anxiset 0.5 tablet - Flupenthixol (0.5mg) medicine

Anxiset 0.5 Tablet (Flupenthixol 0.5 mg): Complete Medicine Guide

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🏭 Obsurge Biotech Ltd 📦 Varies by brand 💊 Allopathy 📅 Updated: Oct 23, 2026
⚠️ Hepatotoxicity Risk 📋 Prescription Required 💊 Generic Available
Medically Reviewed
11 min read
Evidence: Moderate for schizophrenia; limited for other uses.
Reviewed by
SaathiMed Expert Panel | Oct 23, 2026
🩺
Medically Fact-Checked & Clinically Verified by SaathiMed Clinical Review Board
Clinical Reference Standards: CDSCO (Central Drugs Standard Control Organisation), Indian Pharmacopoeia (IP) & WHO | Last Updated: September 2026

When to Call Your Doctor IMMEDIATELY

  • High fever with severe muscle stiffness and confusion
  • Involuntary movements of the face, tongue, or limbs
  • Fainting, palpitations, or irregular heartbeat
  • Yellowing of the skin or eyes
  • Severe allergic reaction with swelling of face, lips, or throat
  • Unusual bruising or bleeding
  • Seizures

If experiencing severe symptoms, call emergency services immediately.

What is anxiset 0.5 tablet used for?

This medicine contains flupenthixol 0.5 mg, a typical antipsychotic used to treat schizophrenia and other psychotic disorders. It works by blocking dopamine receptors in the brain. It is taken orally, usually once daily, and must be prescribed and monitored by a psychiatrist.

  • Generic Name: Flupenthixol
  • Manufacturer: Obsurge Biotech Ltd
  • Form: Allopathy
  • Pregnancy Category: Consult doctor
  • Prescription Required: Yes

🇮🇳 anxiset 0.5 tablet के बारे में (Hindi Summary)

उपयोग: यह दवा फ्लूपेंथिक्सोल 0.5 मिलीग्राम युक्त एक मौखिक गोली है, जिसका उपयोग मुख्य रूप से सिज़ोफ्रेनिया और अन्य मानसिक विकारों के इलाज के लिए किया जाता है। यह मस्तिष्क में डोपामिन रिसेप्टर्स को ब्लॉक करके मतिभ्रम, भ्रम और असंगठित सोच को कम करने में मदद करती है। यह दवा केवल मनोचिकित्सक की सलाह पर ही लेनी चाहिए। इसे अचानक बंद न करें, क्योंकि इससे लक्षण वापस आ सकते हैं।

साइड इफेक्ट्स: इस दवा के सामान्य दुष्प्रभावों में नींद आना, चक्कर आना, मुँह सूखना, कब्ज, धुंधली दृष्टि और वजन बढ़ना शामिल हैं। कुछ लोगों में मांसपेशियों में अकड़न, कंपन या बेचैनी हो सकती है। गंभीर दुष्प्रभाव दुर्लभ हैं, लेकिन अगर आपको तेज बुखार, मांसपेशियों में गंभीर अकड़न, भ्रम, दिल की धड़कन तेज होना, या चेहरे-जीभ में अनैच्छिक हरकतें हों, तो तुरंत डॉक्टर से संपर्क करें।

सुरक्षा सलाह: इस दवा को डॉक्टर के बताए अनुसार ही लें। इसे अचानक बंद न करें। जब तक आपको पता न चले कि यह दवा आप पर कैसा असर करती है, तब तक वाहन न चलाएं और मशीनरी न चलाएं। शराब न पिएं। अपने डॉक्टर को सभी दवाओं के बारे में बताएं जो आप ले रहे हैं। गर्भावस्था या स्तनपान के दौरान डॉक्टर से सलाह लें। नियमित जांच के लिए डॉक्टर के पास जाते रहें।

💡 Did You Know? The Indian pharmaceutical market is expected to reach $130 billion by 2030.

