anmol 50mg/500mg tablet - Nimesulide (50mg) + Paracetamol (500mg) medicine

Anmol 50mg/500mg Tablet: Complete Guide to Uses, Dosage, and Safety

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🏭 Shrinivas Gujarat Laboratories Pvt Ltd 📦 Varies by brand 💊 Allopathy 📅 Updated: Oct 16, 2026
⚠️ Hepatotoxicity Risk ⚠️ Nephrotoxicity Risk 📋 Prescription Required 💊 Generic Available
Medically Reviewed
11 min read
Evidence: Moderate for short-term use in acute pain.
Reviewed by
SaathiMed Expert Panel | Oct 16, 2026
🩺
Medically Fact-Checked & Clinically Verified by SaathiMed Clinical Review Board
Clinical Reference Standards: CDSCO (Central Drugs Standard Control Organisation), Indian Pharmacopoeia (IP) & WHO | Last Updated: September 2026

When to Call Your Doctor IMMEDIATELY

  • Blood in stool or vomit
  • Severe abdominal pain
  • Yellowing of skin or eyes
  • Decreased urine output
  • Swelling of face, lips, or throat
  • Difficulty breathing
  • Severe headache with visual changes
  • Unusual bleeding or bruising

If experiencing severe symptoms, call emergency services immediately.

What is anmol 50mg/500mg tablet used for?

This medicine is a combination of nimesulide and paracetamol used for short-term relief of acute pain, inflammation, and fever. It works by reducing prostaglandins that cause pain and swelling. It should be taken with food and for no more than 5-7 days without medical advice.

  • Generic Name: Nimesulide (50mg) + Paracetamol (500mg)
  • Manufacturer: Shrinivas Gujarat Laboratories Pvt Ltd
  • Form: Allopathy
  • Pregnancy Category: Consult doctor
  • Prescription Required: Yes

🇮🇳 anmol 50mg/500mg tablet के बारे में (Hindi Summary)

उपयोग: यह दवा नाइमेसुलाइड और पैरासिटामोल का संयोजन है, जिसका उपयोग दर्द, सूजन और बुखार के अल्पकालिक उपचार के लिए किया जाता है। यह मांसपेशियों के दर्द, दांत दर्द, सर्जरी के बाद के दर्द और बुखार में राहत देती है। इसे भोजन के बाद लेना चाहिए और डॉक्टर की सलाह के बिना 5-7 दिनों से अधिक नहीं लेना चाहिए।

साइड इफेक्ट्स: इस दवा के सामान्य दुष्प्रभावों में मतली, उल्टी, पेट दर्द, सिरदर्द और चक्कर आना शामिल हैं। गंभीर दुष्प्रभाव दुर्लभ हैं, लेकिन पेट में रक्तस्राव, लिवर या किडनी की समस्या और एलर्जी प्रतिक्रिया हो सकती है। यदि आपको काला मल, खून की उल्टी, आंखों या त्वचा का पीलापन, या सांस लेने में कठिनाई हो, तो तुरंत डॉक्टर से मिलें।

सुरक्षा सलाह: इस दवा को डॉक्टर के निर्देशानुसार ही लें। खुराक या अवधि से अधिक न लें। इसे भोजन या दूध के साथ लें ताकि पेट की जलन कम हो। इस दवा के साथ शराब न लें क्योंकि इससे लिवर और पेट की समस्या बढ़ सकती है। यदि आपको पेट अल्सर, किडनी या लिवर की बीमारी, या अस्थमा है, तो डॉक्टर को बताएं। बिना डॉक्टर की सलाह के 5-7 दिनों से अधिक न लें।

💡 Did You Know? India is the largest provider of generic medicines globally, supplying over 50% of global vaccine demand.

💊 anmol 50mg/500mg tablet Uses & Benefits

[{"condition":"Acute musculoskeletal pain","description":"Relieves pain and inflammation in muscles, joints, and soft tissues due to sprains, strains, or injuries.","evidence":"Well-established"},{"condition":"Dental pain","description":"Provides relief from toothache and pain after dental procedures.","evidence":"Well-established"},{"condition":"Post-operative pain","description":"Used for short-term management of pain after minor surgeries.","evidence":"Moderate"},{"condition":"Fever","description":"Reduces fever due to its paracetamol content.","evidence":"Well-established"},{"condition":"Osteoarthritis","description":"Short-term relief of pain and stiffness in osteoarthritis.","evidence":"Moderate"}]

Off-label uses: [{"condition":"Migraine","description":"Sometimes used for acute migraine attacks, but not first-line.","evidence":"Limited"},{"condition":"Dysmenorrhea","description":"May be used for menstrual cramps, but other NSAIDs are preferred.","evidence":"Limited"}]

Primary treatment for: Acute pain and inflammation

Also treats: Fever, Dental pain, Musculoskeletal pain, Post-operative pain

📋 Drug Information

Generic Name(s)Nimesulide (50mg) + Paracetamol (500mg)
Brand Nameanmol 50mg/500mg tablet
ManufacturerShrinivas Gujarat Laboratories Pvt Ltd
Packaging / FormVaries by brand (Allopathy)
Therapeutic ClassPAIN ANALGESICS
Action Class
Route of AdministrationOral
StorageStore at room temperature (15-30°C) in a dry place, away from direct sunlight and moisture. Keep out of reach of children.
Shelf Life24 months from the date of manufacture.
WHO GuidelineNot established from the available information.
ICMR GuidelineNot established from the available information.

