Alprax 1.5mg Tablet SR: Complete Medicine Guide
Clinical Reference Standards: CDSCO (Central Drugs Standard Control Organisation), Indian Pharmacopoeia (IP) & WHO | Last Updated: September 2026
When to Call Your Doctor IMMEDIATELY
- Difficulty breathing or shortness of breath
- Severe drowsiness or confusion
- Seizures
- Suicidal thoughts or behavior
- Severe allergic reaction (rash, swelling, difficulty breathing)
- Yellowing of skin or eyes (jaundice)
- Unusual bruising or bleeding
- Extreme weakness or fainting
If experiencing severe symptoms, call emergency services immediately.
What is apal sr 1.5mg tablet used for?
This medicine is a sustained-release tablet containing alprazolam, a benzodiazepine used to treat anxiety and panic disorders. It works by enhancing the calming effects of GABA in the brain. It is taken orally, usually once daily, and should not be stopped abruptly due to withdrawal risks.
- Generic Name: Alprazolam
- Manufacturer: Elikem Pharmaceuticals Pvt Ltd
- Form: Allopathy
- Pregnancy Category: Consult doctor
- Prescription Required: Yes
🇮🇳 apal sr 1.5mg tablet के बारे में (Hindi Summary)
उपयोग: यह दवा अल्प्राजोलम नामक सक्रिय तत्व से बनी है और यह एक बेंजोडायजेपाइन वर्ग की दवा है। इसका उपयोग मुख्य रूप से चिंता विकार (एंग्जायटी डिसऑर्डर) और पैनिक डिसऑर्डर के इलाज के लिए किया जाता है। यह मस्तिष्क में गाबा नामक रसायन के प्रभाव को बढ़ाकर काम करती है, जिससे मन शांत होता है और चिंता कम होती है। यह दवा 1.5 मिलीग्राम की सस्टेन्ड-रिलीज़ गोली के रूप में उपलब्ध है और इसे मुँह से लिया जाता है। इसका सेवन डॉक्टर के निर्देशानुसार ही करें। इस दवा को अचानक बंद न करें, क्योंकि इससे गंभीर लक्षण हो सकते हैं।
साइड इफेक्ट्स: इस दवा के सामान्य दुष्प्रभावों में नींद आना, चक्कर आना, थकान, और शरीर में असंतुलन शामिल हैं। कुछ लोगों को याददाश्त की समस्या भी हो सकती है। गंभीर दुष्प्रभाव दुर्लभ हैं, लेकिन सांस लेने में कठिनाई, गंभीर एलर्जी, या आत्महत्या के विचार हो सकते हैं। यदि आपको कोई असामान्य लक्षण दिखे तो तुरंत डॉक्टर से संपर्क करें।
सुरक्षा सलाह: इस दवा को डॉक्टर के बताए अनुसार ही लें। इसे शराब या अन्य नींद लाने वाली दवाओं के साथ न लें। गाड़ी चलाने या मशीन चलाने से बचें जब तक आपको पता न चल जाए कि यह दवा आप पर कैसा असर करती है। इस दवा को अचानक बंद न करें, इससे दौरे पड़ सकते हैं। इसे बच्चों और पालतू जानवरों से दूर रखें। यदि आप गर्भवती हैं या स्तनपान करा रही हैं, तो डॉक्टर से सलाह लें।
💊 apal sr 1.5mg tablet Uses & Benefits
[{"condition":"Generalized Anxiety Disorder","description":"This medicine is used to relieve excessive anxiety and worry that interferes with daily activities.","evidence":"Well-established"},{"condition":"Panic Disorder","description":"This medicine helps reduce the frequency and intensity of panic attacks.","evidence":"Well-established"},{"condition":"Anxiety associated with depression","description":"This medicine may be used as an adjunct to antidepressants to manage anxiety symptoms.","evidence":"Moderate"}]
Off-label uses: [{"condition":"Insomnia","description":"Sometimes prescribed off-label for short-term management of insomnia, but not recommended due to risk of dependence.","evidence":"Limited"},{"condition":"Premenstrual syndrome","description":"May be used off-label for severe premenstrual anxiety symptoms.","evidence":"Limited"}]
Primary treatment for: Anxiety disorders
Also treats: Panic disorder, Anxiety associated with depression
📋 Drug Information
| Generic Name(s) | Alprazolam |
| Brand Name | Alprax 0.25 Tablet |
| Manufacturer | Elikem Pharmaceuticals Pvt Ltd |
| Packaging / Form | Varies by brand (Allopathy) |
| Therapeutic Class | NEURO CNS |
| Action Class | Benzodiazepines |
| Route of Administration | Oral |
| Storage | Store at room temperature between 20°C and 25°C (68°F to 77°F). Keep away from moisture and heat. Store in the original container, tightly closed. Keep out of reach of children and pets. |
| Shelf Life | The shelf life of this medicine is typically 24 months from the date of manufacture. Check the expiry date on the package. Do not use after the expiry date. |
| WHO Guideline | Not established from the available information. |
| ICMR Guideline | Not established from the available information. |
👨⚕️ Doctor's Practical Tips
Evidence-based practical advice from experienced clinicians
🔍 Is This Medicine Right for Your Symptom?
