astharil-ls oral drops - Ambroxol (7.5mg) + Guaifenesin (12.5mg) medicine

Asthakind-P Drops: Comprehensive Medicine Guide

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🏭 Zoic Lifesciences 📦 Varies by brand 💊 Allopathy 📅 Updated: Oct 16, 2026
⚠️ Hepatotoxicity Risk ⚠️ Nephrotoxicity Risk 📋 Prescription Required 💊 Generic Available
Medically Reviewed
12 min read
Evidence: Moderate for symptomatic relief of productive cough.
Reviewed by
SaathiMed Expert Panel | Oct 16, 2026
🩺
Medically Fact-Checked & Clinically Verified by SaathiMed Clinical Review Board
Clinical Reference Standards: CDSCO (Central Drugs Standard Control Organisation), Indian Pharmacopoeia (IP) & WHO | Last Updated: September 2026

When to Call Your Doctor IMMEDIATELY

  • Difficulty breathing or shortness of breath
  • Swelling of face, lips, or throat
  • Severe rash or blistering of skin
  • Blood in cough or vomit
  • High fever with persistent cough
  • Cough lasting more than 7 days
  • Chest pain or tightness

If experiencing severe symptoms, call emergency services immediately.

What is astharil-ls oral drops used for?

This medicine is a combination of Ambroxol and Guaifenesin used to treat productive cough by thinning and loosening mucus, making it easier to cough out. It is available as oral drops.

  • Generic Name: Ambroxol + Guaifenesin
  • Manufacturer: Zoic Lifesciences
  • Form: Allopathy
  • Pregnancy Category: Consult doctor
  • Prescription Required: Yes

🇮🇳 astharil-ls oral drops के बारे में (Hindi Summary)

उपयोग: यह दवा एम्ब्रोक्सोल और गुआइफेनेसिन का संयोजन है, जिसका उपयोग बलगम वाली खांसी के इलाज के लिए किया जाता है। यह बलगम को पतला करके उसे बाहर निकालने में मदद करती है, जिससे छाती की जकड़न और खांसी में राहत मिलती है। यह दवा श्वसन तंत्र में जमे हुए बलगम को साफ करने में सहायक है। यह अक्सर ब्रोंकाइटिस, सर्दी-जुकाम और अन्य श्वसन संक्रमणों में दी जाती है। इसका उपयोग डॉक्टर की सलाह के अनुसार ही करें।

साइड इफेक्ट्स: इस दवा के सामान्य दुष्प्रभावों में मतली, उल्टी, पेट दर्द, दस्त और सीने में जलन शामिल हैं। कुछ लोगों को एलर्जी, चक्कर आना या नींद आ सकती है। गंभीर दुष्प्रभाव दुर्लभ हैं, लेकिन यदि सांस लेने में कठिनाई, चेहरे या गले में सूजन, या त्वचा पर गंभीर दाने हों तो तुरंत डॉक्टर से संपर्क करें।

सुरक्षा सलाह: इस दवा को लेने से पहले अपने डॉक्टर को गर्भावस्था, स्तनपान, यकृत या गुर्दे की बीमारी, या पेप्टिक अल्सर के बारे में बताएं। निर्धारित खुराक से अधिक न लें। इस दवा से नींद या चक्कर आ सकते हैं, इसलिए वाहन चलाने या मशीनरी चलाने से बचें। शराब का सेवन न करें। 7 दिनों से अधिक खांसी रहने पर डॉक्टर से मिलें। बच्चों की पहुंच से दूर रखें।

💡 Did You Know? Over 80% of the antiretroviral drugs used globally to combat AIDS are supplied by Indian pharmaceutical companies.

💊 astharil-ls oral drops Uses & Benefits

[{"condition":"Productive cough (acute bronchitis)","description":"Helps loosen and thin mucus, making it easier to expel, thereby relieving chest congestion.","evidence":"Well-established"},{"condition":"Upper respiratory tract infections with thick mucus","description":"Used as an adjunct to relieve cough and mucus plugging in conditions like common cold, pharyngitis, and sinusitis.","evidence":"Moderate"},{"condition":"Chronic obstructive pulmonary disease (COPD) with mucus hypersecretion","description":"May help in clearing secretions and improving symptoms in some patients, but not a primary treatment.","evidence":"Limited"}]

Off-label uses: [{"condition":"Prevention of postoperative pulmonary complications","description":"Sometimes used to prevent mucus plugging after surgery, but evidence is limited.","evidence":"Limited"},{"condition":"Otitis media with effusion","description":"Occasionally used to reduce middle ear fluid viscosity, but not standard practice.","evidence":"Insufficient"}]

