Averflox MS Syrup: Complete Medicine Guide
Clinical Reference Standards: CDSCO (Central Drugs Standard Control Organisation), Indian Pharmacopoeia (IP) & WHO | Last Updated: September 2026
When to Call Your Doctor IMMEDIATELY
- Blood in stool or vomit
- Severe abdominal pain
- Signs of allergic reaction: rash, swelling, difficulty breathing
- Sudden joint pain or swelling, especially in ankles or wrists
- Numbness, tingling, or burning in hands or feet
- Seizures or confusion
- Yellowing of skin or eyes, dark urine
- Unusual bruising or bleeding
- Severe or persistent diarrhea
If experiencing severe symptoms, call emergency services immediately.
What is averflox ms syrup used for?
This medicine is a combination antibiotic syrup containing Ofloxacin and Metronidazole. It is used to treat mixed bacterial and protozoal infections of the gastrointestinal tract, such as diarrhea, dysentery, and giardiasis. It works by killing bacteria and protozoa. It should be taken exactly as prescribed, and alcohol must be avoided.
- Generic Name: Ofloxacin + Metronidazole
- Manufacturer: Evershine Lifesciences Pvt Ltd
- Form: Allopathy
- Pregnancy Category: Consult doctor
- Prescription Required: Yes
🇮🇳 averflox ms syrup के बारे में (Hindi Summary)
उपयोग: यह दवा ओफ्लोक्सासिन और मेट्रोनिडाजोल का संयोजन है, जिसका उपयोग बैक्टीरिया और प्रोटोजोआ से होने वाले पेट और आंतों के संक्रमण के इलाज के लिए किया जाता है। यह दस्त, पेचिश, अमीबiasis और गियार्डिया जैसी बीमारियों में प्रभावी है। यह दवा कीटाणुओं को मारकर संक्रमण को रोकती है। इसे डॉक्टर के बताए अनुसार ही लें और शराब का सेवन बिल्कुल न करें।
साइड इफेक्ट्स: आम दुष्प्रभावों में मतली, उल्टी, दस्त, पेट में असहजता, मुँह में धातु जैसा स्वाद, सिरदर्द और चक्कर आना शामिल हैं। गंभीर दुष्प्रभाव दुर्लभ हैं लेकिन इनमें टेंडन टूटना, तंत्रिका क्षति, दौरे और एलर्जी प्रतिक्रियाएँ शामिल हो सकती हैं। कोई भी असामान्य लक्षण होने पर तुरंत डॉक्टर से संपर्क करें।
सुरक्षा सलाह: इस दवा को डॉक्टर के निर्देशानुसार ही लें। खुराक न छोड़ें और बेहतर महसूस होने पर भी कोर्स पूरा करें। इलाज के दौरान और आखिरी खुराक के 48 घंटे बाद तक शराब न पिएँ। पर्याप्त पानी पिएँ। चक्कर आने पर वाहन न चलाएँ। गुर्दे या जिगर की बीमारी, मिर्गी या मायस्थेनिया ग्रेविस हो तो डॉक्टर को बताएं। बच्चों की पहुँच से दूर रखें।
💊 averflox ms syrup Uses & Benefits
- [{"condition":"Bacterial diarrhea and dysentery","description":"Used to treat infectious diarrhea caused by susceptible bacteria such as Shigella, Salmonella, and certain E.
