bacstol 200 tablet - Trimethoprim (200mg) medicine

bacstol 200 tablet

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🏭 Ipca Laboratories Ltd 📦 Varies by brand 💊 Allopathy 📅 Updated: Sep 25, 2026
🤰 Pregnancy Category C 📋 Prescription Required 💊 Generic Available
Medically Reviewed
11 min read
Reviewed by
SaathiMed Expert Panel | Sep 25, 2026

What is bacstol 200 tablet used for?

This medicine contains Trimethoprim (200mg) and is used to treat ANTI INFECTIVES. Inhibits bacterial dihydrofolate reductase, blocking the conversion of dihydrofolic acid to tetrahyd. Always consult your doctor before use.

  • Generic Name: Trimethoprim
  • Manufacturer: Ipca Laboratories Ltd
  • Form: Allopathy
  • Pregnancy Category: Category C
  • Prescription Required: Yes
💡 Did You Know? India has the highest number of USFDA-compliant plants outside the USA.

💊 bacstol 200 tablet Uses & Benefits

Treatment of urinary tract infections, acute otitis media, traveler's diarrhea, Pneumocystis jirovecii pneumonia (in combination with sulfamethoxazole), and other bacterial infections.

Off-label uses: Prophylaxis of urinary tract infections, treatment of prostatitis, and some respiratory infections.

📋 Drug Information

Generic Name(s)Trimethoprim
Brand NameBacstol 200 Tablet
ManufacturerIpca Laboratories Ltd
Packaging / FormVaries by brand (Allopathy)
Therapeutic ClassANTI INFECTIVES
Action ClassSulphonamides
Route of AdministrationOral
StorageStore at room temperature (20-25°C); protect from light and moisture.
Shelf LifeAs per manufacturer

🔬 How This Medicine Works (Pharmacology)

Pharmacokinetics

AbsorptionRapidly and well absorbed from the gastrointestinal tract.
DistributionWidely distributed into body tissues and fluids, including cerebrospinal fluid, sputum, and prostatic fluid.
Protein BindingApproximately 40-70% bound to plasma proteins.
MetabolismHepatic metabolism to inactive metabolites.
Half-Life8-10 hours (normal renal function); prolonged in renal impairment.
ExcretionPrimarily excreted unchanged in urine via glomerular filtration and tubular secretion.
BioavailabilityApproximately 90-100% after oral administration.
Onset of Action1-4 hours after oral administration.
Peak Plasma Time1-4 hours after oral administration.
Duration of ActionApproximately 12 hours.

How It Works

Inhibits bacterial dihydrofolate reductase, blocking the conversion of dihydrofolic acid to tetrahydrofolic acid, thereby inhibiting bacterial DNA synthesis.

Mechanism Steps

1Trimethoprim enters bacterial cell via passive diffusion.
2Binds to bacterial dihydrofolate reductase (DHFR) with high affinity.
3Inhibits reduction of dihydrofolic acid to tetrahydrofolic acid.
4Depletes tetrahydrofolate, a cofactor for thymidylate and purine synthesis.
5Disrupts DNA, RNA, and protein synthesis, leading to bacterial growth inhibition.

💡 How to Take bacstol 200 tablet

Follow your doctor's prescription exactly.

⚠️ Side Effects of bacstol 200 tablet

✅ Common Side Effects

Nausea
Vomiting
Diarrhea
Rash
Pruritus
Headache

🚨 Serious Side Effects

Stevens-Johnson syndrome
Toxic epidermal necrolysis
Aplastic anemia
Agranulocytosis
Megaloblastic anemia
Hyperkalemia
Interstitial nephritis

⚠️ Rare Side Effects

Hepatitis
Cholestatic jaundice
Pancreatitis
Pseudomembranous colitis
Photosensitivity
Anaphylaxis

Consult your doctor if you experience any unusual symptoms.

🔬 Drug Interactions

Drug Severity Effect
Methotrexate Major Increased methotrexate toxicity (myelosuppression, hepatotoxicity)
Phenytoin Major Increased phenytoin levels and toxicity
Warfarin Major Increased anticoagulant effect and bleeding risk
Cyclosporine Major Increased nephrotoxicity
Procainamide Major Increased procainamide levels and toxicity
Amantadine Major Increased amantadine levels and CNS toxicity
ACE inhibitors Moderate Increased risk of hyperkalemia
Angiotensin II receptor blockers Moderate Increased risk of hyperkalemia
Potassium-sparing diuretics Moderate Increased risk of hyperkalemia
Digoxin Moderate Increased digoxin levels
Zidovudine Moderate Increased zidovudine levels and toxicity
Lamivudine Moderate Increased lamivudine levels
Oral contraceptives Minor Possible decreased contraceptive efficacy
Rifampin Minor Decreased trimethoprim levels
Primidone Minor Possible decreased primidone levels
Pyrimethamine Minor Additive antifolate effect

🚨 Major Interactions

  • Methotrexate
  • Phenytoin
  • Warfarin
  • Cyclosporine
  • Procainamide
  • Amantadine

⚡ Moderate Interactions

  • ACE inhibitors
  • Angiotensin II receptor blockers
  • Potassium-sparing diuretics
  • Digoxin
  • Zidovudine
  • Lamivudine

🍷 Alcohol Interaction

No known interaction; however, alcohol may increase risk of adverse effects.

🛡️ Safety & Warnings

🚫 Contraindications

Hypersensitivity to trimethoprim; megaloblastic anemia due to folate deficiency; severe renal impairment (CrCl

🤱 Lactation Safety

Excreted in breast milk; caution advised; may interfere with infant folate metabolism.

💊 Overdose Management

Induce emesis or gastric lavage; administer folinic acid (leucovorin) to counteract antifolate effects; supportive care.

⏰ Missed Dose

Take as soon as remembered; if close to next dose, skip missed dose; do not double dose.

🔄 Substitutes for bacstol 200 tablet

View All

Alternative brands with exact same active ingredient:

Medical Note: Always consult your doctor before switching medications.

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