azobril cream - Azelaic Acid (15% w/w) medicine

Aziderm 15% Gel: Complete Medicine Guide for Acne and Dark Spots

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🏭 Brinton Pharmaceuticals Pvt Ltd 📦 Varies by brand 💊 Allopathy 📅 Updated: Sep 20, 2026
📋 Prescription Required 💊 Generic Available
Medically Reviewed
12 min read
Evidence: Well-established for acne vulgaris; moderate for post-inflammatory hyperpigmentation and rosacea.
Reviewed by
SaathiMed Expert Panel | Sep 20, 2026

When to Call Your Doctor IMMEDIATELY

  • Severe burning, swelling, or blistering at the application site
  • Widespread rash or hives after using this medicine
  • Swelling of the face, lips, tongue, or throat
  • Difficulty breathing or tightness in the chest
  • Signs of a serious skin infection such as pus, warmth, or spreading redness
  • Sudden worsening of acne with severe pain or fever

If experiencing severe symptoms, call emergency services immediately.

What is azobril cream used for?

This medicine is a topical gel containing azelaic acid 15% w/w. It is used to treat mild to moderate acne by reducing acne-causing bacteria, unclogging pores, and fading dark spots. It is applied thinly to the affected skin once or twice daily, usually for several weeks.

  • Generic Name: Azelaic Acid
  • Manufacturer: Brinton Pharmaceuticals Pvt Ltd
  • Form: Allopathy
  • Pregnancy Category: Consult doctor
  • Prescription Required: Yes

🇮🇳 azobril cream के बारे में (Hindi Summary)

उपयोग: यह दवा एक टॉपिकल जेल है जिसमें एज़ेलिक एसिड 15% w/w होता है। इसका इस्तेमाल मुख्य रूप से हल्के से मध्यम मुँहासे (एक्ने) के इलाज के लिए किया जाता है। यह मुँहासे पैदा करने वाले बैक्टीरिया को कम करती है, बंद रोमछिद्रों को खोलने में मदद करती है और मुँहासे के बाद बचे काले दाग-धब्बों को हल्का करने में सहायक होती है। इसे चेहरे की प्रभावित त्वचा पर पतली परत में लगाया जाता है। इसका असर दिखने में आमतौर पर कई हफ्ते लगते हैं, इसलिए इसे नियमित रूप से डॉक्टर की सलाह के अनुसार ही लगाएँ।

साइड इफेक्ट्स: इस दवा के सबसे आम दुष्प्रभाव लगाने की जगह पर हल्की जलन, खुजली, लालिमा और सूखापन हैं। ये आमतौर पर कुछ दिनों में अपने आप कम हो जाते हैं। कुछ लोगों में त्वचा का पपड़ीदार होना या छिलना भी देखा जा सकता है। अगर जलन या लालिमा बहुत ज्यादा बढ़ जाए, तो इस दवा का इस्तेमाल बंद कर दें और डॉक्टर से सलाह लें। बहुत कम मामलों में गंभीर एलर्जी हो सकती है, जिसमें सूजन या साँस लेने में तकलीफ हो सकती है। ऐसा होने पर तुरंत डॉक्टर से मिलें।

सुरक्षा सलाह: इस दवा को सिर्फ त्वचा पर ही लगाएँ और डॉक्टर के बताए तरीके से ही इस्तेमाल करें। लगाने से पहले और बाद में हाथ धो लें। आँखों, होंठों और नाक या मुँह के अंदर इस दवा को न लगाएँ। अगर गलती से आँख में चली जाए, तो तुरंत ढेर सारे पानी से धोएँ। इस दवा के साथ तेज स्क्रब, अल्कोहल वाले टोनर या अन्य परेशान करने वाले प्रोडक्ट्स का इस्तेमाल न करें। अगर आप गर्भवती हैं, गर्भधारण की योजना बना रही हैं या स्तनपान करा रही हैं, तो इस्तेमाल से पहले डॉक्टर से सलाह लें। इस दवा को बच्चों की पहुँच से दूर और धूप से बचाकर रखें।

💡 Did You Know? The first generic medicine was introduced in India in 1970 after the Patents Act was amended.