💊 anxiset 0.5 tablet Uses & Benefits

[{"condition":"Schizophrenia and other psychotic disorders","description":"Helps reduce hallucinations, delusions, and disorganized thinking by blocking dopamine receptors in the brain.","evidence":"Well-established"},{"condition":"Agitation and aggression in psychosis","description":"May help calm severe agitation when used as part of a comprehensive treatment plan.","evidence":"Moderate"},{"condition":"Depression with anxiety (low-dose augmentation)","description":"In some countries, very low doses are used as an adjunct for depression with anxiety, but this is not a first-line use.","evidence":"Limited"}]

Off-label uses: [{"condition":"Severe anxiety not responding to standard treatment","description":"Sometimes prescribed off-label by specialists, but evidence is limited and risks must be weighed.","evidence":"Limited"},{"condition":"Behavioral symptoms in dementia","description":"Occasionally used off-label, but antipsychotics carry increased risk in elderly patients with dementia.","evidence":"Limited"}]

Primary treatment for: Schizophrenia and other psychotic disorders

Also treats: Agitation in psychosis, Depression with anxiety (adjunct, low-dose)

📋 Drug Information

Generic Name(s)Flupenthixol
Brand NameAnxiset 0.5 Tablet
ManufacturerObsurge Biotech Ltd
Packaging / FormVaries by brand (Allopathy)
Therapeutic ClassNEURO CNS
Action ClassTypical Antipsychotics
Route of AdministrationOral
StorageStore at room temperature between 15°C and 30°C. Keep in the original container, away from moisture and direct sunlight. Do not refrigerate unless specified by the manufacturer.
Shelf LifeTypically 24 months from the date of manufacture. Check the expiry date on the pack before use.
WHO GuidelineNot established from the available information. Flupenthixol is not included in the WHO Essential Medicines List for oral antipsychotics, but it may be used in some countries for psychosis.
ICMR GuidelineNot established from the available information.

👨‍⚕️ Doctor's Practical Tips

Evidence-based practical advice from experienced clinicians

1
Take this medicine at the same time each day to maintain steady levels.
2
Avoid driving or operating machinery until you know how this medicine affects you.
3
Do not stop this medicine suddenly; always consult your doctor first.
4
Report any unusual movements of the face, tongue, or limbs immediately.
5
Monitor your weight regularly and follow a healthy diet and exercise plan.
6
Tell your doctor if you have heart problems, as this medicine can affect heart rhythm.
7
Avoid alcohol while taking this medicine to prevent excessive drowsiness.

🔍 Is This Medicine Right for Your Symptom?

Educational reference. Always consult a doctor for diagnosis.

✅
Hallucinations
This medicine is commonly prescribed for this.
Likely Use
✅
Delusions
This medicine is commonly prescribed for this.
Likely Use
❌
Severe anxiety
This medicine is not a first-line treatment for anxiety.
Not Primary
❌
Fever
This medicine is not a fever reducer.
Not Primary

🔬 How This Medicine Works (Pharmacology)

Pharmacokinetics

AbsorptionFlupenthixol is absorbed from the gastrointestinal tract after oral administration. The exact bioavailability of the oral tablet is not well established from the available information, but it is considered to be moderate. Food does not significantly affect absorption.
DistributionFlupenthixol is widely distributed throughout the body, including the brain. It is highly lipophilic and crosses the blood-brain barrier. The volume of distribution is not well established from the available information.
Protein BindingFlupenthixol is highly bound to plasma proteins, primarily albumin. The exact percentage is not established from the available information.
MetabolismFlupenthixol is metabolized in the liver, mainly by sulfoxidation and glucuronidation. The cytochrome P450 enzymes involved are not fully characterized, but CYP2D6 may play a minor role. The metabolites are largely inactive.
Half-LifeThe elimination half-life of oral flupenthixol is approximately 20 to 40 hours, but this can vary between individuals. Steady-state levels are usually reached within 5 to 7 days of regular dosing.
ExcretionFlupenthixol and its metabolites are excreted mainly in the feces via bile, and to a lesser extent in the urine. The exact proportions are not established from the available information.
BioavailabilityNot established from the available information.
Onset of ActionThe sedative and calming effects may be noticed within a few hours of the first dose, but the full antipsychotic effect usually takes 1 to 3 weeks of regular use.
Peak Plasma TimePeak plasma levels are reached approximately 3 to 4 hours after oral administration.
Duration of ActionThe antipsychotic effect lasts for about 24 hours after a single oral dose, which is why it is usually taken once daily. The full therapeutic effect builds up over weeks.

