asomex-m 5 tablet pr - Uses, Price, Side Effects & Substitutes
What is asomex-m 5 tablet pr used for?
Asomex-M 5 Tablet PR (S-Amlodipine + S-Metoprolol Tartrate) is used to treat CARDIAC. It contains S-Amlodipine (5mg) + S-Metoprolol Tartrate (25mg), which S-Amlodipine: Inhibits calcium influx across cell membranes in vascular smooth m. Always consult your doctor before use. Take as prescribed.
- Generic Name: S-Amlodipine + S-Metoprolol Tartrate
- Manufacturer: Emcure Pharmaceuticals Ltd
- Form: Allopathy
- Pregnancy Category: A
- Prescription Required: Yes
๐ asomex-m 5 tablet pr Uses & Benefits
Hypertension; stable angina; chronic stable angina; post-myocardial infarction
Off-label uses: Migraine prophylaxis; essential tremor; anxiety (S-Metoprolol); Raynaud's phenomenon (S-Amlodipine)
๐ Drug Information
| Generic Name(s) | S-Amlodipine + S-Metoprolol Tartrate |
| Brand Name | Asomex-M 5 Tablet PR |
| Manufacturer | Emcure Pharmaceuticals Ltd |
| Packaging / Form | Varies by brand (Allopathy) |
| Therapeutic Class | CARDIAC |
| Action Class | Antihypertensive (Calcium Channel Blocker + Beta Blocker) |
| Route of Administration | Oral |
| Storage | Store at 20-25ยฐC; protect from light and moisture |
| Shelf Life | As per manufacturer |
๐ฌ Pharmacology (PK/PD)
Pharmacokinetics
How It Works
S-Amlodipine: Inhibits calcium influx across cell membranes in vascular smooth muscle and cardiac muscle, causing vasodilation and reduced peripheral resistance. S-Metoprolol: Selectively blocks beta-1 adrenergic receptors in the heart, reducing heart rate, contractility, and cardiac output.
Mechanism Steps
๐ก How to Take asomex-m 5 tablet pr
Follow your doctor's prescription exactly.
โ ๏ธ Side Effects of asomex-m 5 tablet pr
โ Common Side Effects
- Edema (ankle/foot)
- Dizziness
- Fatigue
- Headache
- Nausea
- Bradycardia
- Hypotension
- Flushing
๐จ Serious Side Effects
- Heart block
- Severe bradycardia
- Heart failure exacerbation
- Bronchospasm (asthmatics)
- Hepatotoxicity
- Stevens-Johnson syndrome
โ ๏ธ Rare Side Effects
- Gingival hyperplasia
- Leukopenia
- Thrombocytopenia
- Pancreatitis
- Depression
- Impotence
Consult your doctor if you experience any unusual symptoms.
๐ฌ Drug Interactions
| โ ๏ธ Drug | Severity | Effect |
|---|---|---|
| Ketoconazole | Major | Increased S-Amlodipine levels, risk of toxicity |
| Quinidine | Major | Increased S-Metoprolol levels, bradycardia |
| Digoxin | Major | Additive bradycardia |
| Clonidine | Major | Rebound hypertension upon withdrawal |
| NSAIDs | Moderate | Reduced antihypertensive effect |
| Grapefruit juice | Minor | Increased S-Amlodipine levels |
๐จ Major Interactions
- CYP3A4 inhibitors (e.g., ketoconazole, itraconazole, ritonavir)
- CYP2D6 inhibitors (e.g., quinidine, fluoxetine, paroxetine)
- Beta-blockers (additive bradycardia)
- Calcium channel blockers (additive hypotension)
- Digoxin (increased bradycardia)
- Clonidine (rebound hypertension)
โก Moderate Interactions
- CYP3A4 inducers (e.g., rifampin, carbamazepine)
- CYP2D6 inducers (e.g., rifampin)
- NSAIDs (reduced antihypertensive effect)
- Antidiabetic agents (masked hypoglycemia symptoms)
โน๏ธ Minor Interactions
- Grapefruit juice (increased S-Amlodipine levels)
- Cimetidine (increased S-Metoprolol levels)
๐ฝ๏ธ Food Interactions
Avoid grapefruit juice; take with or without food
๐ท Alcohol Interaction
Avoid alcohol; may increase hypotensive effect
๐ก๏ธ Safety & Warnings
๐ซ Contraindications
Hypersensitivity; severe bradycardia; heart block (2nd/3rd degree); cardiogenic shock; decompensated heart failure; sick sinus syndrome; severe hypotension; asthma (S-Metoprolol); concomitant use with MAOIs
๐ Monitoring Parameters
Blood pressure; heart rate; ECG; signs of heart failure; liver function; renal function
๐คฑ Lactation Safety
S-Amlodipine: Excreted in milk, use caution; S-Metoprolol: Excreted in milk, avoid if possible
๐ Overdose Management
Supportive care; atropine for bradycardia; calcium gluconate for S-Amlodipine; glucagon for S-Metoprolol; vasopressors for hypotension
โฐ Missed Dose
Take as soon as remembered; skip if near next dose; do not double dose