Azathioprine 50 mg Tablet: Complete Guide to Uses, Side Effects, and Safety
When to Call Your Doctor IMMEDIATELY
- Fever, chills, or sore throat
- Unusual bruising or bleeding
- Yellowing of skin or eyes
- Severe abdominal pain
- Shortness of breath or chest pain
- Swelling of face, lips, or throat
- Decreased urine output
- Persistent fatigue or weakness
If experiencing severe symptoms, call emergency services immediately.
What is azathent 50mg tablet used for?
Azathioprine is an immunosuppressant used to prevent kidney transplant rejection and treat autoimmune diseases like rheumatoid arthritis and inflammatory bowel disease. It works by suppressing the immune system and requires regular blood monitoring.
- Generic Name: Azathioprine
- Manufacturer: TNT Lifesciences
- Form: Allopathy
- Pregnancy Category: Consult doctor
- Prescription Required: Yes
🇮🇳 azathent 50mg tablet के बारे में (Hindi Summary)
उपयोग: यह दवा एज़ाथियोप्रिन एक इम्यूनोसप्रेसेंट है जिसका उपयोग अंग प्रत्यारोपण के बाद अस्वीकृति को रोकने और ऑटोइम्यून बीमारियों जैसे रूमेटॉइड आर्थराइटिस और इंफ्लेमेटरी बाउल डिजीज के इलाज में किया जाता है। यह शरीर की प्रतिरक्षा प्रणाली को दबाकर काम करती है। इस दवा को डॉक्टर के निर्देशानुसार ही लें और नियमित रक्त जांच कराते रहें।
साइड इफेक्ट्स: आम दुष्प्रभावों में मतली, उल्टी, दस्त, भूख न लगना और थकान शामिल हैं। गंभीर दुष्प्रभावों में संक्रमण का खतरा बढ़ना, रक्त कोशिकाओं का कम होना, लिवर की समस्या और अग्नाशयशोथ हो सकते हैं। अगर आपको बुखार, असामान्य रक्तस्राव, पीलिया या पेट में तेज दर्द हो तो तुरंत डॉक्टर से संपर्क करें।
सुरक्षा सलाह: इस दवा को डॉक्टर के बताए अनुसार ही लें। बिना सलाह के डोज न बदलें और न ही दवा बंद करें। नियमित रूप से रक्त जांच कराएं। संक्रमण से बचने के लिए सावधानी बरतें। लाइव वैक्सीन न लगवाएं। गर्भावस्था के दौरान इस दवा का सेवन डॉक्टर की सलाह के बिना न करें। शराब का सेवन न करें।
💊 azathent 50mg tablet Uses & Benefits
[{"condition":"Kidney transplant rejection prevention","description":"Used as part of immunosuppressive therapy to prevent rejection of a transplanted kidney.","evidence":"Well-established"},{"condition":"Rheumatoid arthritis","description":"Helps reduce joint inflammation and damage in patients with moderate to severe rheumatoid arthritis.","evidence":"Well-established"},{"condition":"Inflammatory bowel disease (Crohn's disease and ulcerative colitis)","description":"Used to maintain remission and reduce steroid dependence in patients with inflammatory bowel disease.","evidence":"Well-established"},{"condition":"Systemic lupus erythematosus","description":"Sometimes used as a steroid-sparing agent in patients with lupus.","evidence":"Moderate"},{"condition":"Myasthenia gravis","description":"May be used to improve muscle strength in patients with myasthenia gravis.","evidence":"Moderate"}]
Off-label uses: [{"condition":"Multiple sclerosis","description":"Occasionally used off-label to reduce relapses in multiple sclerosis.","evidence":"Limited"},{"condition":"Behçet's disease","description":"May be used off-label for severe Behçet's disease with organ involvement.","evidence":"Limited"},{"condition":"Atopic dermatitis","description":"Rarely used off-label for severe atopic dermatitis unresponsive to other treatments.","evidence":"Limited"}]
Primary treatment for: Kidney transplant rejection prevention
Also treats: Rheumatoid arthritis, Inflammatory bowel disease, Systemic lupus erythematosus, Myasthenia gravis
📋 Drug Information
| Generic Name(s) | Azathioprine |
| Brand Name | Azoran Tablet |
| Manufacturer | TNT Lifesciences |
| Packaging / Form | Varies by brand (Allopathy) |
| Therapeutic Class | ANTI NEOPLASTICS |
| Action Class | Immunosuppressant- Purine analogs |
| Route of Administration | Oral |
| Storage | Store at room temperature between 15°C and 30°C (59°F to 86°F). Protect from light and moisture. Keep in the original container. |
| Shelf Life | 24 months from the date of manufacture. |
| WHO Guideline | Not established from the available information. |
| ICMR Guideline | Not established from the available information. |
👨⚕️ Doctor's Practical Tips
Evidence-based practical advice from experienced clinicians
🔍 Is This Medicine Right for Your Symptom?
