Bisgram Tablet: Complete Medicine Guide
Clinical Reference Standards: CDSCO (Central Drugs Standard Control Organisation), Indian Pharmacopoeia (IP) & WHO | Last Updated: September 2026
When to Call Your Doctor IMMEDIATELY
- Blood in vomit or black, tarry stools (not due to medicine)
- Severe abdominal pain or persistent vomiting
- Swelling of face, lips, or throat, or difficulty breathing
- Confusion, muscle twitching, or seizures
- Decreased urine output or swelling in legs
- Severe skin rash with blisters or peeling
If experiencing severe symptoms, call emergency services immediately.
What is bisthera tablet used for?
This medicine contains colloidal bismuth subcitrate, which treats peptic ulcers by forming a protective coating over the stomach lining and fighting Helicobacter pylori bacteria. It is taken orally, usually four times a day with meals.
- Generic Name: Colloidal bismuth subcitrate (120mg)
- Manufacturer: Enactis Healthcare Pvt Ltd
- Form: Allopathy
- Pregnancy Category: Consult doctor
- Prescription Required: Yes
🇮🇳 bisthera tablet के बारे में (Hindi Summary)
उपयोग: यह दवा पेट और आंतों के अल्सर, गैस्ट्राइटिस और अपच के इलाज में उपयोग की जाती है। यह पेट की परत पर एक सुरक्षात्मक परत बनाती है और हेलिकोबैक्टर पाइलोरी बैक्टीरिया को मारती है।
साइड इफेक्ट्स: आम दुष्प्रभावों में जीभ और मल का काला होना, मतली, कब्ज या दस्त शामिल हैं। गंभीर दुष्प्रभाव दुर्लभ हैं लेकिन एलर्जी, भ्रम या दौरे पड़ सकते हैं।
सुरक्षा सलाह: इस दवा को डॉक्टर के निर्देशानुसार ही लें। खाने के साथ लें। एंटासिड या दूध के साथ न लें। गुर्दे की बीमारी में सावधानी बरतें।
💊 bisthera tablet Uses & Benefits
- [{"condition":"Peptic ulcer disease","description":"Helps heal gastric and duodenal ulcers by protecting the ulcer surface and eradicating Helicobacter pylori when used in combination.","evidence":"Well-established"},{"condition":"Gastritis","description":"Provides symptomatic relief in chronic gastritis by forming a protective barrier over inflamed mucosa.","evidence":"Well-established"},{"condition":"Non-ulcer dyspepsia","description":"May reduce symptoms of indigestion such as upper abdominal pain and discomfort.","evidence":"Moderate"},{"condition":"Helicobacter pylori eradication","description":"Used as part of quadruple therapy to eradicate H.
- pylori infection in combination with antibiotics and acid suppressants.","evidence":"Well-established"}]
Off-label uses: [{"condition":"Traveler's diarrhoea","description":"Sometimes used off-label for symptomatic relief, but evidence is limited.","evidence":"Limited"},{"condition":"Halitosis","description":"Occasionally used for bad breath due to its antibacterial action, but not a standard indication.","evidence":"Insufficient"}]
Primary treatment for: Peptic ulcer disease
Also treats: Gastritis, Non-ulcer dyspepsia, Helicobacter pylori infection
📋 Drug Information
| Generic Name(s) | Colloidal bismuth subcitrate (120mg) |
| Brand Name | bisthera tablet |
| Manufacturer | Enactis Healthcare Pvt Ltd |
| Packaging / Form | Varies by brand (Allopathy) |
| Therapeutic Class | GASTRO INTESTINAL |
| Action Class | |
| Route of Administration | Oral |
| Storage | Store at room temperature (15-30°C) in a dry place, away from direct sunlight. |
| Shelf Life | 24 months from the date of manufacture. |
| WHO Guideline | Not established from the available information. |
| ICMR Guideline | Not established from the available information. |
👨⚕️ Doctor's Practical Tips
Evidence-based practical advice from experienced clinicians
🔍 Is This Medicine Right for Your Symptom?
