Brucof Plus Syrup: Complete Medicine Guide
Clinical Reference Standards: CDSCO (Central Drugs Standard Control Organisation), Indian Pharmacopoeia (IP) & WHO | Last Updated: September 2026
When to Call Your Doctor IMMEDIATELY
- Chest pain or pressure
- Severe palpitations or irregular heartbeat
- Difficulty breathing or worsening wheezing after a dose
- Swelling of the face, lips, tongue, or throat
- Severe dizziness or fainting
- Blood in sputum or vomit
- Persistent high fever with worsening cough
If experiencing severe symptoms, call emergency services immediately.
What is brucof plus syrup used for?
This medicine is a combination oral syrup containing guaifenesin, an expectorant that thins mucus, and terbutaline, a bronchodilator that opens the airways. It is used for short-term relief of productive cough with wheezing or bronchospasm, and it should be taken only as prescribed by a doctor.
- Generic Name: Guaifenesin + Terbutaline
- Manufacturer: Brussels Laboratories Pvt Ltd
- Form: Allopathy
- Pregnancy Category: Consult doctor
- Prescription Required: Yes
🇮🇳 brucof plus syrup के बारे में (Hindi Summary)
उपयोग: यह दवा गुआइफेनेसिन और टर्ब्यूटालीन का संयोजन है, जो कफ सिरप के रूप में मुँह से ली जाती है। गुआइफेनेसिन बलगम को पतला करता है जिससे कफ आसानी से निकलता है, और टर्ब्यूटालीन श्वास नलियों को फैलाकर साँस लेने में राहत देता है। यह दवा उन लोगों के लिए है जिन्हें बलगम वाली खांसी के साथ घरघराहट या साँस फूलने की समस्या होती है, जैसे ब्रोंकाइटिस या दमा के दौरे में। यह सूखी खांसी, साधारण सर्दी-जुकाम, या दमा के नियमित इलाज के लिए नहीं है। इसे डॉक्टर की सलाह के बिना न लें, खासकर अगर आपको दिल की बीमारी, थायरॉइड, मधुमेह, या दौरे पड़ते हों। बच्चों, गर्भवती महिलाओं और बुजुर्गों में इसका उपयोग डॉक्टर की देखरेख में ही करना चाहिए।
साइड इफेक्ट्स: इस दवा के आम दुष्प्रभावों में जी मिचलाना, उल्टी, पेट में गड़बड़ी, चक्कर आना, सिरदर्द, घबराहट, हाथ-पैर कांपना, धड़कन तेज होना और दिल की धड़कन महसूस होना शामिल हैं। ये आमतौर पर हल्के होते हैं और कुछ समय में कम हो सकते हैं। गंभीर दुष्प्रभाव कम होते हैं, लेकिन तेज धड़कन, सीने में दर्द, अनियमित धड़कन, गंभीर सिरदर्द, एलर्जी जैसे दाने या चेहरे-होंठों में सूजन, या साँस लेने में कठिनाई हो तो तुरंत डॉक्टर से मिलें। किसी भी असामान्य लक्षण को नजरअंदाज न करें।
सुरक्षा सलाह: इस दवा को डॉक्टर के बताए अनुसार ही लें और मापने वाले कप या सिरिंज से सही मात्रा लें। अपने आप मात्रा या बार-बार लेना न बढ़ाएँ, क्योंकि इससे दिल की धड़कन और कांपने की समस्या बढ़ सकती है। चाय, कॉफी और अन्य उत्तेजक पदार्थों का सेवन कम करें। अगर आपको दिल की बीमारी, उच्च रक्तचाप, मधुमेह, थायरॉइड, दौरे, या गर्भावस्था है, तो डॉक्टर को जरूर बताएं। सूखी खांसी या 7 दिन से ज्यादा खांसी के लिए बिना डॉक्टर की सलाह के इसका इस्तेमाल न करें। दवा को बच्चों की पहुंच से दूर रखें और एक्सपायरी डेट जांचें। सीने में दर्द, तेज धड़कन, गंभीर चक्कर, या साँस लेने में तकलीफ हो तो तुरंत आपातकालीन मदद लें।
💊 brucof plus syrup Uses & Benefits
[{"condition":"Acute bronchitis with bronchospasm","description":"Used for short-term relief of cough and wheezing when a clinician identifies reversible airway narrowing along with thick secretions.","evidence":"Limited to moderate; combination products are used symptomatically but are not first-line for all coughs."},{"condition":"Asthma exacerbation (mild, as adjunct)","description":"Terbutaline provides bronchodilation while guaifenesin may help loosen secretions; however, inhaled therapy remains preferred for asthma.","evidence":"Limited; oral terbutaline is not a preferred asthma treatment."},{"condition":"Productive cough with chest congestion","description":"Guaifenesin thins mucus, making cough more effective when secretions are thick and difficult to clear.","evidence":"Guaifenesin has modest evidence for improving cough clearance."}]
