asier p suspension - Aceclofenac (50mg) + Paracetamol (125mg) medicine

Acemiz Plus Oral Suspension: Complete Medicine Guide

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🏭 Alisier Drugs Pvt Ltd 📦 Varies by brand 💊 Allopathy 📅 Updated: Sep 25, 2026
⚠️ Hepatotoxicity Risk ⚠️ Nephrotoxicity Risk 🤰 Pregnancy Category Not established from the available information. NSAIDs are generally avoided in the third trimester due to risk of premature closure of ductus arteriosus. Paracetamol is considered relatively safe in pregnancy when used at recommended doses. Consult your doctor before use. 📋 Prescription Required 💊 Generic Available
Medically Reviewed
11 min read
Evidence: Well-established for short-term pain and fever management.
Reviewed by
SaathiMed Expert Panel | Sep 25, 2026

When to Call Your Doctor IMMEDIATELY

  • Blood in stool or vomit
  • Severe abdominal pain
  • Chest pain or difficulty breathing
  • Severe headache with visual changes
  • Sudden swelling of face, lips, or throat
  • Yellowing of skin or eyes
  • Decreased urine output
  • Unusual bruising or bleeding

If experiencing severe symptoms, call emergency services immediately.

What is asier p suspension used for?

This medicine is a combination of aceclofenac and paracetamol in an oral suspension, used for short-term relief of pain and fever. It works by reducing inflammation and pain signals. Take it with food, avoid alcohol, and do not exceed the prescribed dose.

  • Generic Name: Aceclofenac + Paracetamol
  • Manufacturer: Alisier Drugs Pvt Ltd
  • Form: Allopathy
  • Pregnancy Category: Consult doctor
  • Prescription Required: Yes

🇮🇳 asier p suspension के बारे में (Hindi Summary)

उपयोग: यह दवा एसिटामिनोफेन और एसिक्लोफेनाक का संयोजन है, जिसका उपयोग दर्द और बुखार के अल्पकालिक उपचार के लिए किया जाता है। यह मांसपेशियों के दर्द, दांत दर्द, सर्जरी के बाद के दर्द और बुखार में राहत देती है। इसे भोजन के साथ लें और शराब से बचें।

साइड इफेक्ट्स: आम दुष्प्रभावों में मतली, उल्टी, पेट दर्द, सिरदर्द और चक्कर आना शामिल हैं। गंभीर दुष्प्रभावों में पेट में रक्तस्राव, गुर्दे की समस्या और यकृत की क्षति शामिल हो सकती है। किसी भी गंभीर लक्षण पर तुरंत डॉक्टर से संपर्क करें।

सुरक्षा सलाह: इस दवा को डॉक्टर के निर्देशानुसार ही लें। खुराक से अधिक न लें। इसे भोजन के साथ लें ताकि पेट की जलन कम हो। शराब का सेवन न करें। अन्य दर्द निवारक दवाओं के साथ इसका सेवन न करें। गर्भावस्था या स्तनपान के दौरान डॉक्टर से सलाह लें।

💡 Did You Know? India has the highest number of USFDA-compliant plants outside the USA.

💊 asier p suspension Uses & Benefits

[{"condition":"Acute musculoskeletal pain","description":"Relieves pain and inflammation in conditions such as sprains, strains, and back pain.","evidence":"Well-established"},{"condition":"Dental pain","description":"Provides relief from toothache and post-dental procedure pain.","evidence":"Well-established"},{"condition":"Post-operative pain","description":"Used for short-term management of pain after surgery.","evidence":"Well-established"},{"condition":"Fever","description":"Reduces fever associated with various conditions.","evidence":"Well-established"},{"condition":"Osteoarthritis","description":"May be used for short-term relief of pain and stiffness in osteoarthritis.","evidence":"Established"}]

Off-label uses: [{"condition":"Migraine","description":"Sometimes used off-label for acute migraine attacks, but evidence is limited.","evidence":"Limited"},{"condition":"Dysmenorrhea","description":"May be used off-label for menstrual pain, but not a first-line option.","evidence":"Limited"}]

Primary treatment for: Acute pain and fever

Also treats: Musculoskeletal pain, Dental pain, Post-operative pain, Osteoarthritis

📋 Drug Information

Generic Name(s)Aceclofenac + Paracetamol
Brand NameAldigesic P
ManufacturerAlisier Drugs Pvt Ltd
Packaging / FormVaries by brand (Allopathy)
Therapeutic ClassPAIN ANALGESICS
Action ClassNSAID + Analgesic/Antipyretic
Route of AdministrationOral
StorageStore at room temperature (15-30°C) in a dry place, away from direct sunlight and moisture. Keep the bottle tightly closed. Do not freeze.
Shelf Life24 months from the date of manufacture.
WHO GuidelineNot established from the available information.
ICMR GuidelineNot established from the available information.

