Axpero 1mg Tablet (Axitinib): Comprehensive Medicine Guide
Clinical Reference Standards: CDSCO (Central Drugs Standard Control Organisation), Indian Pharmacopoeia (IP) & WHO | Last Updated: September 2026
When to Call Your Doctor IMMEDIATELY
- Severe headache, confusion, seizures, or vision changes
- Chest pain, shortness of breath, or swelling in legs
- Blood in stool, vomit, or urine, or severe bruising
- Severe abdominal pain, fever, or vomiting
- Yellowing of skin or eyes, dark urine, or severe fatigue
- Decreased urine output or swelling in feet
- Sudden severe skin rash, blisters, or peeling
If experiencing severe symptoms, call emergency services immediately.
What is axpero 1mg tablet used for?
This medicine is a targeted therapy used to treat advanced kidney cancer. It works by blocking blood vessel growth to tumours, slowing their progression. It is taken orally twice daily under medical supervision.
- Generic Name: Axitinib (1mg)
- Manufacturer: Intas Pharmaceuticals Ltd
- Form: Allopathy
- Pregnancy Category: Consult doctor
- Prescription Required: Yes
🇮🇳 axpero 1mg tablet के बारे में (Hindi Summary)
उपयोग: यह दवा एडवांस्ड रीनल सेल कार्सिनोमा (गुर्दे के कैंसर) के इलाज के लिए इस्तेमाल की जाती है। यह एक टार्गेटेड थेरेपी है जो ट्यूमर के रक्त वाहिकाओं के विकास को रोककर कैंसर की वृद्धि को धीमा करती है। यह दवा केवल कैंसर रोग विशेषज्ञ के परामर्श से ही ली जानी चाहिए।
साइड इफेक्ट्स: इस दवा के सामान्य दुष्प्रभावों में दस्त, उच्च रक्तचाप, थकान, भूख में कमी, मतली, उल्टी, वजन कम होना और आवाज में भारीपन शामिल हैं। गंभीर दुष्प्रभावों में गंभीर रक्तस्राव, रक्त के थक्के, हृदय विफलता, थायरॉइड विकार, यकृत विषाक्तता और गुर्दे की क्षति शामिल हो सकती है। किसी भी असामान्य लक्षण को तुरंत डॉक्टर को बताएं।
सुरक्षा सलाह: यह दवा केवल योग्य कैंसर रोग विशेषज्ञ की देखरेख में ही लें। डॉक्टर की सलाह के बिना खुराक न बदलें। नियमित रूप से रक्तचाप, यकृत और गुर्दे की कार्यप्रणाली और थायरॉइड हार्मोन की जांच कराएं। इस दवा को लेते समय गर्भवती न हों; उपचार के दौरान और अंतिम खुराक के कम से कम एक सप्ताह बाद तक प्रभावी गर्भनिरोधक उपाय अपनाएं। अपने डॉक्टर को सभी अन्य दवाओं के बारे में बताएं। अंगूर और अंगूर के रस से बचें।
💊 axpero 1mg tablet Uses & Benefits
[{"condition":"Advanced renal cell carcinoma","description":"Used as a second-line treatment for patients with advanced kidney cancer after failure of prior systemic therapy.","evidence":"Well-established"}]
Off-label uses: [{"condition":"Hepatocellular carcinoma","description":"Sometimes used off-label in advanced liver cancer, but evidence is limited.","evidence":"Limited"},{"condition":"Thyroid cancer","description":"Occasionally used in medullary thyroid cancer, but not standard.","evidence":"Limited"}]
Primary treatment for: Advanced renal cell carcinoma
Also treats: None established
📋 Drug Information
| Generic Name(s) | Axitinib (1mg) |
| Brand Name | axpero 1mg tablet |
| Manufacturer | Intas Pharmaceuticals Ltd |
| Packaging / Form | Varies by brand (Allopathy) |
| Therapeutic Class | ANTI NEOPLASTICS |
| Action Class | Tyrosine kinase inhibitors |
| Route of Administration | Oral |
| Storage | Store at room temperature between 20°C and 25°C (68°F to 77°F). Keep in the original container to protect from light and moisture. |
| Shelf Life | Refer to the packaging for the expiry date. Do not use after the expiry date. |
| WHO Guideline | Not established from the available information. |
| ICMR Guideline | Not established from the available information. |
👨⚕️ Doctor's Practical Tips
Evidence-based practical advice from experienced clinicians
🔍 Is This Medicine Right for Your Symptom?
Educational reference. Always consult a doctor for diagnosis.
🔬 How This Medicine Works (Pharmacology)
Pharmacokinetics
How It Works
Axitinib selectively inhibits vascular endothelial growth factor receptors (VEGFR-1, VEGFR-2, and VEGFR-3), which are involved in angiogenesis and tumour growth. By blocking these receptors, it reduces blood flow to the tumour and inhibits its growth.
