alkeprost 500mg tablet

4.5 (14 reviews)

Abiraterone Acetate (500mg)

🏭 Alkem Laboratories Ltd 📦 Varies by brand 💊 Allopathy 📅 Updated: Aug 21, 2026

⚠️ Hepatotoxicity Risk 📋 Prescription Required 💊 Generic Available

Medically Reviewed

SaathiMed Expert Panel | Aug 21, 2026

What is alkeprost 500mg tablet used for?

Abirapro 250mg Tablet (Abiraterone Acetate) is used to treat ANTI NEOPLASTICS. It contains Abiraterone Acetate (500mg), which Selectively inhibits CYP17A1 (17α-hydroxylase/C17,20-lyase) in the adrenal glan. Always consult your doctor before use. Take as prescribed.

Generic Name: Abiraterone Acetate
Manufacturer: Alkem Laboratories Ltd
Form: Allopathy
Pregnancy Category: A
Prescription Required: Yes

💡 Did You Know? India is the largest provider of generic medicines globally, supplying over 50% of global vaccine demand.

💊 alkeprost 500mg tablet Uses & Benefits

Metastatic castration-resistant prostate cancer (mCRPC) in combination with prednisone; metastatic high-risk castration-sensitive prostate cancer (mCSPC).

Off-label uses: Breast cancer, Ovarian cancer

📋 Drug Information

Generic Name(s)	Abiraterone Acetate
Brand Name	Abirapro 250mg Tablet
Manufacturer	Alkem Laboratories Ltd
Packaging / Form	Varies by brand (Allopathy)
Therapeutic Class	ANTI NEOPLASTICS
Action Class	Anticancer-others
Route of Administration	Oral
Storage	Store at 20-25°C (68-77°F); protect from moisture and light.
Shelf Life	As per manufacturer

🔬 Pharmacology (PK/PD)

Pharmacokinetics

AbsorptionAbsorbed orally; food increases absorption significantly (up to 10-fold).

DistributionHighly protein bound; distributes extensively into tissues.

Protein Binding>99% bound to plasma proteins (albumin and alpha-1 acid glycoprotein).

MetabolismMetabolized primarily by CYP3A4 and SULT2A1 to active metabolite abiraterone.

Half-LifeApproximately 12 hours (abiraterone).

ExcretionFecal (88%) and renal (5%) as metabolites.

BioavailabilityUnknown; food increases AUC by 10-fold.

Onset of ActionWithin 2-4 weeks for PSA decline.

Peak Plasma Time2 hours (fasted); 4-6 hours (fed).

Duration of ActionContinuous with daily dosing.

How It Works

Selectively inhibits CYP17A1 (17α-hydroxylase/C17,20-lyase) in the adrenal glands and prostate cancer cells, blocking androgen synthesis.

Mechanism Steps

1Abiraterone acetate is hydrolyzed to abiraterone in the body.

2Abiraterone selectively and irreversibly inhibits CYP17A1 (17α-hydroxylase/C17,20-lyase).

3Inhibition of 17α-hydroxylase blocks conversion of pregnenolone to 17α-hydroxypregnenolone.

💡 How to Take alkeprost 500mg tablet

Follow your doctor's prescription exactly.

⚠️ Side Effects of alkeprost 500mg tablet

✅ Common Side Effects

Fatigue
Joint swelling/discomfort
Hot flush
Diarrhea
Hypertension
Hypokalemia
Edema

🚨 Serious Side Effects

Hepatotoxicity
Adrenal insufficiency
Cardiovascular events (MI, stroke)
QT prolongation
Hypoglycemia

⚠️ Rare Side Effects

Interstitial lung disease
Rhabdomyolysis
Anaphylaxis

Consult your doctor if you experience any unusual symptoms.

🔬 Drug Interactions

⚠️ Drug	Severity	Effect
CYP3A4 Inducers (e.g., rifampin)	Major	Decreased abiraterone exposure
CYP3A4 Inhibitors (e.g., ketoconazole)	Major	Increased abiraterone exposure
QT-prolonging agents (e.g., amiodarone)	Major	Increased risk of torsades de pointes
Warfarin	Moderate	Increased INR and bleeding risk
Dextromethorphan	Moderate	Increased dextromethorphan levels
Theophylline	Moderate	Increased theophylline levels
Grapefruit juice	Minor	Mild increase in abiraterone levels
St. John's Wort	Minor	Decreased abiraterone levels

🚨 Major Interactions

CYP3A4 Inducers
CYP3A4 Inhibitors
QT-prolonging agents

⚡ Moderate Interactions

Warfarin
Dextromethorphan
Theophylline

ℹ️ Minor Interactions

Grapefruit juice
St. John's Wort

🍽️ Food Interactions

High-fat meals increase absorption; take on an empty stomach at least 1 hour before or 2 hours after a meal.

🍷 Alcohol Interaction

No specific interaction; avoid excessive alcohol due to hepatotoxicity risk.

🛡️ Safety & Warnings

🚫 Contraindications

Pregnancy, severe hepatic impairment (Child-Pugh C), hypersensitivity to abiraterone.

📊 Monitoring Parameters

Serum PSA, LFTs (ALT, AST, bilirubin), serum potassium, blood pressure, serum cortisol (if symptoms of adrenal insufficiency).

🤱 Lactation Safety

Not recommended; discontinue breastfeeding during treatment.

💊 Overdose Management

No specific antidote; supportive care including monitoring of electrolytes, liver function, and cardiac status.

⏰ Missed Dose

If missed, take as soon as remembered; do not double dose. If >12 hours, skip dose.

👨‍⚕️ Reviewed by Expert

SaathiMed Expert Panel

MD, PhD - Pharmacology

Last reviewed on: Aug 21, 2026

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🔄 Substitutes for alkeprost 500mg tablet

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Alternative brands with exact same active ingredient (Abiraterone Acetate (500mg)):

Medical Note: Always consult your doctor before switching medications.

⭐ User Reviews

Regular Customer Jul 10, 2026

Good quality medicine. Satisfied with the outcome.