Azcold Syrup: Complete Medicine Guide For Cold And Allergy Relief
Clinical Reference Standards: CDSCO (Central Drugs Standard Control Organisation), Indian Pharmacopoeia (IP) & WHO | Last Updated: September 2026
When to Call Your Doctor IMMEDIATELY
- Swelling of the face, lips, tongue, or throat, or difficulty breathing.
- Yellowing of the eyes or skin, dark urine, or severe abdominal pain.
- Unusual bleeding or bruising, or a sore throat with fever.
- Extreme drowsiness, confusion, or inability to stay awake.
- Chest pain, palpitations, or fainting.
- Seizures or severe headache with vision changes.
- Decreased urine output or inability to urinate.
If experiencing severe symptoms, call emergency services immediately.
What is azcold syrup used for?
This medicine is a combination syrup containing chlorpheniramine maleate and paracetamol. It is used for short-term relief of runny nose, sneezing, watery eyes, and mild fever or body ache due to cold or allergies. It can cause drowsiness, so avoid driving. Do not exceed the recommended dose because the paracetamol can harm the liver.
- Generic Name: Chlorpheniramine Maleate (1mg) + Paracetamol (125mg/0.5ml)
- Manufacturer: Medcover Pharmaceuticals (OPC) Private Limited
- Form: Allopathy
- Pregnancy Category: Consult doctor
- Prescription Required: Yes
🇮🇳 azcold syrup के बारे में (Hindi Summary)
उपयोग: यह दवा क्लोरफेनिरामिन मेलिएट और पैरासिटामोल का संयोजन है। इसका उपयोग सर्दी-जुकाम और एलर्जी से होने वाले लक्षणों जैसे नाक बहना, छींक आना, आंखों में पानी आना, गले में खुजली और हल्के बुखार या शरीर दर्द से राहत पाने के लिए किया जाता है। यह दवा लक्षणों को कम करती है, बीमारी का इलाज नहीं करती। इसका सेवन डॉक्टर की सलाह के अनुसार ही करें।
साइड इफेक्ट्स: इस दवा के आम दुष्प्रभावों में नींद आना, चक्कर आना, मुंह सूखना, धुंधला दिखना और पेट खराब होना शामिल हैं। ये प्रभाव आमतौर पर हल्के होते हैं और कुछ समय में कम हो जाते हैं। अगर आपको बहुत अधिक नींद आ रही है, सांस लेने में तकलीफ हो रही है, चेहरे या गले में सूजन आ रही है, या आंखों और त्वचा का रंग पीला पड़ रहा है, तो तुरंत डॉक्टर से संपर्क करें।
सुरक्षा सलाह: इस दवा को डॉक्टर की सलाह के अनुसार ही लें। निर्धारित मात्रा से अधिक न लें क्योंकि इसमें मौजूद पैरासिटामोल लिवर को नुकसान पहुंचा सकता है। इस दवा के साथ शराब न पिएं। दवा लेने के बाद गाड़ी चलाने या मशीन चलाने से बचें क्योंकि इससे नींद आ सकती है। अगर आप गर्भवती हैं, स्तनपान करा रही हैं, या आपको लिवर या किडनी की बीमारी है, तो डॉक्टर को बताएं। बच्चों को डॉक्टर की सलाह के बिना यह दवा न दें।
💊 azcold syrup Uses & Benefits
[{"condition":"Common cold","description":"Provides temporary relief of runny nose, sneezing, watery eyes, and mild fever or body ache associated with the common cold.","evidence":"Well-established for symptomatic relief"},{"condition":"Allergic rhinitis","description":"Helps reduce sneezing, nasal itching, runny nose, and itchy or watery eyes caused by seasonal or perennial allergies.","evidence":"Well-established for symptomatic relief"},{"condition":"Upper respiratory allergy symptoms","description":"Used for short-term relief of allergic symptoms affecting the nose and throat, often when mild pain or fever is also present.","evidence":"Well-established for symptomatic relief"}]
Off-label uses: [{"condition":"Pruritus (itching) from mild skin allergies","description":"Sometimes used for short-term relief of itching due to the antihistamine effect, but not a primary approved use of this combination.","evidence":"Limited"},{"condition":"Adjunctive relief in mild urticaria","description":"May be used when mild hives are accompanied by cold-like symptoms, but not as a first-line standalone treatment.","evidence":"Limited"}]
Primary treatment for: Common cold and allergic rhinitis
Also treats: Upper respiratory tract allergy, Mild fever with cold symptoms, Sneezing and runny nose due to allergies
📋 Drug Information
| Generic Name(s) | Chlorpheniramine Maleate (1mg) + Paracetamol (125mg/0.5ml) |
| Brand Name | azcold syrup |
| Manufacturer | Medcover Pharmaceuticals (OPC) Private Limited |
| Packaging / Form | Varies by brand (Allopathy) |
| Therapeutic Class | RESPIRATORY |
| Action Class | |
| Route of Administration | Oral |
| Storage | Store at room temperature between 15°C and 30°C, away from direct sunlight and moisture. Keep the bottle tightly closed and out of reach of children. Do not freeze. |
| Shelf Life | Refer to the expiry date printed on the pack. Do not use after the expiry date. |
| WHO Guideline | Not established from the available information. |
| ICMR Guideline | Not established from the available information. |
👨⚕️ Doctor's Practical Tips
Evidence-based practical advice from experienced clinicians
🔍 Is This Medicine Right for Your Symptom?
