AP 100mg/325mg Tablet: Complete Medicine Guide
When to Call Your Doctor IMMEDIATELY
- Blood in stool or vomit
- Severe abdominal pain
- Chest pain or difficulty breathing
- Severe headache with visual changes
- Sudden swelling of face, lips, or throat
- Yellowing of skin or eyes
- Decreased urine output
- Unusual bruising or bleeding
If experiencing severe symptoms, call emergency services immediately.
What is avolide p 100mg/325mg tablet used for?
This medicine is a combination of nimesulide and paracetamol used for short-term relief of acute pain and inflammation. It works by reducing prostaglandins that cause pain and swelling. It should be taken with food and not exceeding 3 tablets in 24 hours.
- Generic Name: Nimesulide + Paracetamol
- Manufacturer: Sanity Pharma
- Form: Allopathy
- Pregnancy Category: Consult doctor
- Prescription Required: Yes
🇮🇳 avolide p 100mg/325mg tablet के बारे में (Hindi Summary)
उपयोग: यह दवा नाइमेसुलाइड और पैरासिटामोल का संयोजन है, जिसका उपयोग दर्द और सूजन के अल्पकालिक उपचार के लिए किया जाता है। यह जोड़ों के दर्द, मांसपेशियों के दर्द, दांत दर्द, मासिक धर्म के दर्द और सर्जरी के बाद के दर्द में राहत देती है। यह शरीर में प्रोस्टाग्लैंडिन नामक रसायन को कम करके काम करती है, जो दर्द और सूजन का कारण बनता है। इसे भोजन के साथ लेना चाहिए और 24 घंटे में 3 गोलियों से अधिक नहीं लेनी चाहिए।
साइड इफेक्ट्स: इस दवा के सामान्य दुष्प्रभावों में मतली, उल्टी, पेट दर्द, सीने में जलन, दस्त, कब्ज, चक्कर आना, सिरदर्द और नींद आना शामिल हैं। गंभीर दुष्प्रभावों में पेट या आंतों में रक्तस्राव, अल्सर, गुर्दे की समस्या, यकृत की क्षति, एलर्जी प्रतिक्रियाएं और रक्त विकार शामिल हो सकते हैं। यदि आपको कोई गंभीर या लगातार लक्षण महसूस हो, तो तुरंत डॉक्टर से संपर्क करें।
सुरक्षा सलाह: इस दवा को भोजन या दूध के साथ लें ताकि पेट में जलन न हो। निर्धारित खुराक या उपचार की अवधि से अधिक न लें। इस दवा को लेते समय शराब से बचें क्योंकि इससे यकृत की क्षति और पेट में रक्तस्राव का खतरा बढ़ सकता है। यदि आपको पेट के अल्सर, रक्तस्राव विकार, या गंभीर यकृत या गुर्दे की बीमारी है, तो इस दवा का उपयोग न करें। यदि आप गर्भवती हैं, गर्भवती होने की योजना बना रही हैं, या स्तनपान करा रही हैं, तो अपने डॉक्टर को सूचित करें। बिना डॉक्टर की सलाह के अन्य दर्द निवारक या NSAIDs न लें। बच्चों की पहुंच से दूर रखें।
💊 avolide p 100mg/325mg tablet Uses & Benefits
[{"condition":"Acute musculoskeletal pain","description":"Relieves pain and inflammation associated with sprains, strains, and sports injuries.","evidence":"Well-established"},{"condition":"Osteoarthritis","description":"Reduces joint pain and improves mobility in knee, hip, and hand osteoarthritis.","evidence":"Well-established"},{"condition":"Rheumatoid arthritis","description":"Helps manage pain and swelling in rheumatoid arthritis as an adjunct to disease-modifying therapy.","evidence":"Moderate"},{"condition":"Dental pain","description":"Provides relief from toothache and post-dental procedure pain.","evidence":"Well-established"},{"condition":"Post-operative pain","description":"Used for short-term management of mild to moderate post-surgical pain.","evidence":"Moderate"},{"condition":"Primary dysmenorrhea","description":"Relieves menstrual cramps and associated pain.","evidence":"Moderate"}]
Off-label uses: [{"condition":"Migraine","description":"Sometimes used off-label for acute migraine attacks, but not first-line.","evidence":"Limited"},{"condition":"Fever","description":"Paracetamol component can reduce fever, but combination is not primarily indicated for fever alone.","evidence":"Limited"}]