How It Works

Flupenthixol is a typical antipsychotic of the thioxanthene class. Its main action is to block dopamine D1 and D2 receptors in the brain, especially in the mesolimbic and mesocortical pathways. This blockade reduces the positive symptoms of psychosis such as hallucinations and delusions. It also has some affinity for serotonin 5-HT2 receptors, alpha-1 adrenergic receptors, and histamine H1 receptors, which contributes to its sedative and autonomic side effects. The 0.5 mg immediate-release tablet provides a low dose that is usually used for maintenance or for conditions where a gentle antipsychotic effect is desired.

Mechanism Steps

1
Binding to dopamine receptors: This medicine binds to dopamine D1 and D2 receptors in the brain and blocks them.
2
Reduction of dopamine signaling: Blocking these receptors reduces excessive dopamine activity in the mesolimbic pathway, which is linked to hallucinations and delusions.
3
Additional receptor effects: It also blocks serotonin, histamine, and alpha-adrenergic receptors, which adds to its sedative and autonomic effects.
4
Clinical response: Over days to weeks, the reduction in dopamine signaling leads to fewer psychotic symptoms and improved behavior.

💡 How to Take anxiset 0.5 tablet

Strength: Immediate-release oral tablet containing 0.5 mg of flupenthixol.

1Take this medicine by mouth with a glass of water.
2You can take it with or without food, but taking it with food may reduce stomach upset.
3Swallow the tablet whole. Do not crush or chew it unless your doctor says it is okay.
4Take it at the same time each day to maintain steady levels in your body.
5Do not stop taking this medicine suddenly without talking to your doctor.

Dosage Information

Adult DosageThe usual adult dose of this medicine is individualized by a qualified clinician based on the condition being treated, age, weight, and liver and kidney function. For psychotic disorders, the starting dose is often 1 mg to 3 mg daily, but this 0.5 mg tablet may be used for low-dose maintenance or gradual titration. The dose may be increased slowly under medical supervision. Do not change the dose without consulting your doctor. Dose must be individualized by a qualified clinician based on indication, age, weight, renal and hepatic function.
Pediatric DosagePediatric dosing is not established from available information. Consult a pediatrician.
Elderly DosageElderly patients are more sensitive to the side effects of this medicine, especially drowsiness, dizziness, and movement problems. A lower starting dose is usually recommended, and the dose should be increased slowly. Regular monitoring for falls and confusion is important.
Renal ImpairmentDose adjustment may be needed in patients with severe kidney disease. Use with caution and monitor closely. The exact dose adjustment is not established from the available information.
Hepatic ImpairmentDose adjustment may be needed in patients with liver disease. Use with caution and monitor liver function. The exact dose adjustment is not established from the available information.
Maximum Daily DoseThe maximum daily dose depends on the condition and the patient's response. For oral flupenthixol, doses up to 6 mg daily have been used, but higher doses may be prescribed by specialists. Do not exceed the dose prescribed by your doctor.

Dosage Timeline

🌅 Morning ❌ ☀️ Afternoon ❌ 🌆 Evening ❌ 🌙 Night ❌

🍽️ Food Timing Guide

With food
Take with meals
Reduces stomach upset.
Alcohol
Avoid
Increases sedation and drowsiness.
Grapefruit juice
Use with caution
May affect drug levels, though not well established.

⏰ What to Do If You Miss a Dose

📌 Less than half the dosing interval has passed
→ Take the missed dose as soon as you remember.
💡 Continue with the regular schedule.
📌 More than half the dosing interval has passed
→ Skip the missed dose.
💡 Do not double dose to catch up.

⚠️ Side Effects of anxiset 0.5 tablet

✅ Common Side Effects

Drowsiness (Common (10-20%))
Avoid driving or operating machinery until you know how it affects you. If it persists, talk to your doctor.
Dry mouth (Common (10-20%))
Sip water frequently, chew sugar-free gum, or use a saliva substitute. Consult your doctor if it becomes bothersome.
Constipation (Common (5-10%))
Increase fiber and fluid intake. If it continues, ask your doctor about a stool softener.
Blurred vision (Common (5-10%))
Usually temporary. Do not drive if your vision is affected. Report persistent changes to your doctor.
Weight gain (Common (5-10%))
Monitor your weight and follow a balanced diet. Regular exercise can help. Discuss with your doctor if weight gain is significant.