Off-label uses: [{"condition":"Chronic obstructive pulmonary disease (COPD) with mucus hypersecretion","description":"Sometimes used for short-term symptom relief, but long-acting inhaled bronchodilators are standard of care.","evidence":"Limited; not a recommended routine therapy."}]
Primary treatment for: Productive cough associated with bronchospasm
Also treats: Acute bronchitis, Asthma exacerbation (adjunct), COPD with mucus hypersecretion (short-term, off-label)
📋 Drug Information
| Generic Name(s) | Guaifenesin + Terbutaline |
| Brand Name | Asthakind Expectorant Sugar Free |
| Manufacturer | Brussels Laboratories Pvt Ltd |
| Packaging / Form | Varies by brand (Allopathy) |
| Therapeutic Class | RESPIRATORY |
| Action Class | Expectorant and Bronchodilator |
| Route of Administration | Oral |
| Storage | Store at room temperature, preferably below 30°C, in a dry place away from direct sunlight. Do not freeze. Keep the bottle tightly closed and out of reach of children. |
| Shelf Life | Refer to the expiry date printed on the pack. Do not use after the expiry date. |
| WHO Guideline | Not established from the available information. |
| ICMR Guideline | Not established from the available information. |
👨⚕️ Doctor's Practical Tips
Evidence-based practical advice from experienced clinicians
🔍 Is This Medicine Right for Your Symptom?
Educational reference. Always consult a doctor for diagnosis.
🔬 How This Medicine Works (Pharmacology)
Pharmacokinetics
How It Works
This medicine combines two active ingredients with different actions. Guaifenesin is an expectorant that reduces the viscosity and surface tension of bronchial secretions, helping thick mucus become thinner and easier to cough out. Terbutaline is a selective beta-2 adrenergic receptor agonist that stimulates beta-2 receptors on airway smooth muscle, causing relaxation and bronchodilation. Together, they aim to ease breathing while making cough more productive.
Mechanism Steps
💡 How to Take brucof plus syrup
Strength: Each 5 mL of syrup contains guaifenesin 50 mg and terbutaline 25 mg.
Dosage Information
| Adult Dosage | The usual adult dose of this medicine is individualized by a qualified clinician based on the indication, severity of symptoms, age, weight, and kidney and liver function. A common prescribed schedule is 5 to 10 mL taken two to three times a day, but this must be confirmed by your doctor. Do not self-medicate or exceed the prescribed dose. Dose must be individualized by a qualified clinician based on indication, age, weight, renal and hepatic function. |
| Pediatric Dosage | Pediatric dosing is not established from available information. Consult a pediatrician. Doses for children depend on age, weight, and clinical condition, and should only be determined by a qualified pediatrician. |
| Elderly Dosage | Elderly patients may be more sensitive to the cardiovascular and nervous system effects of terbutaline. Use with caution and only under medical supervision. Dose must be individualized by a qualified clinician based on kidney and liver function and other medicines being taken. |
| Renal Impairment | Dose adjustment may be needed in patients with severe kidney disease because terbutaline and guaifenesin metabolites are excreted by the kidneys. Consult a doctor for individualized dosing. |
| Hepatic Impairment | Use with caution in patients with liver disease because metabolism of both ingredients may be affected. Dose must be individualized by a qualified clinician. |
| Maximum Daily Dose | The maximum daily dose must be determined by a qualified clinician based on the patient's condition and response. Do not exceed the prescribed dose. |
Dosage Timeline
🍽️ Food Timing Guide
⏰ What to Do If You Miss a Dose
⚠️ Side Effects of brucof plus syrup
✅ Common Side Effects
🚨 Serious Side Effects
⚠️ Rare Side Effects
Consult your doctor if you experience any unusual symptoms.
