benzz 180 injection - Uses, Price, Side Effects & Substitutes
What is benzz 180 injection used for?
Adben 100mg Injection (Bendamustine) is used to treat ANTI NEOPLASTICS. It contains Bendamustine (90mg/ml), which Alkylating agent that forms cross-links between DNA strands, inhibiting DNA synt. Always consult your doctor before use. Take as prescribed.
- Generic Name: Bendamustine
- Manufacturer: Intas Pharmaceuticals Ltd
- Form: Allopathy
- Pregnancy Category: D
- Prescription Required: Yes
๐ benzz 180 injection Uses & Benefits
Chronic lymphocytic leukemia (CLL), indolent B-cell non-Hodgkin lymphoma (NHL), multiple myeloma.
Off-label uses: Hodgkin lymphoma, T-cell lymphoma, breast cancer.
๐ Drug Information
| Generic Name(s) | Bendamustine |
| Brand Name | Adben 100mg Injection |
| Manufacturer | Intas Pharmaceuticals Ltd |
| Packaging / Form | Varies by brand (Allopathy) |
| Therapeutic Class | ANTI NEOPLASTICS |
| Action Class | Alkylating agent |
| Route of Administration | Intravenous infusion. |
| Storage | Store at 20-25ยฐC; protect from light; reconstituted solution stable for 24 hours at room temperature. |
| Shelf Life | As per manufacturer |
๐ฌ Pharmacology (PK/PD)
Pharmacokinetics
How It Works
Alkylating agent that forms cross-links between DNA strands, inhibiting DNA synthesis and repair.
Mechanism Steps
๐ก How to Take benzz 180 injection
Follow your doctor's prescription exactly.
โ ๏ธ Side Effects of benzz 180 injection
โ Common Side Effects
- Nausea
- Vomiting
- Diarrhea
- Fatigue
- Fever
- Myelosuppression (neutropenia, thrombocytopenia, anemia)
๐จ Serious Side Effects
- Severe myelosuppression
- Infection
- Tumor lysis syndrome
- Stevens-Johnson syndrome
- Anaphylaxis
โ ๏ธ Rare Side Effects
- Interstitial pneumonitis
- Cardiac arrhythmias
- Secondary malignancies
Consult your doctor if you experience any unusual symptoms.
๐ฌ Drug Interactions
| โ ๏ธ Drug | Severity | Effect |
|---|---|---|
| Ciprofloxacin | Major | Increased bendamustine exposure |
| Warfarin | Moderate | Increased bleeding risk |
| Live vaccines | Moderate | Risk of disseminated infection |
๐จ Major Interactions
- CYP1A2 inhibitors (e.g., ciprofloxacin, fluvoxamine)
- CYP1A2 inducers (e.g., carbamazepine, rifampin)
โก Moderate Interactions
- Live vaccines
- Anticoagulants (e.g., warfarin)
โน๏ธ Minor Interactions
- Acetaminophen
- Allopurinol
๐ฝ๏ธ Food Interactions
No significant food interactions.
๐ท Alcohol Interaction
Avoid alcohol due to potential hepatotoxicity.
๐ก๏ธ Safety & Warnings
๐ซ Contraindications
Hypersensitivity to bendamustine; severe bone marrow suppression; active infection.
๐ Monitoring Parameters
Complete blood count (CBC), liver function tests, renal function, serum electrolytes.
๐คฑ Lactation Safety
Not recommended; discontinue breastfeeding.
๐ Overdose Management
Supportive care; monitor for myelosuppression; no specific antidote.
โฐ Missed Dose
Do not double dose; consult physician if dose missed.