azinorm 10mg tablet dt - Domperidone (10mg) medicine

Azinorm 10mg Tablet DT - Uses, Price, Side Effects

4.5 (20 reviews)

Domperidone (10mg)

🏭 Azine Healthcare Pvt Ltd 📦 Varies by brand 💊 Allopathy 📅 Updated: Aug 22, 2026

📋 Prescription Required 💊 Generic Available

Medically Reviewed

SaathiMed Expert Panel | Aug 22, 2026

What is azinorm 10mg tablet dt used for?

Azinorm 10mg Tablet DT contains Domperidone, a dopamine antagonist that blocks dopamine receptors in the chemoreceptor trigger zone and increases gastric motility. It is used to relieve nausea, vomiting, bloating, and discomfort caused by delayed gastric emptying or gastroesophageal reflux. It works by accelerating stomach emptying and preventing reflux.

Generic Name: Domperidone
Manufacturer: Azine Healthcare Pvt Ltd
Form: Allopathy
Pregnancy Category: A
Prescription Required: Yes

💡 Did You Know? The Indian pharmaceutical market is expected to reach $130 billion by 2030.

💊 azinorm 10mg tablet dt Uses & Benefits

Gastroesophageal reflux disease (GERD), dyspepsia, gastroparesis, nausea and vomiting (including chemotherapy-induced), and to promote gastric emptying.

Off-label uses: Migraine-associated nausea, postoperative nausea and vomiting, diabetic gastroparesis, functional dyspepsia.

📋 Drug Information

Generic Name(s)	Domperidone
Brand Name	Actidom 5mg Oral Suspension
Manufacturer	Azine Healthcare Pvt Ltd
Packaging / Form	Varies by brand (Allopathy)
Therapeutic Class	GASTRO INTESTINAL
Action Class	Dopamine (D2) receptor antagonist-Prokinetic agent
Route of Administration	Oral
Storage	Store at room temperature (20-25°C). Protect from light and moisture. Keep bottle tightly closed.
Shelf Life	As per manufacturer

🔬 Pharmacology (PK/PD)

Pharmacokinetics

AbsorptionRapidly absorbed after oral administration; peak plasma concentrations occur within 30-60 minutes. Bioavailability is approximately 13-17% due to extensive first-pass metabolism.

DistributionWidely distributed in body tissues; crosses the blood-brain barrier to a limited extent. Volume of distribution is about 5.7 L/kg.

Protein Binding91-93% bound to plasma proteins, primarily albumin.

MetabolismExtensively metabolized in the liver via CYP3A4 and CYP2D6 isoenzymes; major metabolites are hydroxylated and N-dealkylated products.

Half-Life7-9 hours in healthy individuals; prolonged in renal impairment.

ExcretionApproximately 31% excreted in urine (mostly as metabolites) and 66% in feces.

Bioavailability13-17% (oral)

Onset of Action30-60 minutes

Peak Plasma Time30-60 minutes

Duration of Action4-6 hours

How It Works

Domperidone is a dopamine D2 receptor antagonist that acts primarily in the chemoreceptor trigger zone (CTZ) and gastrointestinal tract. It blocks dopamine receptors, increasing lower esophageal sphincter pressure, enhancing gastric motility and peristalsis, and accelerating gastric emptying.

Mechanism Steps

1Domperidone binds to and blocks dopamine D2 receptors in the chemoreceptor trigger zone (CTZ) and gastrointestinal tract.

2Blockade of D2 receptors in the CTZ reduces the sensation of nausea and vomiting.

3In the GI tract, D2 receptor blockade increases lower esophageal sphincter pressure.

💡 How to Take azinorm 10mg tablet dt

Follow your doctor's prescription exactly.

Dosage Timeline

🌅 Morning ✅ ☀️ Afternoon ❌ 🌆 Evening ✅ 🌙 Night ❌

⚠️ Side Effects of azinorm 10mg tablet dt

✅ Common Side Effects

Dry mouth
Headache
Diarrhea
Abdominal cramps
Galactorrhea
Gynecomastia
Amenorrhea

🚨 Serious Side Effects

QT prolongation
Torsades de pointes
Cardiac arrest
Extrapyramidal symptoms (dystonia, akathisia)
Neuroleptic malignant syndrome (rare)

⚠️ Rare Side Effects

Allergic reactions (rash, urticaria)
Seizures
Hepatotoxicity
Leukopenia
Thrombocytopenia

Consult your doctor if you experience any unusual symptoms.

🔬 Drug Interactions

⚠️ Drug	Severity	Effect
Anticholinergics	Moderate	May reduce domperidone efficacy
Ketoconazole	Major	Increased risk of QT prolongation
Erythromycin	Major	Increased risk of cardiac arrhythmias

🚨 Major Interactions

Ketoconazole
Erythromycin
Clarithromycin
Amiodarone
Quinidine
Fluconazole
Ritonavir
Saquinavir
Telaprevir
Voriconazole

⚡ Moderate Interactions

Cimetidine
Ranitidine
Omeprazole
Phenothiazines
Tricyclic antidepressants
SSRIs
MAOIs
Lithium
Opioid analgesics
Anticholinergics

ℹ️ Minor Interactions

Aluminum-containing antacids
Sucralfate
Digoxin
Paracetamol
Diazepam

🍽️ Food Interactions

Food may reduce absorption; take 15-30 minutes before meals. Grapefruit juice may increase plasma levels.

🍷 Alcohol Interaction

Alcohol may enhance sedative effects and increase risk of extrapyramidal symptoms.

🛡️ Safety & Warnings

Liver

Low

Kidney

Low

Heart

Low

Pregnancy

Category A

🚫 Contraindications

Hypersensitivity to domperidone; prolactinoma; gastrointestinal hemorrhage, obstruction, or perforation; moderate to severe hepatic impairment; known QT prolongation or concurrent use of QT-prolonging drugs.

📊 Monitoring Parameters

ECG for QT interval in patients at risk; renal function; signs of extrapyramidal symptoms; gastrointestinal symptoms.

🤱 Lactation Safety

Excreted in breast milk; use with caution. May cause adverse effects in nursing infants.

💊 Overdose Management

Symptoms: drowsiness, disorientation, extrapyramidal reactions. Treatment: gastric lavage, activated charcoal, supportive care. Anticholinergic agents may be used for extrapyramidal symptoms.

⏰ Missed Dose

Take the missed dose as soon as remembered. If it is almost time for the next dose, skip the missed dose. Do not double the dose.

👨‍⚕️ Reviewed by Expert

SaathiMed Expert Panel

MD, PhD - Pharmacology

Last reviewed on: Aug 22, 2026

🔗 View Profile

🔄 Substitutes for azinorm 10mg tablet dt

View All

Alternative brands with exact same active ingredient (Domperidone (10mg)):

Medical Note: Always consult your doctor before switching medications.

⭐ User Reviews

Happy Patient Jul 10, 2026

This medicine was effective for me. I followed the doctor's advice.

Trusted Reviewer Jul 10, 2026

Effective and reliable. Worked as expected.