Primary treatment for: Productive cough

Also treats: Acute bronchitis, Upper respiratory tract infections, COPD with mucus hypersecretion

📋 Drug Information

Generic Name(s)Ambroxol + Guaifenesin
Brand NameAmbrolite-S Expectorant
ManufacturerZoic Lifesciences
Packaging / FormVaries by brand (Allopathy)
Therapeutic ClassRESPIRATORY
Action ClassMucolytic and Expectorant
Route of AdministrationOral
StorageStore at room temperature (15-30°C) in a cool, dry place, away from direct sunlight. Keep the container tightly closed. Do not refrigerate unless specified. Keep out of reach of children.
Shelf Life24 months from the date of manufacture.
WHO GuidelineNot established from the available information.
ICMR GuidelineNot established from the available information.

👨‍⚕️ Doctor's Practical Tips

Evidence-based practical advice from experienced clinicians

1
Always measure the dose using the dropper provided; do not use a household spoon.
2
Take this medicine with food if it causes stomach upset.
3
Encourage the patient to drink plenty of fluids to help thin mucus.
4
Do not use this medicine for a dry cough or for more than 7 days without medical advice.
5
Avoid giving this medicine to children without consulting a pediatrician.
6
If the patient is on antibiotics, this medicine can be taken together, but inform the doctor.
7
Monitor for any signs of allergic reactions such as rash, itching, or swelling.

🔍 Is This Medicine Right for Your Symptom?

Educational reference. Always consult a doctor for diagnosis.

✅
Productive cough with thick mucus
This medicine is commonly prescribed for this.
Likely Use
❌
Dry cough
This medicine is not effective for dry cough.
Not Primary
❌
Fever
This medicine is not a primary fever reducer.
Not Primary

🔬 How This Medicine Works (Pharmacology)

Pharmacokinetics

AbsorptionAmbroxol is rapidly absorbed from the gastrointestinal tract after oral administration. Guaifenesin is also well absorbed orally. However, specific absorption data for this combination in drop form is not established from the available information.
DistributionAmbroxol distributes widely into body tissues, including lung tissue, and crosses the blood-brain barrier and placental barrier. Guaifenesin distribution is not well characterized. Specific distribution data for this combination is not established from the available information.
Protein BindingAmbroxol is approximately 95% bound to plasma proteins. Guaifenesin protein binding is not well established. Specific data for this combination is not established from the available information.
MetabolismAmbroxol is extensively metabolized in the liver, primarily by conjugation to glucuronides and sulfates. Guaifenesin is metabolized in the liver via oxidation and conjugation. Specific metabolic data for this combination is not established from the available information.
Half-LifeThe elimination half-life of Ambroxol is approximately 7 to 12 hours. The half-life of Guaifenesin is approximately 1 hour. Specific half-life for this combination is not established from the available information.
ExcretionAmbroxol and its metabolites are primarily excreted in urine. Guaifenesin and its metabolites are also excreted in urine. Specific excretion data for this combination is not established from the available information.
BioavailabilityThe oral bioavailability of Ambroxol is approximately 70-80% due to first-pass metabolism. Guaifenesin bioavailability is not well established. Specific bioavailability for this combination is not established from the available information.
Onset of ActionThe onset of action for Ambroxol is typically within 30 minutes to 1 hour after oral administration. Guaifenesin onset is also within 30 minutes. Specific onset for this combination is not established from the available information.
Peak Plasma TimePeak plasma concentrations of Ambroxol are reached approximately 1 to 3 hours after oral administration. Guaifenesin peaks within 1 hour. Specific peak time for this combination is not established from the available information.
Duration of ActionThe duration of action for Ambroxol is approximately 6 to 12 hours. Guaifenesin duration is approximately 4 to 6 hours. Specific duration for this combination is not established from the available information.

How It Works

This medicine combines two active ingredients with complementary actions. Ambroxol is a mucolytic that reduces mucus viscosity by breaking down acidic mucopolysaccharide fibers and stimulating serous bronchial gland secretion. It also enhances surfactant production and increases ciliary motility, aiding mucus clearance. Guaifenesin is an expectorant that increases the volume and reduces the viscosity of respiratory tract secretions by stimulating gastric mucosal reflexes and possibly directly acting on bronchial glands. Together, they thin and loosen mucus, making cough more productive and easing airway clearance.