Educational reference. Always consult a doctor for diagnosis.
🔬 How This Medicine Works (Pharmacology)
Pharmacokinetics
How It Works
This medicine works locally in the stomach. Colloidal bismuth subcitrate forms a protective coating over ulcer craters and inflamed mucosa, shielding them from acid and pepsin. It also inhibits the activity of pepsin and increases mucus and bicarbonate secretion. Additionally, it has direct antibacterial activity against Helicobacter pylori, disrupting its cell wall and inhibiting its adhesion to the gastric epithelium.
Mechanism Steps
💡 How to Take bisthera tablet
Strength: Tablet, 120 mg
Dosage Information
| Adult Dosage | The usual adult dose is one 120 mg tablet taken orally four times a day, or as prescribed by your doctor. For Helicobacter pylori eradication, it is used in combination with antibiotics and a proton pump inhibitor. Dose must be individualized by a qualified clinician based on indication, age, weight, renal and hepatic function. |
| Pediatric Dosage | Pediatric dosing is not established from available information. Consult a pediatrician. |
| Elderly Dosage | Elderly patients may be more susceptible to side effects, especially renal impairment. Dose adjustment may be necessary based on kidney function. Consult a doctor. |
| Renal Impairment | Use with caution in patients with renal impairment. Dose reduction or avoidance may be necessary. Consult a doctor for individualized dosing. |
| Hepatic Impairment | No specific dose adjustment recommended for hepatic impairment, but consult a doctor. |
| Maximum Daily Dose | The maximum recommended daily dose is 480 mg (four 120 mg tablets) for adults, but should not exceed the prescribed amount. |
Dosage Timeline
🍽️ Food Timing Guide
⏰ What to Do If You Miss a Dose
⚠️ Side Effects of bisthera tablet
✅ Common Side Effects
🚨 Serious Side Effects
⚠️ Rare Side Effects
Consult your doctor if you experience any unusual symptoms.
🔬 Drug Interactions
| Drug | Severity | Effect |
|---|---|---|
| Tetracycline | Major | |
| Ciprofloxacin | Major | |
| Antacids | Moderate | |
| Milk | Moderate |
🚨 Major Interactions
- Tetracycline antibiotics
- Quinolone antibiotics (e.g., ciprofloxacin)
⚡ Moderate Interactions
- Antacids
- Milk and dairy products
🍷 Alcohol Interaction
Alcohol may worsen stomach irritation and increase the risk of gastrointestinal side effects. It is advisable to avoid alcohol while taking this medicine.
🔎 Check Your Other Medicines
Educational tool. Always confirm with your doctor or pharmacist.
🛡️ Safety & Warnings
🚫 Contraindications
["Severe renal impairment","Hypersensitivity to bismuth salts","Pregnancy (unless clearly needed)","Breastfeeding (unless clearly needed)"]
⚠️ Warnings & Precautions
["Do not exceed the recommended dose or duration of treatment.","Avoid concurrent use with antacids, milk, or tetracyclines.","May cause black tongue and stool, which are harmless.","Use with caution in elderly patients and those with renal impairment.","Consult a doctor if symptoms persist or worsen."]
🤱 Lactation Safety
It is not known whether bismuth is excreted in human breast milk. Consult your doctor before using this medicine while breastfeeding.
💊 Overdose Management
Overdose may cause nausea, vomiting, and potentially bismuth encephalopathy. Treatment is supportive and symptomatic. Gastric lavage may be considered if ingestion is recent. Haemodialysis may be considered in severe cases with renal failure. Seek immediate medical attention.
⏰ Missed Dose
If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and continue with your regular schedule. Do not double the dose to catch up.
Additional Safety Advice
Take this medicine exactly as prescribed by your doctor. Do not exceed the recommended dose or duration of treatment. Swallow the tablet whole with a glass of water, preferably with meals. Avoid taking antacids or other medicines within two hours of this medicine, as they may reduce its effectiveness. Do not use this medicine for more than two months without medical advice. If you are pregnant, planning pregnancy, or breastfeeding, consult your doctor before use. Keep out of reach of children. Store in a cool, dry place away from direct sunlight.
