biohist syrup - Chlorpheniramine Maleate (2.5mg) + Ammonium Chloride (125mg) medicine

biohist syrup - Uses, Price, Side Effects & Substitutes

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๐Ÿญ Antigen Healthcare P. Ltd ๐Ÿ“ฆ Varies by brand ๐Ÿ’Š Allopathy ๐Ÿ“… Updated: Jun 27, 2026
๐Ÿ“‹ Prescription Required ๐Ÿ’Š Generic Available
Medically Reviewed
Dr. SaathiMed Expert Panel | Jun 27, 2026

What is biohist syrup used for?

Avicof Syrup (Chlorpheniramine Maleate + Ammonium Chloride) is used to treat RESPIRATORY. It contains Chlorpheniramine Maleate (2.5mg) + Ammonium Chloride (125mg), which Chlorpheniramine: H1-receptor antagonist; Ammonium Chloride: increases bronchial. Always consult your doctor before use. Take as prescribed.

  • Generic Name: Chlorpheniramine Maleate + Ammonium Chloride
  • Manufacturer: Antigen Healthcare P. Ltd
  • Form: Allopathy
  • Pregnancy Category: C
  • Prescription Required: Yes
๐Ÿ’ก Did You Know? The Indian pharmaceutical market is expected to reach $130 billion by 2030.

๐Ÿ’Š biohist syrup Uses & Benefits

Allergic rhinitis, common cold, cough with thick mucus

Off-label uses: Urticaria, pruritus

๐Ÿ“‹ Drug Information

Generic Name(s)Chlorpheniramine Maleate + Ammonium Chloride
Brand NameAvicof Syrup
ManufacturerAntigen Healthcare P. Ltd
Packaging / FormVaries by brand (Allopathy)
Therapeutic ClassRESPIRATORY
Action ClassAntihistamine + Expectorant
Route of AdministrationOral
StorageStore at room temperature (20-25ยฐC), protect from light
Shelf LifeAs per manufacturer

๐Ÿ”ฌ Pharmacology (PK/PD)

Pharmacokinetics

AbsorptionWell absorbed from gastrointestinal tract
DistributionDistributed throughout body; crosses blood-brain barrier
Protein BindingChlorpheniramine: ~72% bound to plasma proteins
MetabolismHepatic metabolism via CYP450 enzymes
Half-LifeChlorpheniramine: 12-15 hours; Ammonium Chloride: variable
ExcretionRenal excretion of metabolites and unchanged drug
BioavailabilityChlorpheniramine: ~25-50% (oral)
Onset of ActionChlorpheniramine: 30-60 minutes
Peak Plasma TimeChlorpheniramine: 2-6 hours
Duration of ActionChlorpheniramine: 4-6 hours

How It Works

Chlorpheniramine: H1-receptor antagonist; Ammonium Chloride: increases bronchial secretions and reduces mucus viscosity

Mechanism Steps

1Chlorpheniramine competitively blocks histamine at H1 receptors, preventing histamine-mediated symptoms.
2Ammonium Chloride irritates gastric mucosa, reflexively increasing bronchial secretions and reducing mucus viscosity.

๐Ÿ’ก How to Take biohist syrup

Follow your doctor's prescription exactly.

โš ๏ธ Side Effects of biohist syrup

โœ… Common Side Effects

  • Drowsiness
  • Dry mouth
  • Dizziness
  • Nausea
  • Thickened bronchial secretions

๐Ÿšจ Serious Side Effects

  • Severe allergic reaction
  • Respiratory depression
  • Urinary retention
  • Blurred vision

โš ๏ธ Rare Side Effects

  • Blood dyscrasias
  • Hypotension
  • Tachycardia

Consult your doctor if you experience any unusual symptoms.

๐Ÿ”ฌ Drug Interactions

โš ๏ธ DrugSeverityEffect
MAOIs Major Increased anticholinergic and CNS depressant effects
CNS depressants Major Additive sedation
Alcohol Major Enhanced CNS depression
Anticholinergics Moderate Additive anticholinergic effects
Tricyclic antidepressants Moderate Increased anticholinergic effects
Antihypertensives Minor Possible reduced antihypertensive effect

๐Ÿšจ Major Interactions

  • MAOIs
  • CNS depressants
  • Alcohol

โšก Moderate Interactions

  • Anticholinergics
  • Tricyclic antidepressants

โ„น๏ธ Minor Interactions

  • Antihypertensives

๐Ÿฝ๏ธ Food Interactions

No significant food interactions

๐Ÿท Alcohol Interaction

Enhanced CNS depression

๐Ÿ›ก๏ธ Safety & Warnings

๐Ÿšซ Contraindications

Hypersensitivity, severe hypertension, coronary artery disease, MAOI use, narrow-angle glaucoma, urinary retention, asthma attack

๐Ÿ“Š Monitoring Parameters

CNS depression, anticholinergic effects, respiratory status

๐Ÿคฑ Lactation Safety

Caution; small amounts excreted in breast milk

๐Ÿ’Š Overdose Management

Gastric lavage, activated charcoal, symptomatic and supportive treatment

โฐ Missed Dose

Take as soon as remembered; skip if near next dose; do not double dose

๐Ÿ‘จโ€โš•๏ธ Reviewed by Expert

Dr. SaathiMed Expert Panel

MD, PhD - Pharmacology

Reviewed: Jun 27, 2026

๐Ÿ”— View Profile

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