Barozyme 192mg/40mg Tablet: Complete Medicine Guide
Clinical Reference Standards: CDSCO (Central Drugs Standard Control Organisation), Indian Pharmacopoeia (IP) & WHO | Last Updated: September 2026
When to Call Your Doctor IMMEDIATELY
- Swelling of the face, lips, or throat, or difficulty breathing
- Severe abdominal pain with vomiting and inability to pass stool or gas
- Blood in stool or vomit
- Persistent vomiting or diarrhea leading to dehydration
- Signs of a severe skin reaction such as blistering or peeling skin
- Yellowing of the skin or eyes
- Decreased urine output or swelling in the legs
If experiencing severe symptoms, call emergency services immediately.
What is barozyme 192mg/40mg tablet used for?
This medicine is a combination of Pancreatin 192 mg and Dimethicone 40 mg used to improve digestion and relieve bloating and flatulence. Pancreatin replaces missing digestive enzymes, while dimethicone helps trapped gas pass more easily. It is taken orally with meals, usually one tablet per meal, but the exact dose must be decided by your doctor.
- Generic Name: Pancreatin (192mg) + Dimethicone (40mg)
- Manufacturer: Baroda Pharma Pvt Ltd
- Form: Allopathy
- Pregnancy Category: Consult doctor
- Prescription Required: Yes
🇮🇳 barozyme 192mg/40mg tablet के बारे में (Hindi Summary)
उपयोग: यह दवा पैंक्रियाटिन 192 मिलीग्राम और डाइमेथिकोन 40 मिलीग्राम का संयोजन है। यह पाचन में सुधार करने, पेट फूलने और गैस की समस्या को कम करने के लिए इस्तेमाल की जाती है। पैंक्रियाटिन में पाचक एंजाइम होते हैं जो भोजन को पचाने में मदद करते हैं, और डाइमेथिकोन पेट में जमी गैस को बाहर निकालने में मदद करता है। यह दवा आमतौर पर भोजन के साथ ली जाती है। यह उन लोगों के लिए है जिनमें पाचक एंजाइम की कमी है या जिन्हें पेट फूलने और गैस की बार-बार शिकायत होती है। इसे डॉक्टर की सलाह के बिना नहीं लेना चाहिए।
साइड इफेक्ट्स: इस दवा के आम दुष्प्रभावों में जी मिचलाना, पेट में हल्का दर्द, दस्त, कब्ज, और मल में बदलाव शामिल हैं। कुछ लोगों को दवा का स्वाद या गंध अप्रिय लग सकता है। कभी-कभी त्वचा पर चकत्ते, खुजली या एलर्जी हो सकती है। गंभीर एलर्जी प्रतिक्रिया में चेहरे, होंठ या गले में सूजन, सांस लेने में कठिनाई हो सकती है। ऐसा होने पर तुरंत डॉक्टर से मिलें। बहुत अधिक मात्रा में लेने से आंतों में गंभीर समस्या हो सकती है, इसलिए दवा की मात्रा डॉक्टर के बताए अनुसार ही लें।
सुरक्षा सलाह: इस दवा को डॉक्टर के बताए अनुसार, आमतौर पर भोजन के साथ लें। गोली को पानी के साथ पूरा निगलें, चबाएं नहीं। दवा की मात्रा खुद से न बढ़ाएं। अगर आप गर्भवती हैं, स्तनपान करा रही हैं या गर्भधारण की योजना बना रही हैं, तो डॉक्टर को बताएं। अपनी सभी दवाओं के बारे में डॉक्टर को जानकारी दें, खासकर एंटासिड और एसिड कम करने वाली दवाओं के बारे में। अगर आपको किडनी, लिवर या गाउट की समस्या है, तो डॉक्टर की सलाह के बिना यह दवा न लें। दवा को ठंडी, सूखी जगह पर, धूप से दूर रखें। बच्चों की पहुंच से दूर रखें।
💊 barozyme 192mg/40mg tablet Uses & Benefits
[{"condition":"Exocrine pancreatic insufficiency","description":"This medicine provides pancreatic enzymes to replace deficient natural enzyme production, helping to digest fats, proteins, and carbohydrates and reducing steatorrhea and malabsorption.","evidence":"Well-established"},{"condition":"Chronic pancreatitis with maldigestion","description":"Used to improve fat absorption and reduce stool frequency and greasiness in patients with chronic pancreatitis and reduced pancreatic enzyme output.","evidence":"Well-established"},{"condition":"Post-pancreatectomy or pancreatic surgery","description":"Prescribed after pancreatic resection to compensate for loss of enzyme-producing tissue and to support normal digestion.","evidence":"Well-established"},{"condition":"Cystic fibrosis with pancreatic insufficiency","description":"Pancreatic enzyme replacement is a standard part of care in cystic fibrosis patients with pancreatic insufficiency, though dosing must be individualized by a specialist.","evidence":"Well-established"},{"condition":"Functional dyspepsia with bloating and flatulence","description":"The dimethicone component helps relieve trapped gas and bloating, while pancreatin may support digestion in people with mild enzyme insufficiency.","evidence":"Limited"},{"condition":"Flatulence and abdominal distension","description":"Dimethicone acts as an antifoaming agent to reduce gas bubble surface tension, making it easier for gas to be expelled.","evidence":"Limited"}]
Off-label uses: [{"condition":"Non-ulcer dyspepsia","description":"Sometimes used to relieve post-meal fullness and gas, although evidence for pancreatic enzyme benefit in this group is limited.","evidence":"Limited"},{"condition":"Irritable bowel syndrome with bloating","description":"Dimethicone may be used for symptomatic gas relief, but it does not treat the underlying IBS.","evidence":"Limited"}]
