Astharil-AS Syrup: Complete Medicine Guide
Clinical Reference Standards: CDSCO (Central Drugs Standard Control Organisation), Indian Pharmacopoeia (IP) & WHO | Last Updated: September 2026
When to Call Your Doctor IMMEDIATELY
- Chest pain or palpitations
- Severe allergic reaction (swelling of face, lips, throat, difficulty breathing)
- Paradoxical bronchospasm (worsening of breathing after taking the medicine)
- Severe headache with visual changes
- Muscle weakness or cramps (possible hypokalemia)
- Irregular heartbeat
- Yellowing of skin or eyes (jaundice)
If experiencing severe symptoms, call emergency services immediately.
What is astharil-as syrup used for?
This medicine is a combination syrup containing ambroxol (30 mg/5 ml) and salbutamol (2 mg/5 ml). It is used to treat productive cough with bronchospasm by thinning mucus and opening airways. It is available by prescription only and should be taken exactly as directed by a doctor.
- Generic Name: Ambroxol + Salbutamol
- Manufacturer: Zoic Lifesciences
- Form: Allopathy
- Pregnancy Category: Consult doctor
- Prescription Required: Yes
🇮🇳 astharil-as syrup के बारे में (Hindi Summary)
उपयोग: यह दवा एम्ब्रोक्सोल और साल्बुटामोल का संयोजन है, जिसका उपयोग बलगम वाली खांसी और सांस की नली में सिकुड़न (ब्रोंकोस्पाज्म) के इलाज के लिए किया जाता है। एम्ब्रोक्सोल गाढ़े बलगम को पतला करता है जिससे उसे खांसकर बाहर निकालना आसान हो जाता है, और साल्बुटामोल सांस की नलियों की मांसपेशियों को ढीला करके सांस लेने में आसानी प्रदान करता है। यह दवा ब्रोंकाइटिस, अस्थमा और अन्य श्वसन रोगों में लाभकारी है। यह केवल डॉक्टर के पर्चे पर मिलती है और डॉक्टर की सलाह के अनुसार ही लेनी चाहिए।
साइड इफेक्ट्स: इस दवा के सामान्य दुष्प्रभावों में जी मिचलाना, सिरदर्द, चक्कर आना, घबराहट, हाथ-पैरों में कंपन, और दिल की धड़कन तेज होना शामिल हैं। ये आमतौर पर हल्के होते हैं और कुछ समय में ठीक हो जाते हैं। गंभीर दुष्प्रभावों में दिल की धड़कन अनियमित होना, सीने में दर्द, सांस लेने में कठिनाई, चेहरे या गले में सूजन, और पोटैशियम की कमी शामिल हैं। अगर कोई गंभीर लक्षण दिखे तो तुरंत डॉक्टर से संपर्क करें।
सुरक्षा सलाह: इस दवा को हमेशा डॉक्टर के बताए अनुसार ही लें। अपनी मर्जी से मात्रा न बढ़ाएं। हर बार उपयोग से पहले बोतल को अच्छी तरह हिलाएं और दवा के साथ दिए गए मापने वाले कप या चम्मच से ही मात्रा लें। इस दवा के साथ शराब न पिएं क्योंकि इससे चक्कर और दिल की धड़कन बढ़ सकती है। अगर आपको दिल की बीमारी, उच्च रक्तचाप, मधुमेह, थायरॉइड, या लिवर-किडनी की समस्या है तो डॉक्टर को पहले बताएं। गाड़ी चलाने या मशीन चलाने से बचें जब तक आपको पता न चल जाए कि यह दवा आप पर कैसा असर करती है। बच्चों की पहुंच से दूर रखें।
💊 astharil-as syrup Uses & Benefits
[{"condition":"Productive cough with bronchospasm","description":"Helps loosen thick mucus and relaxes airway muscles, making it easier to cough out secretions and breathe more comfortably.","evidence":"Well-established"},{"condition":"Acute bronchitis with mucus hypersecretion","description":"Used to reduce mucus viscosity and relieve associated bronchospasm in acute bronchitis.","evidence":"Moderate"},{"condition":"Chronic bronchitis with reversible airway obstruction","description":"Provides symptomatic relief by thinning mucus and opening airways in chronic bronchitis flares.","evidence":"Moderate"},{"condition":"Asthma with thick mucus plugging","description":"May be used as add-on therapy when mucus plugging contributes to breathing difficulty, but not as a sole asthma controller.","evidence":"Limited"}]