🔬 Drug Interactions
| Drug | Severity | Effect |
|---|---|---|
| Propranolol | Major | |
| MAOIs | Major | |
| Tricyclic antidepressants | Major | |
| Pseudoephedrine | Moderate | |
| Furosemide | Moderate | |
| Corticosteroids | Moderate | |
| Digoxin | Moderate | |
| Caffeine | Minor | |
| Antacids | Minor | |
| Alcohol | Moderate |
🚨 Major Interactions
- Non-selective beta-blockers (e.g., propranolol)
- Monoamine oxidase inhibitors (MAOIs)
- Tricyclic antidepressants
⚡ Moderate Interactions
- Other sympathomimetics (e.g., pseudoephedrine)
- Diuretics (e.g., furosemide, thiazides)
- Corticosteroids
- Digoxin
🍷 Alcohol Interaction
Alcohol may increase dizziness, drowsiness, and cardiovascular effects when taken with this medicine. It is best to avoid alcohol while using this product, especially if you are also taking other medicines that affect the heart or nervous system.
🔎 Check Your Other Medicines
Educational tool. Always confirm with your doctor or pharmacist.
🛡️ Safety & Warnings
🚫 Contraindications
["Hypersensitivity to guaifenesin, terbutaline, or any component of this medicine","Severe tachyarrhythmias or uncontrolled cardiac disease","Severe hyperthyroidism","Uncontrolled diabetes mellitus without medical supervision","Use with non-selective beta-blockers","Children below the age recommended by a pediatrician"]
⚠️ Warnings & Precautions
["This medicine can cause palpitations, tremor, and nervousness; avoid driving or operating machinery until you know how it affects you.","Use with caution in patients with heart disease, high blood pressure, diabetes, thyroid disorders, or seizures.","Do not exceed the prescribed dose, because higher doses increase the risk of cardiac and metabolic side effects.","This medicine is not a substitute for inhaled asthma controller or rescue therapy.","Consult a doctor if cough persists beyond 7 days, worsens, or is accompanied by fever, rash, or persistent headache.","Keep out of reach of children and use a proper measuring device for accurate dosing."]
🤱 Lactation Safety
Terbutaline is distributed into breast milk, and guaifenesin may also pass into breast milk. The effects on a breastfed infant are not fully established. Breastfeeding mothers should consult a doctor before using this medicine.
💊 Overdose Management
Overdose of this medicine can cause severe tachycardia, palpitations, tremor, restlessness, nausea, vomiting, chest pain, hypokalemia, and hyperglycemia. If overdose is suspected, seek emergency medical care immediately. Treatment is supportive and may include monitoring of heart rhythm, blood pressure, blood glucose, and electrolytes. Do not try to induce vomiting unless instructed by a healthcare professional.
⏰ Missed Dose
If you miss a dose, take it as soon as you remember if it is almost time for the next dose, skip the missed dose and continue with your regular schedule. Do not take a double dose to make up for a missed one. If you are unsure, contact your doctor or pharmacist.
Additional Safety Advice
Take this medicine exactly as prescribed by your doctor, using a proper measuring device and not a household spoon. Do not increase the dose or frequency on your own, because terbutaline can cause heart rhythm disturbances and tremor at higher doses. Avoid caffeine and other stimulants, as they can worsen nervousness and palpitations. Inform your doctor if you have heart disease, high blood pressure, diabetes, thyroid problems, seizures, or if you are pregnant, planning pregnancy, or breastfeeding. Do not use this medicine for a dry cough or for more than the recommended duration without medical review. Keep it out of reach of children, store it as directed, and check the expiry date before use. If you experience chest pain, severe dizziness, rapid heartbeat, or difficulty breathing, stop the medicine and seek emergency care.
👴 Special Considerations for Elderly
💡 For Patients Above 65
Elderly patients are more likely to experience palpitations, tremor, dizziness, and blood sugar changes from terbutaline. Use this medicine with caution, at the lowest effective dose, and only under medical supervision. Monitor heart rate, blood pressure, and blood sugar if diabetic.
🤰 Pregnancy Planning (TTC)
If you are planning pregnancy, discuss this medicine with your doctor before use. Terbutaline can affect heart rate and blood sugar, and its safety in early pregnancy should be evaluated by a clinician. Do not start or stop any medicine without medical advice.
🏥 Post-Surgery Considerations
After surgery, use this medicine only if prescribed by your surgeon or doctor. It can affect heart rate and blood pressure, which may be important during recovery. Inform your surgical team about all medicines you are taking.
