Anxipose Injection (lorazepam 4mg): Complete Medicine Guide
Clinical Reference Standards: CDSCO (Central Drugs Standard Control Organisation), Indian Pharmacopoeia (IP) & WHO | Last Updated: September 2026
When to Call Your Doctor IMMEDIATELY
- Slow, shallow breathing or difficulty breathing
- Severe drowsiness or unresponsiveness
- Fainting or severe dizziness
- Unusual agitation, hallucinations, or confusion
- Rash, swelling of face, lips, or throat
- Yellowing of skin or eyes
- Seizures despite treatment
If experiencing severe symptoms, call emergency services immediately.
What is anxipose injection used for?
This medicine is a benzodiazepine injection used for severe anxiety, seizures, and preoperative sedation. It works by enhancing the calming effects of GABA in the brain. It must be given by a healthcare professional in a monitored setting.
- Generic Name: Lorazepam
- Manufacturer: Psychotropics India Ltd
- Form: Allopathy
- Pregnancy Category: Consult doctor
- Prescription Required: Yes
🇮🇳 anxipose injection के बारे में (Hindi Summary)
उपयोग: यह दवा लोराज़ेपम का इंजेक्शन है, जिसका उपयोग गंभीर चिंता, दौरे (मिर्गी), और सर्जरी से पहले शांति प्रदान करने के लिए किया जाता है। यह मस्तिष्क में GABA नामक रसायन के प्रभाव को बढ़ाकर काम करती है, जिससे घबराहट कम होती है और दौरे नियंत्रित होते हैं। यह दवा केवल अस्पताल या क्लिनिक में डॉक्टर या नर्स द्वारा ही दी जानी चाहिए। इसे घर पर स्वयं न लगाएं। इसके सेवन के दौरान शराब बिल्कुल न पिएं और वाहन न चलाएं।
साइड इफेक्ट्स: आम दुष्प्रभावों में नींद आना, चक्कर आना, कमजोरी, और अस्थिरता शामिल हैं। गंभीर दुष्प्रभावों में सांस लेने में कठिनाई, निम्न रक्तचाप, और मानसिक भ्रम हो सकता है। यदि आपको सांस लेने में तकलीफ, अत्यधिक नींद, या त्वचा पर चकत्ते दिखें तो तुरंत डॉक्टर से संपर्क करें।
सुरक्षा सलाह: यह दवा केवल योग्य स्वास्थ्य पेशेवर द्वारा निगरानी में ही दी जानी चाहिए। इसे स्वयं न लगाएं। अपने डॉक्टर को सभी दवाओं के बारे में बताएं, खासकर दर्द निवारक और नींद की गोलियां। शराब का सेवन पूरी तरह बंद कर दें। जब तक आप पूरी तरह सतर्क न हों, वाहन न चलाएं। अचानक दवा बंद न करें, इससे दौरे पड़ सकते हैं।
💊 anxipose injection Uses & Benefits
[{"condition":"Severe anxiety","description":"Used for short-term relief of severe anxiety when oral therapy is not feasible or rapid effect is needed.","evidence":"Well-established"},{"condition":"Status epilepticus","description":"Used as an adjunct in the emergency management of prolonged seizures.","evidence":"Well-established"},{"condition":"Preoperative sedation","description":"Administered before surgery to reduce anxiety and facilitate anesthesia.","evidence":"Well-established"},{"condition":"Alcohol withdrawal","description":"Used to manage acute alcohol withdrawal symptoms, including agitation and seizures.","evidence":"Well-established"}]
Off-label uses: [{"condition":"Chemotherapy-induced nausea and vomiting","description":"Sometimes used as an adjunct to standard antiemetics, though evidence is limited.","evidence":"Limited"},{"condition":"Catatonia","description":"May be used in the short-term management of catatonic symptoms, often in combination with other treatments.","evidence":"Limited"}]
Primary treatment for: Severe anxiety
Also treats: Status epilepticus, Alcohol withdrawal, Preoperative anxiety
📋 Drug Information
| Generic Name(s) | Lorazepam |
| Brand Name | Ativan |
| Manufacturer | Psychotropics India Ltd |
| Packaging / Form | Varies by brand (Allopathy) |
| Therapeutic Class | RESPIRATORY |
| Action Class | Benzodiazepines |
| Route of Administration | Parenteral (intramuscular or intravenous) |
| Storage | Store at room temperature (20-25°C). Protect from light. Do not freeze. Keep out of reach of children. |
| Shelf Life | 24 months from the date of manufacture. |
| WHO Guideline | Not established from the available information. |
| ICMR Guideline | Not established from the available information. |
👨⚕️ Doctor's Practical Tips
Evidence-based practical advice from experienced clinicians
🔍 Is This Medicine Right for Your Symptom?
Educational reference. Always consult a doctor for diagnosis.
🔬 How This Medicine Works (Pharmacology)
Pharmacokinetics
How It Works
Lorazepam binds to the benzodiazepine site on the GABA-A receptor, enhancing the inhibitory effect of gamma-aminobutyric acid (GABA) in the central nervous system. This increases chloride ion influx, leading to hyperpolarization of neurons and reduced neuronal excitability. The result is anxiolytic, sedative, muscle relaxant, and anticonvulsant effects.