Educational reference. Always consult a doctor for diagnosis.
🔬 How This Medicine Works (Pharmacology)
Pharmacokinetics
How It Works
Azathioprine is a prodrug that is converted in the body to 6-mercaptopurine and then to active metabolites. These metabolites interfere with the synthesis of DNA and RNA by inhibiting purine metabolism. This action primarily affects rapidly dividing cells, especially lymphocytes, thereby suppressing the immune response. The drug reduces the proliferation of T and B lymphocytes and decreases antibody production. It also inhibits the function of natural killer cells and other immune cells. This immunosuppressive effect helps prevent organ rejection and reduces inflammation in autoimmune diseases.
Mechanism Steps
💡 How to Take azathent 50mg tablet
Strength: Azathioprine 50 mg immediate-release tablet.
Dosage Information
| Adult Dosage | The dose of this medicine is individualized based on the condition being treated, the patient's response, and other factors. For kidney transplant rejection prevention, a common starting dose is 3-5 mg/kg per day orally, often in combination with other immunosuppressants. For rheumatoid arthritis, the starting dose is typically 1 mg/kg per day, which may be increased after 6-8 weeks. For inflammatory bowel disease, the dose is usually 1.5-2.5 mg/kg per day. Dose must be individualized by a qualified clinician based on indication, age, weight, renal and hepatic function. |
| Pediatric Dosage | Pediatric dosing is not established from available information. Consult a pediatrician. |
| Elderly Dosage | Elderly patients may be more susceptible to the toxic effects of azathioprine, particularly bone marrow suppression. Dose should be individualized and monitored closely. |
| Renal Impairment | In patients with renal impairment, the dose of azathioprine may need to be reduced. Monitor renal function and adjust dose accordingly. |
| Hepatic Impairment | In patients with hepatic impairment, azathioprine should be used with caution. Dose reduction may be necessary. Monitor liver function tests regularly. |
| Maximum Daily Dose | The maximum daily dose is not well established and depends on the indication. Doses up to 5 mg/kg per day have been used in transplant patients. Doses above 5 mg/kg per day are not recommended. |
Dosage Timeline
🍽️ Food Timing Guide
⏰ What to Do If You Miss a Dose
⚠️ Side Effects of azathent 50mg tablet
✅ Common Side Effects
🚨 Serious Side Effects
⚠️ Rare Side Effects
Consult your doctor if you experience any unusual symptoms.
🔬 Drug Interactions
| Drug | Severity | Effect |
|---|---|---|
| Allopurinol | Major | |
| Warfarin | Major | |
| Live vaccines | Major | |
| ACE inhibitors | Major | |
| Ribavirin | Major | |
| Methotrexate | Moderate | |
| Aminosalicylates | Moderate | |
| Cotrimoxazole | Moderate | |
| ARBs | Moderate | |
| Antacids | Minor |
🚨 Major Interactions
- Allopurinol
- Warfarin
- Live vaccines
- ACE inhibitors
- Ribavirin
⚡ Moderate Interactions
- Methotrexate
- Aminosalicylates (e.g., mesalamine, sulfasalazine)
- Cotrimoxazole
- Angiotensin II receptor blockers (ARBs)
🍷 Alcohol Interaction
Alcohol may increase the risk of liver damage and should be avoided while taking this medicine.
