Enclex 60 Injection (Enoxaparin 60mg): Comprehensive Medicine Guide
When to Call Your Doctor IMMEDIATELY
- Severe or unusual bleeding (e.g., nosebleeds, gum bleeding, blood in urine or stool)
- Black, tarry stools or vomiting blood
- Severe headache, confusion, or vision changes
- Sudden weakness or numbness on one side of the body
- Difficulty breathing or chest pain
- Swelling or pain in the legs
- Signs of allergic reaction: rash, itching, swelling of face/lips/tongue, difficulty breathing
If experiencing severe symptoms, call emergency services immediately.
What is astraparin 60mg injection used for?
This medicine is an anticoagulant (blood thinner) used to prevent and treat blood clots. It is given by subcutaneous injection and works by inhibiting clotting factors, primarily factor Xa.
- Generic Name: Enoxaparin (60mg)
- Manufacturer: Astranova Biotech
- Form: Allopathy
- Pregnancy Category: Consult doctor
- Prescription Required: Yes
🇮🇳 astraparin 60mg injection के बारे में (Hindi Summary)
उपयोग: यह दवा एक एंटीकोआगुलेंट (रक्त पतला करने वाली) दवा है जिसका उपयोग रक्त के थक्के बनने से रोकने और उनके इलाज के लिए किया जाता है। यह आमतौर पर सर्जरी के बाद, गहरी शिरा घनास्त्रता (DVT) और फुफ्फुसीय अंतःशल्यता (PE) के इलाज और रोकथाम के लिए दी जाती है। यह हृदय की कुछ स्थितियों जैसे अस्थिर एनजाइना और दिल के दौरे में भी उपयोग की जाती है। यह दवा त्वचा के नीचे इंजेक्शन के रूप में दी जाती है।
साइड इफेक्ट्स: इस दवा के आम दुष्प्रभावों में इंजेक्शन स्थल पर दर्द, चोट या लालिमा, मतली, दस्त और हल्की एलर्जी शामिल हैं। गंभीर दुष्प्रभावों में गंभीर रक्तस्राव, हेपरिन-प्रेरित थ्रोम्बोसाइटोपेनिया (HIT) और गंभीर एलर्जी प्रतिक्रियाएं शामिल हैं। यदि आपको असामान्य रक्तस्राव या चोट दिखाई दे तो तुरंत डॉक्टर से संपर्क करें।
सुरक्षा सलाह: इस दवा का उपयोग करने से पहले अपने डॉक्टर को अपनी सभी चिकित्सीय स्थितियों और दवाओं के बारे में बताएं। यदि आपको रक्तस्राव विकार, गुर्दे की समस्या, या हेपरिन-प्रेरित थ्रोम्बोसाइटोपेनिया का इतिहास है तो सावधानी बरतें। गर्भावस्था या स्तनपान के दौरान डॉक्टर से परामर्श करें। इंजेक्शन लगाने के बाद स्थान को रगड़ें नहीं। निर्देशानुसार ही दवा लें।
💊 astraparin 60mg injection Uses & Benefits
[{"condition":"Deep vein thrombosis (DVT) prophylaxis","description":"Prevents blood clot formation in deep veins, especially after surgery or in immobilized patients.","evidence":"Well-established"},{"condition":"Deep vein thrombosis (DVT) treatment","description":"Used to treat existing blood clots in deep veins, often in combination with warfarin.","evidence":"Well-established"},{"condition":"Pulmonary embolism (PE) treatment","description":"Used to treat blood clots that have traveled to the lungs.","evidence":"Well-established"},{"condition":"Unstable angina / Non-ST-elevation myocardial infarction (NSTEMI)","description":"Reduces the risk of heart attack and death in patients with acute coronary syndrome.","evidence":"Well-established"},{"condition":"Venous thromboembolism (VTE) prophylaxis in cancer patients","description":"Prevents clot formation in cancer patients who are at high risk.","evidence":"Well-established"}]
Off-label uses: [{"condition":"Antiphospholipid syndrome","description":"Sometimes used off-label for prevention of thrombosis in pregnant women with antiphospholipid syndrome.","evidence":"Limited"},{"condition":"Superficial vein thrombosis","description":"May be used off-label to prevent progression to DVT.","evidence":"Limited"}]
Primary treatment for: Venous thromboembolism (VTE) prophylaxis and treatment