👴 Special Considerations for Elderly
💡 For Patients Above 65
Elderly patients are at higher risk of bismuth accumulation and renal impairment. Use with caution and monitor renal function and neurological status regularly.
🤰 Pregnancy Planning (TTC)
Consult your doctor before planning pregnancy if you are taking this medicine. Safety in pregnancy is not well established.
🏥 Post-Surgery Considerations
Consult your surgeon before resuming this medicine after surgery, especially if you have had gastrointestinal surgery.
🦷 Dental Procedures
Inform your dentist if you are taking this medicine, as it may cause black tongue which could be mistaken for other conditions.
💚 Lifestyle Tips for Better Results
🏋️ Exercise Considerations
Moderate exercise is generally safe, but avoid strenuous activities if you experience dizziness or fatigue. Consult your doctor before starting any new exercise regimen.
🥗 Diet Recommendations
💼 Impact on Daily Work & Life
This medicine may cause dizziness in some people. If affected, avoid driving or operating heavy machinery until you know how it affects you. Otherwise, it should not significantly impact daily activities.
🛑 When to Stop This Medicine
Stop this medicine if you experience severe allergic reactions, neurological symptoms, or as advised by your doctor. Do not stop abruptly without consulting your doctor if you are on a prescribed course.
📅 Long-Term Use Effects
Long-term use of high doses can lead to bismuth accumulation and potential neurotoxicity. Regular monitoring of renal function and neurological symptoms is advised if prolonged use is necessary. Do not use for more than 2 months without medical supervision.
🌿 Non-Medicine Approaches
These can complement medicine but do not replace prescribed treatment.
Reduce stomach acid and promote ulcer healing.
Evidence: Well-establishedReduce acid secretion and provide symptom relief.
Evidence: Well-establishedDiet changes and stress reduction can complement medical therapy.
Evidence: Moderate💉 Vaccination Considerations
💉 If You're Getting Vaccinated
No specific vaccine interactions reported. Continue routine vaccinations as per schedule.
📦 Storage Guide
✅ DO
Store at room temperature (15-30°C)
❌ DON'T
Do not refrigerate
✅ DO
Keep in original container
❌ DON'T
Do not transfer to unmarked containers
✅ DO
Keep away from direct sunlight
❌ DON'T
Do not store in bathroom cabinet
✈️ Traveling with This Medicine
Carry this medicine in its original packaging with a copy of your prescription. Store at room temperature and protect from direct sunlight. If travelling across time zones, adjust dosing times gradually to maintain consistent intervals. Check customs regulations for carrying prescription medicines.
💰 Cost Analysis & Savings
👥 Real Patient Stories
Educational, anonymized scenarios. Individual results may vary.
💬 Questions Patients Often Ask
A: This medicine starts forming a protective coating within 30-60 minutes, but noticeable symptom relief may take a few days.
A: It can interact with certain antibiotics and antacids. Always inform your doctor about all medicines you take.
A: Consult your doctor before use, as safety is not well established.
🤔 Common Patient Concerns
🔄 Substitutes for bisthera tablet
View AllAlternative brands with exact same active ingredient:
-
pylobis tabletSan Fegan Biotech Pvt Ltd ₹180.00 5.3% CHEAPER
-
bistas tabletWaterley Pharmaceuticals Pvt Ltd ₹206.20 8.5% COSTLIER
-
bisgram tabletIngram Biosciences Pvt Ltd ₹215.60 13.5% COSTLIER
Medical Note: Always consult your doctor before switching medications.
🛑 Myths vs. Facts
- Myth: Colloidal bismuth subcitrate is an antibiotic.
Fact: It is not a conventional antibiotic, but it has antibacterial activity against H. pylori. - Myth: Black stool means internal bleeding.
Fact: Black stool from this medicine is harmless and due to bismuth sulfide formation, not bleeding.
🔄 Alternative Options
Generic Alternatives
- Colloidal bismuth subcitrate 120 mg tablet
Brand Alternatives
- Bisgram tablet