Arrest 500mg/12.5mg Tablet: Comprehensive Medicine Guide
Clinical Reference Standards: CDSCO (Central Drugs Standard Control Organisation), Indian Pharmacopoeia (IP) & WHO | Last Updated: September 2026
When to Call Your Doctor IMMEDIATELY
- Sudden severe headache or confusion
- Chest pain, palpitations, or difficulty breathing
- Sudden weakness or numbness on one side of the body
- Slurred speech or vision changes
- Yellowing of skin or eyes, dark urine
- Severe abdominal pain or persistent vomiting
- Signs of allergic reaction such as rash, swelling of face or throat
If experiencing severe symptoms, call emergency services immediately.
What is arrest 500mg/12.5mg/10mg tablet used for?
This medicine is a combination of Paracetamol (500mg) and Phenylpropanolamine (12.5mg) used for short-term relief of nasal congestion, pain, and fever associated with colds or allergies. It works by reducing pain and fever centrally and narrowing nasal blood vessels. However, due to safety concerns with phenylpropanolamine, it should only be used under medical supervision.
- Generic Name: Paracetamol (500mg) + Phenylpropanolamine (12.5mg)
- Manufacturer: Welbe Life Sciences
- Form: Allopathy
- Pregnancy Category: Consult doctor
- Prescription Required: Yes
🇮🇳 arrest 500mg/12.5mg/10mg tablet के बारे में (Hindi Summary)
उपयोग: यह दवा पैरासिटामोल 500 मिलीग्राम और फेनिलप्रोपेनॉलामाइन 12.5 मिलीग्राम का संयोजन है। इसका उपयोग सर्दी-जुकाम, एलर्जी या साइनसाइटिस से होने वाली नाक की भीड़, दर्द और बुखार में राहत के लिए किया जाता है। पैरासिटामोल दर्द और बुखार कम करता है, जबकि फेनिलप्रोपेनॉलामाइन नाक की रक्त वाहिकाओं को सिकोड़कर जमाव कम करता है। यह दवा केवल डॉक्टर की सलाह से ही लेनी चाहिए, खासकर अगर आपको उच्च रक्तचाप, हृदय रोग या थायरॉइड की समस्या है।
साइड इफेक्ट्स: इस दवा के सामान्य दुष्प्रभावों में मतली, पेट में गड़बड़ी, मुँह सूखना, सिरदर्द, चक्कर आना, घबराहट और नींद न आना शामिल हैं। फेनिलप्रोपेनॉलामाइन के कारण दिल की धड़कन तेज हो सकती है और रक्तचाप बढ़ सकता है। दुर्लभ मामलों में गंभीर उच्च रक्तचाप, स्ट्रोक, हृदय गति विकार और एलर्जी प्रतिक्रिया हो सकती है। अगर आपको सीने में दर्द, तेज सिरदर्द, कमजोरी या सांस लेने में तकलीफ हो, तो तुरंत डॉक्टर से मिलें।
सुरक्षा सलाह: इस दवा को डॉक्टर के बताए अनुसार ही लें। निर्धारित मात्रा से अधिक न लें। शराब का सेवन न करें क्योंकि इससे लीवर को नुकसान का खतरा बढ़ सकता है। पैरासिटामोल युक्त अन्य दवाओं के साथ इसका सेवन न करें। अगर आपको उच्च रक्तचाप, हृदय रोग, मधुमेह, थायरॉइड या गुर्दे/लीवर की बीमारी है, तो डॉक्टर को बताएं। गर्भवती या स्तनपान कराने वाली महिलाएं डॉक्टर से सलाह लें। चक्कर आने पर वाहन न चलाएं। बच्चों की पहुंच से दूर रखें।
💊 arrest 500mg/12.5mg/10mg tablet Uses & Benefits
[{"condition":"Common cold with nasal congestion and pain/fever","description":"Provides temporary relief of nasal stuffiness along with reduction of mild to moderate pain and fever associated with the common cold.","evidence":"Established for individual components; combination use is common but phenylpropanolamine is restricted in many countries."},{"condition":"Allergic rhinitis with congestion","description":"Helps relieve nasal congestion and associated headache or sinus pressure in allergic rhinitis.","evidence":"Established for decongestant effect; safety concerns limit use."},{"condition":"Sinusitis with pain and congestion","description":"Reduces sinus congestion and relieves pain or fever accompanying sinusitis.","evidence":"Symptomatic relief; not a substitute for antibiotics when bacterial infection is present."}]
Off-label uses: []
Primary treatment for: Common cold with nasal congestion and pain/fever
Also treats: Allergic rhinitis, Sinusitis
📋 Drug Information
| Generic Name(s) | Paracetamol (500mg) + Phenylpropanolamine (12.5mg) |
| Brand Name | arrest 500mg/12.5mg/10mg tablet |
| Manufacturer | Welbe Life Sciences |
| Packaging / Form | Varies by brand (Allopathy) |
| Therapeutic Class | RESPIRATORY |
| Action Class | |