💊 azobril cream Uses & Benefits

[{"condition":"Mild to moderate acne vulgaris","description":"This medicine reduces acne-causing bacteria and helps unclog pores, leading to fewer pimples and less inflammation on the face.","evidence":"Well-established"},{"condition":"Post-inflammatory hyperpigmentation","description":"This medicine may help lighten dark marks left behind after acne or other skin injuries by slowing excess melanin production.","evidence":"Moderate"},{"condition":"Rosacea with papules and pustules","description":"This medicine can reduce the number of inflammatory bumps and redness in some people with rosacea.","evidence":"Moderate"},{"condition":"Melasma","description":"This medicine is sometimes used as part of a skin-lightening routine for melasma, though results vary between individuals.","evidence":"Limited"}]

Off-label uses: [{"condition":"Folliculitis","description":"Occasionally prescribed off-label for inflamed hair follicles, but this is not a standard first-line use.","evidence":"Limited"},{"condition":"Keratosis pilaris","description":"Sometimes used off-label to smooth rough bumps on the arms and thighs, but evidence is not strong.","evidence":"Limited"}]

Primary treatment for: Acne vulgaris

Also treats: Post-inflammatory hyperpigmentation, Rosacea, Melasma

📋 Drug Information

Generic Name(s)Azelaic Acid
Brand NameAziderm 20% Cream
ManufacturerBrinton Pharmaceuticals Pvt Ltd
Packaging / FormVaries by brand (Allopathy)
Therapeutic ClassDERMA
Action ClassAntimicrobials- Acne
Route of AdministrationTopical
StorageStore this medicine at room temperature, away from direct sunlight and moisture. Keep the tube tightly closed when not in use. Do not freeze this medicine.
Shelf LifeNot established from the available information. Refer to the expiry date printed on the pack.
WHO GuidelineNot established from the available information.
ICMR GuidelineNot established from the available information.

👨‍⚕️ Doctor's Practical Tips

Evidence-based practical advice from experienced clinicians

1
Apply this medicine to clean, dry skin and use only a thin layer to reduce irritation.
2
Start with once-daily application if your skin is sensitive, then increase to twice daily only if your doctor advises it.
3
Use a gentle, non-comedogenic moisturizer and a broad-spectrum sunscreen every morning while using this medicine.
4
Avoid using strong scrubs, alcohol-based toners, or other peeling products at the same time.
5
Be patient and consistent, because visible improvement usually takes four to eight weeks.
6
If you develop severe burning, swelling, or a rash, stop using this medicine and contact your doctor promptly.
7
Do not apply this medicine to broken skin or areas of active infection.

🔍 Is This Medicine Right for Your Symptom?

Educational reference. Always consult a doctor for diagnosis.

Mild to moderate acne on the face
This medicine is commonly prescribed for this condition.
Likely Use
Dark spots after acne
This medicine may help fade post-inflammatory hyperpigmentation.
Likely Use
Rosacea with bumps
This medicine can reduce inflammatory bumps in some people with rosacea.
Likely Use
Fever
This medicine is not used to treat fever.
Not Primary
Severe cystic acne with pain
This medicine may not be enough for severe acne; consult a dermatologist.
Not Primary

🔬 How This Medicine Works (Pharmacology)

Pharmacokinetics

AbsorptionThis medicine is applied to the skin, and only a small amount is absorbed into the bloodstream. Absorption can increase if it is applied to broken skin or over a large area. Not established from the available information for exact percentages.
DistributionNot established from the available information.
Protein BindingNot established from the available information.
MetabolismNot established from the available information.
Half-LifeNot established from the available information.
ExcretionNot established from the available information.
BioavailabilityNot established from the available information.
Onset of ActionSome people notice less oiliness and fewer new pimples within one to two weeks, but visible improvement in acne usually takes four to eight weeks of regular use.
Peak Plasma TimeNot established from the available information.
Duration of ActionThe effect on the skin lasts between applications, so this medicine is usually applied once or twice daily to maintain benefit.

