Axzyb Tablet (Axitinib 5mg): Comprehensive Medicine Guide
Clinical Reference Standards: CDSCO (Central Drugs Standard Control Organisation), Indian Pharmacopoeia (IP) & WHO | Last Updated: September 2026
When to Call Your Doctor IMMEDIATELY
- Severe headache, confusion, or vision changes
- Chest pain, shortness of breath, or leg swelling
- Blood in vomit, stool, or urine
- Severe abdominal pain with fever
- Yellowing of skin or eyes
- Decreased urine output
- Unusual bleeding or bruising
If experiencing severe symptoms, call emergency services immediately.
What is bdaxit 5mg tablet used for?
Axitinib is a targeted therapy used to treat advanced kidney cancer by blocking blood vessel growth to tumours. It is taken orally as a 5 mg tablet twice daily under medical supervision.
- Generic Name: Axitinib (5mg)
- Manufacturer: BDR Pharmaceuticals Internationals Pvt
- Form: Allopathy
- Pregnancy Category: Consult doctor
- Prescription Required: Yes
🇮🇳 bdaxit 5mg tablet के बारे में (Hindi Summary)
उपयोग: यह दवा एग्जिटिनिब नामक सक्रिय तत्व से बनी है, जो एक लक्षित कैंसर रोधी दवा है। इसका उपयोग मुख्य रूप से उन्नत गुर्दे के कैंसर (रेनल सेल कार्सिनोमा) के इलाज के लिए किया जाता है, खासकर जब अन्य उपचार काम नहीं करते। यह दवा ट्यूमर को रक्त की आपूर्ति करने वाली नई रक्त वाहिकाओं के निर्माण को रोककर कैंसर की वृद्धि को धीमा करती है। यह मौखिक रूप से ली जाने वाली गोली है और इसे केवल कैंसर रोग विशेषज्ञ की देखरेख में ही लेना चाहिए।
साइड इफेक्ट्स: आम दुष्प्रभावों में दस्त, उच्च रक्तचाप, थकान, भूख में कमी, मतली, उल्टी, वजन घटना और आवाज में भारीपन शामिल हैं। गंभीर दुष्प्रभावों में गंभीर रक्तस्राव, रक्त के थक्के, हृदय समस्याएं, यकृत विषाक्तता, गुर्दे की क्षति और जठरांत्र छिद्रण हो सकते हैं। दुर्लभ दुष्प्रभावों में रिवर्सिबल पोस्टीरियर ल्यूकोएन्सेफैलोपैथी सिंड्रोम, थायरॉइड dysfunction और अग्नाशयशोथ शामिल हैं। किसी भी असामान्य लक्षण को तुरंत अपने डॉक्टर को बताएं।
सुरक्षा सलाह: यह दवा केवल योग्य कैंसर रोग विशेषज्ञ की देखरेख में ही लेनी चाहिए। उपचार के दौरान रक्तचाप, यकृत कार्य, गुर्दे की कार्यप्रणाली और थायरॉइड फ़ंक्शन की नियमित निगरानी आवश्यक है। इस दवा को लेते समय गर्भवती होने से बचें; पुरुषों और महिलाओं दोनों को उपचार के दौरान और अंतिम खुराक के कम से कम एक सप्ताह बाद तक प्रभावी गर्भनिरोधक का उपयोग करना चाहिए। उपचार के दौरान स्तनपान न कराएं। अंगूर और अंगूर के रस से बचें क्योंकि ये शरीर में इस दवा के स्तर को बढ़ा सकते हैं। अपने डॉक्टर को सभी अन्य दवाओं के बारे में बताएं, विशेष रूप से रक्त पतला करने वाली दवाएं, रक्तचाप की दवाएं और एंटीफंगल एजेंट। यदि आपको चक्कर आते हैं या थकान महसूस होती है तो वाहन न चलाएं या भारी मशीनरी संचालित न करें। इस दवा को कमरे के तापमान पर नमी और गर्मी से दूर रखें।
💊 bdaxit 5mg tablet Uses & Benefits
[{"condition":"Advanced renal cell carcinoma","description":"Used as a second-line treatment for patients with advanced kidney cancer after failure of prior systemic therapy.","evidence":"Well-established"}]
Off-label uses: [{"condition":"Thyroid cancer","description":"Sometimes used off-label for advanced medullary thyroid cancer or differentiated thyroid cancer.","evidence":"Limited"},{"condition":"Soft tissue sarcoma","description":"Investigated in some types of soft tissue sarcomas but not standard.","evidence":"Limited"}]
Primary treatment for: Advanced renal cell carcinoma
Also treats: Thyroid cancer (off-label), Soft tissue sarcoma (off-label)
📋 Drug Information
| Generic Name(s) | Axitinib (5mg) |
| Brand Name | bdaxit 5mg tablet |
| Manufacturer | BDR Pharmaceuticals Internationals Pvt |
| Packaging / Form | Varies by brand (Allopathy) |
| Therapeutic Class | ANTI NEOPLASTICS |
| Action Class | Tyrosine kinase inhibitors |
| Route of Administration | Oral |
| Storage | Store at room temperature between 20°C and 25°C (68°F and 77°F). Keep away from moisture and heat. |
| Shelf Life | Refer to the packaging for the expiry date. Do not use after the expiry date. |
| WHO Guideline | Not established from the available information. |
| ICMR Guideline | Not established from the available information. |
👨⚕️ Doctor's Practical Tips
Evidence-based practical advice from experienced clinicians
🔍 Is This Medicine Right for Your Symptom?