Primary treatment for: Pain and inflammation
Also treats: Osteoarthritis, Rheumatoid arthritis, Dental pain, Post-operative pain, Dysmenorrhea
📋 Drug Information
| Generic Name(s) | Nimesulide + Paracetamol |
| Brand Name | AP 100mg/325mg Tablet |
| Manufacturer | Sanity Pharma |
| Packaging / Form | Varies by brand (Allopathy) |
| Therapeutic Class | PAIN ANALGESICS |
| Action Class | Nonsteroidal Anti-inflammatory Drug (NSAID) + Analgesic/Antipyretic |
| Route of Administration | Oral |
| Storage | Store at room temperature between 15°C and 30°C (59°F to 86°F) in a dry place, away from direct sunlight and moisture. Keep out of reach of children. |
| Shelf Life | 24 months from the date of manufacture. |
| WHO Guideline | Not established from the available information. |
| ICMR Guideline | Not established from the available information. |
👨⚕️ Doctor's Practical Tips
Evidence-based practical advice from experienced clinicians
🔍 Is This Medicine Right for Your Symptom?
Educational reference. Always consult a doctor for diagnosis.
🔬 How This Medicine Works (Pharmacology)
Pharmacokinetics
How It Works
This medicine combines two active ingredients with complementary mechanisms. Nimesulide is a non-steroidal anti-inflammatory drug that selectively inhibits the cyclooxygenase-2 (COX-2) enzyme, leading to decreased production of prostaglandins, which are mediators of pain, inflammation, and fever. Paracetamol acts primarily in the central nervous system, where it inhibits prostaglandin synthesis and may also modulate pain perception through other pathways. The combination provides both peripheral anti-inflammatory and central analgesic effects.
Mechanism Steps
💡 How to Take avolide p 100mg/325mg tablet
Strength: Each tablet contains nimesulide 100 mg and paracetamol 325 mg.
Dosage Information
| Adult Dosage | The usual adult dose is one tablet taken orally every 6 to 8 hours as needed for pain and inflammation, not to exceed 3 tablets in 24 hours. The dose must be individualized by a qualified clinician based on indication, age, weight, renal and hepatic function. Do not take for more than 5 to 7 days without medical advice. |
| Pediatric Dosage | Pediatric dosing is not established from available information. Consult a pediatrician. |
| Elderly Dosage | Elderly patients (above 65 years) may be more sensitive to the side effects of this medicine, especially gastrointestinal bleeding and kidney problems. Use the lowest effective dose for the shortest duration. Dose must be individualized by a qualified clinician based on renal and hepatic function. |
| Renal Impairment | Use with caution in patients with kidney impairment. Dose reduction may be necessary. In severe kidney impairment (eGFR <30 mL/min), this medicine is contraindicated. Consult a doctor for individualized dosing. |
| Hepatic Impairment | Use with caution in patients with liver impairment. Dose reduction may be necessary. In severe liver impairment, this medicine is contraindicated. Consult a doctor for individualized dosing. |
| Maximum Daily Dose | The maximum daily dose is 3 tablets (300 mg nimesulide and 975 mg paracetamol) in 24 hours. Do not exceed this dose. |
Dosage Timeline
🍽️ Food Timing Guide
⏰ What to Do If You Miss a Dose
⚠️ Side Effects of avolide p 100mg/325mg tablet
✅ Common Side Effects
🚨 Serious Side Effects
⚠️ Rare Side Effects
Consult your doctor if you experience any unusual symptoms.