How It Works

This medicine works through several actions on the skin. Azelaic acid is a dicarboxylic acid that reduces the growth of Cutibacterium acnes, the bacterium involved in acne. It also inhibits the enzyme tyrosinase, which is needed for melanin production, helping to fade dark spots. In addition, it normalizes keratinization inside the hair follicle, preventing dead skin cells from blocking pores. This medicine also has mild anti-inflammatory effects that calm redness and swelling around pimples. Because it acts on bacteria, pigment, and skin cell turnover at the same time, it is useful for both active acne and the marks left behind.

Mechanism Steps

1
Reduction of acne bacteria: This medicine lowers the number of Cutibacterium acnes on the skin, which reduces the bacterial trigger for acne inflammation.
2
Normalization of skin cell turnover: This medicine helps the cells lining the hair follicle shed normally, so dead cells do not build up and block the pore.
3
Inhibition of melanin production: This medicine blocks tyrosinase activity, which reduces excess melanin and helps fade dark marks left by acne.
4
Anti-inflammatory action: This medicine calms the skin's inflammatory response, reducing redness and swelling around pimples.

💡 How to Take azobril cream

Strength: Topical gel containing azelaic acid 15% w/w.

1Wash your hands and the affected skin with a mild cleanser, then pat dry.
2Apply a thin layer of this medicine to the affected area only, avoiding the eyes, lips, and mucous membranes.
3Gently rub it in until it disappears. Do not apply a thick layer.
4Wash your hands after applying this medicine.
5Use it at the same time each day, as advised by your doctor.
6If your doctor has prescribed other skin products, ask how to use them together to avoid irritation.

Dosage Information

Adult DosageFor adults, this medicine is usually applied as a thin layer to the affected skin once or twice daily, or as directed by your doctor. The exact frequency and duration depend on the type and severity of your skin condition. Dose must be individualized by a qualified clinician based on indication, age, weight, renal and hepatic function. Do not apply more than the recommended amount, and avoid using it on normal skin unless your doctor tells you to.
Pediatric DosagePediatric dosing is not established from available information. Consult a pediatrician or dermatologist before using this medicine in children.
Elderly DosageThere is no specific dose adjustment for older adults when this medicine is used on the skin. However, older skin may be more sensitive, so use it only under medical advice and report any irritation promptly.
Renal ImpairmentNo dose adjustment is expected when this medicine is used on the skin, because very little is absorbed into the bloodstream. Consult your doctor if you have severe kidney disease.
Hepatic ImpairmentNo dose adjustment is expected when this medicine is used on the skin, because very little is absorbed into the bloodstream. Consult your doctor if you have severe liver disease.
Maximum Daily DoseNot established from the available information. Use only as directed by your doctor.

Dosage Timeline

🌅 Morning ❌ ☀️ Afternoon ❌ 🌆 Evening ❌ 🌙 Night ❌

🍽️ Food Timing Guide

No specific food restrictions
No timing needed
This medicine is applied to the skin and does not interact with food.

⏰ What to Do If You Miss a Dose

📌 Less than half the dosing interval has passed
→ Apply the missed dose as soon as you remember.
💡 Continue with your regular schedule.
📌 More than half the dosing interval has passed
→ Skip the missed dose.
💡 Do not apply a double amount to catch up.

⚠️ Side Effects of azobril cream

✅ Common Side Effects

Burning or stinging at the application site (Common (up to 10%))
This usually settles within a few days. Apply a smaller amount or use a gentle moisturizer if it continues.
Itching (Common (up to 10%))
Avoid scratching. If itching is severe or comes with a rash, stop using this medicine and consult your doctor.
Redness (Common (up to 10%))
Redness often improves as the skin adjusts. If it worsens, reduce how often you apply this medicine and speak to your doctor.
Dryness or flaking (Common (up to 10%))
Use a mild, non-comedogenic moisturizer. Do not use harsh scrubs or alcohol-based products on the treated area.

