Axpero 5 Tablet (Axitinib 5 mg): Complete Medicine Guide
Clinical Reference Standards: CDSCO (Central Drugs Standard Control Organisation), Indian Pharmacopoeia (IP) & WHO | Last Updated: September 2026
When to Call Your Doctor IMMEDIATELY
- Severe headache, confusion, seizures, or vision changes
- Chest pain, shortness of breath, or irregular heartbeat
- Black, tarry stools or vomiting blood
- Severe abdominal pain with fever or rigidity
- Sudden weakness or difficulty speaking
- Yellowing of skin or eyes, dark urine
- Swelling of hands and feet with blistering or peeling
- Decreased urine output or swelling of legs
If experiencing severe symptoms, call emergency services immediately.
What is axpero 5 tablet used for?
This medicine contains axitinib 5 mg, a targeted anticancer tablet used mainly for advanced kidney cancer. It works by blocking blood vessel growth to the tumour. It is taken twice daily under oncologist supervision.
- Generic Name: Axitinib
- Manufacturer: Intas Pharmaceuticals Ltd
- Form: Allopathy
- Pregnancy Category: Consult doctor
- Prescription Required: Yes
🇮🇳 axpero 5 tablet के बारे में (Hindi Summary)
उपयोग: यह दवा एग्जिटिनिब 5 मिलीग्राम की गोली है, जिसका उपयोग मुख्य रूप से एडवांस्ड रीनल सेल कार्सिनोमा (गुर्दे के कैंसर) के इलाज में किया जाता है। यह एक टार्गेटेड कैंसर दवा है जो ट्यूमर को खून की आपूर्ति करने वाली नई रक्त वाहिकाओं के निर्माण को रोकती है, जिससे ट्यूमर की वृद्धि धीमी हो जाती है। यह दवा मुँह से ली जाती है और इसका सेवन केवल कैंसर रोग विशेषज्ञ की सलाह से ही करना चाहिए।
साइड इफेक्ट्स: इस दवा के सामान्य दुष्प्रभावों में दस्त, उच्च रक्तचाप, थकान, भूख में कमी, मतली, उल्टी, वजन कम होना, आवाज में भारीपन और हाथ-पैर की त्वचा पर लालिमा या छाले शामिल हैं। गंभीर दुष्प्रभावों में गंभीर उच्च रक्तचाप, दिल का दौरा, स्ट्रोक, रक्तस्राव, आंतों में छेद, यकृत की समस्या और मस्तिष्क संबंधी लक्षण हो सकते हैं। कोई भी असामान्य लक्षण दिखने पर तुरंत डॉक्टर से संपर्क करें।
सुरक्षा सलाह: इस दवा को केवल कैंसर रोग विशेषज्ञ की देखरेख में ही लें। बिना डॉक्टर की सलाह के दवा शुरू या बंद न करें। नियमित रूप से रक्तचाप की जाँच कराएँ और बढ़े हुए रक्तचाप की सूचना तुरंत डॉक्टर को दें। यकृत, गुर्दे और थायरॉइड की जाँच समय-समय पर कराते रहें। ग्रेपफ्रूट और उसके जूस का सेवन न करें। गर्भावस्था के दौरान इस दवा का सेवन न करें और उपचार के दौरान प्रभावी गर्भनिरोधक उपाय अपनाएँ। स्तनपान कराने वाली महिलाएँ इस दवा का सेवन न करें।
💊 axpero 5 tablet Uses & Benefits
[{"condition":"Advanced renal cell carcinoma","description":"Used as a second-line treatment for metastatic renal cell carcinoma after failure of one prior systemic therapy, usually a cytokine or another targeted agent.","evidence":"Well-established"},{"condition":"Hepatocellular carcinoma","description":"Sometimes used in advanced hepatocellular carcinoma after other treatments have failed, but evidence is more limited compared with renal cell carcinoma.","evidence":"Limited"},{"condition":"Thyroid cancer","description":"Investigated in some types of advanced thyroid cancer, but not a standard first-line option.","evidence":"Limited"}]
Off-label uses: [{"condition":"Other advanced solid tumours","description":"Occasionally used in clinical trials or selected cases of other advanced solid tumours under specialist supervision.","evidence":"Limited"}]
Primary treatment for: Advanced renal cell carcinoma
Also treats: Hepatocellular carcinoma, Thyroid cancer
📋 Drug Information
| Generic Name(s) | Axitinib |
| Brand Name | Axpero 5 Tablet |
| Manufacturer | Intas Pharmaceuticals Ltd |
| Packaging / Form | Varies by brand (Allopathy) |
| Therapeutic Class | ANTI NEOPLASTICS |
| Action Class | Tyrosine kinase inhibitors |
| Route of Administration | Oral |
| Storage | Store at room temperature between 20°C and 25°C (68°F to 77°F). Keep in the original container, away from moisture and heat. |
| Shelf Life | Refer to the packaging for the expiry date. Do not use after the expiry date. |
| WHO Guideline | Not established from the available information. |
| ICMR Guideline | Not established from the available information. |
👨⚕️ Doctor's Practical Tips
Evidence-based practical advice from experienced clinicians
🔍 Is This Medicine Right for Your Symptom?