🔎 Check Your Other Medicines
Educational tool. Always confirm with your doctor or pharmacist.
🛡️ Safety & Warnings
🚫 Contraindications
["Known hypersensitivity to azathioprine or any component of the formulation","Active serious infections","Severe bone marrow suppression","Pregnancy (unless benefits outweigh risks)","Breastfeeding","Previous treatment with alkylating agents (e.g., cyclophosphamide) may increase risk of neoplasia"]
⚠️ Warnings & Precautions
["Immunosuppression may increase risk of infections and certain cancers.","Regular blood tests are required to monitor for bone marrow suppression.","Avoid live vaccines during treatment.","Use effective contraception during treatment and for at least 3 months after stopping.","Avoid alcohol to reduce risk of liver damage.","Inform your doctor if you develop signs of infection, bleeding, or liver problems.","Caution in patients with renal or hepatic impairment; dose adjustment may be needed.","TPMT deficiency increases risk of severe bone marrow suppression; testing recommended."]
🤱 Lactation Safety
Azathioprine is excreted in breast milk. There are limited data on its effects on the breastfed infant. The manufacturer recommends avoiding breastfeeding while taking this medicine. Consult your doctor to weigh the benefits and risks.
💊 Overdose Management
Overdose of azathioprine can cause severe bone marrow suppression, leading to infections and bleeding. There is no specific antidote. Treatment is supportive and may include blood transfusions, antibiotics, and hospitalization. In case of overdose, seek immediate medical attention.
⏰ Missed Dose
If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and continue with your regular schedule. Do not take a double dose to make up for a missed one.
Additional Safety Advice
Always take this medicine exactly as prescribed by your doctor. Do not change the dose or stop taking it without medical advice. You should have regular blood tests to check your blood cell counts and liver function, as this medicine can affect these. Avoid contact with people who have contagious infections, and practice good hand hygiene. Do not receive live vaccines while taking this medicine. Inform all your healthcare providers, including dentists, that you are on this medicine. Use effective contraception during treatment and for a period after stopping, as this medicine can harm an unborn baby. Avoid alcohol as it may increase the risk of liver problems. If you miss a dose, take it as soon as you remember, but if it is almost time for your next dose, skip the missed dose and continue with your regular schedule. Do not double the dose.
👴 Special Considerations for Elderly
💡 For Patients Above 65
Elderly patients may be more sensitive to the effects of this medicine, especially bone marrow suppression. Doses should be individualized, and blood counts should be monitored closely. The risk of infections and certain cancers increases with age. Regular follow-up is essential.
🤰 Pregnancy Planning (TTC)
This medicine may harm an unborn baby. Women of childbearing potential should use effective contraception during treatment and for at least 3 months after stopping. If you are planning to become pregnant, consult your doctor to discuss alternative treatments. Men taking this medicine should also use contraception as it may affect sperm.
🏥 Post-Surgery Considerations
After surgery, continue taking this medicine as prescribed unless your doctor advises otherwise. Inform your surgeon that you are on this medicine as it may affect wound healing and increase infection risk. Your doctor may adjust the dose temporarily.
🦷 Dental Procedures
Inform your dentist that you are taking this medicine before any dental procedure. You may be more prone to infections and bleeding. Your dentist may recommend antibiotics before certain procedures. Maintain good oral hygiene to reduce the risk of infections.
💚 Lifestyle Tips for Better Results
🏋️ Exercise Considerations
While taking this medicine, you may be more prone to infections and fatigue. Moderate exercise is generally safe, but avoid excessive strenuous activity if you feel unwell. Listen to your body and rest when needed. Consult your doctor before starting a new exercise regimen.
🥗 Diet Recommendations
💼 Impact on Daily Work & Life
This medicine may cause fatigue or dizziness in some people. If you experience these effects, avoid driving or operating heavy machinery until you know how the medicine affects you. It is important to take your doses on time, so plan your work schedule accordingly. Inform your employer about your condition if necessary, especially if you need time off for medical appointments.