🚨 Serious Side Effects

Severe contact dermatitis (Rare (<0.1%))
Stop using this medicine and seek medical attention if you develop a severe rash, swelling, or blistering.
Angioedema or anaphylaxis (Very rare (<0.01%))
Seek emergency care immediately if you have swelling of the face, lips, tongue, or throat, or difficulty breathing.

⚠️ Rare Side Effects

Hypopigmentation (lightening of normal skin)
Stop using this medicine and consult a dermatologist if you notice light patches on normal skin.
Worsening of acne
Some people notice a temporary flare in the first few weeks. If it persists beyond six weeks, consult your doctor.

Consult your doctor if you experience any unusual symptoms.

🔬 Drug Interactions

Drug Severity Effect
Benzoyl peroxide Moderate
Tretinoin Moderate
Salicylic acid Moderate
Alcohol-based toners Moderate
Abrasive scrubs Moderate

⚡ Moderate Interactions

  • Other topical acne treatments (e.g., benzoyl peroxide, retinoids, salicylic acid)
  • Abrasive soaps, scrubs, and alcohol-based toners

🍷 Alcohol Interaction

There is no known direct interaction between this medicine and alcohol when it is used on the skin. However, alcohol can worsen skin dehydration and inflammation, so it is best to limit intake while treating acne.

🔎 Check Your Other Medicines

Educational tool. Always confirm with your doctor or pharmacist.

🛡️ Safety & Warnings

🚫 Contraindications

["Known allergy or hypersensitivity to azelaic acid or any ingredient in this medicine","Application to broken, irritated, or infected skin","Use in the eyes, mouth, or other mucous membranes"]

⚠️ Warnings & Precautions

["For external use only. Do not swallow this medicine.","Avoid contact with the eyes, lips, and inside of the nose or mouth.","Do not apply to large areas of broken skin because more medicine may be absorbed.","Stop using this medicine and consult a doctor if severe irritation or an allergic reaction occurs.","Tell your doctor if you are pregnant, planning pregnancy, or breastfeeding.","Keep this medicine out of reach of children.","Do not use this medicine for any condition other than the one for which it was prescribed."]

🤱 Lactation Safety

This medicine is applied to the skin and very little is expected to pass into breast milk. To be safe, do not apply it to the breast area and wash your hands before feeding. Consult your doctor before use while breastfeeding.

💊 Overdose Management

This medicine is for skin use only. If it is swallowed accidentally, seek medical help immediately. If too much is applied to the skin, wash the area with plenty of water and stop using it until you have spoken to your doctor. There is no specific antidote, and treatment is supportive.

⏰ Missed Dose

If you miss a dose of this medicine, apply it as soon as you remember. If it is almost time for your next dose, skip the missed dose and continue with your regular schedule. Do not apply a double amount to make up for a missed dose.

Additional Safety Advice

General Safety

Use this medicine only on the skin and only as directed by your doctor. Wash your hands before and after applying the gel, and clean the affected area gently with a mild cleanser. Apply a thin layer to the affected skin and avoid the eyes, lips, and inside of the nose or mouth. If the gel accidentally gets into your eyes, rinse thoroughly with plenty of water and seek medical advice if irritation continues. Do not cover the treated area with tight dressings or bandages unless your doctor tells you to. Avoid using other irritating skin products such as strong scrubs, alcohol-based toners, or peeling agents at the same time. Tell your doctor if you are pregnant, planning pregnancy, or breastfeeding before using this medicine. Keep this medicine out of reach of children and store it away from direct sunlight and heat. Do not use this medicine after the expiry date printed on the pack. If your acne does not improve after several weeks of regular use, consult your doctor rather than increasing the amount you apply.