🔬 Drug Interactions
| Drug | Severity | Effect |
|---|---|---|
| Warfarin | Major | |
| Ibuprofen | Major | |
| Aspirin | Major | |
| Methotrexate | Major | |
| Lithium | Major | |
| ACE inhibitors | Moderate | |
| Diuretics | Moderate | |
| SSRIs | Moderate | |
| Corticosteroids | Major | |
| Alcohol | Moderate |
🚨 Major Interactions
- Warfarin
- Other NSAIDs (e.g., ibuprofen, aspirin)
- Corticosteroids
- Methotrexate
- Lithium
⚡ Moderate Interactions
- ACE inhibitors
- Diuretics
- SSRIs
- Alcohol
🍷 Alcohol Interaction
Avoid consuming alcohol while taking this medicine. Alcohol increases the risk of liver damage, especially from paracetamol, and can worsen gastrointestinal irritation and bleeding caused by nimesulide.
🔎 Check Your Other Medicines
Educational tool. Always confirm with your doctor or pharmacist.
🛡️ Safety & Warnings
🚫 Contraindications
["Known hypersensitivity to nimesulide, paracetamol, or any component of the formulation","History of allergic reactions to NSAIDs (e.g., asthma, urticaria, angioedema triggered by aspirin or other NSAIDs)","Active peptic ulcer disease or history of recurrent ulcers","Severe liver impairment or active liver disease","Severe kidney impairment (eGFR
⚠️ Warnings & Precautions
["Take with food to minimize gastrointestinal irritation.","Do not exceed the recommended dose or duration of treatment.","Avoid alcohol consumption while taking this medicine.","Use with caution in elderly patients due to increased risk of side effects.","Monitor liver and kidney function during prolonged use.","Discontinue and consult a doctor if you experience signs of gastrointestinal bleeding, liver problems, or allergic reactions.","Do not use for fever alone unless prescribed.","Inform your doctor about all other medications you are taking."]
🤱 Lactation Safety
Nimesulide and paracetamol are excreted in breast milk in small amounts. The use of this combination during breastfeeding is not recommended unless clearly needed and advised by a doctor. Consult your healthcare provider to weigh the benefits and risks.
💊 Overdose Management
Overdose of this medicine can cause severe liver damage, especially due to paracetamol. Symptoms of overdose may include nausea, vomiting, abdominal pain, confusion, and jaundice. If you suspect an overdose, seek immediate medical attention or contact a poison control center. Treatment may include activated charcoal, N-acetylcysteine for paracetamol toxicity, and supportive care. Do not induce vomiting unless instructed by a healthcare professional.
⏰ Missed Dose
If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and continue with your regular schedule. Do not take a double dose to make up for a missed one.
Additional Safety Advice
Take this medicine with food or milk to reduce stomach upset. Do not exceed the recommended dose or duration of treatment. Avoid alcohol while taking this medicine as it can increase the risk of liver damage and gastrointestinal bleeding. Do not use this medicine if you have a history of stomach ulcers, bleeding disorders, or severe liver or kidney disease. Inform your doctor if you are pregnant, planning to become pregnant, or breastfeeding. Do not take other pain relievers or NSAIDs without consulting your doctor. Keep out of reach of children. Store at room temperature away from direct sunlight and moisture.
👴 Special Considerations for Elderly
💡 For Patients Above 65
Elderly patients are at higher risk of gastrointestinal bleeding, kidney problems, and liver toxicity from this medicine. Use the lowest effective dose for the shortest duration. Regular monitoring of kidney and liver function is recommended.
🤰 Pregnancy Planning (TTC)
If you are planning to become pregnant, consult your doctor before taking this medicine. NSAIDs like nimesulide may affect ovulation and are generally avoided during pregnancy, especially in the third trimester. Paracetamol is considered safer but should be used at the lowest effective dose for the shortest time.
🏥 Post-Surgery Considerations
This medicine may be used for short-term post-operative pain management. However, it can increase the risk of bleeding and should be used with caution after surgery. Follow your surgeon's instructions regarding pain relief.
🦷 Dental Procedures
This medicine can be effective for dental pain and after dental procedures. Inform your dentist if you are taking this medicine, especially if you are scheduled for a procedure that may cause bleeding.
💚 Lifestyle Tips for Better Results
🏋️ Exercise Considerations
While taking this medicine, you may experience dizziness or drowsiness. Avoid strenuous exercise or activities that require alertness until you know how the medicine affects you. Listen to your body and rest if you feel unwell.