Educational reference. Always consult a doctor for diagnosis.
🔬 How This Medicine Works (Pharmacology)
Pharmacokinetics
How It Works
This medicine is a small-molecule tyrosine kinase inhibitor that selectively inhibits vascular endothelial growth factor receptors 1, 2, and 3, as well as platelet-derived growth factor receptor and c-KIT. By blocking these receptors, it reduces angiogenesis, the formation of new blood vessels that supply tumours, thereby slowing tumour growth and progression. It does not directly kill cancer cells but deprives them of blood supply and nutrients.
Mechanism Steps
💡 How to Take axpero 5 tablet
Strength: Axitinib 5 mg immediate-release tablet
Dosage Information
| Adult Dosage | The usual starting dose of this medicine is 5 mg taken orally twice daily, approximately 12 hours apart, with or without food. Dose adjustments may be made by the oncologist based on individual tolerability, blood pressure, liver function, and concomitant medications. The dose may be increased to 7 mg twice daily or decreased to 3 mg twice daily or lower if needed. Dose must be individualized by a qualified clinician based on indication, age, weight, renal and hepatic function. |
| Pediatric Dosage | Pediatric dosing is not established from available information. Consult a pediatric oncologist. |
| Elderly Dosage | No specific dose adjustment is recommended for elderly patients based on age alone. However, elderly patients may be more sensitive to side effects such as hypertension and fatigue, and should be monitored closely. |
| Renal Impairment | No dose adjustment is required for patients with mild to moderate renal impairment. For patients with severe renal impairment or those on dialysis, use with caution and monitor closely. |
| Hepatic Impairment | For patients with moderate hepatic impairment (Child-Pugh B), the starting dose should be reduced by approximately 50%. For severe hepatic impairment (Child-Pugh C), axitinib is not recommended. |
| Maximum Daily Dose | The maximum recommended dose is 10 mg twice daily, but doses above 10 mg twice daily have not been studied. |
Dosage Timeline
🍽️ Food Timing Guide
⏰ What to Do If You Miss a Dose
⚠️ Side Effects of axpero 5 tablet
✅ Common Side Effects
🚨 Serious Side Effects
⚠️ Rare Side Effects
Consult your doctor if you experience any unusual symptoms.
🔬 Drug Interactions
| Drug | Severity | Effect |
|---|---|---|
| Ketoconazole | Major | |
| Rifampicin | Major | |
| Clarithromycin | Major | |
| Carbamazepine | Major | |
| Phenytoin | Major | |
| Erythromycin | Moderate | |
| Fluconazole | Moderate | |
| Amlodipine | Moderate | |
| Warfarin | Moderate | |
| Antacids | Minor |
🚨 Major Interactions
- Strong CYP3A4 inhibitors (e.g., ketoconazole, itraconazole, clarithromycin)
- Strong CYP3A4 inducers (e.g., rifampicin, carbamazepine, phenytoin)
- Grapefruit juice
⚡ Moderate Interactions
- Moderate CYP3A4 inhibitors (e.g., erythromycin, fluconazole)
- Antihypertensive medicines
🍷 Alcohol Interaction
Alcohol may worsen side effects such as dizziness, fatigue, and low blood pressure. It is advisable to avoid or limit alcohol while taking this medicine.
