bigdase dp tablet - Diclofenac (75mg) + Paracetamol (500mg) medicine

bigdase dp tablet

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🏭 BioGold Pharmaceutical Pvt Ltd 📦 Varies by brand 💊 Allopathy 📅 Updated: Sep 25, 2026
📋 Prescription Required 💊 Generic Available
Medically Reviewed
11 min read
Reviewed by
SaathiMed Expert Panel | Sep 25, 2026

What is bigdase dp tablet used for?

This medicine contains Diclofenac (75mg) + Paracetamol (500mg) and is used to treat PAIN ANALGESICS. Diclofenac: Inhibits cyclooxygenase (COX-1 and COX-2), reducing prostaglandin synthesis; Paracetamol. Always consult your doctor before use.

  • Generic Name: Diclofenac + Paracetamol
  • Manufacturer: BioGold Pharmaceutical Pvt Ltd
  • Form: Allopathy
  • Pregnancy Category: Category A
  • Prescription Required: Yes
💡 Did You Know? India is the largest provider of generic medicines globally, supplying over 50% of global vaccine demand.

💊 bigdase dp tablet Uses & Benefits

Management of mild to moderate pain, fever, and inflammation (e.g., headache, dental pain, menstrual cramps, musculoskeletal pain).

Off-label uses: Diclofenac: Topical for actinic keratosis; Paracetamol: None commonly.

📋 Drug Information

Generic Name(s)Diclofenac + Paracetamol
Brand NameAt Sp Tablet
ManufacturerBioGold Pharmaceutical Pvt Ltd
Packaging / FormVaries by brand (Allopathy)
Therapeutic ClassPAIN ANALGESICS
Action ClassNonsteroidal Anti-inflammatory Drug (NSAID) + Analgesic/Antipyretic
Route of AdministrationOral
StorageStore at room temperature (20-25°C), protect from moisture and light.
Shelf LifeAs per manufacturer

🔬 How This Medicine Works (Pharmacology)

Pharmacokinetics

AbsorptionDiclofenac: Rapidly and completely absorbed from GI tract; Paracetamol: Rapidly and almost completely absorbed from GI tract.
DistributionDiclofenac: Highly protein-bound (>99%), distributed to synovial fluid; Paracetamol: Widely distributed, crosses placenta and blood-brain barrier.
Protein BindingDiclofenac: >99%; Paracetamol: 10-25%.
MetabolismDiclofenac: Hepatic via CYP2C9; Paracetamol: Hepatic via conjugation (glucuronidation, sulfation) and CYP2E1 (minor).
Half-LifeDiclofenac: ~2 hours; Paracetamol: ~2-3 hours.
ExcretionDiclofenac: Renal (65%) and biliary (35%); Paracetamol: Renal (90-100% as metabolites).
BioavailabilityDiclofenac: ~50% (oral); Paracetamol: ~88% (oral).
Onset of ActionDiclofenac: 30-60 minutes; Paracetamol: 30-60 minutes.
Peak Plasma TimeDiclofenac: 1-2 hours; Paracetamol: 0.5-2 hours.
Duration of ActionDiclofenac: 4-6 hours; Paracetamol: 4-6 hours.

How It Works

Diclofenac: Inhibits cyclooxygenase (COX-1 and COX-2), reducing prostaglandin synthesis; Paracetamol: Central COX inhibition and activation of descending serotonergic pathways.

Mechanism Steps

1Diclofenac inhibits COX-1 and COX-2 enzymes, reducing conversion of arachidonic acid to prostaglandins.
2Decreased prostaglandins reduce inflammation, pain, and fever.
3Paracetamol primarily inhibits COX-3 in the central nervous system, reducing prostaglandin synthesis.
4Paracetamol also activates descending serotonergic pathways and modulates cannabinoid receptors.
5Combined action provides synergistic analgesic and antipyretic effects.

💡 How to Take bigdase dp tablet

Follow your doctor's prescription exactly.

⚠️ Side Effects of bigdase dp tablet

✅ Common Side Effects

Nausea
Vomiting
Dyspepsia
Abdominal pain
Diarrhea
Constipation
Headache
Dizziness
Rash

🚨 Serious Side Effects

GI bleeding
Peptic ulcer
Hepatotoxicity
Renal failure
Cardiovascular thrombotic events
Stevens-Johnson syndrome
Anaphylaxis

⚠️ Rare Side Effects

Pancreatitis
Hematologic disorders (agranulocytosis, thrombocytopenia)
Interstitial nephritis
Hepatic necrosis
Aseptic meningitis

Consult your doctor if you experience any unusual symptoms.

🔬 Drug Interactions

Drug Severity Effect
Warfarin Major Increased bleeding risk
Methotrexate Major Increased methotrexate toxicity
Lithium Major Increased lithium levels
ACE inhibitors Major Reduced antihypertensive effect
Diuretics Major Reduced diuretic effect, increased nephrotoxicity
Aspirin Major Increased GI bleeding risk
Other NSAIDs Major Additive GI and renal toxicity
Anticoagulants Major Increased bleeding risk
Corticosteroids Moderate Increased GI ulceration risk
SSRIs Moderate Increased bleeding risk
Alcohol Moderate Increased hepatotoxicity and GI bleeding
Cyclosporine Moderate Increased nephrotoxicity
Tacrolimus Moderate Increased nephrotoxicity
Quinolone antibiotics Moderate Increased CNS side effects
Antacids Minor Reduced absorption of diclofenac
Cholestyramine Minor Reduced absorption of diclofenac
Digoxin Minor Increased digoxin levels
Phenytoin Minor Increased phenytoin levels

🚨 Major Interactions

  • Warfarin
  • Methotrexate
  • Lithium
  • ACE inhibitors
  • Diuretics
  • Aspirin
  • Other NSAIDs
  • Anticoagulants

⚡ Moderate Interactions

  • Corticosteroids
  • SSRIs
  • Alcohol
  • Cyclosporine
  • Tacrolimus
  • Quinolone antibiotics

🍷 Alcohol Interaction

Increased risk of hepatotoxicity with chronic alcohol use (paracetamol) and GI bleeding (diclofenac).

🛡️ Safety & Warnings

🚫 Contraindications

Hypersensitivity to diclofenac, paracetamol, or any component; Active peptic ulcer; History of GI bleeding; Severe hepatic or renal impairment; Third trimester of pregnancy; Asthma with NSAID sensitivity; Coronary artery bypass graft surgery.

🤱 Lactation Safety

Diclofenac: Excreted in breast milk in low amounts, generally considered safe; Paracetamol: Excreted

💊 Overdose Management

Paracetamol overdose: Administer N-acetylcysteine; Diclofenac overdose: Supportive care, activated charcoal if recent ingestion.

⏰ Missed Dose

Take as soon as remembered unless near time of next dose; do not double dose.

🔄 Substitutes for bigdase dp tablet

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Alternative brands with exact same active ingredient:

Medical Note: Always consult your doctor before switching medications.

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