Mechanism Steps
💡 How to Take axpero 1mg tablet
Strength: 1 mg immediate-release tablet
Dosage Information
| Adult Dosage | The usual starting dose of this medicine is 5 mg taken orally twice daily, approximately 12 hours apart, with or without food. Dose adjustments may be made based on individual tolerability and response. For patients with moderate hepatic impairment, the starting dose should be reduced. Dose must be individualized by a qualified clinician based on indication, age, weight, renal and hepatic function, and concomitant medications. |
| Pediatric Dosage | Pediatric dosing is not established from available information. Consult a pediatric oncologist. |
| Elderly Dosage | No specific dose adjustment is recommended for elderly patients based on age alone. However, elderly patients may be more sensitive to side effects and should be monitored closely. |
| Renal Impairment | No dose adjustment is required for patients with mild to moderate renal impairment. Caution is advised in patients with severe renal impairment. |
| Hepatic Impairment | For patients with moderate hepatic impairment (Child-Pugh B), the starting dose should be reduced by approximately 50%. Axitinib is not recommended in patients with severe hepatic impairment (Child-Pugh C). |
| Maximum Daily Dose | The maximum recommended dose is 10 mg twice daily, but dose must be individualized by a qualified clinician. |
Dosage Timeline
🍽️ Food Timing Guide
⏰ What to Do If You Miss a Dose
⚠️ Side Effects of axpero 1mg tablet
✅ Common Side Effects
🚨 Serious Side Effects
⚠️ Rare Side Effects
Consult your doctor if you experience any unusual symptoms.
🔬 Drug Interactions
| Drug | Severity | Effect |
|---|---|---|
| Ketoconazole | Major | |
| Rifampin | Major | |
| Clarithromycin | Major | |
| Carbamazepine | Major | |
| Phenytoin | Major | |
| Diltiazem | Moderate | |
| Grapefruit juice | Moderate | |
| Antacids | Minor | |
| Warfarin | Moderate | |
| Antihypertensives | Moderate |
🚨 Major Interactions
- Strong CYP3A4/5 inhibitors (e.g., ketoconazole, itraconazole, clarithromycin)
- Strong CYP3A4/5 inducers (e.g., rifampin, carbamazepine, phenytoin)
⚡ Moderate Interactions
- Moderate CYP3A4 inhibitors (e.g., grapefruit juice, diltiazem)
- Antihypertensives
🍷 Alcohol Interaction
Alcohol may increase the risk of liver toxicity and worsen side effects like dizziness and fatigue. It is advisable to avoid alcohol while taking this medicine.
🔎 Check Your Other Medicines
Educational tool. Always confirm with your doctor or pharmacist.
🛡️ Safety & Warnings
🚫 Contraindications
["Severe hepatic impairment","Uncontrolled hypertension","Recent history of bleeding disorders","Pregnancy and breastfeeding","Hypersensitivity to axitinib or any component of the formulation"]
⚠️ Warnings & Precautions
["Hypertension: Monitor blood pressure regularly and manage with antihypertensives as needed.","Bleeding: May increase risk of bleeding; monitor for signs.","Thrombotic events: May cause arterial and venous thromboembolic events.","Heart failure: Monitor for signs and symptoms.","Gastrointestinal perforation: Rare but serious; seek immediate care.","Thyroid dysfunction: Monitor thyroid function.","Liver toxicity: Monitor liver enzymes.","Renal impairment: Monitor kidney function.","Wound healing: May impair wound healing; discontinue before surgery.","Pregnancy: Can cause fetal harm; use effective contraception."]
🤱 Lactation Safety
It is not known whether axitinib is excreted in human milk. Because of the potential for serious adverse reactions in nursing infants, breastfeeding should be discontinued during treatment and for at least two weeks after the last dose.
💊 Overdose Management
There is no specific antidote for axitinib overdose. Management should be symptomatic and supportive. Monitor vital signs and provide appropriate care. Dialysis is not expected to be effective due to high protein binding.
⏰ Missed Dose
If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and continue with your regular schedule. Do not take two doses at the same time.
Additional Safety Advice
This medicine should only be taken under the supervision of a qualified oncologist. Do not adjust the dose without medical advice. Regular monitoring of blood pressure, liver and kidney function, and thyroid hormones is required. Avoid becoming pregnant while taking this medicine; use effective contraception for both men and women during treatment and for at least one week after the last dose. Inform your doctor about all other medicines, including over-the-counter drugs and herbal supplements, as many can interact with this medicine. Avoid grapefruit and grapefruit juice as they can increase the levels of this medicine in your body. If you experience severe headache, vision changes, chest pain, or difficulty breathing, seek immediate medical attention.
👴 Special Considerations for Elderly
💡 For Patients Above 65
Elderly patients may be more sensitive to the side effects of this medicine, especially hypertension and fatigue. Close monitoring is recommended. No specific dose adjustment is required based on age alone.
