avessa 6 mcg/500 mcg capsule - Formoterol (6mcg) + Fluticasone Propionate (500mcg) medicine

Avessa 6 mcg/500 mcg Capsule: Complete Medicine Guide

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🏭 Sun Pharmaceutical Industries Ltd 📦 Varies by brand 💊 Allopathy 📅 Updated: Sep 25, 2026
📋 Prescription Required 💊 Generic Available
Medically Reviewed
11 min read
Evidence: Well-established for asthma and COPD maintenance therapy.
Reviewed by
SaathiMed Expert Panel | Sep 25, 2026
🩺
Medically Fact-Checked & Clinically Verified by SaathiMed Clinical Review Board
Clinical Reference Standards: CDSCO (Central Drugs Standard Control Organisation), Indian Pharmacopoeia (IP) & WHO | Last Updated: September 2026

When to Call Your Doctor IMMEDIATELY

  • Breathing worsens immediately after using the inhaler
  • Severe allergic reaction with swelling of face, lips, or throat
  • Chest pain or irregular heartbeat
  • Fever with increased cough and difficulty breathing
  • Signs of adrenal insufficiency: extreme fatigue, weakness, dizziness
  • Vision changes or eye pain
  • Yellowing of skin or eyes

If experiencing severe symptoms, call emergency services immediately.

What is avessa 6 mcg/500 mcg capsule used for?

This medicine is a combination inhaler containing formoterol (a long-acting bronchodilator) and fluticasone propionate (an inhaled corticosteroid). It is used for long-term maintenance treatment of asthma and COPD in adults. It should not be used for sudden breathing attacks.

  • Generic Name: Formoterol + Fluticasone Propionate
  • Manufacturer: Sun Pharmaceutical Industries Ltd
  • Form: Allopathy
  • Pregnancy Category: Consult doctor
  • Prescription Required: Yes

🇮🇳 avessa 6 mcg/500 mcg capsule के बारे में (Hindi Summary)

उपयोग: यह दवा अस्थमा और क्रॉनिक ऑब्सट्रक्टिव पल्मोनरी डिजीज (सीओपीडी) के दीर्घकालिक उपचार के लिए उपयोग की जाती है। यह सांस की नली की सूजन को कम करती है और सांस लेने में आसानी प्रदान करती है। यह दवा तुरंत सांस की तकलीफ के लिए नहीं है, बल्कि नियमित रूप से उपयोग करने पर लाभ देती है।

साइड इफेक्ट्स: आम दुष्प्रभावों में गले में जलन, सिरदर्द, आवाज में भारीपन, कंपन और धड़कन शामिल हैं। गंभीर दुष्प्रभाव दुर्लभ हैं लेकिन इनमें एलर्जी, सांस की तकलीफ बढ़ना, और संक्रमण शामिल हो सकते हैं। किसी भी असामान्य लक्षण को तुरंत डॉक्टर को बताएं।

सुरक्षा सलाह: इस दवा का उपयोग करने के बाद मुंह को पानी से धोएं। निर्धारित खुराक से अधिक न लें। तुरंत राहत के लिए एक अलग रेस्क्यू इनहेलर हमेशा पास रखें। दिल, मधुमेह, थायरॉइड या लीवर की समस्या हो तो डॉक्टर को बताएं। डॉक्टर की सलाह के बिना दवा बंद न करें।

💡 Did You Know? India is the largest provider of generic medicines globally, supplying over 50% of global vaccine demand.

💊 avessa 6 mcg/500 mcg capsule Uses & Benefits

[{"condition":"Asthma","description":"Maintenance treatment of asthma in adults who require combination therapy for adequate control.","evidence":"Well-established"},{"condition":"Chronic Obstructive Pulmonary Disease (COPD)","description":"Long-term maintenance therapy to reduce exacerbations and improve lung function in patients with COPD.","evidence":"Well-established"}]

Off-label uses: []

Primary treatment for: Asthma and Chronic Obstructive Pulmonary Disease (COPD)

Also treats: Exercise-induced bronchospasm, Nocturnal asthma

📋 Drug Information

Generic Name(s)Formoterol + Fluticasone Propionate
Brand NameAvessa 250 Inhaler
ManufacturerSun Pharmaceutical Industries Ltd
Packaging / FormVaries by brand (Allopathy)
Therapeutic ClassRESPIRATORY
Action ClassLong-acting beta-2 agonist (LABA) + Corticosteroid
Route of AdministrationInhalation
StorageStore at room temperature (15-30°C) in a dry place, away from direct sunlight. Keep the capsules in the original blister pack until ready to use. Do not refrigerate or freeze.
Shelf Life24 months from the date of manufacture.
WHO GuidelineNot established from the available information.
ICMR GuidelineNot established from the available information.