🔎 Check Your Other Medicines
Educational tool. Always confirm with your doctor or pharmacist.
🛡️ Safety & Warnings
🚫 Contraindications
["Hypersensitivity to axitinib or any component of the formulation","Pregnancy","Breastfeeding","Severe hepatic impairment"]
⚠️ Warnings & Precautions
["Hypertension: monitor and treat promptly.","Arterial thromboembolic events: use with caution in patients with recent cardiovascular events.","Hemorrhage: risk of bleeding; monitor for signs.","Gastrointestinal perforation and fistula: report severe abdominal pain.","Reversible posterior leukoencephalopathy syndrome: report neurological symptoms.","Thyroid dysfunction: monitor thyroid function.","Proteinuria: monitor urine protein.","Hepatic impairment: dose adjustment may be needed.","Avoid grapefruit and strong CYP3A4 inhibitors/inducers."]
🤱 Lactation Safety
It is not known whether axitinib is excreted in human milk. Because of the potential for serious adverse reactions in breastfed infants, breastfeeding should be discontinued during treatment and for at least two weeks after the last dose.
💊 Overdose Management
There is no specific antidote for overdose. In case of suspected overdose, stop the medicine and seek immediate medical attention. Supportive care and monitoring of vital signs and organ function are recommended.
⏰ Missed Dose
If you miss a dose, take it as soon as you remember if it is more than 12 hours before the next scheduled dose. If it is less than 12 hours before the next dose, skip the missed dose and continue with your regular schedule. Do not double the dose.
Additional Safety Advice
This medicine must only be taken under the supervision of a qualified oncologist. Do not start, stop, or change the dose without medical advice. Blood pressure should be checked regularly, and any rise should be reported promptly. Liver and kidney function tests, thyroid function, and urine protein should be monitored as advised. Avoid grapefruit and grapefruit juice because they can increase the levels of this medicine in the body. Use effective contraception during treatment and for at least one week after the last dose, as this medicine can harm an unborn baby. Do not breastfeed while taking this medicine. Inform your doctor about all other medicines, supplements, and herbal products you are taking, especially blood thinners, blood pressure medicines, and drugs that affect liver enzymes. Avoid activities that increase the risk of bleeding or injury. If you miss a dose, follow your doctor's instructions; do not double the dose. Store this medicine at room temperature away from moisture and heat, and keep it out of reach of children.
👴 Special Considerations for Elderly
💡 For Patients Above 65
Elderly patients may be more sensitive to side effects such as hypertension, fatigue, and diarrhoea. Close monitoring and dose adjustments may be needed.
🤰 Pregnancy Planning (TTC)
This medicine can harm an unborn baby. Women of childbearing potential should use effective contraception during treatment and for at least one week after the last dose. Men with female partners of childbearing potential should also use effective contraception. Discuss pregnancy planning with your doctor before starting treatment.
🏥 Post-Surgery Considerations
This medicine may increase the risk of bleeding and impair wound healing. Inform your surgeon and oncologist if you are scheduled for surgery. Treatment may need to be temporarily interrupted before and after surgery.
🦷 Dental Procedures
Inform your dentist that you are taking this medicine, as it may increase the risk of bleeding during dental procedures. Your dentist may recommend precautions or coordinate with your oncologist.
💚 Lifestyle Tips for Better Results
🏋️ Exercise Considerations
Moderate exercise is generally safe, but avoid strenuous activities that may increase the risk of bleeding or injury. Consult your doctor before starting any new exercise programme.