Mechanism Steps

1
Ambroxol breaks down mucus polymers: Ambroxol hydrolyzes acidic mucopolysaccharide fibers in mucus, reducing its thickness and stickiness.
2
Guaifenesin increases secretion volume: Guaifenesin stimulates respiratory tract secretions, adding more fluid to mucus and further lowering its viscosity.
3
Enhanced ciliary movement: Ambroxol increases ciliary beat frequency, helping to move loosened mucus upward for expulsion.
4
Surfactant production: Ambroxol promotes surfactant synthesis in type II pneumocytes, which helps keep airways open and aids mucus transport.
5
Productive cough: The combined effect makes cough more effective at clearing airways, reducing congestion and improving breathing.

💡 How to Take astharil-ls oral drops

Strength: Each ml contains Ambroxol 7.5 mg and Guaifenesin 12.5 mg.

1Shake the bottle well before use.
2Use the dropper provided to measure the exact dose prescribed by your doctor.
3Squeeze the dropper to release the drops directly into the mouth, or mix with a small amount of water or juice if preferred.
4Take with or without food, but with food if it upsets your stomach.
5Do not exceed the recommended dose.
6Wash the dropper after each use and close the bottle tightly.

Dosage Information

Adult DosageThe dosage of this medicine must be individualized by a qualified clinician based on the indication, age, weight, and renal and hepatic function. Typically, for adults, the recommended dose is 2.5 ml to 5 ml orally two to three times a day, but this may vary. Always follow your doctor's prescription. Do not self-medicate.
Pediatric DosagePediatric dosing is not established from available information. Consult a pediatrician for appropriate dosing based on the child's age and weight.
Elderly DosageElderly patients may be more sensitive to the effects of this medicine. Dose should be individualized by a clinician, considering renal and hepatic function. Use with caution.
Renal ImpairmentDose adjustment may be required in patients with renal impairment. Consult your doctor for appropriate dosing.
Hepatic ImpairmentDose adjustment may be required in patients with hepatic impairment. Consult your doctor for appropriate dosing.
Maximum Daily DoseThe maximum daily dose should not exceed the prescribed amount. Typically, for adults, the maximum daily dose is 15 ml per day, but this must be confirmed by a clinician.

Dosage Timeline

🌅 Morning ❌ ☀️ Afternoon ❌ 🌆 Evening ❌ 🌙 Night ❌

🍽️ Food Timing Guide

With food
Take with meals
Reduces stomach upset.
Water
Drink plenty of fluids
Helps thin mucus and soothe the throat.

⏰ What to Do If You Miss a Dose

📌 Less than half the dosing interval has passed
→ Take the missed dose as soon as you remember.
💡 Continue with the regular schedule.
📌 More than half the dosing interval has passed
→ Skip the missed dose.
💡 Do not double dose to catch up.

⚠️ Side Effects of astharil-ls oral drops

✅ Common Side Effects

Nausea (Common (1-10%))
Take with food or milk to reduce nausea. If it persists, consult your doctor.
Vomiting (Common (1-10%))
Stay hydrated with small sips of water. If vomiting is severe or persistent, seek medical advice.
Stomach pain (Common (1-10%))
Take with meals. Avoid spicy foods. If pain is severe, contact your doctor.
Diarrhea (Common (1-10%))
Drink plenty of fluids. If diarrhea persists for more than 2 days, consult a doctor.
Heartburn (Uncommon (0.1-1%))
Avoid lying down immediately after taking the medicine. Antacids may help, but consult your doctor first.

🚨 Serious Side Effects

Severe allergic reaction (anaphylaxis) (Rare (<0.1%))
Seek emergency medical help immediately if you experience difficulty breathing, swelling of face, lips, or throat, or a severe rash.
Stevens-Johnson syndrome (Very rare (<0.01%))
Stop the medicine and seek immediate medical attention if you develop a painful rash, blisters, or peeling skin.
Severe gastrointestinal bleeding (Very rare (<0.01%))
Seek immediate medical care if you notice black, tarry stools or vomit blood.

⚠️ Rare Side Effects

Dizziness
Avoid driving or operating machinery until you feel normal. Consult your doctor if it persists.
Headache
Rest and stay hydrated. If headache is severe or persistent, consult your doctor.
Drowsiness
Avoid activities requiring alertness. Consult your doctor if it interferes with daily life.

Consult your doctor if you experience any unusual symptoms.

🔬 Drug Interactions

Drug Severity Effect
Codeine Major
Dextromethorphan Major
Atropine Moderate
Amoxicillin Moderate
Furosemide Moderate
Antacids Minor

🚨 Major Interactions

  • Cough suppressants (e.g., codeine, dextromethorphan)
  • Anticholinergic drugs (e.g., atropine, hyoscyamine)

⚡ Moderate Interactions

  • Antibiotics (e.g., amoxicillin, cefuroxime)
  • Diuretics (e.g., furosemide)

🍷 Alcohol Interaction

Avoid alcohol while taking this medicine. Alcohol may increase the risk of gastrointestinal side effects such as nausea, vomiting, and stomach pain. It may also worsen drowsiness or dizziness.