Off-label uses: [{"condition":"Prevention of respiratory distress in preterm infants","description":"Ambroxol has been studied off-label for antenatal lung maturation, but this is not a standard use for this combination syrup.","evidence":"Limited"},{"condition":"Chronic obstructive pulmonary disease (COPD) with mucus","description":"Sometimes prescribed off-label for mucus clearance in COPD, but evidence for this fixed combination is limited.","evidence":"Limited"}]
Primary treatment for: Productive cough with bronchospasm
Also treats: Acute bronchitis, Chronic bronchitis, Asthma with mucus plugging
📋 Drug Information
| Generic Name(s) | Ambroxol + Salbutamol |
| Brand Name | Ambrodil-S Syrup |
| Manufacturer | Zoic Lifesciences |
| Packaging / Form | Varies by brand (Allopathy) |
| Therapeutic Class | RESPIRATORY |
| Action Class | Mucolytic + Beta-2 Adrenergic Agonist |
| Route of Administration | Oral |
| Storage | Store at room temperature between 15°C and 30°C. Protect from direct sunlight and moisture. Keep the bottle tightly closed. Do not freeze. |
| Shelf Life | 24 months from the date of manufacture. |
| WHO Guideline | Not established from the available information. |
| ICMR Guideline | Not established from the available information. |
👨⚕️ Doctor's Practical Tips
Evidence-based practical advice from experienced clinicians
🔍 Is This Medicine Right for Your Symptom?
Educational reference. Always consult a doctor for diagnosis.
🔬 How This Medicine Works (Pharmacology)
Pharmacokinetics
How It Works
This medicine combines two active ingredients with complementary actions. Ambroxol is a mucolytic agent that reduces the viscosity of respiratory secretions by breaking down acidic mucopolysaccharide fibers and stimulating surfactant production, which helps thin mucus and aids its clearance. Salbutamol is a short-acting beta-2 adrenergic receptor agonist that binds to beta-2 receptors on bronchial smooth muscle, causing relaxation and bronchodilation. Together, they improve mucus clearance and airway patency in conditions where both thick secretions and bronchospasm coexist.
Mechanism Steps
💡 How to Take astharil-as syrup
Strength: Each 5 ml of syrup contains ambroxol 30 mg and salbutamol 2 mg.
Dosage Information
| Adult Dosage | The usual adult dose of this medicine is 10 ml (2 teaspoons) three times a day, or as prescribed by your doctor. The dose may be adjusted based on your condition and response to treatment. Do not exceed the recommended dose. Dose must be individualized by a qualified clinician based on indication, age, weight, renal and hepatic function. |
| Pediatric Dosage | Pediatric dosing is not established from available information. Consult a pediatrician for appropriate dosing in children. |
| Elderly Dosage | Elderly patients may be more sensitive to the cardiovascular effects of salbutamol. Use with caution and start with a lower dose as prescribed by your doctor. Dose must be individualized by a qualified clinician based on renal and hepatic function. |
| Renal Impairment | Use with caution in patients with severe renal impairment. Dose adjustment may be necessary. Consult your doctor for guidance. |
| Hepatic Impairment | Use with caution in patients with severe hepatic impairment. Dose adjustment may be necessary. Consult your doctor for guidance. |
| Maximum Daily Dose | The maximum recommended daily dose is 30 ml (6 teaspoons) in divided doses, or as prescribed by your doctor. Do not exceed the prescribed dose. |
Dosage Timeline
🍽️ Food Timing Guide
⏰ What to Do If You Miss a Dose
⚠️ Side Effects of astharil-as syrup
✅ Common Side Effects
🚨 Serious Side Effects
⚠️ Rare Side Effects
Consult your doctor if you experience any unusual symptoms.