Also treats: Deep vein thrombosis (DVT), Pulmonary embolism (PE), Acute coronary syndrome (unstable angina, NSTEMI), Cancer-associated thrombosis
📋 Drug Information
| Generic Name(s) | Enoxaparin (60mg) |
| Brand Name | astraparin 60mg injection |
| Manufacturer | Astranova Biotech |
| Packaging / Form | Varies by brand (Allopathy) |
| Therapeutic Class | BLOOD RELATED |
| Action Class | Low molecular weight Heparin (LMWH) |
| Route of Administration | Parenteral (subcutaneous injection) |
| Storage | Store at room temperature (20-25°C). Do not freeze. Keep in the original container. Protect from light. |
| Shelf Life | 24 months from the date of manufacture. |
| WHO Guideline | WHO guidelines recommend the use of low molecular weight heparins like enoxaparin for the prevention and treatment of venous thromboembolism in appropriate clinical settings. |
| ICMR Guideline | ICMR guidelines recommend enoxaparin for VTE prophylaxis in high-risk surgical and medical patients, and for treatment of DVT/PE. |
👨⚕️ Doctor's Practical Tips
Evidence-based practical advice from experienced clinicians
🔍 Is This Medicine Right for Your Symptom?
Educational reference. Always consult a doctor for diagnosis.
🔬 How This Medicine Works (Pharmacology)
Pharmacokinetics
How It Works
This medicine works by binding to antithrombin III, a natural anticoagulant in the blood. This binding enhances antithrombin III's ability to inactivate clotting factors, particularly factor Xa, and to a lesser extent factor IIa (thrombin). By inhibiting factor Xa, it prevents the conversion of prothrombin to thrombin, thereby reducing fibrin formation and clot development. This medicine has a higher ratio of anti-factor Xa to anti-factor IIa activity compared to unfractionated heparin, which contributes to its more predictable anticoagulant effect.
Mechanism Steps
💡 How to Take astraparin 60mg injection
Strength: 60 mg/0.6 mL prefilled syringe for subcutaneous injection.
Dosage Information
| Adult Dosage | The dose of this medicine varies depending on the indication. For prophylaxis of deep vein thrombosis, a common dose is 40 mg subcutaneously once daily, but for treatment of DVT or PE, it may be 1 mg/kg subcutaneously every 12 hours. For acute coronary syndrome, a dose of 1 mg/kg every 12 hours may be used. The dose must be individualized by a qualified clinician based on indication, age, weight, renal and hepatic function. Do not self-administer without proper training. |
| Pediatric Dosage | Pediatric dosing is not established from available information. Consult a pediatrician. |
| Elderly Dosage | Elderly patients may have reduced renal function and are at higher risk of bleeding. Dose adjustment may be necessary based on renal function. Monitor closely. |
| Renal Impairment | In patients with severe renal impairment (creatinine clearance <30 mL/min), dose reduction is recommended. For prophylaxis, 30 mg once daily may be used; for treatment, 1 mg/kg once daily may be considered. Consult a clinician for precise dosing. |
| Hepatic Impairment | No specific dose adjustment is recommended for hepatic impairment, but use with caution and monitor for bleeding. |
| Maximum Daily Dose | The maximum daily dose depends on the indication. For treatment, it is generally 2 mg/kg per day. Do not exceed the prescribed dose. |
Dosage Timeline
🍽️ Food Timing Guide
⏰ What to Do If You Miss a Dose
⚠️ Side Effects of astraparin 60mg injection
✅ Common Side Effects
🚨 Serious Side Effects
⚠️ Rare Side Effects
Consult your doctor if you experience any unusual symptoms.
