brisval 250mg tablet er - Divalproex (250mg) medicine

brisval 250mg tablet er

No reviews yet
Divalproex (250mg)
🏭 Madbris Life Sciences Pvt Ltd 📦 Varies by brand 💊 Allopathy 📅 Updated: Sep 23, 2026
📋 Prescription Required 💊 Generic Available
Medically Reviewed
11 min read
Reviewed by
SaathiMed Expert Panel | Sep 23, 2026

What is brisval 250mg tablet er used for?

This medicine contains Divalproex (250mg) and is used to treat NEURO CNS. Increases GABA levels by inhibiting GABA transaminase and enhancing GABA synthesis; also blocks volt. Always consult your doctor before use.

  • Generic Name: Divalproex
  • Manufacturer: Madbris Life Sciences Pvt Ltd
  • Form: Allopathy
  • Pregnancy Category: Category A
  • Prescription Required: Yes
💡 Did You Know? India has the highest number of USFDA-compliant plants outside the USA.

💊 brisval 250mg tablet er Uses & Benefits

Epilepsy (complex partial, absence, generalized tonic-clonic), bipolar disorder (mania), migraine prophylaxis.

Off-label uses: Neuropathic pain, status epilepticus (IV), agitation in dementia, schizophrenia augmentation.

📋 Drug Information

Generic Name(s)Divalproex
Brand NameAlporate D 500mg Tablet ER
ManufacturerMadbris Life Sciences Pvt Ltd
Packaging / FormVaries by brand (Allopathy)
Therapeutic ClassNEURO CNS
Action ClassSodium channel modulators (AED)
Route of AdministrationOral (extended-release tablet)
StorageStore at 20-25°C (68-77°F); protect from moisture.
Shelf LifeAs per manufacturer

🔬 How This Medicine Works (Pharmacology)

Pharmacokinetics

AbsorptionWell absorbed orally; extended-release formulation provides sustained absorption.
DistributionDistributes widely; crosses blood-brain barrier and placenta.
Protein Binding90-95% bound to plasma proteins, mainly albumin.
MetabolismExtensively metabolized in liver via glucuronidation, beta-oxidation, and CYP450 (minor).
Half-Life9-16 hours (may be longer in hepatic impairment).
ExcretionPrimarily renal (as metabolites); less than 3% excreted unchanged.
BioavailabilityApproximately 90% (oral).
Onset of Action1-4 hours (therapeutic effect may take days to weeks).
Peak Plasma Time4-17 hours (extended-release).
Duration of ActionApproximately 24 hours (with ER formulation).

How It Works

Increases GABA levels by inhibiting GABA transaminase and enhancing GABA synthesis; also blocks voltage-gated sodium channels and T-type calcium channels.

Mechanism Steps

1Inhibits GABA transaminase, increasing GABA levels.
2Enhances glutamic acid decarboxylase activity, increasing GABA synthesis.
3Blocks voltage-gated sodium channels, reducing neuronal excitability.
4Blocks T-type calcium channels, modulating neurotransmitter release.
5Reduces excitatory neurotransmission and stabilizes neuronal membranes.

💡 How to Take brisval 250mg tablet er

Follow your doctor's prescription exactly.

⚠️ Side Effects of brisval 250mg tablet er

✅ Common Side Effects

Nausea
vomiting
dizziness
somnolence
tremor
weight gain
thrombocytopenia
alopecia
asthenia

🚨 Serious Side Effects

Hepatotoxicity
pancreatitis
hyperammonemic encephalopathy
teratogenicity
bone marrow suppression
Stevens-Johnson syndrome

⚠️ Rare Side Effects

Fanconi syndrome
polycystic ovary syndrome
hypothyroidism
vasculitis
lupus-like syndrome

Consult your doctor if you experience any unusual symptoms.

🔬 Drug Interactions

Drug Severity Effect
Carbamazepine Major Decreased valproate levels; increased carbamazepine toxicity
Lamotrigine Major Increased lamotrigine levels; risk of Stevens-Johnson syndrome
Phenytoin Major Altered phenytoin levels; increased valproate toxicity
Phenobarbital Major Increased phenobarbital levels; sedation
Rifampin Major Decreased valproate levels
Topiramate Major Increased risk of hyperammonemia
Warfarin Major Increased bleeding risk
Aspirin Moderate Increased valproate levels; bleeding risk
Cimetidine Moderate Increased valproate levels
Erythromycin Moderate Increased valproate levels
Felbamate Moderate Increased valproate levels
Fluoxetine Moderate Increased valproate levels
Ibuprofen Moderate Increased valproate levels; bleeding risk
Olanzapine Moderate Increased valproate levels
Risperidone Moderate Increased valproate levels
Tricyclic antidepressants Moderate Increased CNS depression
Acetaminophen Minor Possible increased hepatotoxicity
Antacids Minor Decreased valproate absorption
Cholestyramine Minor Decreased valproate absorption
Oral contraceptives Minor Decreased contraceptive efficacy

🚨 Major Interactions

  • Carbamazepine
  • Lamotrigine
  • Phenytoin
  • Phenobarbital
  • Rifampin
  • Topiramate
  • Warfarin

⚡ Moderate Interactions

  • Aspirin
  • Cimetidine
  • Erythromycin
  • Felbamate
  • Fluoxetine
  • Ibuprofen
  • Olanzapine
  • Risperidone
  • Tricyclic antidepressants

🍷 Alcohol Interaction

Avoid alcohol; increases CNS depression and hepatotoxicity risk.

🛡️ Safety & Warnings

🚫 Contraindications

Hypersensitivity, hepatic disease, urea cycle disorders, mitochondrial disorders, porphyria, pregnancy (for migraine prophylaxis).

🤱 Lactation Safety

Excreted in breast milk; caution advised (risk of hepatotoxicity in infant).

💊 Overdose Management

Supportive care; activated charcoal if early; hemodialysis may be effective; monitor for CNS depression, respiratory depression, and hepatic failure.

⏰ Missed Dose

Take as soon as remembered unless near next dose; do not double dose.

🔄 Substitutes for brisval 250mg tablet er

View All

Alternative brands with exact same active ingredient:

Medical Note: Always consult your doctor before switching medications.

😊 Was this information helpful?

Browse Medicines A-Z

A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
Back to Medicines Directory