🔬 Drug Interactions
| Drug | Severity | Effect |
|---|---|---|
| Propranolol | Major | |
| MAOIs | Major | |
| Tricyclic antidepressants | Major | |
| Furosemide | Moderate | |
| Corticosteroids | Moderate | |
| Theophylline | Moderate | |
| Ipratropium | Minor | |
| Digoxin | Minor |
🚨 Major Interactions
- Non-selective beta-blockers (e.g., propranolol)
- Monoamine oxidase inhibitors (MAOIs)
- Tricyclic antidepressants
⚡ Moderate Interactions
- Diuretics (e.g., furosemide)
- Corticosteroids
- Xanthine derivatives (e.g., theophylline)
🍷 Alcohol Interaction
Alcohol may increase dizziness, drowsiness, and heart rate when taken with this medicine. It is best to avoid alcohol while using this medicine.
🔎 Check Your Other Medicines
Educational tool. Always confirm with your doctor or pharmacist.
🛡️ Safety & Warnings
🚫 Contraindications
["Hypersensitivity to ambroxol, salbutamol, or any component of the formulation","Severe cardiovascular disease including severe heart failure, arrhythmias, or recent myocardial infarction","Severe uncontrolled hypertension","Hyperthyroidism","Severe hepatic or renal impairment","Children under 2 years of age (unless specifically prescribed by a pediatrician)"]
⚠️ Warnings & Precautions
["This medicine should be used with caution in patients with heart disease, high blood pressure, or arrhythmias.","Patients with diabetes may experience increased blood sugar levels; monitor glucose regularly.","Use with caution in patients with hyperthyroidism or pheochromocytoma.","Do not exceed the recommended dose; excessive use may cause severe cardiovascular effects.","If you have a history of seizures, consult your doctor before using this medicine.","This medicine may cause dizziness; avoid driving or operating machinery until you know how it affects you.","Do not use this medicine for a dry cough or for prolonged periods without medical advice."]
🤱 Lactation Safety
Salbutamol is excreted in breast milk, but the amount is small and unlikely to harm a nursing infant. Ambroxol is also excreted in breast milk. Consult your doctor before using this medicine while breastfeeding.
💊 Overdose Management
Overdose of this medicine may cause severe tachycardia, palpitations, tremor, headache, nausea, and hypokalemia. In case of overdose, seek immediate medical attention. Treatment is supportive and symptomatic. Monitor heart rate, blood pressure, and serum potassium levels. There is no specific antidote.
⏰ Missed Dose
If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and continue with your regular schedule. Do not double the dose to catch up.
Additional Safety Advice
Always take this medicine exactly as prescribed by your doctor. Do not increase the dose or take it more often than directed. Shake the bottle well before each use and measure the dose with the provided measuring cup or spoon, not a household spoon. Avoid drinking alcohol while taking this medicine because it can worsen dizziness and increase heart rate. If you have heart disease, high blood pressure, diabetes, thyroid problems, or liver or kidney disease, tell your doctor before starting this medicine. Do not drive or operate heavy machinery until you know how this medicine affects you. Keep this medicine out of the reach of children. Store it at room temperature, away from direct sunlight and moisture. Do not use this medicine after the expiry date printed on the pack. If you are pregnant, planning pregnancy, or breastfeeding, consult your doctor before using this medicine.
👴 Special Considerations for Elderly
💡 For Patients Above 65
Elderly patients may be more sensitive to the cardiovascular effects of salbutamol, such as increased heart rate and blood pressure. Use with caution and monitor closely. Dose adjustment may be needed based on kidney and liver function.
🤰 Pregnancy Planning (TTC)
If you are planning pregnancy, consult your doctor before taking this medicine. The safety of this combination in pregnancy has not been well established. Your doctor will weigh the benefits and risks.
🏥 Post-Surgery Considerations
If you have recently had surgery, inform your surgeon and anesthesiologist that you are taking this medicine. Salbutamol can affect heart rate and blood pressure during surgery. Your doctor may adjust the dose or temporarily stop the medicine.
