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benzosed 5mg injection - Midazolam (5mg) medicine

benzosed 5mg injection - Uses, Price, Side Effects & Substitutes

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Midazolam (5mg)
๐Ÿญ Troikaa Pharmaceuticals Ltd ๐Ÿ“ฆ Varies by brand ๐Ÿ’Š Allopathy ๐Ÿ“… Updated: Jun 27, 2026
๐Ÿ“‹ Prescription Required ๐Ÿ’Š Generic Available
Medically Reviewed
SaathiMed Expert Panel | Jun 27, 2026

What is benzosed 5mg injection used for?

Benzosed 5mg Injection (Midazolam) is used to treat NEURO CNS. It contains Midazolam (5mg), which Enhances the effect of gamma-aminobutyric acid (GABA) at GABA-A receptors, incre. Always consult your doctor before use. Take as prescribed.

  • Generic Name: Midazolam
  • Manufacturer: Troikaa Pharmaceuticals Ltd
  • Form: Allopathy
  • Pregnancy Category: A
  • Prescription Required: Yes
๐Ÿ’ก Did You Know? India is the largest provider of generic medicines globally, supplying over 50% of global vaccine demand.

๐Ÿ’Š benzosed 5mg injection Uses & Benefits

Preoperative sedation, anxiolysis, amnesia; induction of anesthesia; procedural sedation; status epilepticus (second-line).

Off-label uses: Insomnia (short-term), acute agitation, alcohol withdrawal syndrome.

๐Ÿ“‹ Drug Information

Generic Name(s)Midazolam
Brand NameBenzosed 5mg Injection
ManufacturerTroikaa Pharmaceuticals Ltd
Packaging / FormVaries by brand (Allopathy)
Therapeutic ClassNEURO CNS
Action ClassBenzodiazepines
Route of AdministrationIntravenous, intramuscular.
StorageStore at 20-25ยฐC (68-77ยฐF); protect from light; do not freeze.
Shelf LifeAs per manufacturer

๐Ÿ”ฌ Pharmacology (PK/PD)

Pharmacokinetics

AbsorptionRapidly absorbed after intramuscular injection; peak plasma concentrations achieved within 30-60 minutes.
DistributionWidely distributed; crosses blood-brain barrier and placenta; high volume of distribution (1-3 L/kg).
Protein BindingApproximately 97% bound to plasma proteins, primarily albumin.
MetabolismExtensively metabolized in the liver via cytochrome P450 3A4 (CYP3A4) to active metabolite 1-hydroxymidazolam.
Half-Life1.5-3.5 hours (prolonged in elderly, obese, and hepatic impairment).
ExcretionPrimarily renal excretion of metabolites (90-95% as glucuronide conjugates); less than 1% excreted unchanged.
BioavailabilityIntravenous: 100%; Intramuscular: >90%.
Onset of ActionIntravenous: 1-2 minutes; Intramuscular: 5-15 minutes.
Peak Plasma TimeIntravenous: 3-5 minutes; Intramuscular: 30-60 minutes.
Duration of Action2-6 hours (dose-dependent).

How It Works

Enhances the effect of gamma-aminobutyric acid (GABA) at GABA-A receptors, increasing chloride ion conductance and neuronal hyperpolarization.

Mechanism Steps

1Midazolam binds to the benzodiazepine site on GABA-A receptors.
2Enhances the affinity of GABA for the receptor.
3Increases frequency of chloride channel opening.

๐Ÿ’ก How to Take benzosed 5mg injection

Follow your doctor's prescription exactly.

โš ๏ธ Side Effects of benzosed 5mg injection

โœ… Common Side Effects

  • Drowsiness
  • Sedation
  • Dizziness
  • Ataxia
  • Nausea
  • Vomiting

๐Ÿšจ Serious Side Effects

  • Respiratory depression
  • Cardiac arrest
  • Hypotension
  • Paradoxical reactions (agitation, aggression)
  • Anterograde amnesia

โš ๏ธ Rare Side Effects

  • Jaundice
  • Blood dyscrasias
  • Allergic reactions (anaphylaxis)
  • Seizures (withdrawal)

Consult your doctor if you experience any unusual symptoms.

๐Ÿ”ฌ Drug Interactions

โš ๏ธ DrugSeverityEffect
Ketoconazole Major Increased midazolam plasma concentration, prolonged sedation
Rifampin Major Decreased midazolam efficacy due to increased metabolism
Opioids Major Additive respiratory depression and sedation
Grapefruit juice Minor Slight increase in midazolam levels

๐Ÿšจ Major Interactions

  • CYP3A4 inhibitors (e.g., ketoconazole, itraconazole, ritonavir)
  • CYP3A4 inducers (e.g., rifampin, carbamazepine, phenytoin)
  • Other CNS depressants (e.g., opioids, barbiturates, alcohol)

โšก Moderate Interactions

  • Cimetidine
  • Erythromycin
  • Diltiazem
  • Verapamil

โ„น๏ธ Minor Interactions

  • Grapefruit juice
  • Oral contraceptives

๐Ÿฝ๏ธ Food Interactions

Grapefruit juice may increase midazolam levels; avoid concurrent use.

๐Ÿท Alcohol Interaction

Additive CNS depression; avoid alcohol.

๐Ÿ›ก๏ธ Safety & Warnings

๐Ÿšซ Contraindications

Hypersensitivity to midazolam or benzodiazepines; acute narrow-angle glaucoma; severe respiratory insufficiency; myasthenia gravis; pregnancy (first trimester).

๐Ÿ“Š Monitoring Parameters

Respiratory rate, oxygen saturation, blood pressure, heart rate, level of sedation.

๐Ÿคฑ Lactation Safety

Excreted in breast milk; avoid breastfeeding for 24 hours after administration.

๐Ÿ’Š Overdose Management

Supportive care; flumazenil (benzodiazepine antagonist) may be used; monitor respiratory and cardiovascular status.

โฐ Missed Dose

Not applicable for procedural use; for scheduled dosing, take as soon as remembered if close to next dose, skip if near.

๐Ÿ‘จโ€โš•๏ธ Reviewed by Expert

SaathiMed Expert Panel

MD, PhD - Pharmacology

Reviewed: Jun 27, 2026

๐Ÿ”— View Profile

๐Ÿ”„ Substitutes for benzosed 5mg injection

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Alternative brands with exact same active ingredient (Midazolam (5mg)):

Medical Note: Always consult your doctor before switching medications.

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