🤰 Pregnancy Planning (TTC)
This medicine can cause fetal harm. Women of childbearing potential should use effective contraception during treatment and for at least one week after the last dose. Men with female partners of childbearing potential should also use effective contraception. If you are planning pregnancy, consult your doctor before starting this medicine.
🏥 Post-Surgery Considerations
This medicine may impair wound healing. It should be stopped at least 24 hours before scheduled surgery. Discuss with your surgeon and oncologist about when to restart after surgery.
🦷 Dental Procedures
Inform your dentist that you are taking this medicine, as it may increase the risk of bleeding during dental procedures. Your dentist may recommend precautions or delay elective procedures.
💚 Lifestyle Tips for Better Results
🏋️ Exercise Considerations
This medicine may cause fatigue, dizziness, or high blood pressure. Avoid strenuous exercise if you feel unwell. Consult your doctor before starting any exercise program. Light activities like walking may be beneficial.
🥗 Diet Recommendations
💼 Impact on Daily Work & Life
This medicine may cause fatigue, dizziness, or high blood pressure, which can affect your ability to drive or operate machinery. Avoid driving if you feel tired or dizzy. Discuss with your doctor about work modifications if needed.
🛑 When to Stop This Medicine
Do not stop taking this medicine without consulting your doctor. Your doctor may decide to stop treatment if the disease progresses or if you experience severe side effects. Always follow your doctor's advice.
📅 Long-Term Use Effects
Long-term use of this medicine may lead to persistent hypertension, thyroid dysfunction, liver and kidney impairment, and increased risk of bleeding or blood clots. Regular monitoring of blood pressure, liver and kidney function, and thyroid hormones is essential. Dose adjustments may be needed based on tolerability and response. The duration of treatment depends on disease progression and side effects.
🌿 Non-Medicine Approaches
These can complement medicine but do not replace prescribed treatment.
Other systemic therapies like immune checkpoint inhibitors may be used in kidney cancer.
Evidence: Well-establishedEnrollment in clinical trials may offer access to new treatments.
Evidence: Varies💉 Vaccination Considerations
💉 If You're Getting Vaccinated
Live vaccines should be avoided during treatment with this medicine due to the risk of infection. Inactivated vaccines may be given, but their effectiveness may be reduced. Consult your doctor before receiving any vaccine.
📦 Storage Guide
✅ DO
Store at room temperature (20-25°C)
❌ DON'T
Do not refrigerate or freeze
✅ DO
Keep in original container
❌ DON'T
Do not transfer to unmarked containers
✅ DO
Keep away from direct sunlight and moisture
❌ DON'T
Do not store in bathroom cabinet
✈️ Traveling with This Medicine
Carry this medicine in its original packaging with a copy of your prescription. Keep it in your carry-on luggage to avoid loss. Store at room temperature and protect from light and moisture. If traveling across time zones, adjust dosing times gradually in consultation with your doctor. Check customs regulations for carrying prescription medicines. Carry enough supply for the entire trip and a little extra in case of delays.
💰 Cost Analysis & Savings
👥 Real Patient Stories
Educational, anonymized scenarios. Individual results may vary.
💬 Questions Patients Often Ask
A: The therapeutic effects develop over days to weeks. Your doctor will monitor your response with regular scans and tests.
A: Yes, you can take it with or without food. However, avoid grapefruit and grapefruit juice as they can increase drug levels.
A: If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and continue with your regular schedule. Do not double dose.
A: No, this medicine can harm the fetus. Use effective contraception during treatment and for at least one week after the last dose. Consult your doctor if you are pregnant or planning pregnancy.
A: It is advisable to avoid alcohol as it may increase the risk of liver toxicity and worsen side effects like dizziness and fatigue.
🤔 Common Patient Concerns
🔄 Substitutes for axpero 1mg tablet
View AllAlternative brands with exact same active ingredient:
-
bdaxit 1mg tabletBDR Pharmaceuticals Internationals Pvt ₹450.00 11.8% CHEAPER
-
inlybest 1mg tabletAprazer Healthcare Pvt Ltd ₹464.06 9.1% CHEAPER
-
Raxitinib 1mg TabletMedicamen Biotech Ltd ₹590.63 15.7% COSTLIER
-
axishil 1mg tabletShilpa Medicare Ltd ₹750.00 46.9% COSTLIER
-
axinib 1mg tabletAMPS Biotech Pvt Ltd ₹1,250.00 144.9% COSTLIER
Medical Note: Always consult your doctor before switching medications.
🛑 Myths vs. Facts
- Myth: Axitinib is a traditional chemotherapy drug.
Fact: Axitinib is a targeted therapy, not traditional chemotherapy. It specifically inhibits VEGFR. - Myth: Axitinib can be taken without regular monitoring.
Fact: Regular monitoring of blood pressure, liver, kidney, and thyroid function is essential. - Myth: Axitinib can be taken during pregnancy.
Fact: Axitinib can harm the fetus and is contraindicated during pregnancy.
🔄 Alternative Options
Generic Alternatives
- Axitinib
Brand Alternatives
- Inlyta