Educational reference. Always consult a doctor for diagnosis.
🔬 How This Medicine Works (Pharmacology)
Pharmacokinetics
How It Works
This medicine combines two active ingredients with different mechanisms. Chlorpheniramine maleate is a first-generation antihistamine that competitively blocks histamine H1 receptors, reducing vascular permeability, itching, sneezing, and runny nose. It also crosses the blood-brain barrier and causes sedation. Paracetamol reduces fever and pain mainly through central actions, including inhibition of prostaglandin synthesis in the brain and modulation of pain pathways. The combination provides symptomatic relief of allergy and cold symptoms along with mild analgesic and antipyretic effects.
Mechanism Steps
💡 How to Take azcold syrup
Strength: Each 5 mL of syrup contains chlorpheniramine maleate 1 mg and paracetamol 125 mg.
Dosage Information
| Adult Dosage | The usual adult dose of this medicine is 5 to 10 mL taken every 4 to 6 hours as needed for symptoms, not to exceed the maximum daily dose stated on the label or prescribed by your doctor. The exact dose depends on the severity of symptoms, age, liver and kidney function, and other medicines you take. Dose must be individualized by a qualified clinician based on indication, age, weight, renal and hepatic function. Do not use for more than a few days without medical advice. |
| Pediatric Dosage | Pediatric dosing is not established from available information. Consult a pediatrician. This medicine should not be given to newborns or premature infants. For older children, the dose depends on age and weight and must be determined by a qualified clinician. |
| Elderly Dosage | Older adults are more sensitive to the sedative and anticholinergic effects of chlorpheniramine, such as drowsiness, confusion, dry mouth, constipation, and urinary retention. Use the lowest effective dose for the shortest possible time. Dose must be individualized by a qualified clinician based on age, weight, renal and hepatic function, and other medicines. |
| Renal Impairment | Use with caution in patients with kidney disease. Chlorpheniramine may accumulate and cause increased drowsiness or urinary retention. Paracetamol is generally safe at recommended doses, but dose adjustment may be needed in severe kidney impairment. Consult a doctor for individualized dosing. |
| Hepatic Impairment | Use with caution in patients with liver disease. The paracetamol component can worsen liver injury, and chlorpheniramine is metabolized by the liver. Dose reduction or avoidance may be necessary. Consult a doctor for individualized dosing. |
| Maximum Daily Dose | Do not exceed the maximum daily dose stated on the product label or prescribed by your doctor. For adults, the maximum daily dose of paracetamol from all sources should not exceed 4 grams (4000 mg) per day. For children, the maximum daily dose must be determined by a pediatrician based on weight and age. |
Dosage Timeline
🍽️ Food Timing Guide
⏰ What to Do If You Miss a Dose
⚠️ Side Effects of azcold syrup
✅ Common Side Effects
🚨 Serious Side Effects
⚠️ Rare Side Effects
Consult your doctor if you experience any unusual symptoms.
🔬 Drug Interactions
| Drug | Severity | Effect |
|---|---|---|
| Warfarin | Moderate | |
| Alcohol | Major | |
| MAOIs | Major | |
| Opioids | Major | |
| Benzodiazepines | Major | |
| Other paracetamol products | Major | |
| Anticholinergics | Moderate | |
| Carbamazepine | Moderate | |
| Rifampin | Moderate | |
| Isoniazid | Moderate |
🚨 Major Interactions
- Other paracetamol-containing products
- Alcohol
- Monoamine oxidase inhibitors (MAOIs)
- Central nervous system depressants (opioids, benzodiazepines, sleep medicines)
⚡ Moderate Interactions
- Warfarin
- Anticholinergic medicines (e.g., oxybutynin, benztropine)
- Carbamazepine, phenytoin, rifampin
- Isoniazid
🍷 Alcohol Interaction
Avoid alcohol while taking this medicine. Alcohol increases the risk of liver damage from paracetamol and adds to the drowsiness, dizziness, and impaired coordination caused by chlorpheniramine. Combining alcohol with this medicine can make you unsafe to drive or operate machinery.