👨‍⚕️ Doctor's Practical Tips

Evidence-based practical advice from experienced clinicians

1
Always prescribe this medicine with food to minimize gastrointestinal irritation.
2
Advise patients to avoid alcohol while taking this medicine.
3
Do not exceed the maximum daily dose of 30 mL.
4
Use with caution in elderly patients and those with renal or hepatic impairment.
5
Monitor for signs of gastrointestinal bleeding, especially in long-term use.
6
Instruct patients to stop the medicine and seek medical attention if they experience severe abdominal pain, black stools, or vomiting blood.
7
Consider alternative analgesics in patients with cardiovascular risk factors.

🔍 Is This Medicine Right for Your Symptom?

Educational reference. Always consult a doctor for diagnosis.

✅
Acute pain
This medicine is commonly prescribed for acute pain.
Likely Use
✅
Fever
This medicine helps reduce fever.
Likely Use
❌
Chronic pain
Not for long-term use without medical supervision.
Not Primary

🔬 How This Medicine Works (Pharmacology)

Pharmacokinetics

AbsorptionAceclofenac is rapidly absorbed after oral administration, with peak plasma concentrations reached in about 1.5 to 2 hours. Paracetamol is also rapidly absorbed, with peak levels in 0.5 to 1 hour. Food may delay absorption slightly but does not significantly affect the extent.
DistributionAceclofenac is highly protein-bound and distributes well into synovial fluid. Paracetamol distributes widely into most body tissues, with a volume of distribution of about 0.9 L/kg.
Protein BindingAceclofenac is approximately 99% bound to plasma proteins. Paracetamol is about 10-25% bound to plasma proteins.
MetabolismAceclofenac is metabolized in the liver primarily by CYP2C9 to inactive metabolites. Paracetamol is metabolized in the liver via glucuronidation and sulfation, with a small fraction metabolized by CYP2E1 to a toxic intermediate (NAPQI) that is detoxified by glutathione.
Half-LifeThe elimination half-life of aceclofenac is approximately 4 hours. Paracetamol has a half-life of about 2-3 hours.
ExcretionAceclofenac metabolites are excreted mainly in urine and bile. Paracetamol metabolites are excreted primarily in urine.
BioavailabilityThe oral bioavailability of aceclofenac is about 80-100%. Paracetamol has a bioavailability of about 80-90%.
Onset of ActionAnalgesic effect begins within 30-60 minutes after oral administration.
Peak Plasma TimeAceclofenac: 1.5-2 hours; Paracetamol: 0.5-1 hour.
Duration of ActionPain relief lasts approximately 4-6 hours, requiring dosing every 6-8 hours as needed.

How It Works

This medicine combines two active ingredients with complementary mechanisms. Aceclofenac, an NSAID, inhibits the cyclooxygenase (COX) enzymes, particularly COX-2, leading to decreased synthesis of prostaglandins, which are mediators of pain, inflammation, and fever. Paracetamol acts primarily centrally to reduce pain and fever, with weak inhibition of prostaglandin synthesis in the central nervous system. Together, they provide effective analgesia and antipyresis.

Mechanism Steps

1
Inhibition of cyclooxygenase enzymes: Aceclofenac inhibits COX-1 and COX-2 enzymes, reducing the conversion of arachidonic acid to prostaglandins.
2
Reduced prostaglandin synthesis: Decreased prostaglandin levels lead to reduced inflammation, pain, and fever.
3
Central analgesic action of paracetamol: Paracetamol acts on the central nervous system to inhibit prostaglandin synthesis and modulate pain perception.
4
Antipyretic effect: Both ingredients act on the hypothalamus to lower elevated body temperature.

💡 How to Take asier p suspension

Strength: Each 5 mL of oral suspension contains Aceclofenac 50 mg and Paracetamol 125 mg.

1Shake the bottle well before each use.
2Use the measuring cup or syringe provided to measure the correct dose.
3Take the medicine orally with a glass of water or milk.
4Take it with food or immediately after a meal to reduce stomach upset.
5Do not exceed the prescribed dose or frequency.
6Wash the measuring device after each use.