| Route of Administration | Oral |
| Storage | Store at room temperature between 15°C and 30°C (59°F to 86°F) in a dry place, away from direct sunlight and moisture. Keep in the original container. |
| Shelf Life | Not established from the available information. Refer to the product packaging for the expiry date. |
| WHO Guideline | Not established from the available information. Phenylpropanolamine has been withdrawn or restricted in many countries due to safety concerns. |
| ICMR Guideline | Not established from the available information. |
👨⚕️ Doctor's Practical Tips
Evidence-based practical advice from experienced clinicians
🔍 Is This Medicine Right for Your Symptom?
Educational reference. Always consult a doctor for diagnosis.
🔬 How This Medicine Works (Pharmacology)
Pharmacokinetics
How It Works
Paracetamol reduces pain and fever mainly by inhibiting prostaglandin synthesis in the central nervous system, with minimal anti-inflammatory action in peripheral tissues. Phenylpropanolamine is a mixed-acting sympathomimetic amine that both releases norepinephrine from nerve endings and directly stimulates alpha-adrenergic receptors, causing vasoconstriction in nasal mucosa and reducing swelling. The combination provides symptomatic relief of congestion and pain/fever.
Mechanism Steps
💡 How to Take arrest 500mg/12.5mg/10mg tablet
Strength: Immediate-release tablet containing Paracetamol 500 mg and Phenylpropanolamine 12.5 mg.
Dosage Information
| Adult Dosage | The usual adult dose of this medicine is one tablet taken orally every 4 to 6 hours as needed for symptoms, not to exceed the maximum daily dose. However, because this combination contains phenylpropanolamine, which has safety concerns, the dose and duration must be individualized by a qualified clinician based on the indication, age, weight, renal and hepatic function, and cardiovascular status. Do not self-medicate or exceed the prescribed dose. |
| Pediatric Dosage | Pediatric dosing is not established from available information. Consult a pediatrician. |
| Elderly Dosage | Elderly patients may be more sensitive to the cardiovascular and central nervous system effects of phenylpropanolamine. Use with caution and lower doses may be appropriate. Dose must be individualized by a qualified clinician. |
| Renal Impairment | Dose adjustment may be required in patients with renal impairment. Consult a doctor for individualized dosing. |
| Hepatic Impairment | Paracetamol should be used with caution in patients with hepatic impairment. Dose reduction or avoidance may be necessary. Consult a doctor for individualized dosing. |
| Maximum Daily Dose | The maximum daily dose of paracetamol should not exceed 4000 mg (8 tablets of 500 mg) from all sources. The maximum daily dose of phenylpropanolamine is not established from the available information. Do not exceed the dose recommended by your doctor. |
Dosage Timeline
🍽️ Food Timing Guide
⏰ What to Do If You Miss a Dose
⚠️ Side Effects of arrest 500mg/12.5mg/10mg tablet
✅ Common Side Effects
🚨 Serious Side Effects
⚠️ Rare Side Effects
Consult your doctor if you experience any unusual symptoms.
🔬 Drug Interactions
| Drug | Severity | Effect |
|---|---|---|
| MAOIs | Major | |
| Other sympathomimetics | Major | |
| Warfarin | Major | |
| Beta-blockers | Moderate | |
| Tricyclic antidepressants | Moderate | |
| Caffeine | Moderate | |
| Antacids | Minor | |
| Cholestyramine | Minor |
🚨 Major Interactions
- Monoamine oxidase inhibitors (MAOIs)
- Other sympathomimetics (e.g., pseudoephedrine, phenylephrine)
- Warfarin
⚡ Moderate Interactions
- Beta-blockers
- Tricyclic antidepressants
- Caffeine
🍷 Alcohol Interaction
Avoid alcohol while taking this medicine. Alcohol increases the risk of paracetamol-induced liver injury and can worsen dizziness, drowsiness, and cardiovascular effects from phenylpropanolamine.
