosage Information

Adult Dosage	The usual adult dose for depression is 150 mg once daily in the morning, which may be increased to 300 mg once daily if needed. For smoking cessation, treatment should begin while the patient is still smoking, with a dose of 150 mg once daily for 3 days, then increased to 150 mg twice daily. Dose must be individualized by a qualified clinician based on indication, age, weight, renal and hepatic function.
Pediatric Dosage	Pediatric dosing is not established from available information. Consult a pediatrician.
Elderly Dosage	Elderly patients may be more sensitive to the effects of this medicine. Start with a lower dose and monitor closely for side effects.
Renal Impairment	In patients with renal impairment, a reduced dose and slower titration may be necessary. Consult your doctor for specific dosing recommendations.
Hepatic Impairment	In patients with hepatic impairment, a reduced dose and slower titration may be necessary. Consult your doctor for specific dosing recommendations.
Maximum Daily Dose	The maximum recommended daily dose is 450 mg for depression and 300 mg for smoking cessation.

Dosage Timeline

🌅 Morning ❌ ☀️ Afternoon ❌ 🌆 Evening ❌ 🌙 Night ❌

🍽️ Food Timing Guide

With food

Take with meals

Reduces stomach upset.

Grapefruit

Avoid

May increase drug levels.

⏰ What to Do If You Miss a Dose

📌 Less than half the dosing interval has passed

→ Take the missed dose as soon as you remember.

💡 Continue with the regular schedule.

📌 More than half the dosing interval has passed

→ Skip the missed dose.

💡 Do not double dose to catch up.

⚠️ Side Effects of buplus 150mg tablet

✅ Common Side Effects

Dry mouth (Common (10-20%))

Sip water frequently, chew sugar-free gum, or use a saliva substitute. Consult your doctor if it persists.

Headache (Common (10-20%))

Rest and stay hydrated. Over-the-counter pain relievers may help, but consult your doctor if headaches are severe or persistent.

Insomnia (Common (10-20%))

Take the medication in the morning to reduce insomnia. Practice good sleep hygiene. Consult your doctor if it continues.

Nausea (Common (5-10%))

Take with food to reduce nausea. If it persists, consult your doctor.

Dizziness (Common (5-10%))

Avoid driving or operating machinery until you know how it affects you. Rise slowly from sitting or lying positions.

🚨 Serious Side Effects

Seizures (Rare (<0.1%))

Seek immediate medical attention if you experience a seizure. Do not drive or operate machinery until cleared by your doctor.

Severe allergic reactions (Rare (<0.1%))

Seek emergency help if you experience rash, itching, swelling, severe dizziness, or trouble breathing.

Suicidal thoughts (Uncommon (0.1-1%))

Contact your doctor immediately if you have new or worsening thoughts of self-harm. Close monitoring is required, especially at the start of treatment.

Severe hypertension (Rare (<0.1%))

Monitor blood pressure regularly. Seek medical attention if you experience severe headache, blurred vision, or chest pain.

⚠️ Rare Side Effects

Stevens-Johnson syndrome

Seek immediate medical attention if you develop a rash with blisters, peeling skin, or sores in the mouth.

Liver failure

Report yellowing of skin or eyes, dark urine, or severe abdominal pain to your doctor immediately.

Consult your doctor if you experience any unusual symptoms.

🔬 Drug Interactions

Drug	Severity	Effect
MAOIs	Major
Carbamazepine	Major
Metoprolol	Moderate
Alcohol	Moderate
Caffeine	Minor

🚨 Major Interactions

Monoamine oxidase inhibitors (MAOIs)
Anticonvulsants (e.g., carbamazepine, phenytoin)
CYP2D6 substrates (e.g., metoprolol, tamoxifen)

⚡ Moderate Interactions

Alcohol
Beta-blockers (e.g., metoprolol)

🍷 Alcohol Interaction

Avoid alcohol while taking this medicine. Alcohol can increase the risk of seizures and may worsen side effects such as dizziness and drowsiness.

🔎 Check Your Other Medicines

Educational tool. Always confirm with your doctor or pharmacist.

🛡️ Safety & Warnings

🚫 Contraindications

["Seizure disorder","Current or prior diagnosis of bulimia or anorexia nervosa","Abrupt discontinuation of alcohol, benzodiazepines, barbiturates, or antiepileptic drugs","Use of MAOIs within 14 days","Hypersensitivity to bupropion or any component of the formulation"]

⚠️ Warnings & Precautions

["May increase the risk of suicidal thoughts and behaviors in children, adolescents, and young adults.","Can cause seizures, especially at higher doses or in patients with predisposing factors.","May cause agitation, insomnia, and anxiety.","Can increase blood pressure; monitor regularly.","May impair cognitive and motor performance; use caution when driving or operating machinery.","Do not crush, chew, or split extended-release tablets; swallow whole."]