👨‍⚕️ Doctor's Practical Tips

Evidence-based practical advice from experienced clinicians

1
Always rinse your mouth with water after inhaling this medicine to prevent oral thrush.
2
Use a spacer device if you have difficulty coordinating inhalation.
3
Keep a fast-acting rescue inhaler with you at all times for sudden breathing difficulty.
4
Do not exceed the prescribed dose; serious heart-related side effects may occur.
5
Inform your doctor if you have diabetes, heart disease, or thyroid problems before using this medicine.
6
Regular follow-up with lung function tests is important to monitor your response.
7
Do not stop this medicine abruptly without consulting your doctor.

🔍 Is This Medicine Right for Your Symptom?

Educational reference. Always consult a doctor for diagnosis.

✅
Wheezing and shortness of breath
This medicine is prescribed for maintenance treatment of asthma and COPD.
Likely Use
❌
Acute asthma attack
This medicine is not for immediate relief. Use a rescue inhaler.
Not Primary
✅
Chronic cough with sputum
May be used in COPD to reduce exacerbations.
Likely Use

🔬 How This Medicine Works (Pharmacology)

Pharmacokinetics

AbsorptionFormoterol is rapidly absorbed from the lungs after inhalation, with peak plasma levels occurring within 10 to 20 minutes. Fluticasone propionate is absorbed from the lungs and also from the gastrointestinal tract if swallowed, but systemic absorption is low due to poor oral bioavailability.
DistributionBoth drugs are distributed widely in the body. Formoterol has a volume of distribution of approximately 4 L/kg. Fluticasone propionate is highly bound to plasma proteins and has a large volume of distribution.
Protein BindingFormoterol is about 50% bound to plasma proteins. Fluticasone propionate is approximately 99% bound to plasma proteins, primarily albumin and corticosteroid-binding globulin.
MetabolismFormoterol is metabolized primarily by glucuronidation and O-demethylation. Fluticasone propionate is metabolized in the liver by cytochrome P450 3A4 to an inactive carboxylic acid metabolite.
Half-LifeThe elimination half-life of formoterol is approximately 10 hours. Fluticasone propionate has a plasma elimination half-life of about 7.8 hours.
ExcretionFormoterol and its metabolites are excreted mainly in the urine and feces. Fluticasone propionate metabolites are excreted primarily in the feces, with a small amount in urine.
BioavailabilityThe systemic bioavailability of inhaled formoterol is about 20-25% due to lung absorption. Fluticasone propionate has a low oral bioavailability of less than 1% due to first-pass metabolism, but lung bioavailability is approximately 30%.
Onset of ActionBronchodilation from formoterol begins within 5 minutes after inhalation, but the full anti-inflammatory effect of fluticasone propionate takes several hours to days to develop.
Peak Plasma TimePeak plasma concentrations of formoterol occur within 10 to 20 minutes after inhalation. Fluticasone propionate reaches peak plasma levels within 1 to 2 hours.
Duration of ActionThe bronchodilator effect of formoterol lasts for at least 12 hours. The anti-inflammatory effect of fluticasone propionate persists for 24 hours or more with regular use.

How It Works

This medicine combines two active ingredients with complementary actions. Fluticasone propionate is a synthetic corticosteroid that binds to glucocorticoid receptors inside cells, reducing the production of inflammatory mediators and suppressing the recruitment of inflammatory cells in the airways. Formoterol is a long-acting beta-2 adrenergic agonist that selectively stimulates beta-2 receptors on airway smooth muscle, causing relaxation and bronchodilation. Together, they reduce inflammation and keep airways open for extended periods.

Mechanism Steps

1
Glucocorticoid receptor binding: Fluticasone propionate enters airway cells and binds to the glucocorticoid receptor, forming a complex that moves into the nucleus.
2
Anti-inflammatory gene regulation: The complex alters gene transcription, decreasing pro-inflammatory proteins and increasing anti-inflammatory proteins like lipocortin-1.
3
Beta-2 receptor stimulation: Formoterol binds to beta-2 adrenergic receptors on bronchial smooth muscle, activating adenylate cyclase.
4
Cyclic AMP increase: Activation of adenylate cyclase raises cyclic AMP levels, leading to relaxation of bronchial smooth muscle.
5
Bronchodilation and symptom relief: The combined effects reduce airway narrowing, making breathing easier and preventing asthma attacks.

💡 How to Take avessa 6 mcg/500 mcg capsule

Strength: Inhalation capsule containing formoterol 6 mcg and fluticasone propionate 500 mcg.