🦷 Dental Procedures
Inform your dentist if you are taking this medicine, especially if you have heart conditions or are taking other medicines. It does not usually require stopping before dental work, but your dentist may check your heart rate and blood pressure.
💚 Lifestyle Tips for Better Results
🏋️ Exercise Considerations
Avoid strenuous exercise while you have active cough, wheezing, or breathlessness. Gentle walking and breathing exercises may be helpful once symptoms improve. If exercise triggers wheezing, stop and consult your doctor before resuming intense activity.
🥗 Diet Recommendations
💼 Impact on Daily Work & Life
This medicine can cause dizziness, tremor, or palpitations, which may affect your ability to drive or operate machinery. Avoid driving until you know how it affects you. Office work is usually fine, but take breaks and stay hydrated. If your job involves heavy physical exertion or working at heights, discuss with your doctor before continuing.
🛑 When to Stop This Medicine
Stop this medicine and consult your doctor if your cough does not improve within the prescribed duration, if it worsens, or if you develop chest pain, severe palpitations, difficulty breathing, or allergic reactions. Do not stop or change the dose without medical advice if you are using it for a chronic condition.
📅 Long-Term Use Effects
Long-term use of this medicine is not recommended without medical supervision. Prolonged use of terbutaline can lead to tolerance, increased heart rate, tremor, and metabolic effects such as raised blood sugar and low potassium. Guaifenesin is generally well tolerated, but ongoing cough lasting more than a few weeks needs evaluation for underlying causes such as asthma, reflux, or infection. Regular review by a doctor is important if symptoms persist.
🌿 Non-Medicine Approaches
These can complement medicine but do not replace prescribed treatment.
Helps loosen mucus and soothe airways naturally.
Evidence: Supportive care; commonly recommended.Preferred for asthma or recurrent bronchospasm because it targets the lungs with fewer systemic effects.
Evidence: Well-established for asthma and COPD.Techniques to help clear secretions in people with thick mucus.
Evidence: Moderate evidence in selected patients.💉 Vaccination Considerations
💉 If You're Getting Vaccinated
There is no known interaction between this medicine and routine vaccines. If you have an active infection with fever, your doctor may advise delaying vaccination until you recover. Follow your doctor's advice regarding influenza and pneumococcal vaccines if you have chronic lung disease.
📦 Storage Guide
✅ DO
Store at room temperature below 30°C
❌ DON'T
Do not freeze or refrigerate unless specified
✅ DO
Keep the bottle tightly closed in its original carton
❌ DON'T
Do not transfer to unmarked containers
✅ DO
Keep away from direct sunlight and heat
❌ DON'T
Do not store in a bathroom cabinet or near a stove
✅ DO
Keep out of reach of children
❌ DON'T
Do not use after the expiry date
✈️ Traveling with This Medicine
Carry this medicine in its original packaging with the prescription label intact. Keep a copy of your prescription with you, especially for international travel, because terbutaline-containing products may be regulated in some countries. Store it at room temperature and protect it from direct sunlight and extreme heat. If you are crossing time zones, continue your doses at the intervals advised by your doctor, and do not double up. Check customs rules before traveling, and carry enough supply for the entire trip.
💰 Cost Analysis & Savings
👥 Real Patient Stories
Educational, anonymized scenarios. Individual results may vary.
💬 Questions Patients Often Ask
A: Terbutaline may start opening the airways within 15 to 30 minutes, but the full effect on cough and mucus can take longer. Follow your doctor's advice on how long to use it.
A: Yes, you can take it with food if it upsets your stomach. Follow your doctor's instructions.
A: Use during pregnancy only if prescribed by a doctor. Terbutaline can affect the mother and baby, so medical supervision is required.
A: Seek emergency medical care immediately. Overdose can cause severe palpitations, tremor, and other serious effects.
🤔 Common Patient Concerns
🛑 Myths vs. Facts
- Myth: This medicine can cure any type of cough.
Fact: It is intended for productive cough with bronchospasm, not for dry cough or simple viral colds. - Myth: More syrup means faster relief.
Fact: Taking more than prescribed can cause serious heart and nervous system side effects. - Myth: It is safe to take with any other medicine.
Fact: It can interact with beta-blockers, MAOIs, and other stimulants, so always inform your doctor about all medicines you take.
🔄 Alternative Options
Generic Alternatives
- Guaifenesin + terbutaline oral syrup (generic equivalents may be available)
Brand Alternatives
- Brucof Plus Syrup