Educational reference. Always consult a doctor for diagnosis.
🔬 How This Medicine Works (Pharmacology)
Pharmacokinetics
How It Works
Axitinib is a selective inhibitor of vascular endothelial growth factor receptors (VEGFR-1, VEGFR-2, and VEGFR-3). By blocking these receptors, it inhibits angiogenesis, the formation of new blood vessels that supply tumours, thereby slowing tumour growth and metastasis.
Mechanism Steps
💡 How to Take bdaxit 5mg tablet
Strength: Axitinib 5 mg immediate-release tablet
Dosage Information
| Adult Dosage | The recommended starting dose of axitinib for advanced renal cell carcinoma is 5 mg taken orally twice daily, approximately 12 hours apart, with or without food. Dose adjustments may be made based on individual tolerability and response, with increases up to 10 mg twice daily or reductions to 2 mg twice daily. Dose must be individualized by a qualified clinician based on indication, age, weight, renal and hepatic function, and concomitant medications. |
| Pediatric Dosage | Pediatric dosing is not established from available information. Consult a pediatric oncologist. |
| Elderly Dosage | No specific dose adjustment is recommended for elderly patients, but they may be more sensitive to side effects. Monitor closely. |
| Renal Impairment | No dose adjustment is required for patients with mild to moderate renal impairment. Use with caution in severe renal impairment. |
| Hepatic Impairment | For patients with moderate hepatic impairment (Child-Pugh B), the starting dose should be reduced by approximately 50%. Not recommended in severe hepatic impairment. |
| Maximum Daily Dose | The maximum recommended dose is 10 mg twice daily (20 mg per day). |
Dosage Timeline
🍽️ Food Timing Guide
⏰ What to Do If You Miss a Dose
⚠️ Side Effects of bdaxit 5mg tablet
✅ Common Side Effects
🚨 Serious Side Effects
⚠️ Rare Side Effects
Consult your doctor if you experience any unusual symptoms.
🔬 Drug Interactions
| Drug | Severity | Effect |
|---|---|---|
| Ketoconazole | Major | |
| Rifampicin | Major | |
| Warfarin | Moderate | |
| Amlodipine | Moderate | |
| Clarithromycin | Major | |
| Carbamazepine | Major | |
| Phenytoin | Major | |
| St. John's Wort | Major | |
| Itraconazole | Major | |
| Ritonavir | Major |
🚨 Major Interactions
- CYP3A4 inhibitors (e.g., ketoconazole, clarithromycin)
- CYP3A4 inducers (e.g., rifampicin, carbamazepine)
⚡ Moderate Interactions
- Antihypertensives
- Anticoagulants (e.g., warfarin)
🍷 Alcohol Interaction
Alcohol may increase the risk of liver toxicity and worsen side effects like dizziness and fatigue. It is advisable to avoid alcohol while taking this medicine.
🔎 Check Your Other Medicines
Educational tool. Always confirm with your doctor or pharmacist.
🛡️ Safety & Warnings
🚫 Contraindications
["Hypersensitivity to axitinib or any component of the formulation","Pregnancy","Breastfeeding","Severe hepatic impairment"]
⚠️ Warnings & Precautions
["Hypertension: Monitor blood pressure regularly and manage with antihypertensives.","Hemorrhage: May cause severe bleeding; monitor for signs.","Gastrointestinal perforation: Seek immediate medical attention for severe abdominal pain.","Thyroid dysfunction: Monitor thyroid function.","Proteinuria: Monitor urine protein.","Reversible posterior leukoencephalopathy syndrome: Report severe headache, seizures, or vision changes.","Wound healing: May impair wound healing; discontinue before surgery."]
🤱 Lactation Safety
It is not known whether axitinib is excreted in human milk. Because of the potential for serious adverse reactions in breastfed infants, breastfeeding should be discontinued during treatment and for at least 2 weeks after the last dose.
💊 Overdose Management
There is no specific antidote for axitinib overdose. Treatment should be symptomatic and supportive. Monitor vital signs and provide appropriate care.
⏰ Missed Dose
If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and continue with your regular schedule. Do not take two doses at the same time.
