bicoba-fc 2500 injection - Folic Acid (0.7mg) + Methylcobalamin (2500mcg) medicine

bicoba-fc 2500 injection

4.5 (18 reviews)
๐Ÿญ Bioclix Remedies ๐Ÿ“ฆ Varies by brand ๐Ÿ’Š Allopathy ๐Ÿ“… Updated: Aug 24, 2026
๐Ÿ“‹ Prescription Required ๐Ÿ’Š Generic Available
Medically Reviewed
SaathiMed Expert Panel | Aug 24, 2026

What is bicoba-fc 2500 injection used for?

Amyvit Plus Injection (Folic Acid + Methylcobalamin) is used to treat VITAMINS MINERALS NUTRIENTS. It contains Folic Acid (0.7mg) + Methylcobalamin (2500mcg), which Folic acid and methylcobalamin are essential cofactors for DNA synthesis, red bl. Always consult your doctor before use. Take as prescribed.

  • Generic Name: Folic Acid + Methylcobalamin
  • Manufacturer: Bioclix Remedies
  • Form: Allopathy
  • Pregnancy Category: A
  • Prescription Required: Yes
๐Ÿ’ก Did You Know? India is the largest provider of generic medicines globally, supplying over 50% of global vaccine demand.

๐Ÿ’Š bicoba-fc 2500 injection Uses & Benefits

Megaloblastic anemia due to folic acid or vitamin B12 deficiency; peripheral neuropathy; hyperhomocysteinemia

Off-label uses: Cognitive decline, depression (adjunct), chronic fatigue syndrome

๐Ÿ“‹ Drug Information

Generic Name(s)Folic Acid + Methylcobalamin
Brand NameAmyvit Plus Injection
ManufacturerBioclix Remedies
Packaging / FormVaries by brand (Allopathy)
Therapeutic ClassVITAMINS MINERALS NUTRIENTS
Action ClassVitamins
Route of AdministrationIntramuscular injection
StorageStore at 20-25ยฐC (68-77ยฐF); protect from light
Shelf LifeAs per manufacturer

๐Ÿ”ฌ Pharmacology (PK/PD)

Pharmacokinetics

AbsorptionRapidly absorbed after intramuscular injection
DistributionWidely distributed in body tissues; crosses placenta and enters breast milk
Protein BindingFolic acid: ~50-60% bound to plasma proteins; Methylcobalamin: highly bound to transcobalamins
MetabolismFolic acid: metabolized in liver to active forms; Methylcobalamin: converted to other cobalamins in tissues
Half-LifeFolic acid: ~0.7 hours; Methylcobalamin: ~6 days (plasma)
ExcretionFolic acid: primarily renal; Methylcobalamin: biliary and renal
Bioavailability100% (intramuscular injection)
Onset of ActionWithin 24-48 hours for hematologic response
Peak Plasma TimeFolic acid: 30-60 minutes; Methylcobalamin: 1-2 hours
Duration of ActionSeveral days to weeks depending on dose and condition

How It Works

Folic acid and methylcobalamin are essential cofactors for DNA synthesis, red blood cell formation, and neurological function.

Mechanism Steps

1Folic acid is reduced to dihydrofolate (DHF) then to tetrahydrofolate (THF) by dihydrofolate reductase.
2THF acts as a cofactor for one-carbon transfer reactions in purine and pyrimidine synthesis.
3Methylcobalamin is a cofactor for methionine synthase, which converts homocysteine to methionine.

๐Ÿ’ก How to Take bicoba-fc 2500 injection

Follow your doctor's prescription exactly.

โš ๏ธ Side Effects of bicoba-fc 2500 injection

โœ… Common Side Effects

  • Injection site pain
  • Redness
  • Swelling
  • Mild diarrhea
  • Nausea

๐Ÿšจ Serious Side Effects

  • Allergic reactions (rash, itching, swelling)
  • Anaphylaxis (rare)

โš ๏ธ Rare Side Effects

  • Hypokalemia
  • Polycythemia vera (with prolonged high doses)

Consult your doctor if you experience any unusual symptoms.

๐Ÿ”ฌ Drug Interactions

โš ๏ธ DrugSeverityEffect
Methotrexate Major Decreased efficacy of methotrexate; increased toxicity
Phenytoin Major Decreased phenytoin levels
Primidone Major Decreased primidone levels
Pyrimethamine Major Decreased pyrimethamine efficacy
Trimethoprim Major Decreased trimethoprim efficacy
Oral contraceptives Moderate Reduced folate levels
Chloramphenicol Moderate Decreased response to vitamin B12
Colchicine Moderate Decreased absorption of vitamin B12
Neomycin Moderate Decreased absorption of vitamin B12
Metformin Moderate Decreased vitamin B12 levels
Aminosalicylic acid Minor Decreased absorption of vitamin B12
Cholestyramine Minor Decreased absorption of folic acid
H2-receptor antagonists Minor Decreased absorption of vitamin B12
Proton pump inhibitors Minor Decreased absorption of vitamin B12

๐Ÿšจ Major Interactions

  • Methotrexate
  • Phenytoin
  • Primidone
  • Pyrimethamine
  • Trimethoprim

โšก Moderate Interactions

  • Oral contraceptives
  • Chloramphenicol
  • Colchicine
  • Neomycin
  • Metformin

โ„น๏ธ Minor Interactions

  • Aminosalicylic acid
  • Cholestyramine
  • H2-receptor antagonists
  • Proton pump inhibitors

๐Ÿฝ๏ธ Food Interactions

None significant

๐Ÿท Alcohol Interaction

Chronic alcohol use may impair folate absorption and metabolism

๐Ÿ›ก๏ธ Safety & Warnings

๐Ÿšซ Contraindications

Hypersensitivity to any component; pernicious anemia (unless combined with B12)

๐Ÿ“Š Monitoring Parameters

Complete blood count, serum folate, vitamin B12 levels, homocysteine levels

๐Ÿคฑ Lactation Safety

Both components are excreted in breast milk; considered compatible with breastfeeding

๐Ÿ’Š Overdose Management

Supportive care; folic acid and methylcobalamin are water-soluble and excess is excreted

โฐ Missed Dose

Administer as soon as remembered; if close to next dose, skip missed dose

๐Ÿ‘จโ€โš•๏ธ Reviewed by Expert

SaathiMed Expert Panel

MD, PhD - Pharmacology

Last reviewed on: Aug 24, 2026

๐Ÿ”— View Profile

โญ User Reviews

Verified User Jul 10, 2026

Helpful and effective medicine as per my experience. Always consult a doctor.

Verified User Jul 10, 2026

Found this to be a helpful product. Good results.

Certified Buyer Jul 10, 2026

This medicine was effective for me. I followed the doctor's advice.

Trusted Reviewer Jul 10, 2026

Helpful and effective medicine as per my experience. Always consult a doctor.

Verified User Jul 10, 2026

Good quality medicine. Satisfied with the outcome.

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