alkeprost 500mg tablet - Uses, Price, Side Effects & Substitutes
What is alkeprost 500mg tablet used for?
Abirapro 250mg Tablet (Abiraterone Acetate) is used to treat ANTI NEOPLASTICS. It contains Abiraterone Acetate (500mg), which Selectively inhibits CYP17A1 (17ฮฑ-hydroxylase/C17,20-lyase) in the adrenal glan. Always consult your doctor before use. Take as prescribed.
- Generic Name: Abiraterone Acetate
- Manufacturer: Alkem Laboratories Ltd
- Form: Allopathy
- Pregnancy Category: A
- Prescription Required: Yes
๐ alkeprost 500mg tablet Uses & Benefits
Metastatic castration-resistant prostate cancer (mCRPC) in combination with prednisone; metastatic high-risk castration-sensitive prostate cancer (mCSPC).
Off-label uses: Breast cancer, Ovarian cancer
๐ Drug Information
| Generic Name(s) | Abiraterone Acetate |
| Brand Name | Abirapro 250mg Tablet |
| Manufacturer | Alkem Laboratories Ltd |
| Packaging / Form | Varies by brand (Allopathy) |
| Therapeutic Class | ANTI NEOPLASTICS |
| Action Class | Anticancer-others |
| Route of Administration | Oral |
| Storage | Store at 20-25ยฐC (68-77ยฐF); protect from moisture and light. |
| Shelf Life | As per manufacturer |
๐ฌ Pharmacology (PK/PD)
Pharmacokinetics
How It Works
Selectively inhibits CYP17A1 (17ฮฑ-hydroxylase/C17,20-lyase) in the adrenal glands and prostate cancer cells, blocking androgen synthesis.
Mechanism Steps
๐ก How to Take alkeprost 500mg tablet
Follow your doctor's prescription exactly.
โ ๏ธ Side Effects of alkeprost 500mg tablet
โ Common Side Effects
- Fatigue
- Joint swelling/discomfort
- Hot flush
- Diarrhea
- Hypertension
- Hypokalemia
- Edema
๐จ Serious Side Effects
- Hepatotoxicity
- Adrenal insufficiency
- Cardiovascular events (MI, stroke)
- QT prolongation
- Hypoglycemia
โ ๏ธ Rare Side Effects
- Interstitial lung disease
- Rhabdomyolysis
- Anaphylaxis
Consult your doctor if you experience any unusual symptoms.
๐ฌ Drug Interactions
| โ ๏ธ Drug | Severity | Effect |
|---|---|---|
| CYP3A4 Inducers (e.g., rifampin) | Major | Decreased abiraterone exposure |
| CYP3A4 Inhibitors (e.g., ketoconazole) | Major | Increased abiraterone exposure |
| QT-prolonging agents (e.g., amiodarone) | Major | Increased risk of torsades de pointes |
| Warfarin | Moderate | Increased INR and bleeding risk |
| Dextromethorphan | Moderate | Increased dextromethorphan levels |
| Theophylline | Moderate | Increased theophylline levels |
| Grapefruit juice | Minor | Mild increase in abiraterone levels |
| St. John's Wort | Minor | Decreased abiraterone levels |
๐จ Major Interactions
- CYP3A4 Inducers
- CYP3A4 Inhibitors
- QT-prolonging agents
โก Moderate Interactions
- Warfarin
- Dextromethorphan
- Theophylline
โน๏ธ Minor Interactions
- Grapefruit juice
- St. John's Wort
๐ฝ๏ธ Food Interactions
High-fat meals increase absorption; take on an empty stomach at least 1 hour before or 2 hours after a meal.
๐ท Alcohol Interaction
No specific interaction; avoid excessive alcohol due to hepatotoxicity risk.
๐ก๏ธ Safety & Warnings
๐ซ Contraindications
Pregnancy, severe hepatic impairment (Child-Pugh C), hypersensitivity to abiraterone.
๐ Monitoring Parameters
Serum PSA, LFTs (ALT, AST, bilirubin), serum potassium, blood pressure, serum cortisol (if symptoms of adrenal insufficiency).
๐คฑ Lactation Safety
Not recommended; discontinue breastfeeding during treatment.
๐ Overdose Management
No specific antidote; supportive care including monitoring of electrolytes, liver function, and cardiac status.
โฐ Missed Dose
If missed, take as soon as remembered; do not double dose. If >12 hours, skip dose.
๐จโโ๏ธ Reviewed by Expert
๐ Substitutes for alkeprost 500mg tablet
View AllAlternative brands with exact same active ingredient (Abiraterone Acetate (500mg)):
-
mytera 500 tabletMylan Pharmaceuticals Pvt Ltd โน17,990.00 47.6% COSTLIER
-
abura 500 tabletMSN Laboratories โน18,750.00 53.8% COSTLIER
-
xbira 500 tabletCipla Ltd โน20,000.00 64.1% COSTLIER
-
bdron 500 tabletBDR Pharmaceuticals Internationals Pvt โน20,250.00 66.2% COSTLIER
-
zelgor 500mg tabletSun Pharmaceutical Industries Ltd โน22,500.00 84.6% COSTLIER
-
zabpro 500mg tabletIpca Laboratories Ltd โน24,000.00 96.9% COSTLIER
-
abione 500 tabletIntas Pharmaceuticals Ltd โน25,968.75 113.1% COSTLIER
-
abirapro 500mg tabletGlenmark Pharmaceuticals Ltd โน26,250.00 115.4% COSTLIER
-
zecyte 500mg tabletCipla Ltd โน29,500.00 142.1% COSTLIER
-
zybiraa 500 tabletZydus Cadila โน29,980.00 146% COSTLIER
Medical Note: Always consult your doctor before switching medications.