🔬 Drug Interactions
| Drug | Severity | Effect |
|---|---|---|
| Warfarin | Major | |
| Aspirin | Major | |
| Ibuprofen | Major | |
| Clopidogrel | Major | |
| Rivaroxaban | Major | |
| Apixaban | Major | |
| Alteplase | Moderate | |
| Corticosteroids | Moderate | |
| Dextran | Moderate | |
| Digoxin | Minor |
🚨 Major Interactions
- Warfarin
- Direct oral anticoagulants (DOACs) (e.g., rivaroxaban, apixaban)
- Antiplatelet agents (e.g., aspirin, clopidogrel)
- NSAIDs (e.g., ibuprofen, naproxen)
⚡ Moderate Interactions
- Thrombolytic agents (e.g., alteplase)
- Corticosteroids
- Dextran
🍷 Alcohol Interaction
Alcohol may increase the risk of gastrointestinal bleeding when used with this medicine. It is advisable to avoid or limit alcohol consumption while on this medicine.
🔎 Check Your Other Medicines
Educational tool. Always confirm with your doctor or pharmacist.
🛡️ Safety & Warnings
🚫 Contraindications
["Active major bleeding","History of heparin-induced thrombocytopenia (HIT)","Hypersensitivity to enoxaparin, heparin, or other low molecular weight heparins","Prosthetic heart valves with a history of HIT","Severe renal impairment (creatinine clearance
⚠️ Warnings & Precautions
["Increased risk of bleeding, especially in patients with renal impairment, recent surgery, or concomitant use of other anticoagulants.","Heparin-induced thrombocytopenia (HIT) can occur; monitor platelet counts.","Spinal or epidural hematomas can occur with neuraxial anesthesia or spinal puncture; monitor for neurological signs.","Use with caution in patients with a history of gastrointestinal bleeding or peptic ulcer disease.","Not recommended for use in patients with mechanical heart valves, especially pregnant women.","Avoid intramuscular injections to prevent hematoma.","Do not use if solution is discolored or contains particles."]
🤱 Lactation Safety
This medicine is excreted in breast milk in small amounts. It is generally considered safe during breastfeeding, but consult your doctor before use.
💊 Overdose Management
Overdose may lead to severe bleeding. If overdose is suspected, seek immediate medical attention. The anticoagulant effect can be partially reversed by protamine sulfate, but it is less effective than for unfractionated heparin. Supportive care and monitoring are essential.
⏰ Missed Dose
If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and continue with your regular schedule. Do not double dose to catch up.
Additional Safety Advice
Before using this medicine, inform your doctor if you have any bleeding disorders, kidney problems, liver disease, uncontrolled high blood pressure, or a history of heparin-induced thrombocytopenia. Also, tell your doctor about all other medications you are taking, especially blood thinners, antiplatelet drugs, and NSAIDs. Do not take this medicine if you are pregnant or planning to become pregnant without consulting your doctor. Avoid activities that increase the risk of bleeding or injury. Do not rub the injection site after administering the injection. Follow your doctor's instructions carefully regarding dose and administration. Do not share this medicine with others. Keep out of reach of children.
👴 Special Considerations for Elderly
💡 For Patients Above 65
Elderly patients are at higher risk of bleeding and may have reduced renal function. Dose adjustment and close monitoring are recommended.
🤰 Pregnancy Planning (TTC)
If you are planning pregnancy, consult your doctor. This medicine is considered safe during pregnancy when clearly needed, but requires monitoring. It does not cross the placenta significantly.
🏥 Post-Surgery Considerations
This medicine is often used after surgery to prevent DVT. Follow your surgeon's instructions regarding duration and monitoring. Avoid strenuous activities that may increase bleeding risk.
🦷 Dental Procedures
Inform your dentist that you are on this medicine before any dental procedure. You may need to stop it temporarily or adjust the dose to prevent excessive bleeding. Consult your doctor.
💚 Lifestyle Tips for Better Results
🏋️ Exercise Considerations
Avoid contact sports or activities that can cause bleeding or injury. Consult your doctor before starting any new exercise regimen.