🚨 Serious Side Effects

Neuroleptic malignant syndrome (NMS) (Rare (<0.1%))
Seek emergency medical help if you develop high fever, severe muscle stiffness, confusion, sweating, or fast heartbeat.
Tardive dyskinesia (Uncommon (0.1-1%))
Report any involuntary movements of the face, tongue, or limbs to your doctor immediately. It may be irreversible.
Severe allergic reaction (Rare (<0.1%))
Get emergency help if you have swelling of the face, lips, or throat, difficulty breathing, or a severe rash.
Blood disorders (e.g., agranulocytosis) (Rare (<0.1%))
Tell your doctor if you develop fever, sore throat, or unusual bruising or bleeding. Blood tests may be needed.
Heart rhythm problems (QT prolongation) (Rare (<0.1%))
Seek medical attention if you feel faint, dizzy, or have palpitations. Your doctor may check your heart with an ECG.

⚠️ Rare Side Effects

Jaundice
Report yellowing of the skin or eyes to your doctor immediately.
Seizures
Seek emergency care if you have a seizure.
Priapism (prolonged erection)
This is a medical emergency. Go to the nearest emergency department immediately.

Consult your doctor if you experience any unusual symptoms.

🔬 Drug Interactions

Drug Severity Effect
Levodopa Major
Amiodarone Major
Diazepam Moderate
Trihexyphenidyl Moderate
Metoprolol Moderate
Fluoxetine Moderate
Carbamazepine Moderate
Warfarin Minor
Antacids Minor
Caffeine Minor

🚨 Major Interactions

  • Other antipsychotics or dopamine antagonists
  • Levodopa and dopamine agonists
  • QT-prolonging drugs (e.g., amiodarone, sotalol, some antibiotics)

⚡ Moderate Interactions

  • CNS depressants (e.g., benzodiazepines, opioids, alcohol)
  • Anticholinergic drugs (e.g., trihexyphenidyl, benztropine)
  • Antihypertensive drugs

🍷 Alcohol Interaction

Do not drink alcohol while taking this medicine. Alcohol increases the sedative effects of flupenthixol and can cause excessive drowsiness, dizziness, and difficulty concentrating. It may also worsen mental health symptoms and increase the risk of accidents.

🔎 Check Your Other Medicines

Educational tool. Always confirm with your doctor or pharmacist.

🛡️ Safety & Warnings

🚫 Contraindications

["Known allergy to flupenthixol or any ingredient in the tablet","Severe liver disease","Severe kidney disease","Parkinson's disease","Blood disorders such as agranulocytosis","Phaeochromocytoma","Severe heart disease or arrhythmias","Comatose states or severe CNS depression","Children under 18 years unless prescribed by a specialist"]

⚠️ Warnings & Precautions

["This medicine may cause drowsiness. Do not drive or operate machinery until you know how it affects you.","Avoid alcohol while taking this medicine.","Do not stop this medicine suddenly, as it can cause withdrawal symptoms or relapse.","Tell your doctor if you have a history of heart problems, liver disease, kidney disease, or blood disorders.","This medicine can increase the risk of falls, especially in elderly patients.","Use with caution in people with a history of seizures.","This medicine may affect your ability to regulate body temperature. Avoid extreme heat.","Tell your doctor if you are pregnant, planning pregnancy, or breastfeeding.","Keep all follow-up appointments for monitoring."]

🤱 Lactation Safety

Flupenthixol may pass into breast milk in small amounts. Breastfeeding while taking this medicine is not recommended unless advised by a specialist. If breastfeeding is essential, monitor the baby for drowsiness, poor feeding, or unusual movements.

💊 Overdose Management

Overdose of this medicine can cause severe drowsiness, coma, low blood pressure, fast or irregular heartbeat, and severe extrapyramidal symptoms. If you suspect an overdose, call emergency services immediately. Treatment is supportive and may include activated charcoal if taken recently, intravenous fluids, and medications to control movement symptoms. There is no specific antidote.

⏰ Missed Dose

If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and continue with your regular schedule. Do not take a double dose to make up for a missed one.