🔎 Check Your Other Medicines
Educational tool. Always confirm with your doctor or pharmacist.
🛡️ Safety & Warnings
🚫 Contraindications
["Known allergy or hypersensitivity to chlorpheniramine, paracetamol, or any other ingredient in this medicine","Severe liver disease or active liver failure","Newborns and premature infants","Narrow-angle glaucoma","Urinary retention or severe prostate enlargement","Severe kidney disease without medical supervision","Use of monoamine oxidase inhibitors within the last 14 days"]
⚠️ Warnings & Precautions
["This medicine may cause drowsiness. Do not drive or operate heavy machinery until you know how it affects you.","Avoid alcohol while taking this medicine because it increases the risk of liver damage and sedation.","Do not take more than the recommended dose. The paracetamol in this medicine can cause liver injury in high doses.","Check other medicines for paracetamol or antihistamine content to avoid accidental overdose.","Use with caution in older adults because they are more sensitive to drowsiness, confusion, and urinary retention.","Consult a doctor before use if you have liver disease, kidney disease, heart disease, glaucoma, or prostate enlargement.","Do not use for longer than directed without medical advice.","Keep out of reach of children."]
🤱 Lactation Safety
Chlorpheniramine may pass into breast milk and can cause drowsiness or irritability in a breastfed infant. Paracetamol passes into breast milk in small amounts and is generally considered compatible with breastfeeding. Consult your doctor before using this medicine while breastfeeding.
💊 Overdose Management
Overdose of this medicine can cause serious liver injury due to paracetamol and severe drowsiness, confusion, or anticholinergic effects due to chlorpheniramine. Seek emergency medical help immediately, even if you feel well, because liver damage may not cause symptoms at first. Do not wait for symptoms to appear. Treatment for paracetamol overdose includes activated charcoal if given early and acetylcysteine, which is most effective when started within 8 to 10 hours of ingestion. Supportive care may be needed for chlorpheniramine effects. Carry the medicine container or label to the hospital.
⏰ Missed Dose
If you miss a dose, take it as soon as you remember, unless it is almost time for your next dose. If it is almost time for the next dose, skip the missed dose and continue with your regular schedule. Do not take a double dose to make up for a missed one.
Additional Safety Advice
Use this medicine only for the condition and duration advised by your doctor. Do not exceed the recommended dose because the paracetamol in this medicine can harm the liver in high amounts. Avoid drinking alcohol while taking this medicine, as it increases the risk of liver damage and worsens drowsiness. Do not drive or operate machinery until you know how this medicine affects you. Check other medicines you take for paracetamol or antihistamines to avoid doubling up. Tell your doctor if you are pregnant, planning pregnancy, breastfeeding, or have liver or kidney problems. Keep this medicine out of reach of children and store it as directed on the label.
👴 Special Considerations for Elderly
💡 For Patients Above 65
Older adults are more sensitive to the sedative and anticholinergic effects of chlorpheniramine, including drowsiness, confusion, dry mouth, constipation, blurred vision, and urinary retention. They are also at higher risk of falls. Use the lowest effective dose for the shortest time and consult a doctor before use, especially if you have prostate enlargement, glaucoma, or heart disease.
🤰 Pregnancy Planning (TTC)
If you are planning pregnancy or are pregnant, consult your doctor before using this medicine. Chlorpheniramine and paracetamol have been used in pregnancy, but this fixed-dose combination should only be used if clearly needed and advised by a doctor. Avoid unnecessary use, especially in the first trimester.
🏥 Post-Surgery Considerations
Consult your doctor before using this medicine after surgery. Chlorpheniramine can cause drowsiness and interact with anesthetics and pain medicines. Paracetamol may be used for pain after surgery, but the dose must be carefully controlled to avoid liver injury, especially if you are taking other pain medicines.
🦷 Dental Procedures
Inform your dentist if you are taking this medicine before any dental procedure. Chlorpheniramine can cause dry mouth, which may increase the risk of dental problems. It can also interact with sedatives used during dental procedures. Your dentist may advise adjusting the dose or timing.