🤱 Lactation Safety

This medicine is excreted in human breast milk. Because of the potential for serious adverse reactions in nursing infants, a decision should be made whether to discontinue nursing or to discontinue the drug, taking into account the importance of the drug to the mother.

💊 Overdose Management

In case of overdose, seek emergency medical attention immediately. Symptoms of overdose may include seizures, hallucinations, loss of consciousness, and rapid heart rate. Treatment is supportive and symptomatic. There is no specific antidote.

⏰ Missed Dose

If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and continue with your regular schedule. Do not double the dose to catch up.

Additional Safety Advice

General Safety

Before taking this medicine, inform your doctor about all your medical conditions, especially if you have a history of seizures, head injury, heart disease, high blood pressure, or liver or kidney problems. Do not drink alcohol while taking this medicine, as it can increase the risk of seizures. This medicine may impair your ability to drive or operate machinery; avoid these activities until you know how it affects you. Do not stop taking this medicine abruptly without consulting your doctor, as this can lead to withdrawal symptoms. Keep this medicine out of reach of children. Store it at room temperature away from moisture and heat.

👴 Special Considerations for Elderly

💡 For Patients Above 65

Elderly patients may be more sensitive to the side effects of this medicine, especially dizziness, insomnia, and hypertension. Start with a lower dose and monitor closely.

🤰 Pregnancy Planning (TTC)

If you are planning to become pregnant, consult your doctor before taking this medicine. It should be used during pregnancy only if clearly needed. Discuss risks and benefits with your healthcare provider.

🏥 Post-Surgery Considerations

Inform your surgeon and anesthesiologist that you are taking this medicine. It may interact with certain anesthetic agents and increase the risk of seizures.

🦷 Dental Procedures

Inform your dentist that you are taking this medicine. It may cause dry mouth, which can affect oral health. Maintain good oral hygiene.

💚 Lifestyle Tips for Better Results

🏃

Maintain a regular sleep schedule to improve mood and reduce insomnia.

🥗

Engage in regular physical activity, but avoid excessive caffeine.

😴

Practice stress-reduction techniques such as meditation or deep breathing.

💧

Stay connected with supportive friends and family.

🧘

Avoid alcohol and recreational drugs.

🏋️ Exercise Considerations

This medicine may cause dizziness or drowsiness. Avoid strenuous exercise until you know how it affects you. Stay hydrated during exercise.

🥗 Diet Recommendations

Eat a balanced diet rich in fruits, vegetables, and whole grains.

Limit caffeine intake as it may increase jitteriness.

Stay well hydrated.

Avoid alcohol.

💼 Impact on Daily Work & Life

This medicine may impair your ability to drive or operate machinery. Avoid these activities until you know how it affects you. It may also affect your sleep, so plan your work schedule accordingly.

🛑 When to Stop This Medicine

Do not stop taking this medicine without consulting your doctor. Abrupt discontinuation may cause withdrawal symptoms such as irritability, anxiety, and insomnia. Your doctor will gradually taper the dose.

📅 Long-Term Use Effects

Long-term use of this medicine may require periodic monitoring of blood pressure, mood, and seizure risk. Some patients may experience weight loss or gain. It is important to have regular follow-ups with your doctor to assess effectiveness and adjust treatment as needed.

🌿 Non-Medicine Approaches

These can complement medicine but do not replace prescribed treatment.

Cognitive Behavioral Therapy (CBT)

Can be used alone or in combination with medication for depression and smoking cessation.

Evidence: Well-established

Nicotine Replacement Therapy

Alternative for smoking cessation, often used in combination with behavioral support.

Evidence: Well-established

💉 Vaccination Considerations

💉 If You're Getting Vaccinated

No specific interactions with vaccines are known. However, consult your doctor before receiving any vaccine while on this medicine.

📦 Storage Guide

✅ DO

Store at room temperature (20-25°C)

❌ DON'T

Do not refrigerate

✅ DO

Keep in original container

❌ DON'T

Do not transfer to unmarked containers

✅ DO

Keep away from direct sunlight

❌ DON'T

Do not store in bathroom cabinet

✈️ Traveling with This Medicine

When traveling, carry this medicine in its original packaging along with a copy of your prescription. Keep it in your carry-on luggage to avoid loss. Store at room temperature and protect from moisture. If crossing time zones, consult your doctor about adjusting dosing times. Check local customs regulations for controlled substances.

💰 Cost Analysis & Savings

👥 Real Patient Stories

Educational, anonymized scenarios. Individual results may vary.

👤 A 35-year-old woman with major depressive disorder

She started Bupron XL 150 as prescribed. After 3 weeks, she noticed improved mood and energy. She experienced mild dry mouth and insomnia initially, which subsided after a few weeks. She emphasized taking the medication in the morning and avoiding alcohol.