Primary treatment for: Exocrine pancreatic insufficiency and associated maldigestion
Also treats: Chronic pancreatitis, Cystic fibrosis with pancreatic insufficiency, Post-pancreatic surgery, Functional dyspepsia with bloating, Flatulence and abdominal distension
📋 Drug Information
| Generic Name(s) | Pancreatin (192mg) + Dimethicone (40mg) |
| Brand Name | barozyme 192mg/40mg tablet |
| Manufacturer | Baroda Pharma Pvt Ltd |
| Packaging / Form | Varies by brand (Allopathy) |
| Therapeutic Class | GASTRO INTESTINAL |
| Action Class | |
| Route of Administration | Oral |
| Storage | Store at room temperature between 15°C and 30°C in a cool, dry place. Protect from direct sunlight and moisture. Keep the tablets in their original container with the lid tightly closed. |
| Shelf Life | Typically 24 months from the date of manufacture, but always check the expiry date printed on the pack. Do not use after the expiry date. |
| WHO Guideline | Not established from the available information. |
| ICMR Guideline | Not established from the available information. |
👨⚕️ Doctor's Practical Tips
Evidence-based practical advice from experienced clinicians
🔍 Is This Medicine Right for Your Symptom?
Educational reference. Always consult a doctor for diagnosis.
🔬 How This Medicine Works (Pharmacology)
Pharmacokinetics
How It Works
This medicine combines two active ingredients with different actions. Pancreatin is a mixture of porcine-derived pancreatic enzymes, mainly amylase, lipase, and protease. Amylase breaks down starches into simpler sugars, lipase breaks down triglycerides into fatty acids and glycerol, and protease breaks down proteins into peptides and amino acids. These enzymes work in the small intestine to replace missing or insufficient natural pancreatic enzymes, improving digestion and absorption of nutrients. Dimethicone is a silicone-based antifoaming agent that lowers the surface tension of gas bubbles in the stomach and intestines. This causes small gas bubbles to merge into larger bubbles that can be passed more easily, reducing bloating and flatulence. Dimethicone is not absorbed into the bloodstream to any significant extent and acts locally in the gut.
Mechanism Steps
💡 How to Take barozyme 192mg/40mg tablet
Strength: Tablet containing Pancreatin 192 mg and Dimethicone 40 mg, immediate release.
Dosage Information
| Adult Dosage | The usual adult dose of this medicine is one tablet taken orally with each meal or as directed by your doctor. The exact dose and frequency depend on the indication, the severity of pancreatic insufficiency, and your response to treatment. Dose must be individualized by a qualified clinician based on indication, age, weight, renal and hepatic function. Do not self-adjust the dose. Swallow the tablet whole with water; do not crush or chew unless advised. If you are also taking acid-suppressing drugs, your doctor may adjust the timing or dose of this medicine. |
| Pediatric Dosage | Pediatric dosing is not established from available information. Consult a pediatrician. Pancreatic enzyme dosing in children must be individualized by a specialist based on weight, diet, and the underlying condition. |
| Elderly Dosage | Elderly patients can usually take the same adult dose, but they should be monitored for side effects and nutritional status. Dose adjustments may be needed if kidney or liver function is reduced. Always follow your doctor's advice. |
| Renal Impairment | No specific dose adjustment is established for patients with kidney disease. Use with caution and under medical supervision. Your doctor may monitor kidney function and adjust the dose if needed. |
| Hepatic Impairment | No specific dose adjustment is established for patients with liver disease. Use with caution and under medical supervision. Your doctor may monitor liver function and adjust the dose if needed. |
| Maximum Daily Dose | The maximum daily dose must be determined by a qualified clinician based on the indication and patient factors. Do not exceed the prescribed dose. High doses of pancreatic enzymes have been associated with serious bowel complications, especially in children with cystic fibrosis. |
Dosage Timeline
🍽️ Food Timing Guide
⏰ What to Do If You Miss a Dose
⚠️ Side Effects of barozyme 192mg/40mg tablet
✅ Common Side Effects
🚨 Serious Side Effects
⚠️ Rare Side Effects
Consult your doctor if you experience any unusual symptoms.