Additional Safety Advice

General Safety

Take this medicine exactly as prescribed by your doctor. Do not change the dose or stop it suddenly, as this can cause withdrawal symptoms or a relapse of your condition. Avoid driving or operating heavy machinery until you know how this medicine affects you, because it can cause drowsiness and slow reactions. Do not drink alcohol while taking this medicine, as it can increase drowsiness and other side effects. Tell your doctor about all other medicines you are taking, including over-the-counter products and herbal supplements. If you are pregnant, planning pregnancy, or breastfeeding, talk to your doctor before taking this medicine. Keep all follow-up appointments so your doctor can monitor your response and check for side effects. Store this medicine in its original container at room temperature, away from moisture and direct sunlight. Keep it out of reach of children.

👴 Special Considerations for Elderly

💡 For Patients Above 65

Elderly patients are more sensitive to the side effects of this medicine, especially drowsiness, dizziness, confusion, and falls. A lower starting dose is recommended, and the dose should be increased slowly. Regular monitoring for movement disorders and heart rhythm is important. Antipsychotics may increase the risk of stroke and death in elderly patients with dementia, so they should be used with caution.

🤰 Pregnancy Planning (TTC)

If you are planning pregnancy, talk to your doctor before conceiving. This medicine may need to be adjusted or changed. It is important to weigh the benefits and risks. Do not stop the medicine suddenly without medical advice, as relapse can be harmful to both mother and baby.

🏥 Post-Surgery Considerations

Inform your surgeon and anesthesiologist that you are taking this medicine before any surgery. It may interact with anesthetic agents and increase the risk of low blood pressure or heart rhythm problems. Your doctor may advise you to stop it temporarily before surgery.

🦷 Dental Procedures

Tell your dentist that you are taking this medicine before any dental procedure. It can cause dry mouth, which may increase the risk of dental problems. It may also interact with sedatives used in dentistry. Maintain good oral hygiene and regular dental check-ups.

💚 Lifestyle Tips for Better Results

🏃
Maintain a healthy weight through balanced diet and regular exercise.
🥗
Get adequate sleep and follow a consistent sleep schedule.
😴
Avoid alcohol and recreational drugs.
💧
Practice stress-reducing activities like meditation or deep breathing.
🧘
Stay connected with your support network and attend follow-up appointments.

🏋️ Exercise Considerations

This medicine can cause drowsiness and dizziness, so avoid strenuous exercise or activities that require high alertness until you know how it affects you. Light to moderate exercise like walking is generally safe and beneficial.

🥗 Diet Recommendations

Eat a balanced diet rich in fruits, vegetables, and whole grains.
Limit sugary and processed foods to manage weight.
Stay well hydrated.
Include omega-3 fatty acids from fish or flaxseed.
Avoid alcohol.

💼 Impact on Daily Work & Life

This medicine can cause drowsiness and slow reaction times, which may affect your ability to drive or operate machinery. It may also affect concentration. Discuss with your doctor before returning to work that requires alertness. Most people can continue their usual activities once they know how the medicine affects them.

🛑 When to Stop This Medicine

Do not stop this medicine without consulting your doctor. If you experience severe side effects such as neuroleptic malignant syndrome, tardive dyskinesia, or severe allergic reactions, seek immediate medical attention. Your doctor will decide if and when to stop the medicine, usually by tapering the dose gradually.

📅 Long-Term Use Effects

Long-term use of this medicine may increase the risk of tardive dyskinesia, weight gain, and metabolic changes. Regular monitoring of weight, blood sugar, and movement symptoms is recommended. Some patients may need periodic blood tests and heart checks. The dose should be reviewed regularly by your doctor to ensure it is still appropriate.

🌿 Non-Medicine Approaches

These can complement medicine but do not replace prescribed treatment.

Cognitive behavioral therapy (CBT)

Can help manage psychotic symptoms and improve coping skills.

Evidence: Well-established
Family therapy and psychoeducation

Helps families support the patient and understand the illness.

Evidence: Well-established
Lifestyle changes

Regular sleep, exercise, and stress management can complement medicine.

Evidence: Moderate

💉 Vaccination Considerations

💉 If You're Getting Vaccinated

There are no specific vaccine interactions known with this medicine. However, if you have a fever or infection, consult your doctor before taking any vaccine. Routine vaccinations can generally be given, but inform the healthcare provider about all medicines you are taking.