Additional Safety Advice
This medicine should only be taken under the supervision of a qualified oncologist. Regular monitoring of blood pressure, liver function, kidney function, and thyroid function is required. Avoid becoming pregnant while taking this medicine; use effective contraception for both men and women during treatment and for at least one week after the last dose. Do not breastfeed during treatment. Avoid grapefruit and grapefruit juice as they can increase the levels of this medicine in your body. Inform your doctor about all other medicines you are taking, especially blood thinners, blood pressure medicines, and antifungal agents. Do not drive or operate heavy machinery if you feel dizzy or tired. Store this medicine at room temperature away from moisture and heat.
👴 Special Considerations for Elderly
💡 For Patients Above 65
Elderly patients may be more sensitive to side effects. Monitor blood pressure, liver, and kidney function closely. Dose adjustments may be needed.
🤰 Pregnancy Planning (TTC)
This medicine can cause fetal harm. Women of childbearing potential should use effective contraception during treatment and for at least 1 week after the last dose. Men should also use contraception. Consult your doctor if you are planning pregnancy.
🏥 Post-Surgery Considerations
This medicine may impair wound healing. It should be discontinued at least 24 hours before scheduled surgery. Consult your surgeon and oncologist.
🦷 Dental Procedures
Inform your dentist that you are taking this medicine. It may increase bleeding risk. Your dentist may recommend precautions.
💚 Lifestyle Tips for Better Results
🏋️ Exercise Considerations
Exercise may be beneficial but avoid strenuous activities if you feel fatigued or dizzy. Consult your doctor before starting any exercise program.
🥗 Diet Recommendations
💼 Impact on Daily Work & Life
This medicine may cause fatigue and dizziness, which can affect your ability to drive or operate machinery. Avoid these activities until you know how the medicine affects you. Adjust work schedules as needed.
🛑 When to Stop This Medicine
Do not stop taking this medicine without consulting your doctor. If you experience severe side effects, your doctor may adjust the dose or discontinue treatment.
📅 Long-Term Use Effects
Long-term use may lead to chronic hypertension, kidney impairment, and thyroid dysfunction. Regular monitoring of blood pressure, liver, kidney, and thyroid function is essential. Dose adjustments may be needed over time. Report any new or worsening symptoms to your doctor.
🌿 Non-Medicine Approaches
These can complement medicine but do not replace prescribed treatment.
Other systemic therapies like immune checkpoint inhibitors may be used.
Evidence: Well-establishedEnrollment in clinical trials for novel agents.
Evidence: Varies💉 Vaccination Considerations
💉 If You're Getting Vaccinated
Live vaccines should be avoided during treatment due to potential risk. Inactivated vaccines may be given but response may be reduced. Consult your doctor.
📦 Storage Guide
✅ DO
Store at room temperature (20-25°C)
❌ DON'T
Do not refrigerate
✅ DO
Keep in original container
❌ DON'T
Do not transfer to unmarked containers
✅ DO
Keep away from direct sunlight
❌ DON'T
Do not store in bathroom cabinet
✈️ Traveling with This Medicine
Carry this medicine in its original packaging with a copy of your prescription. Keep it in your carry-on luggage to avoid loss. Store at room temperature and protect from moisture. If crossing time zones, adjust dosing times gradually under medical guidance. Check customs regulations for controlled substances; this is not a controlled substance but carry documentation.
💰 Cost Analysis & Savings
👥 Real Patient Stories
Educational, anonymized scenarios. Individual results may vary.
💬 Questions Patients Often Ask
A: The effects develop over days to weeks. Your doctor will monitor your response with regular scans.
A: Yes, you can take it with or without food, but be consistent.
A: If you miss a dose, take it as soon as you remember unless it's almost time for the next dose. Do not double dose.
🤔 Common Patient Concerns
🔄 Substitutes for bdaxit 5mg tablet
View AllAlternative brands with exact same active ingredient:
-
tykinax 5mg tabletDr Reddy's Laboratories Ltd ₹1,406.02 32.1% CHEAPER
-
inlybest 5mg tabletAprazer Healthcare Pvt Ltd ₹1,870.31 9.6% CHEAPER
-
axpero 5 tabletIntas Pharmaceuticals Ltd ₹2,057.34 0.6% CHEAPER
-
raxitinib 5mg tabletMedicamen Biotech Ltd ₹2,160.00 4.3% COSTLIER
-
axishil 5mg tabletShilpa Medicare Ltd ₹3,735.00 80.4% COSTLIER
Medical Note: Always consult your doctor before switching medications.
🛑 Myths vs. Facts
- Myth: Axitinib is a traditional chemotherapy drug.
Fact: Axitinib is a targeted therapy, not traditional chemotherapy. It specifically inhibits VEGFR. - Myth: Axitinib can be taken without monitoring.
Fact: Regular monitoring of blood pressure, liver, kidney, and thyroid function is essential.