🔬 Drug Interactions
| Drug | Severity | Effect |
|---|---|---|
| Omeprazole | Major | |
| Ranitidine | Major | |
| Calcium carbonate | Moderate | |
| Ferrous sulfate | Moderate | |
| Metformin | Moderate | |
| Warfarin | Minor | |
| Levothyroxine | Minor | |
| Folic acid | Minor | |
| Vitamin B12 | Minor | |
| Anticholinergic drugs | Minor |
🚨 Major Interactions
- Acid-suppressing drugs (proton pump inhibitors, H2 blockers)
- Antacids containing calcium carbonate or magnesium hydroxide
⚡ Moderate Interactions
- Iron supplements
- Oral antidiabetic drugs
🍷 Alcohol Interaction
Alcohol can worsen pancreatitis and may reduce the effectiveness of pancreatic enzyme replacement. It is advisable to avoid alcohol while taking this medicine, especially if you have a history of pancreatitis or liver disease.
🔎 Check Your Other Medicines
Educational tool. Always confirm with your doctor or pharmacist.
🛡️ Safety & Warnings
🚫 Contraindications
["Known allergy to porcine-derived pancreatic enzymes or any component of this medicine","Acute pancreatitis or acute exacerbation of chronic pancreatitis","Acute abdomen or suspected bowel obstruction","Fibrosing colonopathy","Children without specialist supervision"]
⚠️ Warnings & Precautions
["Do not exceed the prescribed dose, as high doses of pancreatic enzymes have been linked to fibrosing colonopathy in children with cystic fibrosis.","Use with caution in patients with gout or hyperuricemia because pancreatin contains purines.","Use with caution in patients with kidney or liver disease.","Inform your doctor if you are pregnant, planning pregnancy, or breastfeeding.","Tell your doctor about all other medicines, especially acid-suppressing drugs and antacids.","Do not use this medicine to treat undiagnosed abdominal pain.","Keep out of reach of children.","Store in a cool, dry place away from direct sunlight."]
🤱 Lactation Safety
It is not known whether pancreatin or dimethicone pass into breast milk in significant amounts. Because they act locally in the gut and are not absorbed systemically to a meaningful degree, the risk to a breastfed infant is expected to be very low. However, consult your doctor before using this medicine while breastfeeding.
💊 Overdose Management
Overdose with this medicine is unlikely to cause serious systemic toxicity because pancreatin and dimethicone act locally in the gut. However, very high doses of pancreatic enzymes can cause nausea, vomiting, diarrhea, and abdominal pain. In case of suspected overdose, stop the medicine and seek medical attention. Treatment is supportive and symptomatic. Do not try to induce vomiting unless advised by a healthcare professional.
⏰ Missed Dose
If you miss a dose, take it as soon as you remember if it is still close to the scheduled time. If it is almost time for your next dose, skip the missed dose and continue with your regular schedule. Do not take a double dose to make up for a missed one. If you miss doses often, talk to your doctor about adjusting your schedule.
Additional Safety Advice
Take this medicine exactly as prescribed by your doctor, usually with meals or snacks. Swallow the tablet whole with a glass of water; do not crush or chew unless your doctor or pharmacist advises otherwise. Do not take more than the recommended dose because higher doses of pancreatic enzymes can cause serious bowel problems. Keep this medicine out of reach of children. Inform your doctor if you are pregnant, planning pregnancy, or breastfeeding. Tell your doctor about all other medicines, especially antacids, acid-suppressing drugs, and iron supplements, because they can affect how well pancreatic enzymes work. If you have kidney disease, liver disease, gout, or a history of bowel obstruction, use this medicine only under medical supervision. Do not use this medicine to treat sudden severe abdominal pain without a diagnosis. Store the tablets in a cool, dry place away from direct sunlight and moisture. Do not use after the expiry date printed on the pack.
👴 Special Considerations for Elderly
💡 For Patients Above 65
Elderly patients can usually take the same adult dose, but they should be monitored for side effects and nutritional status. Dose adjustments may be needed if kidney or liver function is reduced. Always follow your doctor's advice.
🤰 Pregnancy Planning (TTC)
If you are planning pregnancy, discuss this medicine with your doctor. It is generally considered acceptable when clinically indicated, but your doctor will weigh the benefits and risks. Do not start or stop this medicine without medical advice.
🏥 Post-Surgery Considerations
If you have recently had surgery, especially pancreatic or abdominal surgery, your doctor will decide if this medicine is appropriate for you. It may be used to support digestion after pancreatic surgery. Follow your surgeon's and doctor's instructions carefully.