📦 Storage Guide

✅ DO

Store at room temperature (15-30°C)

❌ DON'T

Do not refrigerate unless specified

✅ DO

Keep in original container

❌ DON'T

Do not transfer to unmarked containers

✅ DO

Keep away from direct sunlight

❌ DON'T

Do not store in bathroom cabinet

✈️ Traveling with This Medicine

When traveling, carry this medicine in its original packaging with a copy of your prescription. Keep it in your hand luggage to avoid loss. Store it at room temperature and protect it from extreme heat or moisture. If crossing time zones, adjust your dosing schedule gradually under medical advice. Check local customs regulations for controlled medicines before you travel.

💰 Cost Analysis & Savings

👥 Real Patient Stories

Educational, anonymized scenarios. Individual results may vary.

👤 A 32-year-old man with schizophrenia
He was started on this medicine 0.5 mg once daily. After 3 weeks, his hallucinations reduced significantly. He felt sleepy initially but this improved after 2 weeks. He was advised not to drive until the drowsiness settled.
💡 Lesson: Regular dosing and patience are key. Side effects like drowsiness often improve with time.
👤 A 45-year-old woman with severe anxiety and depression
She was prescribed this medicine as an add-on to her antidepressant. She noticed better sleep and reduced anxiety within 10 days. She was monitored for weight gain and movement symptoms.
💡 Lesson: Low-dose flupenthixol can help some patients with anxiety, but close monitoring is essential.

💬 Questions Patients Often Ask

Q: How long does it take to work?

A: The sedative effect may be felt within hours, but the full antipsychotic effect usually takes 1 to 3 weeks of regular use.

Q: Can I stop this medicine suddenly?

A: No, stopping suddenly can cause withdrawal symptoms or a relapse. Always consult your doctor before stopping.

Q: What should I do if I miss a dose?

A: If you remember within a few hours, take it. If it is almost time for your next dose, skip the missed dose and continue as usual. Do not double dose.

Q: Is this medicine safe in pregnancy?

A: It should only be used in pregnancy if the benefits outweigh the risks. Consult your doctor immediately if you are pregnant or planning pregnancy.

🤔 Common Patient Concerns

💭 These are the concerns patients most commonly raise

  • Can I take this medicine long-term?
  • Will it affect my kidney function?
  • Can I drive after taking this medicine?
  • Does it interact with my blood pressure medicine?
  • What if I miss a dose?
  • Can I drink alcohol while taking this?
  • Will it cause weight gain?
  • Is it safe during pregnancy?

🔄 Substitutes for anxiset 0.5 tablet

View All

Alternative brands with exact same active ingredient:

Medical Note: Always consult your doctor before switching medications.

🛑 Myths vs. Facts

  • Myth: This medicine is addictive.
    Fact: This medicine is not addictive in the way that opioids or benzodiazepines are. However, it should not be stopped suddenly without medical advice.
  • Myth: This medicine will cure my mental illness permanently.
    Fact: This medicine controls symptoms but does not cure the underlying condition. It is usually part of a long-term treatment plan.
  • Myth: I can stop taking this medicine once I feel better.
    Fact: Stopping suddenly can cause a relapse or withdrawal symptoms. Always consult your doctor before stopping.

🔄 Alternative Options

Generic Alternatives

  • Flupenthixol 0.5 mg tablet

Brand Alternatives

  • Anxiset 0.5 tablet

📊 Comparison with Similar Medicines

[{"medicine":"Flupenthixol","class":"Typical antipsychotic","main_use":"Schizophrenia, psychosis","sedation":"Moderate","extrapyramidal_risk":"Moderate to high","weight_gain":"Moderate"},{"medicine":"Haloperidol","class":"Typical antipsychotic","main_use":"Schizophrenia, acute agitation","sedation":"Low to moderate","extrapyramidal_risk":"High","weight_gain":"Low"},{"medicine":"Risperidone","class":"Atypical antipsychotic","main_use":"Schizophrenia, bipolar mania","sedation":"Moderate","extrapyramidal_risk":"Moderate","weight_gain":"Moderate to high"}]

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