Mechanism Steps
💡 How to Take anxipose injection
Strength: Injection: 4 mg/mL
Dosage Information
| Adult Dosage | The dosage of this medicine must be individualized by a qualified clinician based on the indication, patient's age, weight, renal and hepatic function, and clinical response. For severe anxiety, a typical intramuscular dose is 0.5 to 2 mg, repeated every 4 to 6 hours if needed. For status epilepticus, an initial intravenous dose of 4 mg may be given slowly, with repeat after 10-15 minutes if seizures persist. For preoperative sedation, 2 to 4 mg intramuscularly is often used 1-2 hours before surgery. Always follow the prescribed dose and never self-administer. |
| Pediatric Dosage | Pediatric dosing is not established from available information. Consult a pediatrician. |
| Elderly Dosage | Elderly patients are more sensitive to the effects of lorazepam. Lower initial doses (e.g., 0.5 to 1 mg) are recommended, and doses should be titrated carefully. Monitor for excessive sedation, confusion, and falls. |
| Renal Impairment | No specific dose adjustment is generally required for renal impairment, but use with caution and monitor closely. |
| Hepatic Impairment | Use with caution in patients with hepatic impairment. Lower doses may be necessary due to reduced clearance. Monitor for excessive sedation. |
| Maximum Daily Dose | The maximum daily dose should not exceed 10 mg per day in adults, but this must be determined by a qualified clinician based on the patient's condition and response. |
Dosage Timeline
🍽️ Food Timing Guide
⏰ What to Do If You Miss a Dose
⚠️ Side Effects of anxipose injection
✅ Common Side Effects
🚨 Serious Side Effects
⚠️ Rare Side Effects
Consult your doctor if you experience any unusual symptoms.
🔬 Drug Interactions
| Drug | Severity | Effect |
|---|---|---|
| Opioids | Major | |
| Other benzodiazepines | Major | |
| Clozapine | Major | |
| Fluoxetine | Moderate | |
| Sertraline | Moderate | |
| Sedating antihistamines | Moderate | |
| Antihypertensives | Moderate | |
| Cimetidine | Minor | |
| Oral contraceptives | Minor | |
| Alcohol | Major |
🚨 Major Interactions
- Opioids (e.g., morphine, fentanyl)
- Other benzodiazepines or sedative-hypnotics
- Clozapine
⚡ Moderate Interactions
- Antidepressants (e.g., fluoxetine, sertraline)
- Antihistamines (sedating)
- Antihypertensives
🍷 Alcohol Interaction
Alcohol should be completely avoided while receiving this medicine. The combination can lead to severe sedation, respiratory depression, and even death. Patients should be warned about the dangers of drinking alcohol during treatment.
🔎 Check Your Other Medicines
Educational tool. Always confirm with your doctor or pharmacist.
🛡️ Safety & Warnings
🚫 Contraindications
["Hypersensitivity to lorazepam or other benzodiazepines","Severe respiratory insufficiency","Acute narrow-angle glaucoma","Severe hepatic impairment","Sleep apnea syndrome","Myasthenia gravis"]
⚠️ Warnings & Precautions
["Risk of dependence and withdrawal symptoms with prolonged use.","Potential for severe respiratory depression, especially with opioids or other sedatives.","May impair mental and physical abilities; avoid driving or operating machinery.","Use with caution in elderly or debilitated patients; increased risk of falls and confusion.","Paradoxical reactions (agitation, hallucinations) may occur, requiring discontinuation.","Not recommended for patients with a history of substance abuse.","Avoid abrupt discontinuation after long-term use to prevent withdrawal seizures."]
🤱 Lactation Safety
Lorazepam is excreted in breast milk and may cause sedation in the infant. Breastfeeding is not recommended during treatment. Consult your doctor for alternative options.
💊 Overdose Management
Overdose of lorazepam can cause severe drowsiness, confusion, respiratory depression, coma, and death. Management includes supportive care, monitoring of vital signs, and administration of flumazenil (a benzodiazepine antagonist) if appropriate. Flumazenil should be used with caution as it can precipitate seizures in dependent patients. Contact a poison control center immediately.
⏰ Missed Dose
This medicine is typically administered by a healthcare professional in a controlled setting. If you miss a scheduled dose, inform your healthcare provider immediately. Do not attempt to self-administer a double dose.
Additional Safety Advice
This medicine must only be administered by a qualified healthcare professional in a monitored setting. Do not attempt to self-administer or use it outside of a hospital or clinic. Inform your doctor about all medications you are taking, especially opioids, other sedatives, or antidepressants, as these can increase the risk of severe sedation and breathing difficulties. Avoid alcohol completely while receiving this medicine. Do not drive or operate heavy machinery until you are fully alert and your doctor approves. If you experience excessive drowsiness, slow breathing, or unusual muscle weakness, seek immediate medical attention. Never stop this medicine abruptly after prolonged use without medical guidance, as withdrawal seizures can occur.