Dosage Information

Adult DosageThe usual adult dose of this medicine is 10 mL (providing 50 mg aceclofenac and 125 mg paracetamol) orally every 8 hours as needed for pain and fever. Do not exceed 30 mL in 24 hours. Dose must be individualized by a qualified clinician based on indication, age, weight, renal and hepatic function. Use the lowest effective dose for the shortest duration.
Pediatric DosagePediatric dosing is not established from available information. Consult a pediatrician.
Elderly DosageElderly patients may be more sensitive to the effects of this medicine, especially gastrointestinal and renal side effects. Use with caution and lower doses may be appropriate. Dose must be individualized by a qualified clinician.
Renal ImpairmentUse with caution in patients with renal impairment. Dose reduction may be necessary. Avoid in severe renal impairment (creatinine clearance <30 mL/min). Consult a doctor for individualized dosing.
Hepatic ImpairmentUse with caution in patients with hepatic impairment. Dose reduction may be necessary. Avoid in severe hepatic impairment. Consult a doctor for individualized dosing.
Maximum Daily DoseMaximum daily dose: 30 mL (150 mg aceclofenac and 375 mg paracetamol) in divided doses. Do not exceed this limit.

Dosage Timeline

🌅 Morning ❌ ☀️ Afternoon ❌ 🌆 Evening ❌ 🌙 Night ❌

🍽️ Food Timing Guide

With food
Take with meals
Reduces stomach upset.
Alcohol
Avoid
Increases risk of gastrointestinal bleeding and liver damage.
Caffeine
Limit
May increase stomach irritation.

⏰ What to Do If You Miss a Dose

📌 Less than 4 hours since missed dose
→ Take the missed dose as soon as you remember.
💡 Continue with the regular schedule.
📌 More than 4 hours since missed dose
→ Skip the missed dose.
💡 Do not double dose to catch up.

⚠️ Side Effects of asier p suspension

✅ Common Side Effects

Nausea (Common (5-10%))
Take with food or milk. If persistent, consult your doctor.
Vomiting (Common (5-10%))
Stay hydrated. If severe or persistent, seek medical advice.
Stomach pain (Common (5-10%))
Take with food. Avoid alcohol. If severe, contact your doctor.
Indigestion (Common (5-10%))
Take with meals. Antacids may help, but consult your doctor first.
Headache (Common (5-10%))
Usually resolves on its own. If persistent, consult your doctor.
Dizziness (Uncommon (1-5%))
Avoid driving or operating machinery until you know how it affects you.
Drowsiness (Uncommon (1-5%))
Avoid alcohol and activities requiring alertness.

🚨 Serious Side Effects

Gastrointestinal bleeding (Rare (<0.1%))
Seek immediate medical attention if you notice black, tarry stools, vomiting blood, or severe abdominal pain.
Peptic ulcer (Rare (<0.1%))
Report persistent stomach pain or heartburn to your doctor immediately.
Kidney impairment (Rare (<0.1%))
Seek medical attention if you experience decreased urine output, swelling, or fatigue.
Liver damage (Rare (<0.1%))
Report yellowing of skin or eyes, dark urine, or severe fatigue to your doctor immediately.
Severe allergic reaction (Rare (<0.1%))
Seek emergency care if you experience rash, swelling of face or throat, or difficulty breathing.
Cardiovascular events (Rare (<0.1%))
Seek immediate medical attention if you experience chest pain, shortness of breath, or swelling of legs.

⚠️ Rare Side Effects

Blood disorders (e.g., thrombocytopenia, leukopenia)
Report unusual bruising, bleeding, or signs of infection to your doctor.
Pancreatitis
Seek immediate care for severe abdominal pain radiating to the back.
Severe skin reactions (e.g., Stevens-Johnson syndrome)
Stop the medicine and seek emergency care if you develop a rash with blisters or peeling skin.

Consult your doctor if you experience any unusual symptoms.

🔬 Drug Interactions

Drug Severity Effect
Warfarin Major
Ibuprofen Major
Methotrexate Major
ACE inhibitors Major
Furosemide Moderate
Lithium Moderate
SSRIs Moderate
Antacids Minor
Cholestyramine Minor
Corticosteroids Major

🚨 Major Interactions

  • Warfarin
  • Other NSAIDs (e.g., ibuprofen, naproxen)
  • Corticosteroids
  • Methotrexate
  • ACE inhibitors and ARBs

⚡ Moderate Interactions

  • Diuretics (e.g., furosemide, hydrochlorothiazide)
  • Lithium
  • SSRIs
  • Antihypertensives (e.g., beta-blockers, calcium channel blockers)

🍷 Alcohol Interaction

Avoid alcohol while taking this medicine. Alcohol increases the risk of gastrointestinal bleeding, ulceration, and liver damage, especially when combined with paracetamol and NSAIDs.