👴 Special Considerations for Elderly

💡 For Patients Above 65

Older adults may have more sensitive or dry skin, so this medicine should be used with caution and only under medical advice. Start with once-daily application and use a moisturizer to reduce irritation.

🤰 Pregnancy Planning (TTC)

If you are planning pregnancy, speak to your doctor before using this medicine. Topical azelaic acid is generally considered low risk, but your doctor will decide whether it is suitable for you.

🏥 Post-Surgery Considerations

If you have recently had skin surgery or a procedure, do not apply this medicine to the treated area until your doctor says it is safe. Avoid using it on healing or broken skin.

🦷 Dental Procedures

This medicine is applied to the skin and does not usually interfere with dental procedures. Inform your dentist about all medicines you are using, including this one.

💚 Lifestyle Tips for Better Results

🏃
Wash your face gently twice daily with a mild cleanser and avoid scrubbing.
🥗
Use a non-comedogenic moisturizer to prevent dryness and flaking.
😴
Apply a broad-spectrum sunscreen every morning, as treated skin may be more sensitive to the sun.
💧
Avoid picking or squeezing pimples, which can worsen marks and scarring.
🧘
Maintain a balanced diet and stay well hydrated to support skin health.
🌞
Get adequate sleep and manage stress, as stress can trigger acne flare-ups.

🏋️ Exercise Considerations

You can exercise while using this medicine, but wash your face gently after sweating to prevent pores from clogging. Avoid sharing towels or gym equipment that may irritate the treated skin. If you swim, rinse your face with fresh water afterward and reapply moisturizer if needed.

🥗 Diet Recommendations

Include plenty of fruits and vegetables rich in antioxidants.
Limit high-sugar and highly processed foods, which may worsen acne in some people.
Stay well hydrated by drinking enough water throughout the day.
Consider omega-3 rich foods such as fish, walnuts, and flaxseeds to support skin health.

💼 Impact on Daily Work & Life

This medicine is applied to the skin and does not usually affect your ability to drive or operate machinery. You can continue your normal work and daily activities. If you experience mild stinging after application, it usually settles within a few minutes and does not interfere with work.

🛑 When to Stop This Medicine

Do not stop using this medicine without consulting your doctor, especially if your acne is improving. If you develop severe irritation, an allergic reaction, or a skin infection, stop using it and seek medical advice. Your doctor will decide whether to continue, adjust the frequency, or switch to another treatment.

📅 Long-Term Use Effects

Long-term use of this medicine is generally well tolerated when applied to the skin as directed. Some people may experience persistent dryness or sensitivity, which can usually be managed with a gentle moisturizer. There is no known serious systemic toxicity from long-term topical use. Regular follow-up with your doctor is advised to assess benefit and decide whether to continue treatment.

🌿 Non-Medicine Approaches

These can complement medicine but do not replace prescribed treatment.

Gentle skincare routine

Using a mild cleanser, non-comedogenic moisturizer, and sunscreen can support acne treatment and reduce irritation.

Evidence: Well-established
Dietary changes

Reducing high-glycemic foods and dairy may help some people with acne, though evidence is mixed.

Evidence: Limited
Other topical treatments

Benzoyl peroxide, retinoids, or topical antibiotics may be alternatives or add-ons, depending on your skin.

Evidence: Well-established

💉 Vaccination Considerations

💉 If You're Getting Vaccinated

There are no known interactions between this medicine and vaccines. You can receive vaccinations while using this medicine.

📦 Storage Guide

✅ DO

Store at room temperature, away from direct sunlight.

❌ DON'T

Do not freeze this medicine.

✅ DO

Keep the tube tightly closed when not in use.

❌ DON'T

Do not leave the cap open or store it loosely.

✅ DO

Keep this medicine out of reach of children.

❌ DON'T

Do not transfer it to unmarked containers.

✈️ Traveling with This Medicine

When travelling, carry this medicine in its original packaging with the prescription label visible. Keep a copy of your prescription or doctor&#039;s note in case customs or security asks about it. Store the tube at room temperature and avoid leaving it in a hot car or in direct sunlight. If you are crossing time zones, continue applying it at your usual times as closely as possible. Pack it in your hand luggage if you need it during the journey, and make sure the cap is tightly closed to prevent leakage.