1Wash and dry your hands thoroughly.
2Remove one capsule from the blister pack just before use.
3Open the inhaler device as instructed by your healthcare provider.
4Place the capsule into the capsule chamber.
5Close the inhaler device until you hear a click.
6Exhale fully away from the inhaler.
7Place the mouthpiece in your mouth and seal your lips around it.
8Press the button once to pierce the capsule, then inhale deeply and steadily through your mouth.
9Hold your breath for about 10 seconds, then exhale slowly.
10Remove the empty capsule and discard it properly.
11Rinse your mouth with water and spit it out; do not swallow.
12Clean the inhaler device regularly as instructed.

Dosage Information

Adult DosageThe usual adult dose is one inhalation capsule (formoterol 6 mcg + fluticasone propionate 500 mcg) inhaled twice daily, approximately 12 hours apart. The dose may be adjusted by your doctor based on your condition and response to treatment. Dose must be individualized by a qualified clinician based on indication, age, weight, renal and hepatic function. Do not exceed the prescribed dose.
Pediatric DosagePediatric dosing is not established from available information. Consult a pediatrician.
Elderly DosageNo specific dose adjustment is required for elderly patients, but they should be monitored for cardiovascular effects and adrenal suppression. Dose must be individualized by a qualified clinician.
Renal ImpairmentNo specific dose adjustment is recommended for renal impairment. However, use with caution in severe renal impairment as formoterol is excreted renally.
Hepatic ImpairmentUse with caution in patients with severe hepatic impairment. Fluticasone propionate exposure may increase. Dose must be individualized by a qualified clinician.
Maximum Daily DoseThe maximum recommended daily dose is two inhalations (formoterol 12 mcg + fluticasone propionate 1000 mcg) per day. Do not exceed this dose.

Dosage Timeline

🌅 Morning ❌ ☀️ Afternoon ❌ 🌆 Evening ❌ 🌙 Night ❌

🍽️ Food Timing Guide

Grapefruit
Avoid
May increase fluticasone levels by inhibiting CYP3A4.
Any food
No specific timing
Inhalation route bypasses gastrointestinal absorption.

⏰ What to Do If You Miss a Dose

📌 Less than 6 hours since missed dose
→ Take the missed dose as soon as you remember.
💡 Continue with the regular schedule.
📌 More than 6 hours since missed dose
→ Skip the missed dose.
💡 Do not double dose to catch up.

⚠️ Side Effects of avessa 6 mcg/500 mcg capsule

✅ Common Side Effects

Throat irritation (Common (5-10%))
Rinse mouth with water after each dose. Consult doctor if it persists.
Headache (Common (5-10%))
Usually resolves on its own. Stay hydrated and rest. Consult doctor if severe.
Hoarseness of voice (Common (5-10%))
Rinsing mouth and using a spacer device can help. Consult doctor if it continues.
Tremor (Uncommon (1-5%))
Usually temporary. Avoid caffeine. Consult doctor if bothersome.
Palpitations (Uncommon (1-5%))
Report to your doctor if you feel a rapid or irregular heartbeat.

🚨 Serious Side Effects

Paradoxical bronchospasm (Rare (<0.1%))
Stop using the medicine and seek immediate medical attention if breathing worsens after inhalation.
Severe allergic reactions (Rare (<0.1%))
Seek emergency care if you experience rash, swelling of face, lips, or throat, or difficulty breathing.
Adrenal suppression (Rare (<0.1%))
Long-term high-dose use may suppress adrenal function. Report fatigue, weakness, or dizziness to your doctor.
Pneumonia (Uncommon (1-5%))
Seek medical advice if you develop fever, chills, increased cough, or difficulty breathing.
Increased blood sugar (Uncommon (1-5%))
Monitor blood glucose if diabetic. Report persistent high readings to your doctor.

⚠️ Rare Side Effects

Cataracts
Regular eye check-ups are advised for long-term users. Report vision changes.
Osteoporosis
Ensure adequate calcium and vitamin D intake. Bone density monitoring may be needed.
Glaucoma
Report eye pain or vision changes immediately.
Cardiac arrhythmias
Seek immediate medical attention if you experience palpitations, chest pain, or fainting.

Consult your doctor if you experience any unusual symptoms.