🔎 Check Your Other Medicines

Educational tool. Always confirm with your doctor or pharmacist.

🛡️ Safety & Warnings

🚫 Contraindications

["Known hypersensitivity to aceclofenac, paracetamol, or any component of the formulation","Active peptic ulcer or history of recurrent peptic ulcer","Severe heart failure","Severe hepatic impairment","Severe renal impairment (creatinine clearance

⚠️ Warnings & Precautions

["Take with food to minimize gastrointestinal irritation.","Avoid alcohol consumption.","Do not exceed recommended dose or duration.","Use with caution in elderly patients.","Monitor for signs of gastrointestinal bleeding.","Use with caution in patients with cardiovascular risk factors.","Do not use concurrently with other NSAIDs or paracetamol-containing products.","Consult doctor before use in pregnancy or breastfeeding.","May cause dizziness; avoid driving if affected.","Keep out of reach of children."]

🤱 Lactation Safety

Aceclofenac and paracetamol are excreted in breast milk in small amounts. Limited data suggest it may be acceptable during breastfeeding, but consult your doctor to weigh benefits and risks.

💊 Overdose Management

Overdose of this medicine can cause severe liver damage due to paracetamol and gastrointestinal bleeding due to aceclofenac. Symptoms of paracetamol overdose include nausea, vomiting, abdominal pain, and liver failure. Seek immediate medical attention. Treatment includes activated charcoal, N-acetylcysteine for paracetamol toxicity, and supportive care. Do not induce vomiting unless advised by a healthcare professional.

⏰ Missed Dose

If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and continue with your regular schedule. Do not double dose to catch up.

Additional Safety Advice

General Safety

Take this medicine exactly as prescribed by your doctor. Do not exceed the recommended dose or duration. Take it with food or milk to reduce stomach upset. Avoid alcohol while taking this medicine as it can increase the risk of gastrointestinal bleeding and liver damage. Do not take other NSAIDs or paracetamol-containing products simultaneously to avoid overdose. Inform your doctor if you have a history of stomach ulcers, kidney or liver disease, heart problems, or asthma. Use with caution in the elderly. Do not use this medicine for more than 7 days without medical advice. Keep out of reach of children. Store at room temperature away from direct sunlight and moisture.

👴 Special Considerations for Elderly

💡 For Patients Above 65

Elderly patients are at higher risk of gastrointestinal, renal, and cardiovascular side effects. Use with caution, lower doses may be needed, and monitor renal and hepatic function regularly.

🤰 Pregnancy Planning (TTC)

Consult your doctor before planning pregnancy if you are taking this medicine. NSAIDs may affect ovulation and are generally avoided in the third trimester.

🏥 Post-Surgery Considerations

This medicine may be used for post-operative pain, but consult your surgeon before use, especially if you are on other medications or have bleeding risks.

🦷 Dental Procedures

Inform your dentist if you are taking this medicine before any dental procedure, as it may increase bleeding risk.

💚 Lifestyle Tips for Better Results

🏃
Maintain a healthy weight to reduce stress on joints.
🥗
Engage in regular low-impact exercise like walking or swimming.
😴
Practice good posture to prevent musculoskeletal pain.
💧
Include anti-inflammatory foods like omega-3 fatty acids in your diet.
🧘
Get adequate sleep to promote healing.
🌞
Stay hydrated to support kidney function.

🏋️ Exercise Considerations

Avoid strenuous exercise while taking this medicine, especially if you have pain or inflammation. Consult your doctor before starting any exercise program.

🥗 Diet Recommendations

Include omega-3 rich foods like fish and flaxseeds.
Reduce processed and fried foods.
Stay well hydrated.
Eat plenty of fruits and vegetables.

💼 Impact on Daily Work & Life

This medicine may cause dizziness or drowsiness in some people. Avoid driving or operating heavy machinery until you know how it affects you. It may also cause stomach upset, so take it with food.

🛑 When to Stop This Medicine

Stop taking this medicine and consult your doctor if you experience severe side effects such as stomach pain, black stools, vomiting blood, yellowing of eyes, or decreased urine output. Do not stop abruptly if you are on a prescribed regimen without consulting your doctor.

📅 Long-Term Use Effects

Long-term use of this medicine can increase the risk of gastrointestinal bleeding, kidney impairment, liver damage, and cardiovascular events. It should be used for the shortest duration possible. Regular monitoring of liver and kidney function is advised if prolonged use is necessary.