🔎 Check Your Other Medicines
Educational tool. Always confirm with your doctor or pharmacist.
🛡️ Safety & Warnings
🚫 Contraindications
["Known hypersensitivity to paracetamol, phenylpropanolamine, or any component of the formulation","Uncontrolled hypertension or severe coronary artery disease","Hyperthyroidism","History of stroke or transient ischemic attack","Use within 14 days of stopping an MAOI","Severe liver disease or severe renal impairment","Pregnancy (phenylpropanolamine component)"]
⚠️ Warnings & Precautions
["Phenylpropanolamine has been associated with an increased risk of hemorrhagic stroke; use only under medical supervision.","Do not exceed the recommended dose of paracetamol; high doses can cause serious liver damage.","Avoid alcohol while taking this medicine.","Use with caution in patients with cardiovascular disease, hypertension, diabetes, or thyroid disorders.","May cause dizziness or drowsiness; avoid driving or operating machinery until you know how it affects you.","Do not use for longer than directed without consulting a doctor.","Keep out of reach of children."]
🤱 Lactation Safety
Paracetamol is considered compatible with breastfeeding. Phenylpropanolamine may pass into breast milk and could cause stimulation or other effects in the infant. Consult your doctor before using this medicine while breastfeeding.
💊 Overdose Management
Overdose of this medicine can cause severe liver damage from paracetamol and serious cardiovascular effects from phenylpropanolamine. Seek emergency medical attention immediately. Treatment for paracetamol overdose includes administration of N-acetylcysteine as early as possible. Management of phenylpropanolamine toxicity is supportive and may include blood pressure control and cardiac monitoring. Do not induce vomiting unless instructed by a healthcare professional.
⏰ Missed Dose
If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and continue with your regular schedule. Do not double the dose to catch up.
Additional Safety Advice
Take this medicine exactly as prescribed by your doctor. Do not exceed the recommended dose or duration. Avoid alcohol while taking this medicine because it increases the risk of liver damage from paracetamol and may worsen dizziness or drowsiness. Do not use other products containing paracetamol simultaneously to prevent accidental overdose. If you have high blood pressure, heart disease, diabetes, thyroid problems, or kidney or liver disease, inform your doctor before taking this medicine. Do not drive or operate heavy machinery if you feel dizzy or drowsy. Pregnant or breastfeeding women should consult a doctor before use. Keep this medicine out of reach of children. Store at room temperature away from moisture and heat. If symptoms persist beyond a few days or worsen, stop the medicine and consult your doctor.
👴 Special Considerations for Elderly
💡 For Patients Above 65
Elderly patients are more sensitive to the cardiovascular and central nervous system effects of phenylpropanolamine. They may experience increased blood pressure, palpitations, dizziness, and confusion. Use with caution, at lower doses if prescribed, and monitor blood pressure regularly. Paracetamol should be used at the lowest effective dose due to potential liver and kidney changes with age.
🤰 Pregnancy Planning (TTC)
This medicine is not recommended for use during pregnancy or when planning pregnancy because phenylpropanolamine may pose risks to the fetus. Consult your doctor for safer alternatives to manage cold symptoms. Paracetamol alone may be considered if needed, but always under medical guidance.
🏥 Post-Surgery Considerations
After surgery, the use of this medicine should be discussed with your surgeon or anesthesiologist. Phenylpropanolamine can increase blood pressure and heart rate, which may be undesirable during recovery. Paracetamol may be used for pain relief if approved. Do not self-medicate.
🦷 Dental Procedures
Inform your dentist if you are taking this medicine before any dental procedure. Phenylpropanolamine can interact with local anesthetics containing epinephrine and may increase cardiovascular effects. Your dentist may advise you to stop the medicine temporarily or adjust your treatment plan.
💚 Lifestyle Tips for Better Results
🏋️ Exercise Considerations
This medicine may cause dizziness, drowsiness, or palpitations. Avoid strenuous exercise or activities that require mental alertness until you know how the medicine affects you. If you experience chest pain, shortness of breath, or severe dizziness during exercise, stop immediately and seek medical attention.