- coli strains.","evidence":"Well-established"},{"condition":"Amoebic dysentery","description":"Effective against Entamoeba histolytica, a protozoan that causes amoebic colitis and liver abscess.","evidence":"Well-established"},{"condition":"Giardiasis","description":"Treats Giardia lamblia infection, a common cause of prolonged watery diarrhea.","evidence":"Well-established"},{"condition":"Intra-abdominal infections","description":"Used in combination for mixed aerobic and anaerobic infections such as peritonitis and abscesses.","evidence":"Established"},{"condition":"Pelvic inflammatory disease","description":"Part of combination therapy for PID caused by mixed organisms including anaerobes.","evidence":"Established"}]
Off-label uses: [{"condition":"Traveler's diarrhea","description":"Sometimes prescribed for moderate to severe traveler's diarrhea when bacterial cause is suspected.","evidence":"Limited"},{"condition":"Diverticulitis","description":"May be used in mild cases as part of outpatient management, though guidelines vary.","evidence":"Limited"}]
Primary treatment for: Mixed bacterial and protozoal gastrointestinal infections
Also treats: Amoebic dysentery, Giardiasis, Bacterial diarrhea, Intra-abdominal infections, Pelvic inflammatory disease
📋 Drug Information
| Generic Name(s) | Ofloxacin + Metronidazole |
| Brand Name | Averflox MS Syrup |
| Manufacturer | Evershine Lifesciences Pvt Ltd |
| Packaging / Form | Varies by brand (Allopathy) |
| Therapeutic Class | GASTRO INTESTINAL |
| Action Class | Antibiotic + Antiprotozoal |
| Route of Administration | Oral |
| Storage | Store at room temperature between 15°C and 30°C (59°F to 86°F). Protect from light and moisture. Keep the bottle tightly closed. Do not freeze. |
| Shelf Life | 24 months from the date of manufacture, or as indicated on the packaging. |
| WHO Guideline | Not established from the available information. |
| ICMR Guideline | Not established from the available information. |
👨⚕️ Doctor's Practical Tips
Evidence-based practical advice from experienced clinicians
🔍 Is This Medicine Right for Your Symptom?
Educational reference. Always consult a doctor for diagnosis.
🔬 How This Medicine Works (Pharmacology)
Pharmacokinetics
How It Works
This medicine combines two antimicrobials with different mechanisms. Ofloxacin inhibits bacterial DNA gyrase and topoisomerase IV, preventing DNA replication and cell division. Metronidazole enters anaerobic organisms and is reduced to reactive intermediates that damage DNA, leading to cell death. The combination provides broad coverage against aerobic and anaerobic bacteria as well as protozoa.
Mechanism Steps
💡 How to Take averflox ms syrup
Strength: Each 5 mL of syrup contains Ofloxacin 50 mg and Metronidazole 120 mg.
Dosage Information
| Adult Dosage | The usual adult dose of this medicine is 10 mL (providing 50 mg ofloxacin and 120 mg metronidazole) taken orally every 12 hours, or as prescribed by your doctor. The dose and duration depend on the type and severity of infection, your kidney and liver function, and your response to treatment. Always follow your doctor's instructions. Do not self-adjust the dose. Dose must be individualized by a qualified clinician based on indication, age, weight, renal and hepatic function. |
| Pediatric Dosage | Pediatric dosing is not established from available information. Consult a pediatrician. |
| Elderly Dosage | Elderly patients may be more susceptible to side effects such as tendon rupture, CNS effects, and renal impairment. Dose adjustment may be necessary based on kidney function. Use with caution and monitor closely. |
| Renal Impairment | In patients with renal impairment, the dose of ofloxacin may need to be reduced. For creatinine clearance less than 50 mL/min, a reduced dose or increased dosing interval is recommended. Metronidazole generally does not require adjustment in renal impairment, but metabolites may accumulate. Consult your doctor for specific dosing. |
| Hepatic Impairment | In patients with severe hepatic impairment, metronidazole dose may need to be reduced due to reduced metabolism. Ofloxacin does not require significant adjustment in hepatic impairment. Monitor liver function. Consult your doctor. |
| Maximum Daily Dose | The maximum recommended daily dose is 20 mL (100 mg ofloxacin and 240 mg metronidazole) in divided doses, but this may vary based on the indication and clinical judgment. Do not exceed the prescribed dose. |
Dosage Timeline
🍽️ Food Timing Guide
⏰ What to Do If You Miss a Dose
⚠️ Side Effects of averflox ms syrup
✅ Common Side Effects
🚨 Serious Side Effects
⚠️ Rare Side Effects
Consult your doctor if you experience any unusual symptoms.