Educational reference. Always consult a doctor for diagnosis.
🔬 How This Medicine Works (Pharmacology)
Pharmacokinetics
How It Works
This medicine works by binding to specific sites on the GABA-A receptor complex in the brain. This binding enhances the inhibitory effect of GABA, the primary inhibitory neurotransmitter in the central nervous system. By increasing the frequency of chloride channel opening, it hyperpolarizes neurons and reduces their excitability. This results in sedation, anxiety relief, muscle relaxation, and anticonvulsant effects. The sustained-release formulation is designed to release the active ingredient gradually over an extended period, providing more stable plasma levels and potentially reducing the frequency of dosing.
Mechanism Steps
💡 How to Take apal sr 1.5mg tablet
Strength: This medicine is available as a 1.5 mg sustained-release tablet for oral administration.
Dosage Information
| Adult Dosage | The dosage of this medicine must be individualized by a qualified clinician based on the indication, severity of symptoms, patient's age, and hepatic function. For anxiety, the usual starting dose of alprazolam sustained-release is 0.5 mg to 1 mg once daily, which may be gradually increased to a maximum of 10 mg per day in divided doses. For panic disorder, the starting dose is 0.5 mg to 1 mg once daily, with a maximum of 10 mg per day. The 1.5 mg strength is typically used for maintenance therapy. Do not adjust the dose without consulting your doctor. |
| Pediatric Dosage | Pediatric dosing is not established from available information. Consult a pediatrician. |
| Elderly Dosage | Elderly patients (above 65 years) are more sensitive to the effects of benzodiazepines. The starting dose should be lower, typically 0.5 mg once daily, and increased cautiously. The maximum dose should not exceed 2 mg per day unless otherwise directed by a doctor. Regular monitoring for side effects is recommended. |
| Renal Impairment | In patients with renal impairment, the elimination half-life of alprazolam may be prolonged. Dose adjustment may be necessary. Start with a lower dose and titrate slowly. Consult your doctor for specific dosing recommendations. |
| Hepatic Impairment | In patients with hepatic impairment, the clearance of alprazolam is reduced. A lower starting dose and slower titration are recommended. The maximum dose should be reduced. Regular monitoring of liver function is advised. |
| Maximum Daily Dose | The maximum recommended daily dose of alprazolam for adults is 10 mg per day, but this may vary based on the indication and patient's response. For elderly patients, the maximum is generally 2 mg per day. Do not exceed the prescribed dose. |
Dosage Timeline
🍽️ Food Timing Guide
⏰ What to Do If You Miss a Dose
⚠️ Side Effects of apal sr 1.5mg tablet
✅ Common Side Effects
🚨 Serious Side Effects
⚠️ Rare Side Effects
Consult your doctor if you experience any unusual symptoms.
🔬 Drug Interactions
| Drug | Severity | Effect |
|---|---|---|
| Ketoconazole | Major | |
| Opioids | Major | |
| Alcohol | Major | |
| Fluoxetine | Moderate | |
| Erythromycin | Moderate | |
| Oral contraceptives | Moderate | |
| Cimetidine | Minor | |
| Antacids | Minor | |
| Rifampin | Moderate | |
| St. John's Wort | Moderate |
🚨 Major Interactions
- CYP3A4 inhibitors (e.g., ketoconazole, itraconazole, ritonavir)
- CNS depressants (e.g., opioids, alcohol, barbiturates)
- Clozapine
⚡ Moderate Interactions
- Oral contraceptives
- Macrolide antibiotics (e.g., erythromycin)
- SSRIs (e.g., fluoxetine, fluvoxamine)
🍷 Alcohol Interaction
Alcohol should be completely avoided while taking this medicine. Alcohol enhances the central nervous system depressant effects of alprazolam, leading to increased drowsiness, impaired coordination, respiratory depression, and increased risk of overdose. This combination can be life-threatening.