💡 Lesson: Consistent morning dosing and patience are key; side effects often diminish over time.

👤 A 50-year-old man wanting to quit smoking

He began Bupron XL 150 while still smoking. Within 2 weeks, his cravings reduced significantly, and he set a quit date. He reported vivid dreams but otherwise tolerated the medication well. He successfully quit smoking after 6 weeks.

💡 Lesson: Bupron XL 150 can effectively reduce nicotine cravings when combined with a quit date and behavioral support.

💬 Questions Patients Often Ask

Q: How long does it take to work?

A: For depression, it may take 1 to 2 weeks for initial effects and 4 to 6 weeks for full benefits. For smoking cessation, effects may begin within 1 to 2 weeks.

Q: Can I take this medicine at night?

A: It is best taken in the morning to avoid insomnia. If you experience drowsiness, consult your doctor about timing.

Q: What should I do if I miss a dose?

A: Take it as soon as you remember if it's not close to the next dose. If it's almost time, skip the missed dose and continue your regular schedule. Do not double dose.

🤔 Common Patient Concerns

💭 These are the concerns patients most commonly raise

Can I take this medicine long-term?
Will it affect my kidney function?
Can I drive after taking this medicine?
Does it interact with my blood pressure medicine?
What if I miss a dose?
Can I drink alcohol while taking this?

🔄 Substitutes for buplus 150mg tablet

View All

Alternative brands with exact same active ingredient:

Medical Note: Always consult your doctor before switching medications.

🛑 Myths vs. Facts

Myth: Bupron XL 150 is a sleeping pill.
Fact: This medicine is an antidepressant and smoking cessation aid, not a sleeping pill. It may actually cause insomnia.
Myth: Bupron XL 150 is addictive.
Fact: This medicine is not considered addictive, but it should be used under medical supervision and not stopped abruptly.

🔄 Alternative Options

Generic Alternatives

Bupropion extended-release tablets

Brand Alternatives

Wellbutrin XL
Zyban
Bupron SR

📊 Comparison with Similar Medicines

[{"medicine":"Bupron XL 150","class":"Aminoketone antidepressant","primary_use":"Depression, smoking cessation","half_life":"20-21 hours"},{"medicine":"Sertraline","class":"SSRI","primary_use":"Depression, anxiety","half_life":"22-36 hours"},{"medicine":"Venlafaxine","class":"SNRI","primary_use":"Depression, anxiety","half_life":"5 hours"}]

Bupron XL 150 Tablet: Comprehensive Guide

When to Call Your Doctor IMMEDIATELY

What is buplus 150mg tablet used for?

🇮🇳 buplus 150mg tablet के बारे में (Hindi Summary)

💊 buplus 150mg tablet Uses & Benefits

📋 Drug Information

👨‍⚕️ Doctor's Practical Tips

🔍 Is This Medicine Right for Your Symptom?

🔬 How This Medicine Works (Pharmacology)

Pharmacokinetics

How It Works

Mechanism Steps

💡 How to Take buplus 150mg tablet

Dosage Information

Dosage Timeline

🍽️ Food Timing Guide

⏰ What to Do If You Miss a Dose

⚠️ Side Effects of buplus 150mg tablet

✅ Common Side Effects

🚨 Serious Side Effects

⚠️ Rare Side Effects

🔬 Drug Interactions

🚨 Major Interactions

⚡ Moderate Interactions

🍷 Alcohol Interaction

🔎 Check Your Other Medicines

🛡️ Safety & Warnings

🚫 Contraindications

⚠️ Warnings & Precautions

🤱 Lactation Safety

💊 Overdose Management

⏰ Missed Dose

Additional Safety Advice

👴 Special Considerations for Elderly

💡 For Patients Above 65

🤰 Pregnancy Planning (TTC)

🏥 Post-Surgery Considerations

🦷 Dental Procedures

💚 Lifestyle Tips for Better Results

🏋️ Exercise Considerations

🥗 Diet Recommendations

💼 Impact on Daily Work & Life

🛑 When to Stop This Medicine

📅 Long-Term Use Effects

🌿 Non-Medicine Approaches

💉 Vaccination Considerations

💉 If You're Getting Vaccinated

📦 Storage Guide

✅ DO

❌ DON'T

✅ DO

❌ DON'T

✅ DO

❌ DON'T

✈️ Traveling with This Medicine

💰 Cost Analysis & Savings

👥 Real Patient Stories

💬 Questions Patients Often Ask

🤔 Common Patient Concerns

💭 These are the concerns patients most commonly raise

🔄 Substitutes for buplus 150mg tablet

🛑 Myths vs. Facts

🔄 Alternative Options

Generic Alternatives

Brand Alternatives

📊 Comparison with Similar Medicines

😊 Was this information helpful?

Browse Medicines A-Z

✍️ Write a Review

❓ Ask a Question

⚠️ Report an Issue