🔬 Drug Interactions
| Drug | Severity | Effect |
|---|---|---|
| Warfarin | Major | |
| Alcohol | Major | |
| Antacids (Al/Mg) | Major | |
| Theophylline | Major | |
| NSAIDs | Major | |
| Cimetidine | Moderate | |
| Lithium | Moderate | |
| Phenytoin | Moderate | |
| Cyclosporine | Moderate | |
| Caffeine | Minor |
🚨 Major Interactions
- Warfarin
- Alcohol
- Antacids containing aluminum or magnesium
- Theophylline
- NSAIDs
⚡ Moderate Interactions
- Cimetidine
- Lithium
- Phenytoin
- Cyclosporine
🍷 Alcohol Interaction
Alcohol must be strictly avoided while taking this medicine and for at least 48 hours after the last dose. Metronidazole can cause a disulfiram-like reaction with symptoms such as severe nausea, vomiting, flushing, headache, and rapid heartbeat. This reaction can be dangerous.
🔎 Check Your Other Medicines
Educational tool. Always confirm with your doctor or pharmacist.
🛡️ Safety & Warnings
🚫 Contraindications
["Known hypersensitivity to ofloxacin, metronidazole, or other fluoroquinolones/nitroimidazoles","History of tendon disorders associated with fluoroquinolone use","Myasthenia gravis (may worsen muscle weakness)","Severe renal impairment (requires dose adjustment, not absolute contraindication)","First trimester of pregnancy (relative contraindication; consult doctor)","Use of disulfiram within past 2 weeks"]
⚠️ Warnings & Precautions
["Fluoroquinolones can cause tendonitis and tendon rupture, especially in older adults and those on corticosteroids.","May cause peripheral neuropathy; discontinue if symptoms occur.","Can exacerbate myasthenia gravis; avoid in known cases.","May cause CNS effects including seizures, dizziness, and confusion.","Avoid alcohol due to disulfiram-like reaction.","May cause photosensitivity; avoid excessive sun exposure.","Use with caution in patients with QT prolongation or risk factors.","Not recommended for children unless specifically indicated by a pediatrician.","May alter blood glucose levels; monitor in diabetic patients."]
🤱 Lactation Safety
Ofloxacin and metronidazole are excreted in breast milk. Because of the potential for serious adverse reactions in nursing infants, a decision should be made whether to discontinue nursing or to discontinue the drug, taking into account the importance of the drug to the mother. Consult your doctor.
💊 Overdose Management
Overdose may cause nausea, vomiting, dizziness, and potentially seizures. There is no specific antidote. Treatment is supportive and symptomatic. In case of overdose, seek immediate medical attention. Gastric lavage may be considered if within 1-2 hours of ingestion. Monitor vital signs and provide supportive care.
⏰ Missed Dose
If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and continue with your regular schedule. Do not double the dose to catch up.
Additional Safety Advice
Take this medicine exactly as prescribed by your doctor. Do not skip doses or stop early, even if you feel better. Avoid alcohol completely during treatment and for at least 48 hours after the last dose, as it can cause severe nausea and vomiting. Drink plenty of fluids to stay hydrated. Do not drive or operate heavy machinery if you feel dizzy. Inform your doctor if you have kidney or liver problems, epilepsy, or myasthenia gravis. Keep out of reach of children.
👴 Special Considerations for Elderly
💡 For Patients Above 65
Elderly patients are at higher risk of tendon rupture, peripheral neuropathy, and renal impairment. Dose adjustment may be needed based on kidney function. Monitor closely for side effects.
🤰 Pregnancy Planning (TTC)
If you are planning pregnancy, consult your doctor before taking this medicine. Both ofloxacin and metronidazole should be used during pregnancy only if clearly needed. Discuss alternative treatments if possible.
🏥 Post-Surgery Considerations
This medicine may be prescribed after surgery if there is a risk of mixed bacterial and protozoal infection. Follow your surgeon's instructions carefully. Inform your surgeon if you are taking this medicine before any surgery.
🦷 Dental Procedures
Inform your dentist if you are taking this medicine. It may interact with other medications used during dental procedures. No specific precautions are required, but maintain good oral hygiene.
💚 Lifestyle Tips for Better Results
🏋️ Exercise Considerations
Avoid strenuous exercise while you are recovering from an infection. If you experience joint pain, swelling, or tendon pain, stop exercising and consult your doctor immediately, as fluoroquinolones can increase the risk of tendon rupture.
🥗 Diet Recommendations
💼 Impact on Daily Work & Life
This medicine may cause dizziness, headache, or fatigue. Avoid driving or operating heavy machinery until you know how it affects you. Take time off work if you have severe diarrhea or fever to rest and prevent spreading infection.