🔎 Check Your Other Medicines
Educational tool. Always confirm with your doctor or pharmacist.
🛡️ Safety & Warnings
🚫 Contraindications
["Known hypersensitivity to alprazolam or other benzodiazepines.","Narrow-angle glaucoma.","Severe hepatic impairment.","Acute narrow-angle glaucoma.","Concurrent use with strong CYP3A4 inhibitors such as ketoconazole, itraconazole, and ritonavir.","Pregnancy and lactation (relative contraindication)."]
⚠️ Warnings & Precautions
["This medicine can cause physical and psychological dependence. Use with caution in patients with a history of substance abuse.","Abrupt discontinuation can precipitate withdrawal symptoms, including seizures. Taper gradually under medical supervision.","May cause drowsiness and impair ability to drive or operate machinery. Avoid these activities until you know how the medicine affects you.","Concurrent use with opioids or alcohol can cause severe respiratory depression, coma, and death. Avoid such combinations.","Use with caution in elderly patients due to increased sensitivity to benzodiazepines.","Not recommended for the treatment of depression or psychosis.","May cause anterograde amnesia; patients should be cautioned about this effect."]
🤱 Lactation Safety
Alprazolam is excreted in human breast milk. Because of the potential for serious adverse reactions in nursing infants, a decision should be made whether to discontinue nursing or to discontinue the drug, taking into account the importance of the drug to the mother. Consult your doctor before breastfeeding.
💊 Overdose Management
Overdose of this medicine can cause severe central nervous system depression, respiratory depression, coma, and death. If overdose is suspected, seek emergency medical attention immediately. The specific benzodiazepine receptor antagonist flumazenil may be used as an antidote, but it should be used with caution, especially in patients with a history of seizures or chronic benzodiazepine use. Supportive care, including airway management and monitoring of vital signs, is essential. Hemodialysis is not effective in removing alprazolam.
⏰ Missed Dose
If you miss a dose of this medicine, take it as soon as you remember. However, if it is almost time for your next dose, skip the missed dose and continue with your regular dosing schedule. Do not take a double dose to make up for a missed one. If you are unsure, consult your doctor or pharmacist.
Additional Safety Advice
Always take this medicine exactly as prescribed by your doctor. Do not increase or decrease the dose without medical advice. Avoid driving or operating heavy machinery until you know how this medicine affects you. Do not consume alcohol or other central nervous system depressants while taking this medicine, as it can increase the risk of severe drowsiness, respiratory depression, and other serious effects. Inform your doctor about all other medications you are taking, including over-the-counter drugs and herbal supplements. Do not stop taking this medicine abruptly, as it can cause withdrawal symptoms such as seizures, tremors, and anxiety rebound. Store this medicine in a secure place, out of reach of children and pets. If you are pregnant, planning to become pregnant, or breastfeeding, consult your doctor before using this medicine.
👴 Special Considerations for Elderly
💡 For Patients Above 65
Elderly patients are more sensitive to the effects of benzodiazepines, including increased drowsiness, dizziness, and risk of falls. The starting dose should be lower, and dose increases should be done cautiously. Regular monitoring for cognitive impairment and falls is recommended.
🤰 Pregnancy Planning (TTC)
If you are planning to become pregnant, consult your doctor before taking this medicine. Benzodiazepines may cause fetal harm. Your doctor may recommend alternative treatments or a gradual taper before conception.
🏥 Post-Surgery Considerations
This medicine may interact with anesthetics and other medications used during surgery. Inform your surgeon and anesthesiologist that you are taking this medicine. It may also increase the risk of respiratory depression post-surgery. Close monitoring is advised.
🦷 Dental Procedures
Inform your dentist that you are taking this medicine, as it may interact with sedatives or anesthetics used during dental procedures. It may also cause dry mouth, which can affect dental health.
💚 Lifestyle Tips for Better Results
🏋️ Exercise Considerations
This medicine can cause drowsiness and dizziness, which may affect your coordination. Avoid activities that require mental alertness, such as driving or operating heavy machinery, until you know how the medicine affects you. Light to moderate exercise is generally safe, but listen to your body and avoid overexertion.
🥗 Diet Recommendations
💼 Impact on Daily Work & Life
This medicine can cause drowsiness and impair your ability to concentrate, which may affect your work performance. Avoid driving or operating machinery until you know how the medicine affects you. Inform your employer if your job requires alertness. With proper dose adjustment, many people can continue their daily activities, but caution is advised.