🥗 Diet Recommendations
💼 Impact on Daily Work & Life
This medicine may cause dizziness or fatigue in some people. Avoid driving or operating heavy machinery if you feel unwell. Most people can continue their normal activities with caution to avoid injury.
🛑 When to Stop This Medicine
Do not stop this medicine without consulting your doctor. Stopping suddenly can increase the risk of blood clots. Your doctor will determine the appropriate duration of treatment based on your condition.
📅 Long-Term Use Effects
Long-term use of this medicine may increase the risk of osteoporosis and bleeding. Regular monitoring of platelet counts, renal function, and signs of bleeding is recommended. Prolonged use should be periodically reassessed by a clinician.
🌿 Non-Medicine Approaches
These can complement medicine but do not replace prescribed treatment.
Can help prevent DVT in high-risk patients.
Evidence: Well-establishedGetting moving soon after surgery reduces clot risk.
Evidence: Well-establishedUsed when anticoagulation is contraindicated.
Evidence: Well-established💉 Vaccination Considerations
💉 If You're Getting Vaccinated
This medicine does not interact with vaccines. However, intramuscular injections should be avoided while on this medicine due to bleeding risk. Inform your healthcare provider before receiving any vaccine.
📦 Storage Guide
✅ DO
Store at room temperature (20-25°C)
❌ DON'T
Do not freeze
✅ DO
Keep in original container
❌ DON'T
Do not transfer to unmarked containers
✅ DO
Protect from light
❌ DON'T
Do not store in bathroom cabinet
✅ DO
Check expiration date before use
❌ DON'T
Do not use if solution is discolored or contains particles
✈️ Traveling with This Medicine
When traveling with this medicine, carry it in its original packaging with the prescription label. Keep a copy of your prescription and a doctor's note explaining the need for injections. Store it at room temperature and protect it from extreme temperatures. If traveling across time zones, consult your doctor about adjusting the dosing schedule. Carry enough doses for the entire trip and extra in case of delays. Declare it at customs if required.
💰 Cost Analysis & Savings
👥 Real Patient Stories
Educational, anonymized scenarios. Individual results may vary.
💬 Questions Patients Often Ask
A: This medicine starts working within 1 to 2 hours after injection, with peak effects in 3 to 5 hours.
A: Dose adjustment may be needed. Consult your doctor; monitoring of renal function is important.
A: Seek immediate medical attention if bleeding is severe or unusual. Minor bruising at injection site is common.
A: Yes, carry it in original packaging with prescription. Store at room temperature and protect from extreme temperatures.
🤔 Common Patient Concerns
🔄 Substitutes for astraparin 60mg injection
View AllAlternative brands with exact same active ingredient:
-
enoxacare 60mg/0.6ml injectionIpca Laboratories Ltd ₹187.50 68.7% CHEAPER
-
oxprin 60mg/0.6ml injectionMicro Labs Ltd ₹312.50 47.8% CHEAPER
-
hepanox 60mg injectionMinova Life Sciences Pvt Ltd ₹422.67 29.4% CHEAPER
-
noxprin 60mg injectionAjanta Pharma Ltd ₹432.68 27.8% CHEAPER
-
medoparin 60 injectionMHS Pharmaceuticals Pvt Ltd ₹440.47 26.5% CHEAPER
Medical Note: Always consult your doctor before switching medications.
🛑 Myths vs. Facts
- Myth: This medicine can be taken orally.
Fact: This medicine is given by subcutaneous injection only. It is not effective orally. - Myth: This medicine can be used interchangeably with heparin.
Fact: This medicine is a low molecular weight heparin with different properties and dosing. It should not be used interchangeably without medical advice. - Myth: This medicine is safe for everyone.
Fact: This medicine is contraindicated in certain conditions such as active bleeding and HIT. Consult your doctor.
🔄 Alternative Options
Generic Alternatives
- Enoxaparin sodium injection
Brand Alternatives
- Clexane
- Lovenox
- Xaparin