💚 Lifestyle Tips for Better Results
🏋️ Exercise Considerations
Avoid strenuous exercise or activities that require alertness while taking this medicine because it can cause drowsiness and dizziness. Light activity is fine if you feel well, but stop if you feel dizzy or short of breath.
🥗 Diet Recommendations
💼 Impact on Daily Work & Life
This medicine can cause drowsiness, dizziness, and blurred vision, which may affect your ability to drive, operate machinery, or perform tasks requiring alertness. Avoid driving or operating heavy equipment until you know how it affects you. Inform your employer if your job requires alertness. Take the medicine at bedtime if your doctor advises, to reduce daytime drowsiness.
🛑 When to Stop This Medicine
Stop taking this medicine when your symptoms improve or as advised by your doctor. Do not use it for longer than recommended without medical advice. If you experience serious side effects such as severe drowsiness, confusion, yellowing of the eyes or skin, or difficulty breathing, stop the medicine and seek medical help immediately. Do not stop prescribed medicines without consulting your doctor.
📅 Long-Term Use Effects
Long-term use of this medicine is not recommended without medical supervision. Prolonged use of chlorpheniramine can cause persistent drowsiness, dry mouth, constipation, and urinary retention. Regular high-dose use of paracetamol can increase the risk of liver and kidney problems. If you need this medicine for more than a few days, consult your doctor to determine the cause of your symptoms and to consider safer alternatives.
🌿 Non-Medicine Approaches
These can complement medicine but do not replace prescribed treatment.
Rinsing the nose with saline solution can help relieve nasal congestion and runny nose without medicine.
Evidence: Well-establishedInhaling steam can temporarily ease nasal congestion and soothe irritated airways.
Evidence: LimitedFor itchy, watery eyes, antihistamine eye drops may be an alternative to oral antihistamines.
Evidence: Well-establishedReducing exposure to dust, pollen, and other triggers can decrease the need for medicine.
Evidence: Well-established💉 Vaccination Considerations
💉 If You're Getting Vaccinated
This medicine does not interact with vaccines. However, if you have a fever or are acutely unwell, your doctor may advise postponing vaccination until you recover. Follow your doctor's advice regarding vaccination timing.
📦 Storage Guide
✅ DO
Store at room temperature between 15°C and 30°C.
❌ DON'T
Do not refrigerate or freeze unless specified.
✅ DO
Keep the bottle tightly closed in its original carton.
❌ DON'T
Do not transfer to unmarked containers.
✅ DO
Keep away from direct sunlight and moisture.
❌ DON'T
Do not store in the bathroom cabinet.
✅ DO
Keep out of reach of children.
❌ DON'T
Do not use after the expiry date.
✈️ Traveling with This Medicine
Carry this medicine in its original packaging with the prescription label intact. Bring a copy of your prescription if you are traveling internationally. Store it at room temperature and protect it from direct sunlight and moisture. If you are crossing time zones, continue your doses at the usual intervals as advised by your doctor. Check local customs rules for carrying medicines. Do not leave it in a hot car or checked luggage.
💰 Cost Analysis & Savings
👥 Real Patient Stories
Educational, anonymized scenarios. Individual results may vary.
💬 Questions Patients Often Ask
A: This medicine usually starts relieving symptoms within 30 to 60 minutes after taking a dose.
A: Use it only for a short time as advised by your doctor. If symptoms last more than a few days, consult your doctor.
A: Yes, the chlorpheniramine in this medicine commonly causes drowsiness. Avoid driving or operating machinery until you know how it affects you.
A: No. Alcohol increases the risk of liver damage from paracetamol and worsens drowsiness. Avoid alcohol while taking this medicine.
A: Pediatric dosing is not established from available information. Consult a pediatrician. Do not give to newborns or premature infants.
A: Seek emergency medical help immediately, even if you feel well, because paracetamol overdose can cause serious liver damage.
🤔 Common Patient Concerns
🛑 Myths vs. Facts
- Myth: This medicine can cure the common cold.
Fact: This medicine only relieves symptoms such as runny nose, sneezing, and mild fever. It does not cure the underlying viral infection. - Myth: More medicine means faster relief.
Fact: Taking more than the recommended dose does not speed up relief and can cause serious liver damage from paracetamol. - Myth: It is safe to take with alcohol.
Fact: Alcohol increases the risk of liver damage and worsens drowsiness. Avoid alcohol while taking this medicine. - Myth: This medicine is safe for newborns.
Fact: This medicine should not be given to newborns or premature infants. Consult a pediatrician for young children.
🔄 Alternative Options
Generic Alternatives
- Chlorpheniramine maleate + Paracetamol syrup
Brand Alternatives
- Azcold syrup