🛑 When to Stop This Medicine
You should not stop taking this medicine abruptly. Your doctor will gradually reduce the dose over weeks or months to prevent withdrawal symptoms. If you experience side effects that are bothersome, consult your doctor before making any changes. The decision to stop should be based on your clinical response and under medical supervision.
📅 Long-Term Use Effects
Long-term use of this medicine can lead to tolerance, meaning you may need higher doses to achieve the same effect. It can also cause physical and psychological dependence. Withdrawal symptoms can occur upon discontinuation, especially if stopped abruptly. Long-term use may also affect memory and cognition. Regular monitoring and periodic reassessment of the need for continued therapy are essential. It is recommended to use this medicine for the shortest duration possible.
🌿 Non-Medicine Approaches
These can complement medicine but do not replace prescribed treatment.
A type of talk therapy that helps change negative thought patterns and behaviors contributing to anxiety.
Evidence: Well-establishedAntidepressants that are first-line for long-term management of anxiety disorders.
Evidence: Well-establishedPractices that can help reduce stress and anxiety.
Evidence: Moderate💉 Vaccination Considerations
💉 If You're Getting Vaccinated
There are no known interactions between this medicine and vaccines. However, if you are scheduled for vaccination, inform your healthcare provider about all medications you are taking.
📦 Storage Guide
✅ DO
Store at room temperature (20-25°C)
❌ DON'T
Do not refrigerate unless specified
✅ DO
Keep in original container
❌ DON'T
Do not transfer to unmarked containers
✅ DO
Keep away from direct sunlight and moisture
❌ DON'T
Do not store in bathroom cabinet
✅ DO
Keep out of reach of children and pets
❌ DON'T
Do not use after expiry date
✈️ Traveling with This Medicine
When traveling, carry this medicine in its original packaging along with a copy of your prescription. Keep it in your carry-on luggage to avoid loss. Store it at room temperature and protect it from extreme heat or cold. If crossing time zones, consult your doctor about adjusting the dosing schedule. Be aware of customs regulations regarding controlled substances in your destination country.
💰 Cost Analysis & Savings
👥 Real Patient Stories
Educational, anonymized scenarios. Individual results may vary.
💬 Questions Patients Often Ask
A: This medicine starts to work within 1 to 2 hours, but the full anxiolytic effect may take a few days to weeks. The sustained-release formulation provides a more gradual onset and longer duration of action.
A: You should inform your doctor about all other medications you are taking, as this medicine can interact with many drugs, including opioids, antidepressants, and certain antibiotics. Some combinations should be avoided.
A: Withdrawal symptoms may include anxiety, insomnia, irritability, sweating, tremors, and in severe cases, seizures. These can be avoided by gradually tapering the dose under medical supervision.
A: This medicine may harm the fetus. It should be used during pregnancy only if the potential benefit justifies the potential risk. Consult your doctor if you are pregnant or planning to become pregnant.
A: This medicine can cause drowsiness and impair your ability to drive or operate machinery. Avoid driving until you know how the medicine affects you.
🤔 Common Patient Concerns
🔄 Substitutes for apal sr 1.5mg tablet
View AllAlternative brands with exact same active ingredient:
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nulam 1.5mg tablet srNusearch Organic ₹23.57 1.8% CHEAPER
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zolipax 1.5mg tablet srReliance Formulation Pvt Ltd ₹28.13 17.2% COSTLIER
-
zolam 1.5mg tablet srStadmed Pvt Ltd ₹35.90 49.6% COSTLIER
-
alzocum 1.5mg tabletTaj Pharma India Ltd ₹38.10 58.8% COSTLIER
-
ancolam 1.5mg tablet srSigmund Promedica ₹39.42 64.3% COSTLIER
Medical Note: Always consult your doctor before switching medications.
🛑 Myths vs. Facts
- Myth: This medicine is safe to take long-term without any risks.
Fact: This medicine can cause dependence and withdrawal symptoms with long-term use. It should be used for the shortest duration possible under medical supervision. - Myth: You can stop taking this medicine whenever you want.
Fact: Abrupt discontinuation can cause severe withdrawal symptoms, including seizures. Always taper gradually under a doctor's guidance. - Myth: This medicine is safe to take with alcohol.
Fact: Alcohol increases the sedative effects of this medicine and can cause severe respiratory depression, coma, and death. Avoid alcohol completely.
🔄 Alternative Options
Generic Alternatives
- Alprazolam sustained-release tablet
Brand Alternatives
- Alprax 1.5mg Tablet SR