🔬 Drug Interactions

Drug Severity Effect
Ketoconazole Major
Propranolol Major
Furosemide Moderate
Theophylline Moderate
Prednisone Moderate
Ritonavir Major
Metoprolol Moderate
Amitriptyline Moderate
Hydrochlorothiazide Moderate
Diphenhydramine Minor

🚨 Major Interactions

  • Strong CYP3A4 inhibitors (e.g., ketoconazole, ritonavir)
  • Beta-blockers (e.g., propranolol)
  • Monoamine oxidase inhibitors (MAOIs) and tricyclic antidepressants

⚡ Moderate Interactions

  • Diuretics (e.g., furosemide)
  • Xanthine derivatives (e.g., theophylline)
  • Other corticosteroids

🍷 Alcohol Interaction

Alcohol may increase the risk of dizziness and drowsiness. It is advisable to limit or avoid alcohol while using this medicine, especially if you experience tremors or palpitations.

🔎 Check Your Other Medicines

Educational tool. Always confirm with your doctor or pharmacist.

🛡️ Safety & Warnings

🚫 Contraindications

["Hypersensitivity to formoterol, fluticasone propionate, or any component of the formulation","Acute asthma attack or status asthmaticus","Children under 18 years (unless specifically prescribed by a specialist)","Severe hypersensitivity to milk proteins (some formulations may contain lactose)"]

⚠️ Warnings & Precautions

["Do not use for acute bronchospasm; a short-acting beta-2 agonist should be used for immediate relief.","Do not exceed the recommended dose; serious cardiovascular effects may occur.","Rinse mouth after inhalation to prevent oral candidiasis.","Use with caution in patients with cardiovascular disorders, seizure disorders, thyroid disease, diabetes, and hepatic impairment.","Monitor for signs of adrenal insufficiency when transferring from systemic corticosteroids.","May cause paradoxical bronchospasm; discontinue and seek medical help if it occurs.","Long-term use may increase risk of pneumonia, cataracts, and osteoporosis.","Do not stop abruptly without medical supervision."]

🤱 Lactation Safety

It is not known whether formoterol or fluticasone propionate are excreted in human breast milk. Caution is advised when administering to a nursing woman. Consult your doctor.

💊 Overdose Management

Overdose may cause tachycardia, tremor, hypokalemia, and hyperglycemia. In case of overdose, seek immediate medical attention. Treatment is supportive and symptomatic. Monitor cardiac function, potassium levels, and blood glucose. There is no specific antidote.

⏰ Missed Dose

If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and continue with your regular schedule. Do not double the dose to catch up.

Additional Safety Advice

General Safety

Always rinse your mouth with water after inhaling this medicine to prevent oral thrush. Do not exceed the prescribed dose. Keep a fast-acting rescue inhaler available for sudden breathing difficulty. Inform your doctor if you have heart disease, diabetes, thyroid disorders, or liver problems. Do not stop this medicine abruptly without medical advice. Regular follow-up and lung function tests are important. Avoid exposure to people with active respiratory infections. This medicine is not for acute asthma attacks.

👴 Special Considerations for Elderly

💡 For Patients Above 65

Elderly patients may be more susceptible to cardiovascular effects and adrenal suppression. Monitor blood glucose, potassium, and bone density regularly. Use the lowest effective dose.

🤰 Pregnancy Planning (TTC)

If you are planning pregnancy, consult your doctor. This medicine should be used during pregnancy only if clearly needed. Your doctor will weigh the benefits and risks.

🏥 Post-Surgery Considerations

Inform your surgeon and anesthesiologist that you are using this medicine. It may need to be continued during the perioperative period, but your doctor will advise.

🦷 Dental Procedures

Inhaled corticosteroids can increase the risk of oral thrush. Inform your dentist that you use this inhaler. Rinsing your mouth after inhalation helps prevent this.

💚 Lifestyle Tips for Better Results

🏃
Avoid smoking and exposure to secondhand smoke.
🥗
Maintain a healthy weight to reduce strain on your lungs.
😴
Practice breathing exercises as advised by your doctor.
💧
Get vaccinated against influenza and pneumonia.
🧘
Avoid known allergens and pollutants.
🌞
Use a peak flow meter to monitor your lung function at home.

🏋️ Exercise Considerations

Exercise is generally encouraged, but if you have exercise-induced bronchospasm, use your rescue inhaler before exercise. Consult your doctor for personalized advice.

🥗 Diet Recommendations

Eat a balanced diet rich in fruits and vegetables.
Include omega-3 fatty acids from fish or flaxseed.
Limit processed foods and added sugars.
Stay well hydrated.
Ensure adequate calcium and vitamin D for bone health.

💼 Impact on Daily Work & Life

This medicine may cause tremor or palpitations in some people, which could affect driving or operating machinery. If you experience these side effects, avoid such activities until you know how the medicine affects you.

🛑 When to Stop This Medicine

Do not stop this medicine without consulting your doctor. Abrupt discontinuation can lead to worsening of asthma or COPD. Your doctor will gradually reduce the dose if needed.