🥗 Diet Recommendations
💼 Impact on Daily Work & Life
This medicine can cause dizziness, drowsiness, or nervousness, which may affect your ability to drive, operate machinery, or perform tasks requiring concentration. It is advisable to avoid such activities until you know how the medicine affects you. Inform your employer or colleagues if you need to take this medicine during work hours, especially if your job involves safety-sensitive tasks.
🛑 When to Stop This Medicine
Stop taking this medicine and consult your doctor if your symptoms do not improve within a few days, if they worsen, or if you experience any serious side effects such as chest pain, severe headache, palpitations, or signs of an allergic reaction. Do not stop abruptly if you have been taking it regularly for a long time without consulting your doctor.
📅 Long-Term Use Effects
Long-term use of this medicine is not recommended due to the risk of cardiovascular effects from phenylpropanolamine and potential liver injury from paracetamol. Prolonged use may lead to tolerance, rebound congestion, and increased blood pressure. Regular monitoring of blood pressure, liver function, and renal function may be required if extended use is unavoidable. Consult your doctor if symptoms persist beyond a few days.
🌿 Non-Medicine Approaches
These can complement medicine but do not replace prescribed treatment.
Helps moisturize and clear nasal passages without systemic effects.
Evidence: Well-established for symptomatic relief of congestion.Can temporarily relieve nasal congestion by loosening mucus.
Evidence: Commonly used, limited clinical evidence.For allergic rhinitis, antihistamines can reduce sneezing and runny nose but may not decongest.
Evidence: Well-established for allergy symptoms.💉 Vaccination Considerations
💉 If You're Getting Vaccinated
There are no known interactions between this medicine and vaccines. However, if you are scheduled to receive a vaccine, inform your healthcare provider about all medicines you are taking. It is generally safe to receive vaccines while on this medicine, but follow your doctor's advice.
📦 Storage Guide
✅ DO
Store at room temperature (15-30°C).
❌ DON'T
Do not refrigerate unless specified.
✅ DO
Keep in the original container.
❌ DON'T
Do not transfer to unmarked containers.
✅ DO
Keep away from direct sunlight and moisture.
❌ DON'T
Do not store in the bathroom cabinet.
✈️ Traveling with This Medicine
When traveling, carry this medicine in its original packaging along with a copy of your prescription. Store it at room temperature and protect it from extreme heat or moisture. If crossing time zones, continue your regular dosing schedule as prescribed, but do not exceed the maximum daily dose. Check local regulations regarding phenylpropanolamine, as it may be restricted or banned in some countries. Always declare your medicines at customs if required.
💰 Cost Analysis & Savings
👥 Real Patient Stories
Educational, anonymized scenarios. Individual results may vary.
💬 Questions Patients Often Ask
A: Paracetamol usually starts relieving pain and fever within 30-60 minutes. The decongestant effect of phenylpropanolamine may also begin within 30-60 minutes, but individual response can vary.
A: Yes, taking it with food or milk can help reduce stomach upset.
A: No, this medicine contains phenylpropanolamine, which can raise blood pressure. It should be avoided in people with uncontrolled hypertension unless specifically directed by a doctor.
A: If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and continue with your regular schedule. Do not double the dose.
🤔 Common Patient Concerns
🔄 Substitutes for arrest 500mg/12.5mg/10mg tablet
View AllAlternative brands with exact same active ingredient:
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m cold plus tabletAbbott ₹5.79 66.9% CHEAPER
-
veerest tabletVivid Labs Pvt Ltd ₹10.31 41.1% CHEAPER
-
acelamine tabletOrison Pharma International ₹13.13 25% CHEAPER
-
nosopen tabletBhavishya Pharmaceuticals Pvt Ltd ₹20.00 14.3% COSTLIER
-
s cold tabletSarb Pharmaceuticals ₹20.00 14.3% COSTLIER
Medical Note: Always consult your doctor before switching medications.
🛑 Myths vs. Facts
- Myth: This medicine is safe for everyone with a cold.
Fact: It is not safe for people with high blood pressure, heart disease, or those taking certain medications. Consult a doctor first. - Myth: More tablets will relieve symptoms faster.
Fact: Taking more than the recommended dose can cause serious liver damage and cardiovascular effects. Never exceed the dose.