🥗 Diet Recommendations
💼 Impact on Daily Work & Life
This medicine may cause fatigue, dizziness, or high blood pressure, which can affect your ability to drive or operate machinery. Avoid driving if you feel unwell. Discuss with your doctor about work adjustments if needed.
🛑 When to Stop This Medicine
Do not stop taking this medicine without consulting your oncologist. If you experience severe side effects, your doctor may temporarily stop or reduce the dose. Stopping suddenly can lead to tumour progression.
📅 Long-Term Use Effects
Long-term use of this medicine may lead to persistent hypertension, thyroid dysfunction, proteinuria, and liver enzyme abnormalities. Regular monitoring of blood pressure, thyroid function, liver and kidney function, and urine protein is essential. Dose adjustments may be needed over time. Patients should be reviewed regularly by their oncologist to assess benefits and risks.
🌿 Non-Medicine Approaches
These can complement medicine but do not replace prescribed treatment.
Other tyrosine kinase inhibitors such as pazopanib or sunitinib may be options.
Evidence: Well-establishedImmune checkpoint inhibitors may be used alone or in combination.
Evidence: Well-established💉 Vaccination Considerations
💉 If You're Getting Vaccinated
Live vaccines should be avoided during treatment with this medicine because of the potential risk of infection. Inactivated vaccines may be given, but response may be reduced. Consult your doctor before any vaccination.
📦 Storage Guide
✅ DO
Store at room temperature (20-25°C)
❌ DON'T
Do not refrigerate unless specified
✅ DO
Keep in original container
❌ DON'T
Do not transfer to unmarked containers
✅ DO
Keep away from direct sunlight and moisture
❌ DON'T
Do not store in bathroom cabinet
✈️ Traveling with This Medicine
Carry this medicine in its original packaging with a copy of your prescription. Keep it in your hand luggage to avoid loss or temperature extremes. If crossing time zones, adjust dosing times gradually in consultation with your doctor. Store at room temperature and avoid direct sunlight. Check customs regulations for carrying prescription medicines.
💰 Cost Analysis & Savings
👥 Real Patient Stories
Educational, anonymized scenarios. Individual results may vary.
💬 Questions Patients Often Ask
A: The effects on tumour growth are gradual and may take several weeks to become evident. Your doctor will monitor your response with regular scans.
A: Yes, you can take it with or without food, but avoid grapefruit and grapefruit juice.
A: If you miss a dose, take it as soon as you remember if it is more than 12 hours before the next dose. Otherwise, skip it and continue with your regular schedule. Do not double the dose.
A: No, this medicine can harm an unborn baby. Use effective contraception during treatment and for at least one week after the last dose.
🤔 Common Patient Concerns
🔄 Substitutes for axpero 5 tablet
View AllAlternative brands with exact same active ingredient:
-
tykinax 5mg tabletDr Reddy's Laboratories Ltd ₹1,406.02 31.7% CHEAPER
-
inlybest 5mg tabletAprazer Healthcare Pvt Ltd ₹1,870.31 9.1% CHEAPER
-
bdaxit 5mg tabletBDR Pharmaceuticals Internationals Pvt ₹2,070.00 0.6% COSTLIER
-
raxitinib 5mg tabletMedicamen Biotech Ltd ₹2,160.00 5% COSTLIER
-
axishil 5mg tabletShilpa Medicare Ltd ₹3,735.00 81.5% COSTLIER
Medical Note: Always consult your doctor before switching medications.
🛑 Myths vs. Facts
- Myth: Axitinib is a traditional chemotherapy that kills all fast-growing cells.
Fact: Axitinib is a targeted therapy that mainly blocks blood vessel growth to the tumour, not a general chemotherapy. - Myth: You can stop taking axitinib once you feel better.
Fact: Stopping without medical advice can lead to tumour progression. Always consult your oncologist. - Myth: Axitinib has no side effects because it is targeted.
Fact: Targeted therapies also have side effects, including high blood pressure, diarrhoea, and fatigue.
🔄 Alternative Options
Generic Alternatives
- Axitinib
Brand Alternatives
- Axpero 5 Tablet