🛑 When to Stop This Medicine
Do not stop taking this medicine without consulting your doctor, even if you feel better. Stopping early can lead to recurrence of infection and antibiotic resistance. If you experience serious side effects, contact your doctor immediately; they may advise you to stop.
📅 Long-Term Use Effects
Long-term use of this medicine may increase the risk of antibiotic resistance, fungal infections, and rare side effects such as peripheral neuropathy and tendon damage. It should only be used for the prescribed duration. Regular monitoring of kidney and liver function may be needed if used for prolonged periods.
🌿 Non-Medicine Approaches
These can complement medicine but do not replace prescribed treatment.
Essential for managing dehydration from diarrhea, used alongside antibiotics.
Evidence: Well-establishedMay help restore gut flora and reduce antibiotic-associated diarrhea.
Evidence: ModerateCan reduce duration and severity of diarrhea in children.
Evidence: Well-established for children💉 Vaccination Considerations
💉 If You're Getting Vaccinated
There are no specific vaccine interactions known with this medicine. However, antibiotics may reduce the efficacy of live bacterial vaccines such as typhoid vaccine. Consult your doctor for timing.
📦 Storage Guide
✅ DO
Store at room temperature (15-30°C)
❌ DON'T
Do not refrigerate unless specified
✅ DO
Keep in original container
❌ DON'T
Do not transfer to unmarked containers
✅ DO
Keep away from direct sunlight
❌ DON'T
Do not store in bathroom cabinet
✅ DO
Keep out of reach of children
❌ DON'T
Do not use after expiry date
✈️ Traveling with This Medicine
When traveling, carry this medicine in its original packaging with a copy of your prescription. Keep it in your carry-on luggage to avoid temperature extremes. If crossing time zones, adjust dosing times gradually to maintain even intervals. Store at room temperature and protect from light. Check customs regulations for carrying prescription medicines.
💰 Cost Analysis & Savings
👥 Real Patient Stories
Educational, anonymized scenarios. Individual results may vary.
💬 Questions Patients Often Ask
A: You may start feeling better within 24-48 hours, but it is important to complete the full course as prescribed.
A: Yes, you can take it with food to reduce stomach upset. However, avoid taking it with dairy products, antacids, or iron supplements within 2 hours.
A: If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and continue with your regular schedule. Do not double the dose.
A: No, you must avoid alcohol completely during treatment and for at least 48 hours after the last dose, as it can cause a severe reaction.
A: This medicine is not recommended for children unless specifically prescribed by a pediatrician. Consult your child's doctor for appropriate dosing.
🤔 Common Patient Concerns
🔄 Substitutes for averflox ms syrup
View AllAlternative brands with exact same active ingredient:
-
macgyl o syrupTorque Pharmaceuticals Pvt Ltd ₹14.06 76.9% CHEAPER
-
ofpil m suspensionPsychotropics India Ltd ₹15.58 74.4% CHEAPER
-
owin m 50mg/120mg syrupAlembic Pharmaceuticals Ltd ₹24.61 59.6% CHEAPER
-
otex m syrupBiocare Remedies ₹27.66 54.6% CHEAPER
-
urofin-m oral suspensionPositif Life sciences ₹30.00 50.8% CHEAPER
Medical Note: Always consult your doctor before switching medications.
🛑 Myths vs. Facts
- Myth: This medicine can cure any type of diarrhea.
Fact: This medicine only works for specific bacterial and protozoal infections. It is not effective for viral diarrhea or diarrhea caused by other conditions. - Myth: You can stop taking this medicine once you feel better.
Fact: You must complete the full course as prescribed, even if symptoms improve, to prevent recurrence and resistance. - Myth: It is safe to drink alcohol while taking this medicine.
Fact: Alcohol can cause a severe reaction with metronidazole. Avoid alcohol completely during treatment and for 48 hours after.
🔄 Alternative Options
Generic Alternatives
- Ofloxacin + Metronidazole oral suspension
- Ofloxacin oral suspension + Metronidazole oral suspension
Brand Alternatives
- Oflox-M Syrup
- Metrogyl-O Syrup
- Ofloxacin-Metronidazole Suspension