azin 5mg tablet - Asenapine (5mg) medicine

Azin 5mg Tablet - Uses, Price, Side Effects

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๐Ÿญ Intas Pharmaceuticals Ltd ๐Ÿ“ฆ Varies by brand ๐Ÿ’Š Allopathy ๐Ÿ“… Updated: Jun 28, 2026
๐Ÿ“‹ Prescription Required ๐Ÿ’Š Generic Available
Medically Reviewed
SaathiMed Expert Panel | Jun 28, 2026

What is azin 5mg tablet used for?

Azin 5mg Tablet contains Asenapine, an atypical antipsychotic used to treat schizophrenia and acute manic episodes in bipolar disorder. It works by balancing dopamine and serotonin levels in the brain to improve mood and reduce hallucinations. Take as prescribed, usually twice daily sublingually.

  • Generic Name: Asenapine
  • Manufacturer: Intas Pharmaceuticals Ltd
  • Form: Allopathy
  • Pregnancy Category: A
  • Prescription Required: Yes
๐Ÿ’ก Did You Know? The first generic medicine was introduced in India in 1970 after the Patents Act was amended.

๐Ÿ’Š azin 5mg tablet Uses & Benefits

Schizophrenia; acute treatment of manic or mixed episodes associated with bipolar I disorder.

Off-label uses: Treatment-resistant depression; Tourette syndrome; borderline personality disorder.

๐Ÿ“‹ Drug Information

Generic Name(s)Asenapine
Brand NameAzin 10mg Tablet
ManufacturerIntas Pharmaceuticals Ltd
Packaging / FormVaries by brand (Allopathy)
Therapeutic ClassNEURO CNS
Action ClassAtypical Antipsychotics
Route of AdministrationSublingual (tablet placed under tongue until dissolved).
StorageStore at 20-25ยฐC (68-77ยฐF); protect from moisture.
Shelf LifeAs per manufacturer

๐Ÿ”ฌ Pharmacology (PK/PD)

Pharmacokinetics

AbsorptionRapidly absorbed after sublingual administration; bioavailability is approximately 35% due to extensive first-pass metabolism.
DistributionVolume of distribution is approximately 20-25 L/kg; highly protein bound.
Protein Binding95% bound to plasma proteins, mainly albumin and alpha-1-acid glycoprotein.
MetabolismExtensively metabolized in the liver via glucuronidation (UGT1A4) and oxidative metabolism (CYP1A2); also metabolized by CYP3A4 and CYP2D6 to a lesser extent.
Half-LifeApproximately 24 hours.
ExcretionAbout 50% excreted in urine and 40% in feces, mostly as metabolites.
Bioavailability35% (sublingual); oral bioavailability is negligible due to first-pass metabolism.
Onset of ActionWithin 1-2 hours.
Peak Plasma Time0.5-1.5 hours after sublingual administration.
Duration of ActionApproximately 24 hours.

How It Works

Antagonist at dopamine D2 and serotonin 5-HT2A receptors; also has affinity for other receptors.

Mechanism Steps

1Asenapine binds to dopamine D2 receptors in the mesolimbic pathway, reducing positive symptoms of schizophrenia.
2Antagonism of serotonin 5-HT2A receptors in the frontal cortex improves negative symptoms and reduces extrapyramidal side effects.
3Blockade of 5-HT2C receptors may contribute to weight gain and metabolic effects.

๐Ÿ’ก How to Take azin 5mg tablet

Follow your doctor's prescription exactly.

Dosage Timeline

๐ŸŒ… Morning โœ… โ˜€๏ธ Afternoon โŒ ๐ŸŒ† Evening โœ… ๐ŸŒ™ Night โŒ

โš ๏ธ Side Effects of azin 5mg tablet

โœ… Common Side Effects

  • Somnolence
  • Dizziness
  • Extrapyramidal symptoms
  • Weight gain
  • Increased appetite
  • Dry mouth
  • Constipation
  • Dysgeusia

๐Ÿšจ Serious Side Effects

  • Neuroleptic malignant syndrome
  • Tardive dyskinesia
  • QT prolongation
  • Seizures
  • Hyperglycemia
  • Dyslipidemia

โš ๏ธ Rare Side Effects

  • Hepatic failure
  • Agranulocytosis
  • Pancreatitis
  • Priapism
  • Allergic reactions

Consult your doctor if you experience any unusual symptoms.

๐Ÿ”ฌ Drug Interactions

โš ๏ธ DrugSeverityEffect
Alcohol Major Increased CNS depression
Levodopa Moderate Reduced efficacy of levodopa
Antihypertensives Moderate Increased risk of hypotension

๐Ÿšจ Major Interactions

  • CYP1A2 inhibitors (e.g., fluvoxamine)
  • CYP1A2 inducers (e.g., carbamazepine)
  • Dopamine agonists
  • Levodopa

โšก Moderate Interactions

  • Antihypertensives
  • CNS depressants (e.g., alcohol, benzodiazepines)
  • QTc-prolonging drugs

โ„น๏ธ Minor Interactions

  • CYP2D6 substrates
  • CYP3A4 substrates

๐Ÿฝ๏ธ Food Interactions

Grapefruit juice may increase asenapine levels; avoid high-fat meals within 10 minutes of administration.

๐Ÿท Alcohol Interaction

Avoid alcohol; may increase CNS depression and hypotensive effects.

๐Ÿ›ก๏ธ Safety & Warnings

Liver
Moderate
Kidney
Low
Heart
Moderate
Pregnancy
Category A

๐Ÿšซ Contraindications

Hypersensitivity to asenapine or any excipients; severe hepatic impairment.

๐Ÿ“Š Monitoring Parameters

Mental status, blood pressure, heart rate, ECG (QTc interval), liver function tests, blood glucose, lipid profile, weight.

๐Ÿคฑ Lactation Safety

Not recommended; excreted in breast milk in animal studies.

๐Ÿ’Š Overdose Management

Supportive care; monitor vital signs, ECG, and mental status; no specific antidote.

โฐ Missed Dose

Take as soon as remembered; if close to next dose, skip missed dose; do not double dose.

๐Ÿ‘จโ€โš•๏ธ Reviewed by Expert

SaathiMed Expert Panel

MD, PhD - Pharmacology

Reviewed: Jun 28, 2026

๐Ÿ”— View Profile

๐Ÿ”„ Substitutes for azin 5mg tablet

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Alternative brands with exact same active ingredient (Asenapine (5mg)):

Medical Note: Always consult your doctor before switching medications.

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