🛑 When to Stop This Medicine
Do not stop taking this medicine without consulting your doctor. Stopping suddenly can lead to a flare-up of your condition or organ rejection. Your doctor will decide if and when to stop based on your response and side effects. If you experience severe side effects, contact your doctor immediately; they may adjust the dose or switch to another medicine.
📅 Long-Term Use Effects
Long-term use of this medicine may increase the risk of certain cancers, particularly skin cancer and lymphoma. It can also cause chronic bone marrow suppression and liver toxicity. Regular monitoring of blood counts, liver function, and skin examinations is recommended. The risk of infections remains elevated as long as the immune system is suppressed. Patients should use sun protection and report any new skin lesions or swollen lymph nodes.
🌿 Non-Medicine Approaches
These can complement medicine but do not replace prescribed treatment.
Can help maintain joint function and reduce pain in rheumatoid arthritis.
Evidence: Well-establishedAnti-inflammatory diet may complement treatment for autoimmune diseases.
Evidence: LimitedTechniques like yoga and meditation can improve quality of life.
Evidence: Moderate💉 Vaccination Considerations
💉 If You're Getting Vaccinated
Live vaccines should be avoided while taking this medicine due to the risk of serious infections. Inactivated vaccines are generally safe, but their effectiveness may be reduced. Consult your doctor about appropriate vaccinations before starting treatment and during therapy. Annual flu shots are recommended.
📦 Storage Guide
✅ DO
Store at room temperature (15-30°C)
❌ DON'T
Do not refrigerate unless specified
✅ DO
Keep in original container
❌ DON'T
Do not transfer to unmarked containers
✅ DO
Keep away from direct sunlight
❌ DON'T
Do not store in bathroom cabinet
✈️ Traveling with This Medicine
When traveling, carry this medicine in its original packaging with a copy of your prescription. Keep it in your carry-on luggage to avoid loss. Store at room temperature and protect from extreme heat or cold. If crossing time zones, continue taking your doses at the same intervals as prescribed. Check local regulations regarding carrying prescription medicines. Carry enough supply for your entire trip and a little extra in case of delays.
💰 Cost Analysis & Savings
👥 Real Patient Stories
Educational, anonymized scenarios. Individual results may vary.
💬 Questions Patients Often Ask
A: It may take several weeks to months to see the full benefit of this medicine. Your doctor will monitor your progress.
A: No, you should not stop taking this medicine without consulting your doctor. Stopping suddenly can cause a flare-up of your condition or organ rejection.
A: Avoid alcohol, live vaccines, and contact with people who have infections. Use sun protection as this medicine may increase skin cancer risk.
A: This medicine may affect fertility in some people. Discuss family planning with your doctor before starting treatment.
🤔 Common Patient Concerns
🔄 Substitutes for azathent 50mg tablet
View AllAlternative brands with exact same active ingredient:
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davaindia azathioprine 50mg tabletDavaindia Generic Pharmacy ₹30.00 72% CHEAPER
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imuzat 50mg tabletElder Pharmaceuticals Ltd ₹55.12 48.5% CHEAPER
-
azithioprine 50mg tabletAlkem Laboratories Ltd ₹58.50 45.3% CHEAPER
-
a pin 50mg tabletParry Pharma Pvt Ltd ₹60.00 43.9% CHEAPER
-
transimune 50mg tabletTroikaa Pharmaceuticals Ltd ₹67.26 37.1% CHEAPER
Medical Note: Always consult your doctor before switching medications.
🛑 Myths vs. Facts
- Myth: Azathioprine is a painkiller.
Fact: Azathioprine is an immunosuppressant, not a painkiller. It works by suppressing the immune system. - Myth: You can stop azathioprine once you feel better.
Fact: You should never stop azathioprine without consulting your doctor, as this can lead to flare-ups or rejection. - Myth: Azathioprine weakens your immune system permanently.
Fact: The immune suppression is reversible after stopping the medicine, but long-term effects on cancer risk require monitoring.
🔄 Alternative Options
Generic Alternatives
- Azathioprine 50 mg tablet (generic)
Brand Alternatives
- Azoran 50 mg tablet
- Imuran 50 mg tablet
- Azathioprine 50 mg tablet (various manufacturers)