💰 Cost Analysis & Savings

👥 Real Patient Stories

Educational, anonymized scenarios. Individual results may vary.

👤 A 22-year-old college student with mild facial acne and dark spots
She was advised to apply this medicine once daily at night after washing her face. For the first week she felt mild stinging, which settled by the second week. After about six weeks, she noticed fewer new pimples and a gradual fading of old dark marks. She also started using a gentle moisturizer and sunscreen daily.
💡 Lesson: Consistent once-daily use, along with moisturizer and sunscreen, improves both tolerance and results.
👤 A 30-year-old woman with rosacea and occasional bumps
Her dermatologist prescribed this medicine to be applied twice daily to the affected areas. She initially applied too much and developed redness and peeling. After reducing the amount to a thin layer and using a mild moisturizer, her skin calmed down and the bumps reduced over eight weeks.
💡 Lesson: Using only a thin layer and adjusting frequency with your doctor's guidance helps prevent irritation.

💬 Questions Patients Often Ask

Q: How long does this medicine take to work?

A: Most people notice some improvement in oiliness and new pimples within two to four weeks, but full benefit for acne and dark spots usually takes eight to twelve weeks of regular use.

Q: Can I use this medicine with other acne treatments?

A: It can be used with some other treatments, but combining it with benzoyl peroxide, retinoids, or salicylic acid may increase irritation. Ask your doctor how to use them together safely.

Q: Is this medicine safe during pregnancy?

A: This medicine is applied to the skin and is generally considered low risk, but it should only be used if advised by your doctor during pregnancy.

Q: What should I do if I miss a dose?

A: If you remember soon after your scheduled time, apply the missed dose. If it is almost time for the next dose, skip it and continue your regular schedule. Do not apply a double amount.

Q: Can this medicine be used on the whole face?

A: It can be applied to the affected areas of the face as directed by your doctor. Avoid the eyes, lips, and mucous membranes.

🤔 Common Patient Concerns

💭 These are the concerns patients most commonly raise

  • Can I use this medicine every day?
  • Will this medicine make my skin dry?
  • Can I use makeup over this medicine?
  • Does this medicine bleach clothes?
  • Can I use this medicine with sunscreen?
  • What if I forget to apply this medicine?
  • Is this medicine safe for long-term use?

🔄 Substitutes for azobril cream

View All

Alternative brands with exact same active ingredient:

Medical Note: Always consult your doctor before switching medications.

🛑 Myths vs. Facts

  • Myth: This medicine works overnight.
    Fact: This medicine usually takes several weeks of regular use before visible improvement in acne occurs.
  • Myth: Applying more gel will clear acne faster.
    Fact: Applying more than a thin layer increases irritation without improving results.
  • Myth: This medicine can be used on any skin problem.
    Fact: This medicine is meant for specific conditions like acne and should be used only as advised by a doctor.
  • Myth: You can stop using this medicine as soon as pimples clear.
    Fact: Stopping too early may cause acne to return. Follow your doctor's advice on how long to continue.

🔄 Alternative Options

Generic Alternatives

  • Azelaic acid 15% w/w gel

Brand Alternatives

  • Aziderm 15% Gel

📊 Comparison with Similar Medicines

[{"medicine":"This medicine (azelaic acid 15% gel)","class":"Dicarboxylic acid","main_use":"Acne, dark spots","how_used":"Once or twice daily","notes":"Also helps fade pigmentation"},{"medicine":"Benzoyl peroxide gel","class":"Antibacterial","main_use":"Acne","how_used":"Once or twice daily","notes":"Can bleach fabrics and cause dryness"},{"medicine":"Adapalene gel","class":"Retinoid","main_use":"Acne","how_used":"Usually at night","notes":"Can cause peeling and sun sensitivity"}]

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