📅 Long-Term Use Effects

Long-term use of high doses may increase the risk of pneumonia, cataracts, glaucoma, osteoporosis, and adrenal suppression. Regular monitoring of lung function, blood glucose, potassium, bone density, and eye examinations is recommended. Use the lowest effective dose for the shortest duration necessary.

🌿 Non-Medicine Approaches

These can complement medicine but do not replace prescribed treatment.

Pulmonary rehabilitation

Exercise and education program to improve lung function and quality of life.

Evidence: Well-established
Allergen avoidance

Reducing exposure to allergens can help control asthma symptoms.

Evidence: Well-established

💉 Vaccination Considerations

💉 If You're Getting Vaccinated

Annual influenza vaccination and pneumococcal vaccination are recommended for patients with asthma or COPD to reduce the risk of respiratory infections.

📦 Storage Guide

✅ DO

Store at room temperature (15-30°C)

❌ DON'T

Do not refrigerate or freeze

✅ DO

Keep capsules in original blister pack

❌ DON'T

Do not remove capsules until ready to use

✅ DO

Keep away from direct sunlight and moisture

❌ DON'T

Do not store in bathroom

✈️ Traveling with This Medicine

Carry your inhaler in its original packaging with a copy of your prescription. Keep it in your carry-on luggage. Store at room temperature and protect from extreme heat or cold. If traveling across time zones, consult your doctor about adjusting dosing times. Declare your medication at customs if required.

💰 Cost Analysis & Savings

👥 Real Patient Stories

Educational, anonymized scenarios. Individual results may vary.

👤 A 52-year-old man with moderate persistent asthma
He was prescribed this medicine twice daily. Initially he had throat irritation, but rinsing his mouth after each dose helped. After 4 weeks, his nighttime awakenings reduced significantly and he could exercise without wheezing.
💡 Lesson: Proper inhalation technique and mouth rinsing improve tolerability and effectiveness.
👤 A 65-year-old woman with COPD
She started this medicine along with pulmonary rehabilitation. She noticed fewer exacerbations over 6 months. She was advised to monitor her blood sugar as she had diabetes, and her levels remained stable with regular monitoring.
💡 Lesson: Regular monitoring of blood sugar is important for diabetic patients using inhaled corticosteroids.

💬 Questions Patients Often Ask

Q: How long does it take to work?

A: The bronchodilator effect starts within 5 minutes, but the full anti-inflammatory effect may take several days to weeks of regular use.

Q: Can I use this medicine during an asthma attack?

A: No, this medicine is for maintenance therapy only. You need a fast-acting rescue inhaler for acute attacks.

Q: Is it safe to use during pregnancy?

A: Consult your doctor. Use only if the potential benefit justifies the potential risk to the fetus.

Q: What should I do if I miss a dose?

A: Take it as soon as you remember if less than 6 hours have passed. Otherwise, skip the missed dose and continue with your regular schedule. Do not double dose.

🤔 Common Patient Concerns

💭 These are the concerns patients most commonly raise

  • Can I take this medicine long-term?
  • Will it affect my blood sugar?
  • Can I drive after taking this medicine?
  • Does it interact with my blood pressure medicine?
  • What if I miss a dose?
  • Can I drink alcohol while taking this?

🔄 Substitutes for avessa 6 mcg/500 mcg capsule

View All

Alternative brands with exact same active ingredient:

Medical Note: Always consult your doctor before switching medications.

🛑 Myths vs. Facts

  • Myth: This medicine can be used for immediate relief during an asthma attack.
    Fact: This medicine is a maintenance therapy and should not be used for acute attacks. A fast-acting rescue inhaler is needed for sudden symptoms.
  • Myth: Inhaled steroids are dangerous and cause weight gain.
    Fact: Inhaled steroids act mainly in the lungs and have minimal systemic effects. Weight gain is not a common side effect.
  • Myth: Once symptoms improve, you can stop using the inhaler.
    Fact: Stopping suddenly can lead to worsening of asthma or COPD. Always consult your doctor before stopping.

📊 Comparison with Similar Medicines

[{"medicine":"Formoterol + Fluticasone propionate","class":"LABA + ICS","onset":"5 minutes","duration":"12 hours","use":"Asthma, COPD"},{"medicine":"Salmeterol + Fluticasone propionate","class":"LABA + ICS","onset":"30 minutes","duration":"12 hours","use":"Asthma, COPD"},{"medicine":"Formoterol + Budesonide","class":"LABA + ICS","onset":"5 minutes","duration":"12 hours","use":"Asthma, COPD"}]

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