Ofloxacin 200mg: Comprehensive Medical Information
What is azoflox 200mg tablet used for?
Ofloxacin is a fluoroquinolone antibiotic used to treat bacterial infections such as UTIs, bronchitis, and gonorrhea. It works by inhibiting bacterial DNA replication. Common side effects include nausea, diarrhea, and headache. Serious risks include tendon damage and nerve problems. Take as prescribed, avoid dairy and antacids around dosing, and complete the full course.
- Generic Name: Ofloxacin (200mg)
- Manufacturer: Mac Millon Pharmaceuticals Pvt Ltd
- Form: Allopathy
- Pregnancy Category: Category C
- Prescription Required: Yes
💊 azoflox 200mg tablet Uses & Benefits
- Ofloxacin is primarily used to treat bacterial infections including: acute and chronic bronchitis, community-acquired pneumonia, uncomplicated and complicated urinary tract infections (UTIs), pyelonephritis, prostatitis, skin and soft tissue infections, and sexually transmitted infections such as gonorrhea and chlamydia.
- It is also used for gastrointestinal infections like traveler's diarrhea and typhoid fever.
- Ophthalmic preparations are used for bacterial conjunctivitis and corneal ulcers.
Off-label uses: Off-label uses include treatment of multidrug-resistant tuberculosis (as part of combination therapy), leprosy, and some mycobacterial infections. It has also been used for pelvic inflammatory disease and epididymitis.
Primary treatment for: Bacterial infections
Also treats: Urinary tract infections, Respiratory tract infections, Skin and soft tissue infections, Sexually transmitted infections
📋 Drug Information
| Generic Name(s) | Ofloxacin (200mg) |
| Brand Name | azoflox 200mg tablet |
| Manufacturer | Mac Millon Pharmaceuticals Pvt Ltd |
| Packaging / Form | Varies by brand (Allopathy) |
| Therapeutic Class | Antibiotic |
| Action Class | Fluoroquinolone |
| Route of Administration | Oral, Intravenous, Ophthalmic |
| Storage | Store at room temperature (20-25°C), protect from light and moisture. |
| Shelf Life | 2-3 years (check packaging) |
| WHO Guideline | WHO Model List of Essential Medicines: Ofloxacin is included as a reserve antibiotic for specific indications. |
| ICMR Guideline | ICMR Treatment Guidelines for Antimicrobial Use in Common Syndromes: Ofloxacin is recommended for certain UTIs and diarrheal diseases. |
🔬 How This Medicine Works (Pharmacology)
Pharmacokinetics
How It Works
Ofloxacin is a fluoroquinolone antibiotic that inhibits bacterial DNA gyrase (topoisomerase II) and topoisomerase IV, enzymes required for DNA replication, transcription, repair, and recombination. By binding to these enzymes, it prevents the supercoiling and uncoiling of bacterial DNA, leading to inhibition of DNA synthesis and ultimately bacterial cell death. This mechanism is bactericidal and concentration-dependent.
Mechanism Steps
💡 How to Take azoflox 200mg tablet
Dosage Information
| Adult Dosage | 200-400 mg orally every 12 hours for 7-14 days depending on infection. For uncomplicated UTI: 200 mg every 12 hours for 3 days. For gonorrhea: 400 mg single dose. |
| Pediatric Dosage | Not recommended for children <18 years due to risk of arthropathy. In exceptional cases, dose based on body weight: 7.5-15 mg/kg/day divided every 12 hours (max 400 mg/day). |
| Elderly Dosage | No specific adjustment except based on renal function. Start at lower end of dosing range. |
| Renal Impairment | CrCl 20-50 mL/min: 200-400 mg every 24 hours. CrCl <20 mL/min: 200 mg every 24 hours. Hemodialysis: 200 mg every 24 hours. |
| Hepatic Impairment | No adjustment required in mild to moderate hepatic impairment. Use with caution in severe hepatic impairment. |
| Maximum Daily Dose | 800 mg/day |
Dosage Timeline
⚠️ Side Effects of azoflox 200mg tablet
✅ Common Side Effects
🚨 Serious Side Effects
⚠️ Rare Side Effects
Consult your doctor if you experience any unusual symptoms.