👴 Special Considerations for Elderly
💡 For Patients Above 65
Elderly patients are at increased risk of sedation, confusion, falls, and respiratory depression. Lower doses are recommended, and close monitoring is essential. Avoid long-term use if possible.
🤰 Pregnancy Planning (TTC)
If you are planning pregnancy, consult your doctor before using this medicine. It may cause fetal harm. Alternative treatments may be considered. Effective contraception is advised while on this medicine.
🏥 Post-Surgery Considerations
This medicine may be used for preoperative sedation. After surgery, it can add to the sedative effects of anesthetics and pain medications. Close monitoring is required. Inform your surgeon and anesthesiologist about all medications you take.
🦷 Dental Procedures
Inform your dentist if you are receiving this medicine, as it can increase sedation when combined with dental anesthetics or sedatives. Your dentist may need to adjust medications or take extra precautions.
💚 Lifestyle Tips for Better Results
🏋️ Exercise Considerations
This medicine can cause drowsiness and unsteadiness, increasing the risk of falls during exercise. Avoid strenuous activities or exercises that require balance until you know how the medicine affects you. Light walking may be safe if you feel alert, but always use caution.
🥗 Diet Recommendations
💼 Impact on Daily Work & Life
This medicine can significantly impair your ability to drive, operate machinery, or perform tasks requiring alertness. It is usually administered in a healthcare setting, and you should not return to work until the effects have worn off and your doctor approves. It may also cause memory problems, affecting work performance.
🛑 When to Stop This Medicine
This medicine is typically used short-term. Do not stop abruptly after prolonged use, as withdrawal symptoms including seizures can occur. Your doctor will gradually taper the dose. If you experience severe side effects, seek immediate medical attention. Always consult your doctor before stopping.
📅 Long-Term Use Effects
Long-term use of this medicine can lead to tolerance, physical dependence, and withdrawal symptoms upon discontinuation. It may also cause cognitive impairment, especially in elderly patients. Prolonged use should be avoided, and if used for more than a few weeks, tapering is necessary. Regular monitoring for dependence and cognitive effects is recommended.
🌿 Non-Medicine Approaches
These can complement medicine but do not replace prescribed treatment.
Can be effective for anxiety disorders and may reduce the need for medication.
Evidence: Well-establishedDeep breathing, meditation, and yoga can help manage anxiety.
Evidence: Well-establishedFor long-term management of anxiety, SSRIs may be prescribed instead of benzodiazepines.
Evidence: Well-established💉 Vaccination Considerations
💉 If You're Getting Vaccinated
No specific interactions with vaccines are known. However, if you are scheduled for vaccination, inform your healthcare provider that you are receiving this medicine.
📦 Storage Guide
✅ DO
Store at room temperature (20-25°C)
❌ DON'T
Do not freeze
✅ DO
Keep in original container
❌ DON'T
Do not transfer to unmarked containers
✅ DO
Protect from light
❌ DON'T
Do not store in bathroom cabinet
✈️ Traveling with This Medicine
When traveling, carry this medicine in its original packaging along with a copy of your prescription. Since it is an injectable controlled substance, check the laws of your destination country regarding importation of benzodiazepines. Store it at room temperature and protect it from light. If you need to administer it during travel, ensure you have access to a healthcare professional. Never pack it in checked luggage; keep it in your carry-on. Carry a letter from your doctor explaining the medical necessity.
💰 Cost Analysis & Savings
👥 Real Patient Stories
Educational, anonymized scenarios. Individual results may vary.
💬 Questions Patients Often Ask
A: This medicine starts working within 5 to 20 minutes after intramuscular injection, with peak effects in 1 to 2 hours.
A: The effects typically last 6 to 8 hours, but this can be longer in elderly patients or those with liver problems.
A: This medicine may harm the fetus. It should only be used during pregnancy if clearly needed and under medical supervision.
A: This medicine passes into breast milk and may cause sedation in the infant. Breastfeeding is not recommended during treatment.
A: Avoid alcohol, driving, and operating heavy machinery. Also avoid other sedatives unless prescribed.
🤔 Common Patient Concerns
🔄 Substitutes for anxipose injection
View AllAlternative brands with exact same active ingredient:
-
neolore 4mg injectionNeon Laboratories Ltd ₹14.58 14.7% CHEAPER
-
neulora 4mg injectionLinux Laboratories ₹15.50 9.4% CHEAPER
-
lotranz 4mg tabletEast West Pharma ₹42.66 149.5% COSTLIER
Medical Note: Always consult your doctor before switching medications.
🛑 Myths vs. Facts
- Myth: This medicine is safe to use at home without supervision.
Fact: This medicine is a potent injectable benzodiazepine that must only be administered by a healthcare professional in a monitored setting due to the risk of severe respiratory depression and sedation. - Myth: This medicine is not addictive.
Fact: This medicine can cause physical and psychological dependence, especially with prolonged use. It should be used short-term and under strict medical supervision. - Myth: It is safe to drink alcohol while receiving this medicine.
Fact: Alcohol greatly increases the risk of severe sedation, respiratory depression, and death. It must be completely avoided.
🔄 Alternative Options
Generic Alternatives
- Lorazepam injection
Brand Alternatives
- Ativan
- Lorazepam Injection