🔎 Check Your Other Medicines

Educational tool. Always confirm with your doctor or pharmacist.

🛡️ Safety & Warnings

🚫 Contraindications

["Known hypersensitivity to Ambroxol, Guaifenesin, or any component of the formulation.","Severe hepatic impairment.","Severe renal impairment.","Active peptic ulcer disease."]

⚠️ Warnings & Precautions

["Do not exceed the recommended dose.","Use with caution in patients with a history of peptic ulcer disease.","Use with caution in patients with asthma or COPD; consult a doctor.","May cause drowsiness; avoid driving or operating machinery until you know how it affects you.","Avoid alcohol while taking this medicine.","Consult a doctor if cough persists for more than 7 days, or if it is accompanied by fever, rash, or persistent headache.","Keep out of reach of children.","Do not use if the seal is broken or the solution is discolored."]

🤱 Lactation Safety

It is not known whether Ambroxol and Guaifenesin pass into breast milk. Consult your doctor before using this medicine while breastfeeding.

💊 Overdose Management

Overdose may cause nausea, vomiting, diarrhea, and abdominal pain. In severe cases, it may lead to drowsiness, dizziness, or allergic reactions. If you suspect an overdose, seek immediate medical attention or contact a poison control center. Treatment is symptomatic and supportive.

⏰ Missed Dose

If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and continue with your regular schedule. Do not double the dose to catch up.

Additional Safety Advice

General Safety

Before taking this medicine, inform your doctor if you are pregnant, planning to become pregnant, or breastfeeding. Do not exceed the recommended dose. This medicine may cause drowsiness or dizziness in some individuals; avoid driving or operating heavy machinery until you know how it affects you. Avoid alcohol consumption while taking this medicine, as it may increase the risk of gastrointestinal side effects. If you have a history of kidney or liver disease, or peptic ulcer, use this medicine only under medical supervision. Do not use this medicine for a chronic cough or a cough that produces a lot of mucus for more than 7 days without consulting a doctor. Keep out of reach of children. Store in a cool, dry place away from direct sunlight. Do not use if the seal is broken or the solution appears discolored. Always check the expiry date before use.

👴 Special Considerations for Elderly

💡 For Patients Above 65

Elderly patients may be more sensitive to the side effects of this medicine, especially drowsiness and dizziness. Dose should be individualized by a clinician. Use with caution in those with renal or hepatic impairment.

🤰 Pregnancy Planning (TTC)

If you are planning to become pregnant, consult your doctor before taking this medicine. The safety of this medicine during pregnancy is not well established.

🏥 Post-Surgery Considerations

If you have recently had surgery, consult your doctor before taking this medicine, as it may affect cough reflex and mucus clearance. It is sometimes used to prevent postoperative pulmonary complications, but only under medical supervision.

🦷 Dental Procedures

Inform your dentist if you are taking this medicine before any dental procedure. It may cause dry mouth or interact with medications used during dental work.

💚 Lifestyle Tips for Better Results

🏃
Stay well hydrated by drinking plenty of water and warm fluids.
🥗
Use a humidifier to add moisture to the air, which can help loosen mucus.
😴
Avoid smoking and exposure to secondhand smoke.
💧
Get plenty of rest to help your body recover.
🧘
Practice good hand hygiene to prevent infections.
🌞
Avoid cold drinks and ice cream if they trigger cough.

🏋️ Exercise Considerations

Avoid strenuous exercise if you have a cough or fever. Light activity like walking may be okay if you feel up to it. Consult your doctor before resuming intense exercise.

🥗 Diet Recommendations

Include warm soups and broths
Drink warm water with honey and lemon
Avoid cold and processed foods
Include fruits rich in vitamin C
Stay hydrated

💼 Impact on Daily Work & Life

This medicine may cause drowsiness or dizziness in some people. Avoid driving or operating heavy machinery until you know how it affects you. It is generally safe to work if you feel well, but take precautions.

🛑 When to Stop This Medicine

Stop taking this medicine and consult your doctor if your cough persists for more than 7 days, if it worsens, or if you experience any severe side effects. Do not stop abruptly if you have been on it for a long time without medical advice.

📅 Long-Term Use Effects

Long-term use of this medicine is generally not recommended without medical supervision. Prolonged use may mask underlying conditions. If used for more than 7 days, consult a doctor. Monitor for any signs of liver or kidney impairment if used long-term in patients with pre-existing conditions.

