biocof- d syrup - Bromhexine (4mg) + Dextromethorphan Hydrobromide (5mg) medicine

biocof- d syrup - Uses, Price, Side Effects & Substitutes

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๐Ÿญ Biochem Pharmaceutical Industries ๐Ÿ“ฆ Varies by brand ๐Ÿ’Š Allopathy ๐Ÿ“… Updated: Jun 26, 2026
๐Ÿ“‹ Prescription Required ๐Ÿ’Š Generic Available
Medically Reviewed
Dr. SaathiMed Expert Panel | Jun 26, 2026

What is biocof- d syrup used for?

Ascodex Cough Syrup (Bromhexine + Dextromethorphan Hydrobromide) is used to treat RESPIRATORY. It contains Bromhexine (4mg) + Dextromethorphan Hydrobromide (5mg), which Bromhexine increases respiratory tract secretions and reduces mucus viscosity; D. Always consult your doctor before use. Take as prescribed.

  • Generic Name: Bromhexine + Dextromethorphan Hydrobromide
  • Manufacturer: Biochem Pharmaceutical Industries
  • Form: Allopathy
  • Pregnancy Category: C
  • Prescription Required: Yes
๐Ÿ’ก Did You Know? India is the largest provider of generic medicines globally, supplying over 50% of global vaccine demand.

๐Ÿ’Š biocof- d syrup Uses & Benefits

Productive and non-productive cough associated with respiratory tract infections

Off-label uses: None well-established

๐Ÿ“‹ Drug Information

Generic Name(s)Bromhexine + Dextromethorphan Hydrobromide
Brand NameAscodex Cough Syrup
ManufacturerBiochem Pharmaceutical Industries
Packaging / FormVaries by brand (Allopathy)
Therapeutic ClassRESPIRATORY
Action ClassMucolytic and Antitussive
Route of AdministrationOral
StorageStore at room temperature (15-30ยฐC), protect from light
Shelf LifeAs per manufacturer

๐Ÿ”ฌ Pharmacology (PK/PD)

Pharmacokinetics

AbsorptionRapidly absorbed from gastrointestinal tract
DistributionDistributed widely in body tissues
Protein BindingBromhexine: 99%; Dextromethorphan: 60-70%
MetabolismBromhexine: Hepatic; Dextromethorphan: Hepatic (CYP2D6)
Half-LifeBromhexine: 12 hours; Dextromethorphan: 3-6 hours
ExcretionBromhexine: Renal; Dextromethorphan: Renal
BioavailabilityBromhexine: 75-80%; Dextromethorphan: 11%
Onset of ActionBromhexine: 30 minutes; Dextromethorphan: 15-30 minutes
Peak Plasma TimeBromhexine: 1 hour; Dextromethorphan: 2.5 hours
Duration of ActionBromhexine: 6-8 hours; Dextromethorphan: 4-6 hours

How It Works

Bromhexine increases respiratory tract secretions and reduces mucus viscosity; Dextromethorphan suppresses cough by acting on cough center in medulla oblongata

Mechanism Steps

1Bromhexine stimulates bronchial glands to increase secretion of thin mucus
2Bromhexine breaks down mucopolysaccharides reducing mucus viscosity
3Dextromethorphan binds to NMDA receptors in cough center

๐Ÿ’ก How to Take biocof- d syrup

Follow your doctor's prescription exactly.

โš ๏ธ Side Effects of biocof- d syrup

โœ… Common Side Effects

  • Nausea
  • Vomiting
  • Dizziness
  • Drowsiness
  • Headache

๐Ÿšจ Serious Side Effects

  • Respiratory depression
  • Serotonin syndrome
  • Allergic reactions

โš ๏ธ Rare Side Effects

  • Confusion
  • Hallucinations
  • Urinary retention

Consult your doctor if you experience any unusual symptoms.

๐Ÿ”ฌ Drug Interactions

โš ๏ธ DrugSeverityEffect
MAOIs Major Risk of serotonin syndrome
SSRIs Major Risk of serotonin syndrome
Linezolid Major Risk of serotonin syndrome
Selegiline Major Risk of serotonin syndrome
CNS depressants Moderate Increased sedation
Alcohol Moderate Increased CNS depression
Quinidine Moderate Increased dextromethorphan levels
Amiodarone Moderate Increased dextromethorphan levels
Grapefruit juice Minor Increased dextromethorphan levels
Cimetidine Minor Increased dextromethorphan levels

๐Ÿšจ Major Interactions

  • MAOIs
  • SSRIs
  • Linezolid
  • Selegiline

โšก Moderate Interactions

  • CNS depressants
  • Alcohol
  • Quinidine
  • Amiodarone

โ„น๏ธ Minor Interactions

  • Grapefruit juice
  • Cimetidine

๐Ÿฝ๏ธ Food Interactions

Grapefruit juice may increase dextromethorphan levels

๐Ÿท Alcohol Interaction

Increased CNS depression

๐Ÿ›ก๏ธ Safety & Warnings

๐Ÿšซ Contraindications

Hypersensitivity, concurrent MAOI therapy, asthma, COPD, respiratory depression

๐Ÿ“Š Monitoring Parameters

Cough frequency, sputum characteristics, respiratory status

๐Ÿคฑ Lactation Safety

Use with caution; not recommended

๐Ÿ’Š Overdose Management

Activated charcoal, supportive care, naloxone for respiratory depression

โฐ Missed Dose

Take as soon as remembered; skip if near next dose

๐Ÿ‘จโ€โš•๏ธ Reviewed by Expert

Dr. SaathiMed Expert Panel

MD, PhD - Pharmacology

Reviewed: Jun 26, 2026

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