🦷 Dental Procedures
This medicine does not usually interfere with dental procedures. However, inform your dentist about all medicines you take. If you need to fast before a procedure, ask your doctor how to adjust your dose.
💚 Lifestyle Tips for Better Results
🏋️ Exercise Considerations
This medicine is not known to impair exercise capacity. However, if you have abdominal pain or bloating, avoid strenuous exercise until you feel better. Gentle walking and light activity can help with digestion.
🥗 Diet Recommendations
💼 Impact on Daily Work & Life
This medicine is not known to affect your ability to drive or operate machinery. You can continue your normal daily activities while taking it. If you experience dizziness or unusual tiredness, avoid driving until you feel better.
🛑 When to Stop This Medicine
Do not stop this medicine without consulting your doctor, especially if you are taking it for chronic pancreatic insufficiency. If you experience serious side effects such as severe allergic reactions, severe abdominal pain, or signs of bowel obstruction, stop the medicine and seek immediate medical help. Your doctor will decide if and when to stop or change the medicine.
📅 Long-Term Use Effects
Long-term use of this medicine is generally safe when taken at prescribed doses under medical supervision. In patients with chronic pancreatic insufficiency, it helps maintain nutrition and reduce symptoms. However, very high doses of pancreatic enzymes have been associated with fibrosing colonopathy, especially in children with cystic fibrosis. Regular follow-up with your doctor is important to monitor your response, nutritional status, and any side effects. Your doctor may adjust the dose based on your condition and may monitor uric acid levels if you have gout.
🌿 Non-Medicine Approaches
These can complement medicine but do not replace prescribed treatment.
Eating smaller, low-fat meals may help reduce symptoms of bloating and indigestion.
Evidence: Well-establishedMay help improve gut health and reduce bloating in some people.
Evidence: LimitedRegular light exercise can help improve digestion and reduce bloating.
Evidence: Well-established💉 Vaccination Considerations
💉 If You're Getting Vaccinated
There are no known interactions between this medicine and vaccines. You can receive vaccines as scheduled. If you have any concerns, discuss them with your doctor.
📦 Storage Guide
✅ DO
Store at room temperature (15-30°C)
❌ DON'T
Do not refrigerate unless specified
✅ DO
Keep in original container
❌ DON'T
Do not transfer to unmarked containers
✅ DO
Keep away from direct sunlight
❌ DON'T
Do not store in bathroom cabinet
✈️ Traveling with This Medicine
When traveling, carry this medicine in its original packaging with the prescription label clearly visible. Keep a copy of your prescription with you in case customs or security asks for it. Store the tablets in a cool, dry place and avoid leaving them in a hot car or in direct sunlight. If you are crossing time zones, take the tablet with your meals according to local meal times. Do not stop the medicine suddenly without consulting your doctor. If you are traveling for a long period, carry enough supply to last the entire trip.
💰 Cost Analysis & Savings
👥 Real Patient Stories
Educational, anonymized scenarios. Individual results may vary.
💬 Questions Patients Often Ask
A: This medicine starts working within 30 to 60 minutes after you take it with food. You may notice improvement in bloating and digestion after a few doses, but the full benefit may take a few days.
A: It is best to take this medicine with food because the pancreatic enzymes need to mix with food to help digestion. Taking it without food may reduce its effectiveness.
A: It can be used long-term under medical supervision, especially in chronic pancreatic insufficiency. Your doctor will monitor your symptoms and may adjust the dose as needed.
A: Antacids can reduce the effectiveness of pancreatic enzymes. Ask your doctor about the best timing, and usually separate the doses by 1 to 2 hours.
A: If you miss a dose, take it as soon as you remember if it is still close to the scheduled time. If it is almost time for your next dose, skip the missed dose and continue with your regular schedule. Do not double dose.
🤔 Common Patient Concerns
🛑 Myths vs. Facts
- Myth: This medicine can cure pancreatitis.
Fact: This medicine does not cure pancreatitis. It only helps replace digestive enzymes and relieve symptoms. - Myth: More tablets mean better digestion.
Fact: Taking more than the prescribed dose can be harmful and does not improve digestion beyond the recommended amount. - Myth: This medicine is a painkiller.
Fact: This medicine is not a painkiller. It helps with digestion and gas, not pain. - Myth: Anyone with bloating should take this medicine.
Fact: This medicine is meant for specific conditions. Bloating can have many causes, and you should consult a doctor before using it.
🔄 Alternative Options
Generic Alternatives
- Pancreatin + Dimethicone tablet (generic versions may be available)
Brand Alternatives
- Creon
- Pancreaze
- Zenpep
- Pertzye
- Viokace