applevit d tablet - Uses, Price, Side Effects & Substitutes
What is applevit d tablet used for?
Absolut DM Capsule (Methylcobalamin + Alpha Lipoic Acid) is used to treat VITAMINS MINERALS NUTRIENTS. It contains Methylcobalamin (1500mcg) + Alpha Lipoic Acid (100mg), which Methylcobalamin acts as a cofactor for methionine synthase and methylmalonyl-CoA. Always consult your doctor before use. Take as prescribed.
- Generic Name: Methylcobalamin + Alpha Lipoic Acid
- Manufacturer: Apple Lifescience
- Form: Allopathy
- Pregnancy Category: A
- Prescription Required: Yes
๐ applevit d tablet Uses & Benefits
Diabetic neuropathy, peripheral neuropathy, vitamin B12 deficiency, antioxidant support.
Off-label uses: Glaucoma, multiple sclerosis, Alzheimer's disease (limited evidence).
๐ Drug Information
| Generic Name(s) | Methylcobalamin + Alpha Lipoic Acid |
| Brand Name | Absolut DM Capsule |
| Manufacturer | Apple Lifescience |
| Packaging / Form | Varies by brand (Allopathy) |
| Therapeutic Class | VITAMINS MINERALS NUTRIENTS |
| Action Class | Vitamins and Nutrients |
| Route of Administration | Oral |
| Storage | Store at room temperature (20-25ยฐC), protect from light and moisture. |
| Shelf Life | As per manufacturer |
๐ฌ Pharmacology (PK/PD)
Pharmacokinetics
How It Works
Methylcobalamin acts as a cofactor for methionine synthase and methylmalonyl-CoA mutase; alpha lipoic acid acts as an antioxidant and cofactor for mitochondrial enzymes.
Mechanism Steps
๐ก How to Take applevit d tablet
Follow your doctor's prescription exactly.
โ ๏ธ Side Effects of applevit d tablet
โ Common Side Effects
- Nausea
- Vomiting
- Diarrhea
- Skin rash
- Headache
๐จ Serious Side Effects
- Anaphylaxis
- Peripheral neuropathy (rare)
- Hypoglycemia (with alpha lipoic acid)
โ ๏ธ Rare Side Effects
- Insulin autoimmune syndrome (alpha lipoic acid)
- Thrombocytopenia
Consult your doctor if you experience any unusual symptoms.
๐ฌ Drug Interactions
| โ ๏ธ Drug | Severity | Effect |
|---|---|---|
| Chloramphenicol | Major | May decrease response to methylcobalamin |
| Colchicine | Major | May decrease absorption of methylcobalamin |
| Metformin | Major | May decrease absorption of methylcobalamin |
| Proton pump inhibitors | Major | May decrease absorption of methylcobalamin |
| Anticonvulsants | Moderate | May decrease levels of methylcobalamin |
| Oral contraceptives | Moderate | May decrease levels of methylcobalamin |
| Aminoglycosides | Moderate | May decrease absorption of methylcobalamin |
| Vitamin C | Minor | May increase absorption of methylcobalamin |
| Folic acid | Minor | Synergistic effect on homocysteine metabolism |
๐จ Major Interactions
- Chloramphenicol
- Colchicine
- Metformin
- Proton pump inhibitors
โก Moderate Interactions
- Anticonvulsants
- Oral contraceptives
- Aminoglycosides
โน๏ธ Minor Interactions
- Vitamin C
- Folic acid
๐ฝ๏ธ Food Interactions
Alcohol may reduce absorption of methylcobalamin; high-fat meals may reduce absorption of alpha lipoic acid.
๐ท Alcohol Interaction
Alcohol may decrease absorption and increase excretion of methylcobalamin.
๐ก๏ธ Safety & Warnings
๐ซ Contraindications
Hypersensitivity to any component; pernicious anemia (for methylcobalamin without intrinsic factor).
๐ Monitoring Parameters
Serum vitamin B12 levels, homocysteine levels, neurological function, blood glucose (in diabetics).
๐คฑ Lactation Safety
Methylcobalamin is safe; alpha lipoic acid is likely safe but limited data.
๐ Overdose Management
Methylcobalamin: no specific antidote, supportive care; alpha lipoic acid: gastric lavage, activated charcoal, supportive care.
โฐ Missed Dose
Take as soon as remembered unless near next dose; skip missed dose if close to next dose.