antidol 100 mg/125 mg tablet - Ibuprofen (100mg) + Paracetamol (125mg) medicine

Antidol 100 mg/125 mg Tablet - Uses, Price, Side Effects

4.6 (19 reviews)
๐Ÿญ Omega Pharmaceuticals Pvt Ltd ๐Ÿ“ฆ Varies by brand ๐Ÿ’Š Allopathy ๐Ÿ“… Updated: Aug 22, 2026
๐Ÿ“‹ Prescription Required ๐Ÿ’Š Generic Available
Medically Reviewed
SaathiMed Expert Panel | Aug 22, 2026

What is antidol 100 mg/125 mg tablet used for?

Antidol 100 mg/125 mg Tablet is a combination of Ibuprofen (100mg) and Paracetamol (125mg) used for relief of mild to moderate pain and fever. Ibuprofen works by reducing hormones that cause inflammation and pain, while Paracetamol works on the brain to lower fever. It is commonly used for headaches, toothaches, menstrual cramps, and fever.

  • Generic Name: Ibuprofen + Paracetamol
  • Manufacturer: Omega Pharmaceuticals Pvt Ltd
  • Form: Allopathy
  • Pregnancy Category: A
  • Prescription Required: Yes
๐Ÿ’ก Did You Know? The Indian pharmaceutical market is expected to reach $130 billion by 2030.

๐Ÿ’Š antidol 100 mg/125 mg tablet Uses & Benefits

Mild to moderate pain, fever, inflammation (e.g., headache, dental pain, dysmenorrhea, osteoarthritis).

Off-label uses: Patent ductus arteriosus closure (ibuprofen), migraine (paracetamol).

๐Ÿ“‹ Drug Information

Generic Name(s)Ibuprofen + Paracetamol
Brand NameAdiflam Plus 400 mg/500 mg Tablet
ManufacturerOmega Pharmaceuticals Pvt Ltd
Packaging / FormVaries by brand (Allopathy)
Therapeutic ClassPAIN ANALGESICS
Action ClassNonsteroidal Anti-inflammatory Drug (NSAID) + Analgesic/Antipyretic
Route of AdministrationOral
StorageStore at room temperature (20-25ยฐC), protect from moisture.
Shelf LifeAs per manufacturer

๐Ÿ”ฌ Pharmacology (PK/PD)

Pharmacokinetics

AbsorptionIbuprofen: Rapidly absorbed from GI tract; Paracetamol: Rapidly and completely absorbed from GI tract.
DistributionIbuprofen: Widely distributed, crosses placenta; Paracetamol: Uniformly distributed in body fluids, crosses placenta.
Protein BindingIbuprofen: ~99%; Paracetamol: 10-25%.
MetabolismIbuprofen: Hepatic via CYP2C9; Paracetamol: Hepatic via conjugation (glucuronidation, sulfation) and CYP2E1 (minor).
Half-LifeIbuprofen: 2-4 hours; Paracetamol: 1.5-3 hours.
ExcretionIbuprofen: Renal (90% as metabolites); Paracetamol: Renal (mostly as conjugates).
BioavailabilityIbuprofen: ~80-100%; Paracetamol: ~70-90%.
Onset of ActionIbuprofen: 30-60 min; Paracetamol: 30-60 min.
Peak Plasma TimeIbuprofen: 1-2 hours; Paracetamol: 30-60 min.
Duration of ActionIbuprofen: 4-6 hours; Paracetamol: 4-6 hours.

How It Works

Ibuprofen inhibits COX-1 and COX-2, reducing prostaglandin synthesis; Paracetamol inhibits COX in CNS, reducing pain and fever.

Mechanism Steps

1Ibuprofen inhibits COX-1 and COX-2 enzymes, reducing prostaglandin synthesis.
2Paracetamol inhibits COX in the central nervous system, reducing pain and fever.
3Decreased prostaglandins lead to reduced inflammation, pain, and fever.

๐Ÿ’ก How to Take antidol 100 mg/125 mg tablet

Follow your doctor's prescription exactly.

Dosage Timeline

๐ŸŒ… Morning โœ… โ˜€๏ธ Afternoon โŒ ๐ŸŒ† Evening โœ… ๐ŸŒ™ Night โŒ

โš ๏ธ Side Effects of antidol 100 mg/125 mg tablet

โœ… Common Side Effects

  • Nausea
  • Dyspepsia
  • Headache
  • Dizziness
  • Rash

๐Ÿšจ Serious Side Effects

  • GI bleeding
  • Renal failure
  • Hepatotoxicity
  • Cardiovascular events
  • Stevens-Johnson syndrome

โš ๏ธ Rare Side Effects

  • Aplastic anemia
  • Agranulocytosis
  • Pancreatitis
  • Anaphylaxis

Consult your doctor if you experience any unusual symptoms.

๐Ÿ”ฌ Drug Interactions

โš ๏ธ DrugSeverityEffect
Warfarin Major Increased bleeding risk
Methotrexate Moderate Increased methotrexate toxicity
Aspirin Moderate Increased risk of gastrointestinal bleeding

๐Ÿšจ Major Interactions

  • Warfarin
  • Methotrexate
  • Lithium
  • Aspirin
  • Other NSAIDs

โšก Moderate Interactions

  • ACE inhibitors
  • Diuretics
  • Anticoagulants
  • Corticosteroids

โ„น๏ธ Minor Interactions

  • Antacids
  • Caffeine
  • Cholestyramine

๐Ÿฝ๏ธ Food Interactions

Food may delay absorption; avoid high-fat meals.

๐Ÿท Alcohol Interaction

Increased risk of GI bleeding and hepatotoxicity.

๐Ÿ›ก๏ธ Safety & Warnings

Liver
Moderate
Kidney
Low
Heart
Low
Pregnancy
Category A

๐Ÿšซ Contraindications

Hypersensitivity, active GI bleeding, severe renal/hepatic impairment, third trimester pregnancy, history of asthma with NSAIDs.

๐Ÿ“Š Monitoring Parameters

Renal function, hepatic function, blood pressure, signs of GI bleeding.

๐Ÿคฑ Lactation Safety

Ibuprofen: Safe in low doses; Paracetamol: Safe.

๐Ÿ’Š Overdose Management

Activated charcoal, supportive care; for paracetamol overdose: N-acetylcysteine.

โฐ Missed Dose

Take as soon as remembered; if near next dose, skip missed dose.

๐Ÿ‘จโ€โš•๏ธ Reviewed by Expert

SaathiMed Expert Panel

MD, PhD - Pharmacology

Last reviewed on: Aug 22, 2026

๐Ÿ”— View Profile

โญ User Reviews

Happy Patient Jul 10, 2026

Effective and reliable. Worked as expected.

Certified Buyer Jul 10, 2026

Helpful and effective medicine as per my experience. Always consult a doctor.

Certified Buyer Jul 10, 2026

This medicine was effective for me. I followed the doctor's advice.

Certified Buyer Jul 10, 2026

This medicine was effective for me. I followed the doctor's advice.

Certified Buyer Jul 10, 2026

This medicine was effective for me. I followed the doctor's advice.

๐Ÿ˜Š Was this information helpful?

Browse Medicines A-Z

Search our extensive medical database alphabetically.

A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
Back to Medicines Directory