antof plus tablet - Uses, Price, Side Effects & Substitutes
What is antof plus tablet used for?
Antof Plus Tablet (Lactobacillus + Ofloxacin) is used to treat GASTRO INTESTINAL. It contains Lactobacillus (120Million spores) + Ofloxacin (200mg), which Ofloxacin inhibits bacterial DNA gyrase and topoisomerase IV, preventing DNA rep. Always consult your doctor before use. Take as prescribed.
- Generic Name: Lactobacillus + Ofloxacin
- Manufacturer: Progressive Life Care
- Form: Allopathy
- Pregnancy Category: A
- Prescription Required: Yes
๐ antof plus tablet Uses & Benefits
Infectious diarrhea, gastrointestinal infections, bacterial enteritis, prophylaxis of traveler's diarrhea.
Off-label uses: Not commonly used off-label.
๐ Drug Information
| Generic Name(s) | Lactobacillus + Ofloxacin |
| Brand Name | Antof Plus Tablet |
| Manufacturer | Progressive Life Care |
| Packaging / Form | Varies by brand (Allopathy) |
| Therapeutic Class | GASTRO INTESTINAL |
| Action Class | Antibiotic + Probiotic |
| Route of Administration | Oral |
| Storage | Store at room temperature (20-25ยฐC), protect from light and moisture. |
| Shelf Life | As per manufacturer |
๐ฌ Pharmacology (PK/PD)
Pharmacokinetics
How It Works
Ofloxacin inhibits bacterial DNA gyrase and topoisomerase IV, preventing DNA replication; Lactobacillus restores gut flora.
Mechanism Steps
๐ก How to Take antof plus tablet
Follow your doctor's prescription exactly.
โ ๏ธ Side Effects of antof plus tablet
โ Common Side Effects
- Nausea
- Diarrhea
- Headache
- Dizziness
- Insomnia
- Abdominal pain
๐จ Serious Side Effects
- Tendon rupture
- Peripheral neuropathy
- CNS effects (seizures, confusion)
- QT prolongation
- Clostridium difficile colitis
- Severe allergic reactions
โ ๏ธ Rare Side Effects
- Hepatotoxicity
- Nephrotoxicity
- Blood dyscrasias
- Photosensitivity
- Tendinitis
Consult your doctor if you experience any unusual symptoms.
๐ฌ Drug Interactions
| โ ๏ธ Drug | Severity | Effect |
|---|---|---|
| Warfarin | Major | Increased bleeding risk |
| Antacids (Mg/Al) | Major | Reduced ofloxacin absorption |
| Sucralfate | Major | Reduced ofloxacin absorption |
| Iron supplements | Major | Reduced ofloxacin absorption |
| Zinc supplements | Major | Reduced ofloxacin absorption |
| NSAIDs | Moderate | Increased CNS stimulation risk |
| Corticosteroids | Moderate | Increased tendon rupture risk |
| Cyclosporine | Moderate | Increased nephrotoxicity |
| Theophylline | Moderate | Increased theophylline levels |
| Caffeine | Moderate | Increased caffeine levels |
| Calcium supplements | Minor | Slightly reduced absorption |
| Multivitamins | Minor | Slightly reduced absorption |
๐จ Major Interactions
- Warfarin
- Antacids containing Mg/Al
- Sucralfate
- Iron supplements
- Zinc supplements
โก Moderate Interactions
- NSAIDs
- Corticosteroids
- Cyclosporine
- Theophylline
- Caffeine
โน๏ธ Minor Interactions
- Calcium supplements
- Multivitamins
๐ฝ๏ธ Food Interactions
Dairy products may reduce absorption; avoid with high calcium foods.
๐ท Alcohol Interaction
May increase CNS effects; avoid.
๐ก๏ธ Safety & Warnings
๐ซ Contraindications
Hypersensitivity to fluoroquinolones, history of tendon disorders, epilepsy, children <18 years (except specific indications), pregnancy (relative).
๐ Monitoring Parameters
Renal function, liver enzymes, blood glucose, signs of tendonitis, CNS effects.
๐คฑ Lactation Safety
Ofloxacin excreted in milk; use caution. Lactobacillus safe.
๐ Overdose Management
Supportive care; gastric lavage if recent; monitor ECG, renal function.
โฐ Missed Dose
Take as soon as remembered unless near next dose; skip if close.