🥗 Diet Recommendations
💼 Impact on Daily Work & Life
This medicine may cause dizziness or drowsiness in some people. Avoid driving or operating heavy machinery until you know how it affects you. It is generally safe to continue desk work, but take breaks and stay hydrated.
🛑 When to Stop This Medicine
Stop taking this medicine and consult your doctor if your pain does not improve within 5 to 7 days, or if you experience any serious side effects such as stomach bleeding, liver problems, or allergic reactions. Do not stop abruptly if you have been taking it for a long time without medical advice.
📅 Long-Term Use Effects
Long-term use of this medicine can increase the risk of serious side effects such as gastrointestinal bleeding, ulcers, kidney damage, and liver toxicity. It is not recommended for chronic use without regular monitoring of liver and kidney function. If you need pain relief for more than a few days, consult your doctor for alternative treatments.
🌿 Non-Medicine Approaches
These can complement medicine but do not replace prescribed treatment.
Can complement medicine for chronic pain and improve mobility.
Evidence: Well-establishedApplying heat or cold packs can help reduce pain and inflammation.
Evidence: ModerateMay provide pain relief for some individuals with chronic pain.
Evidence: Limited💉 Vaccination Considerations
💉 If You're Getting Vaccinated
There are no known interactions between this medicine and vaccines. However, if you are scheduled for vaccination, inform your healthcare provider about all medications you are taking.
📦 Storage Guide
✅ DO
Store at room temperature (15-30°C)
❌ DON'T
Do not refrigerate unless specified
✅ DO
Keep in original container
❌ DON'T
Do not transfer to unmarked containers
✅ DO
Keep away from direct sunlight
❌ DON'T
Do not store in bathroom cabinet
✈️ Traveling with This Medicine
When traveling, carry this medicine in its original packaging along with a copy of your prescription. Store it at room temperature, away from direct sunlight and moisture. If crossing time zones, continue taking it as prescribed, but adjust the timing gradually to avoid missing doses. Check the customs regulations of your destination country regarding carrying prescription medications. Always keep it in your carry-on luggage.
💰 Cost Analysis & Savings
👥 Real Patient Stories
Educational, anonymized scenarios. Individual results may vary.
💬 Questions Patients Often Ask
A: This medicine usually starts relieving pain within 30 to 60 minutes after taking it orally.
A: It is best taken with food or milk to reduce the risk of stomach upset and ulcers.
A: Do not take other NSAIDs or painkillers without consulting your doctor, as it may increase the risk of side effects.
A: It is intended for short-term use, usually not more than 5 to 7 days, unless advised by your doctor.
🤔 Common Patient Concerns
🔄 Substitutes for avolide p 100mg/325mg tablet
View AllAlternative brands with exact same active ingredient:
-
jumolid plus 100 mg/325 mg tabletPsychotropics India Ltd ₹3.25 89.3% CHEAPER
-
junocip 100 mg/325 mg tabletPsychotropics India Ltd ₹3.52 88.4% CHEAPER
-
sunocet 100mg/325mg tabletShreya Life Sciences Pvt Ltd ₹3.52 88.4% CHEAPER
-
nimelide plus 100 mg/325 mg tabletCadila Pharmaceuticals Ltd ₹5.50 81.9% CHEAPER
-
nimotas p 100mg/325mg tabletIntas Pharmaceuticals Ltd ₹5.69 81.3% CHEAPER
Medical Note: Always consult your doctor before switching medications.
🛑 Myths vs. Facts
- Myth: This medicine is safe to take for long periods without doctor supervision.
Fact: This medicine is intended for short-term use only. Prolonged use can cause serious side effects like liver and kidney damage. - Myth: This medicine can be taken on an empty stomach.
Fact: It should be taken with food to reduce the risk of stomach upset and ulcers. - Myth: This medicine is safe for children.
Fact: It is not recommended for children under 12 years due to safety concerns.
🔄 Alternative Options
Generic Alternatives
- Nimesulide 100 mg + Paracetamol 325 mg tablet
Brand Alternatives
- Nise-MD
- Nimulid-P
- Nimesulide-P
- Nimsaid-P