🌿 Non-Medicine Approaches

These can complement medicine but do not replace prescribed treatment.

Steam inhalation

Helps loosen mucus and soothe airways.

Evidence: Well-established
Saline nasal irrigation

Can help clear nasal congestion and postnasal drip.

Evidence: Moderate
Honey and warm fluids

Soothes the throat and can reduce cough.

Evidence: Moderate

💉 Vaccination Considerations

💉 If You're Getting Vaccinated

There are no known interactions between this medicine and vaccines. However, if you are scheduled for vaccination, inform your doctor about all medicines you are taking.

📦 Storage Guide

✅ DO

Store at room temperature (15-30°C)

❌ DON'T

Do not refrigerate unless specified

✅ DO

Keep in original container

❌ DON'T

Do not transfer to unmarked containers

✅ DO

Keep away from direct sunlight

❌ DON'T

Do not store in bathroom cabinet

✈️ Traveling with This Medicine

When traveling, carry this medicine in its original packaging with the prescription label intact. Keep a copy of your prescription with you. Store it at room temperature and protect it from direct sunlight. If traveling across time zones, continue with your regular dosing schedule as prescribed; no specific time zone adjustment is needed for this medicine. Declare it at customs if required. Keep it in your carry-on luggage to avoid temperature extremes.

💰 Cost Analysis & Savings

👥 Real Patient Stories

Educational, anonymized scenarios. Individual results may vary.

👤 A 35-year-old man with acute bronchitis
He was prescribed this medicine for a productive cough with thick mucus. After taking it as directed for 5 days, he noticed significant relief as the mucus became thinner and easier to cough out. He experienced mild nausea initially, which subsided when he took it with food.
💡 Lesson: Taking this medicine with food can reduce stomach upset and improve tolerability.
👤 A 4-year-old child with upper respiratory tract infection
The child had a persistent cough with mucus. The pediatrician prescribed this medicine in drop form. The parents administered it accurately using the dropper. Within 3 days, the child's cough improved, and the mucus was cleared. No side effects were observed.
💡 Lesson: Accurate dosing with the dropper is crucial for children, and this medicine can be effective in pediatric patients when prescribed by a doctor.

💬 Questions Patients Often Ask

Q: How long does it take to work?

A: This medicine typically starts working within 30 minutes to 1 hour after oral administration, but noticeable relief may take a few doses.

Q: Can I take this medicine with antibiotics?

A: Yes, it can be taken with antibiotics, but inform your doctor. Ambroxol may increase the concentration of some antibiotics in the lungs, which can be beneficial.

Q: Is this medicine safe for children?

A: This medicine should be given to children only under a pediatrician's supervision. The dose depends on the child's age and weight.

Q: What should I do if I miss a dose?

A: Take the missed dose as soon as you remember. If it is almost time for your next dose, skip the missed dose and continue with your regular schedule. Do not double the dose.

🤔 Common Patient Concerns

💭 These are the concerns patients most commonly raise

  • Can I take this medicine long-term?
  • Will it affect my kidney function?
  • Can I drive after taking this medicine?
  • Does it interact with my blood pressure medicine?
  • What if I miss a dose?
  • Can I drink alcohol while taking this?

🔄 Substitutes for astharil-ls oral drops

View All

Alternative brands with exact same active ingredient:

Medical Note: Always consult your doctor before switching medications.

🛑 Myths vs. Facts

  • Myth: This medicine can cure any type of cough.
    Fact: This medicine is only for productive cough with mucus. It is not effective for dry cough or cough due to other causes.
  • Myth: It is safe to take this medicine without a prescription.
    Fact: This medicine should be taken only as prescribed by a doctor, as the dose and duration depend on the underlying condition.
  • Myth: More medicine means faster relief.
    Fact: Taking more than the recommended dose can increase the risk of side effects and does not provide faster relief.

🔄 Alternative Options

Generic Alternatives

  • Ambroxol + Guaifenesin oral drops (various manufacturers)

Brand Alternatives

  • Asthakind-P Drops

📊 Comparison with Similar Medicines

[{"medicine":"This medicine","composition":"Ambroxol 7.5 mg + Guaifenesin 12.5 mg per ml","form":"Oral drops","primary_use":"Productive cough"},{"medicine":"Ambroxol alone","composition":"Ambroxol only","form":"Syrup/Tablet","primary_use":"Productive cough"},{"medicine":"Guaifenesin alone","composition":"Guaifenesin only","form":"Syrup/Tablet","primary_use":"Productive cough"}]

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