🌿 Non-Medicine Approaches

These can complement medicine but do not replace prescribed treatment.

Physical therapy

Can complement medicine for chronic pain management.

Evidence: Well-established
Hot/cold therapy

May help reduce pain and inflammation.

Evidence: Limited
Acupuncture

Some evidence for pain relief.

Evidence: Limited

💉 Vaccination Considerations

💉 If You're Getting Vaccinated

No known interactions with vaccines. However, if you have a fever, consult your doctor before vaccination.

📦 Storage Guide

✅ DO

Store at room temperature (15-30°C)

❌ DON'T

Do not refrigerate unless specified

✅ DO

Keep in original container

❌ DON'T

Do not transfer to unmarked containers

✅ DO

Keep away from direct sunlight

❌ DON'T

Do not store in bathroom cabinet

✈️ Traveling with This Medicine

When traveling, carry this medicine in its original packaging with a copy of your prescription. Store it at room temperature, away from direct sunlight and moisture. If traveling across time zones, adjust dosing intervals as advised by your doctor. Check customs regulations for carrying prescription medicines. Always keep it in your carry-on luggage.

💰 Cost Analysis & Savings

👥 Real Patient Stories

Educational, anonymized scenarios. Individual results may vary.

👤 A 35-year-old man with acute back pain
He was prescribed this medicine for severe back pain. He took it with food as directed and experienced significant relief within an hour. He was advised to avoid alcohol and not to exceed the dose. He recovered fully within a week without any side effects.
💡 Lesson: Taking the medicine with food and adhering to the prescribed dose ensures safety and efficacy.
👤 A 60-year-old woman with osteoarthritis
She used this medicine for knee pain but developed stomach upset after a few days. Her doctor advised her to take it with food and added a gastroprotective agent. Her pain improved, and the stomach upset resolved.
💡 Lesson: Gastrointestinal side effects can be managed by taking the medicine with food and adding a proton pump inhibitor if needed.

💬 Questions Patients Often Ask

Q: How long does it take to work?

A: This medicine usually starts relieving pain within 30-60 minutes after taking it.

Q: Can I take it on an empty stomach?

A: It is best to take it with food or milk to reduce stomach upset.

Q: Is it safe for children?

A: Pediatric dosing is not established. Consult a pediatrician before giving it to a child.

Q: Can I take it with other painkillers?

A: Do not take it with other NSAIDs or paracetamol-containing products without consulting your doctor.

🤔 Common Patient Concerns

💭 These are the concerns patients most commonly raise

  • Can I take this medicine long-term?
  • Will it affect my kidney function?
  • Can I drive after taking this medicine?
  • Does it interact with my blood pressure medicine?
  • What if I miss a dose?
  • Can I drink alcohol while taking this?

🔄 Substitutes for asier p suspension

View All

Alternative brands with exact same active ingredient:

Medical Note: Always consult your doctor before switching medications.

🛑 Myths vs. Facts

  • Myth: This medicine is completely safe and can be taken long-term without monitoring.
    Fact: This medicine can cause serious side effects like GI bleeding and kidney problems, especially with prolonged use. It should be used for the shortest duration possible under medical supervision.
  • Myth: It is okay to take extra doses if pain is severe.
    Fact: Taking more than the recommended dose can lead to severe liver damage and other complications. Always stick to the prescribed dose.
  • Myth: This medicine can be taken on an empty stomach without any issues.
    Fact: Taking it with food reduces the risk of stomach upset and gastrointestinal irritation.

🔄 Alternative Options

Generic Alternatives

  • Aceclofenac + Paracetamol oral suspension (generic)

Brand Alternatives

  • Acemiz Plus Oral Suspension

📊 Comparison with Similar Medicines

[{"medicine":"This medicine","composition":"Aceclofenac 50mg + Paracetamol 125mg per 5mL","onset":"30-60 minutes","duration":"4-6 hours","common_side_effects":"Nausea, stomach pain, headache"},{"medicine":"Ibuprofen + Paracetamol","composition":"Ibuprofen 100mg + Paracetamol 125mg per 5mL","onset":"30-60 minutes","duration":"4-6 hours","common_side_effects":"Nausea, stomach pain, dizziness"},{"medicine":"Diclofenac + Paracetamol","composition":"Diclofenac 50mg + Paracetamol 125mg per 5mL","onset":"30-60 minutes","duration":"4-6 hours","common_side_effects":"Nausea, stomach pain, headache"}]

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