bretolap tablet

4.3 (6 reviews)

Lapatinib (250mg)

🏭 Alkem Laboratories Ltd 📦 Varies by brand 💊 Allopathy 📅 Updated: Aug 22, 2026

⚠️ Hepatotoxicity Risk 📋 Prescription Required 💊 Generic Available

Medically Reviewed

SaathiMed Expert Panel | Aug 22, 2026

What is bretolap tablet used for?

Bretolap Tablet (Lapatinib) is used to treat ANTI NEOPLASTICS. It contains Lapatinib (250mg), which Reversible tyrosine kinase inhibitor that inhibits both epidermal growth factor . Always consult your doctor before use. Take as prescribed.

Generic Name: Lapatinib
Manufacturer: Alkem Laboratories Ltd
Form: Allopathy
Pregnancy Category: A
Prescription Required: Yes

💡 Did You Know? India has the highest number of USFDA-compliant plants outside the USA.

💊 bretolap tablet Uses & Benefits

Advanced or metastatic breast cancer with HER2 overexpression, in combination with capecitabine or letrozole.

Off-label uses: Non-small cell lung cancer, Head and neck cancer, Esophageal cancer

📋 Drug Information

Generic Name(s)	Lapatinib
Brand Name	Bretolap Tablet
Manufacturer	Alkem Laboratories Ltd
Packaging / Form	Varies by brand (Allopathy)
Therapeutic Class	ANTI NEOPLASTICS
Action Class	Tyrosine kinase inhibitors
Route of Administration	Oral
Storage	Store at 20-25°C (68-77°F); protect from moisture.
Shelf Life	As per manufacturer

🔬 Pharmacology (PK/PD)

Pharmacokinetics

AbsorptionIncomplete and variable oral absorption; absorption is increased with food.

DistributionExtensively distributed into tissues; crosses the blood-brain barrier to a limited extent.

Protein Binding>99% bound to albumin and alpha-1 acid glycoprotein.

MetabolismExtensively metabolized in the liver, primarily by CYP3A4 and CYP3A5, with minor contribution from CYP2C8.

Half-LifeApproximately 24 hours (range 11-45 hours).

ExcretionPrimarily eliminated in feces (about 90%) as metabolites; less than 2% excreted unchanged in urine.

BioavailabilityNot well defined; oral bioavailability is variable and incomplete.

Onset of ActionNot well defined; therapeutic effects may take several weeks.

Peak Plasma TimeApproximately 4-6 hours after oral administration.

Duration of ActionNot well defined; sustained inhibition of EGFR and ErbB2 pathways.

How It Works

Reversible tyrosine kinase inhibitor that inhibits both epidermal growth factor receptor (EGFR/ErbB1) and human epidermal growth factor receptor 2 (ErbB2/HER2).

Mechanism Steps

1Lapatinib binds reversibly to the ATP-binding site of EGFR and HER2 tyrosine kinases.

2Inhibits autophosphorylation and downstream signaling pathways (MAPK, PI3K/Akt).

3Blocks cell cycle progression at G1/S phase.

💡 How to Take bretolap tablet

Follow your doctor's prescription exactly.

⚠️ Side Effects of bretolap tablet

✅ Common Side Effects

Diarrhea
Nausea
Vomiting
Fatigue
Rash
Anorexia

🚨 Serious Side Effects

Hepatotoxicity
Cardiotoxicity (LVEF decline)
QT prolongation
Interstitial lung disease
Severe diarrhea

⚠️ Rare Side Effects

Stevens-Johnson syndrome
Angioedema
Pancreatitis
Pulmonary embolism

Consult your doctor if you experience any unusual symptoms.

🔬 Drug Interactions

⚠️ Drug	Severity	Effect
Ketoconazole	Major	Increased lapatinib exposure
Carbamazepine	Major	Decreased lapatinib exposure
Warfarin	Moderate	Increased INR

🚨 Major Interactions

CYP3A4 inducers
CYP3A4 inhibitors
P-glycoprotein inhibitors
Grapefruit juice

⚡ Moderate Interactions

Antacids
H2 receptor antagonists
Proton pump inhibitors

ℹ️ Minor Interactions

Substrates of CYP3A4
Substrates of P-glycoprotein

🍽️ Food Interactions

High-fat meals increase absorption; avoid grapefruit juice.

🍷 Alcohol Interaction

No specific interaction reported; caution due to hepatotoxicity risk.

🛡️ Safety & Warnings

🚫 Contraindications

Hypersensitivity to lapatinib, severe hepatic impairment, pregnancy.

📊 Monitoring Parameters

Liver function tests, cardiac function (LVEF), ECG for QT interval, diarrhea, and skin reactions.

🤱 Lactation Safety

Not recommended; excreted in breast milk in animal studies.

💊 Overdose Management

No specific antidote; symptomatic and supportive care; monitor for QT prolongation.

⏰ Missed Dose

If a dose is missed, take it as soon as remembered unless it is less than 12 hours until the next dose; do not double dose.

👨‍⚕️ Reviewed by Expert

SaathiMed Expert Panel

MD, PhD - Pharmacology

Last reviewed on: Aug 22, 2026

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🔄 Substitutes for bretolap tablet

View All

Alternative brands with exact same active ingredient (Lapatinib (250mg)):

Medical Note: Always consult your doctor before switching medications.

⭐ User Reviews

Happy Patient Jul 10, 2026

Helpful and effective medicine as per my experience. Always consult a doctor.

Trusted Reviewer Jul 10, 2026

This medicine was effective for me. I followed the doctor's advice.

Regular Customer Jul 10, 2026