🦷 Dental Procedures
Inform your dentist that you are taking this medicine before any dental procedure. Salbutamol can cause dry mouth and may interact with certain medications used in dentistry. Your dentist may recommend taking the medicine as usual unless advised otherwise.
💚 Lifestyle Tips for Better Results
🏋️ Exercise Considerations
Avoid strenuous exercise until your breathing improves. Gentle walking and breathing exercises are usually safe. Consult your doctor before starting any exercise program.
🥗 Diet Recommendations
💼 Impact on Daily Work & Life
This medicine may cause dizziness, tremor, or increased heart rate, which can affect your ability to drive or operate machinery. Avoid these activities until you know how the medicine affects you. It is usually safe to continue desk work, but take breaks if you feel dizzy.
🛑 When to Stop This Medicine
Stop taking this medicine and consult your doctor if your symptoms do not improve within 5 to 7 days, if they worsen, or if you experience any serious side effects. Do not stop abruptly if you have been taking it regularly for a long time without consulting your doctor.
📅 Long-Term Use Effects
Long-term use of this medicine should be under medical supervision. Prolonged use of salbutamol may lead to tolerance and reduced effectiveness. Regular monitoring of heart rate, blood pressure, and potassium levels is advised. Do not use this medicine for longer than prescribed without consulting your doctor.
🌿 Non-Medicine Approaches
These can complement medicine but do not replace prescribed treatment.
Helps loosen mucus and soothe airways.
Evidence: TraditionalTechniques to help clear mucus from the lungs.
Evidence: Well-establishedCan help clear nasal congestion and improve breathing.
Evidence: Moderate💉 Vaccination Considerations
💉 If You're Getting Vaccinated
There are no known interactions between this medicine and vaccines. However, if you are scheduled for a vaccination, inform your healthcare provider that you are taking this medicine.
📦 Storage Guide
✅ DO
Store at room temperature (15-30°C)
❌ DON'T
Do not refrigerate unless specified
✅ DO
Keep in original container
❌ DON'T
Do not transfer to unmarked containers
✅ DO
Keep away from direct sunlight
❌ DON'T
Do not store in bathroom cabinet
✅ DO
Keep out of reach of children
❌ DON'T
Do not use after expiry date
✈️ Traveling with This Medicine
When traveling, carry this medicine in its original packaging with the prescription label intact. Bring a copy of your prescription in case customs or security asks for it. Store it in a cool, dry place away from direct sunlight. If you are crossing time zones, adjust your dosing schedule gradually to avoid missing doses. Do not leave the medicine in a hot car or checked luggage. Check the expiry date before you travel.
💰 Cost Analysis & Savings
👥 Real Patient Stories
Educational, anonymized scenarios. Individual results may vary.
💬 Questions Patients Often Ask
A: The bronchodilator effect usually starts within 15 to 30 minutes, while the mucolytic effect may take a few hours to become noticeable.
A: Yes, it is best to take this medicine with food to reduce stomach upset.
A: If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and continue with your regular schedule. Do not double the dose.
A: Consult your doctor before taking this medicine if you are pregnant or planning pregnancy. The safety of this combination in pregnancy has not been well studied.
A: No, this medicine is only for productive cough with bronchospasm. It is not effective for dry cough.
🤔 Common Patient Concerns
🔄 Substitutes for astharil-as syrup
View AllAlternative brands with exact same active ingredient:
Medical Note: Always consult your doctor before switching medications.
🛑 Myths vs. Facts
- Myth: This medicine can cure any type of cough.
Fact: This medicine is only for productive cough with bronchospasm. It is not effective for dry cough or cough due to other causes. - Myth: More medicine means faster relief.
Fact: Taking more than the prescribed dose can cause serious side effects like rapid heartbeat and low potassium. Always follow the prescribed dose. - Myth: It is safe to take without a prescription.
Fact: This medicine contains salbutamol, which can affect the heart and blood pressure. It should only be used under medical supervision.
🔄 Alternative Options
Generic Alternatives
- Ambroxol + Salbutamol syrup (various manufacturers)