🔬 Drug Interactions
| Drug | Severity | Effect |
|---|---|---|
| Warfarin | Major | Increased INR and bleeding risk |
| Antidiabetic agents | Major | Enhanced hypoglycemic effect |
| NSAIDs | Major | Increased risk of CNS stimulation and seizures |
| QT-prolonging agents | Major | Increased risk of ventricular arrhythmias |
| Corticosteroids | Moderate | Increased risk of tendon rupture |
| Cyclosporine | Moderate | Increased nephrotoxicity |
| Probenecid | Moderate | Decreased renal excretion of ofloxacin |
| Theophylline | Moderate | Increased theophylline levels |
| Antacids (Mg/Al/Ca) | Minor | Reduced absorption of ofloxacin |
| Sucralfate | Minor | Reduced absorption of ofloxacin |
| Iron/Zinc supplements | Minor | Reduced absorption of ofloxacin |
| Dairy products | Minor | Reduced absorption of ofloxacin |
🚨 Major Interactions
- Warfarin (increased anticoagulant effect)
- Antidiabetic agents (increased hypoglycemic effect)
- NSAIDs (increased risk of CNS stimulation and seizures)
- QT-prolonging agents (increased risk of arrhythmias)
⚡ Moderate Interactions
- Corticosteroids (increased risk of tendon rupture)
- Cyclosporine (increased nephrotoxicity)
- Probenecid (decreased renal excretion of ofloxacin)
- Theophylline (increased theophylline levels)
🍷 Alcohol Interaction
Alcohol may increase the risk of CNS side effects (dizziness, drowsiness). Avoid alcohol during treatment.
🛡️ Safety & Warnings
🚫 Contraindications
Hypersensitivity to ofloxacin or any fluoroquinolone. History of tendon disorders related to fluoroquinolone use. Avoid in children and adolescents (
⚠️ Warnings & Precautions
Fluoroquinolones, including ofloxacin, have been associated with disabling and potentially irreversible serious adverse reactions involving tendons, muscles, joints, nerves, and the central nervous system. Discontinue immediately if signs of tendon pain, swelling, or rupture occur. Avoid in patients with a history of tendon disorders. Use with caution in patients with renal impairment (adjust dose), epilepsy, or other CNS disorders. May exacerbate myasthenia gravis. Monitor for signs of peripheral neuropathy. Avoid excessive sunlight/UV exposure due to photosensitivity. QT prolongation risk; avoid in patients with known QT prolongation, electrolyte imbalances, or concurrent use of QT-prolonging drugs. Clostridioides difficile-associated diarrhea has been reported. Use with caution in patients with aortic aneurysm or history of aortic dissection.
🤱 Lactation Safety
Ofloxacin is excreted in breast milk. Use with caution in nursing mothers; consider discontinuing br
💊 Overdose Management
In case of overdose, symptomatic and supportive care is recommended. No specific antidote. Monitor ECG for QT prolongation. Hemodialysis removes only a small amount of ofloxacin (10-20%).
⏰ Missed Dose
Take the missed dose as soon as you remember. If it is almost time for the next dose, skip the missed dose and resume the regular schedule. Do not double the dose.
🔄 Substitutes for azoflox 200mg tablet
View AllAlternative brands with exact same active ingredient:
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cachof 200mg tabletCachet Pharmaceuticals Pvt Ltd ₹9.12 80.3% CHEAPER
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protoflox 200mg tabletPCI Pharmaceuticals ₹9.38 79.8% CHEAPER
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oflocin 200mg tabletLaborate Pharmaceuticals India Ltd ₹10.72 76.9% CHEAPER
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cipdose 200mg infusionShreya Life Sciences Pvt Ltd ₹10.87 76.6% CHEAPER
-
ciprofloxacin usp 200mg infusionAlbert David Ltd ₹10.94 76.4% CHEAPER
Medical Note: Always consult your doctor before switching medications.
🛑 Myths vs. Facts
- Myth: Ofloxacin is safe to take with any food.
Fact: Dairy products and calcium-fortified foods can reduce absorption. Take ofloxacin on an empty stomach or 2 hours after meals.
🔄 Alternative Options
Generic Alternatives
- Ofloxacin
- Ofloxacin (various manufacturers)
Brand Alternatives
- Zanocin
- Oflox
- Oflomac
- Oflovid
- Tarivid