acelamine tablet - Paracetamol (500mg) + Phenylpropanolamine (12.5mg) medicine

Acelamine Tablet - Uses, Price, Side Effects

4.6 (11 reviews)

Paracetamol (500mg) Phenylpropanolamine (12.5mg)

🏭 Orison Pharma International 📦 Varies by brand 💊 Allopathy 📅 Updated: Aug 21, 2026

📋 Prescription Required 💊 Generic Available

Medically Reviewed

SaathiMed Expert Panel | Aug 21, 2026

What is acelamine tablet used for?

Acelamine Tablet is a combination medicine containing Paracetamol (500mg) and Phenylpropanolamine (12.5mg). It is used to relieve symptoms of common cold and flu, such as fever, headache, body aches, nasal congestion, and sinus pressure. Paracetamol works as a pain reliever and fever reducer, while Phenylpropanolamine is a decongestant that reduces swelling in nasal passages.

Generic Name: Paracetamol + Phenylpropanolamine
Manufacturer: Orison Pharma International
Form: Allopathy
Pregnancy Category: A
Prescription Required: Yes

💡 Did You Know? India is the largest provider of generic medicines globally, supplying over 50% of global vaccine demand.

💊 acelamine tablet Uses & Benefits

Fever, headache, cold symptoms, nasal congestion.

Off-label uses: None established.

📋 Drug Information

Generic Name(s)	Paracetamol + Phenylpropanolamine
Brand Name	Anglocet Plus Tablet
Manufacturer	Orison Pharma International
Packaging / Form	Varies by brand (Allopathy)
Therapeutic Class	RESPIRATORY
Action Class	Analgesic, Antipyretic, Decongestant
Route of Administration	Oral
Storage	Store at room temperature (15-30°C), protect from moisture.
Shelf Life	As per manufacturer

🔬 Pharmacology (PK/PD)

Pharmacokinetics

AbsorptionParacetamol: Rapidly and completely absorbed from GI tract. Phenylpropanolamine: Well absorbed orally.

DistributionParacetamol: Widely distributed; crosses placenta. Phenylpropanolamine: Distributed throughout body; crosses blood-brain barrier.

Protein BindingParacetamol: 10-25%. Phenylpropanolamine: Not extensively bound.

MetabolismParacetamol: Hepatic via conjugation (glucuronidation, sulfation) and CYP450 (minor). Phenylpropanolamine: Hepatic via deamination and hydroxylation.

Half-LifeParacetamol: 1.5-3 hours. Phenylpropanolamine: 3-5 hours.

ExcretionParacetamol: Renal (mostly metabolites). Phenylpropanolamine: Renal (unchanged and metabolites).

BioavailabilityParacetamol: 60-90%. Phenylpropanolamine: ~100%.

Onset of ActionParacetamol: 30-60 min. Phenylpropanolamine: 15-30 min.

Peak Plasma TimeParacetamol: 30-60 min. Phenylpropanolamine: 1-2 hours.

Duration of ActionParacetamol: 4-6 hours. Phenylpropanolamine: 3-4 hours.

How It Works

Paracetamol: Inhibits COX enzymes centrally, reducing prostaglandin synthesis. Phenylpropanolamine: Alpha-1 adrenergic agonist causing vasoconstriction.

Mechanism Steps

1Paracetamol inhibits COX-1 and COX-2 in the CNS, reducing prostaglandin synthesis.

2Decreased prostaglandins lead to reduced pain perception and fever.

3Phenylpropanolamine activates alpha-1 adrenergic receptors on nasal blood vessels.

💡 How to Take acelamine tablet

Follow your doctor's prescription exactly.

Dosage Timeline

🌅 Morning ✅ ☀️ Afternoon ❌ 🌆 Evening ✅ 🌙 Night ❌

⚠️ Side Effects of acelamine tablet

✅ Common Side Effects

Nausea
Dizziness
Insomnia
Dry mouth

🚨 Serious Side Effects

Hepatotoxicity
Hypertension
Arrhythmias
Allergic reactions

⚠️ Rare Side Effects

Thrombocytopenia
Agranulocytosis
Cerebral hemorrhage

Consult your doctor if you experience any unusual symptoms.

🔬 Drug Interactions

⚠️ Drug	Severity	Effect
Warfarin	Major	Increased bleeding risk
MAOIs	Major	Hypertensive crisis
Alcohol	Moderate	Increased liver toxicity

🚨 Major Interactions

MAOIs
Warfarin
Alcohol (chronic use)

⚡ Moderate Interactions

Antihypertensives
Beta-blockers
Tricyclic antidepressants

ℹ️ Minor Interactions

Caffeine
Oral contraceptives

🍽️ Food Interactions

Food may delay absorption of paracetamol.

🍷 Alcohol Interaction

Chronic alcohol use increases hepatotoxicity risk of paracetamol.

🛡️ Safety & Warnings

Liver

Moderate

Kidney

Low

Heart

Moderate

Pregnancy

Category A

🚫 Contraindications

Hypersensitivity, severe hypertension, coronary artery disease, MAOI use, hyperthyroidism.

📊 Monitoring Parameters

Liver function, blood pressure, heart rate.

🤱 Lactation Safety

Paracetamol safe; Phenylpropanolamine excreted in milk, use caution.

💊 Overdose Management

Activated charcoal, N-acetylcysteine for paracetamol; supportive care for phenylpropanolamine.

⏰ Missed Dose

Take as soon as remembered; skip if near next dose.

👨‍⚕️ Reviewed by Expert

SaathiMed Expert Panel

MD, PhD - Pharmacology

Last reviewed on: Aug 21, 2026

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⭐ User Reviews

Verified User Jul 10, 2026

Found this to be a helpful product. Good results.

Regular Customer Jul 10, 2026

This medicine was effective for me. I followed the doctor's advice.

Happy Patient Jul 10, 2026