👨‍⚕️ Doctor's Practical Tips

Evidence-based practical advice from experienced clinicians

1
Always take this medicine after food to minimize stomach irritation.
2
Do not use this medicine for more than 5-7 days without consulting a doctor.
3
Avoid alcohol completely while taking this medicine to prevent liver damage.
4
If you have a history of stomach ulcers, kidney or liver disease, inform your doctor before taking this medicine.
5
Do not take other paracetamol-containing products simultaneously to avoid overdose.
6
Stay well hydrated while taking this medicine to support kidney function.
7
If pain persists or worsens after 3 days, consult your doctor for reevaluation.

🔍 Is This Medicine Right for Your Symptom?

Educational reference. Always consult a doctor for diagnosis.

✅
Acute musculoskeletal pain
This medicine is commonly prescribed for this.
Likely Use
✅
Fever
This medicine contains paracetamol, which reduces fever.
Likely Use
✅
Dental pain
This medicine is effective for dental pain.
Likely Use
❌
Chronic pain
This medicine is not for long-term use. Consult a doctor for chronic pain management.
Not Primary

🔬 How This Medicine Works (Pharmacology)

Pharmacokinetics

AbsorptionNimesulide is rapidly absorbed from the gastrointestinal tract after oral administration, with peak plasma concentrations reached in 1.5-3 hours. Paracetamol is also rapidly and completely absorbed, with peak levels in 0.5-2 hours. Food may slightly delay absorption but does not significantly affect the extent.
DistributionNimesulide is highly protein-bound and distributes well into tissues, including synovial fluid. Paracetamol distributes widely throughout most body tissues, with a volume of distribution of about 0.9 L/kg.
Protein BindingNimesulide is approximately 99% bound to plasma proteins. Paracetamol is about 10-25% bound to plasma proteins.
MetabolismNimesulide is extensively metabolized in the liver, primarily by CYP2C9, to several metabolites, including 4-hydroxynimesulide, which is pharmacologically active. Paracetamol is metabolized in the liver via glucuronidation and sulfation, and a small fraction via CYP2E1 to a toxic metabolite, N-acetyl-p-benzoquinone imine (NAPQI), which is detoxified by glutathione.
Half-LifeNimesulide: 1.8-4.7 hours; Paracetamol: 2-3 hours.
ExcretionNimesulide metabolites are excreted mainly in urine (about 70%) and feces (about 20%). Paracetamol metabolites are excreted in urine, with about 90% of the dose excreted within 24 hours.
BioavailabilityNimesulide: approximately 80-90% after oral administration. Paracetamol: approximately 80-100% after oral administration.
Onset of ActionPain relief typically begins within 30-60 minutes after oral intake.
Peak Plasma TimeNimesulide: 1.5-3 hours; Paracetamol: 0.5-2 hours.
Duration of ActionPain relief lasts approximately 4-6 hours.

How It Works

This medicine combines two active ingredients with different mechanisms. Nimesulide is a non-steroidal anti-inflammatory drug that selectively inhibits the cyclooxygenase-2 (COX-2) enzyme, reducing the production of prostaglandins, which are mediators of pain, inflammation, and fever. Paracetamol acts primarily in the central nervous system by inhibiting prostaglandin synthesis and possibly activating descending serotonergic pathways, leading to pain relief and fever reduction. Together, they provide synergistic analgesic and antipyretic effects.

Mechanism Steps

1
COX-2 inhibition by nimesulide: Nimesulide selectively binds to and inhibits the COX-2 enzyme, reducing the conversion of arachidonic acid to prostaglandins.
2
Reduced prostaglandin synthesis: Lower levels of prostaglandins lead to decreased inflammation, pain, and fever.
3
Central action of paracetamol: Paracetamol acts on the central nervous system to inhibit prostaglandin synthesis and modulate pain perception.
4
Synergistic analgesic effect: The combined actions of nimesulide and paracetamol provide enhanced pain relief and fever reduction.

💡 How to Take anmol 50mg/500mg tablet

Strength: Tablet containing Nimesulide 50 mg and Paracetamol 500 mg.

1Take the tablet orally with a glass of water.
2Take it after meals to reduce stomach upset.
3Swallow the tablet whole; do not crush or chew.
4Do not exceed the prescribed dose.
5Complete the prescribed course or use for the shortest duration necessary.

Dosage Information

Adult DosageThe usual adult dose is one tablet (nimesulide 50 mg + paracetamol 500 mg) taken orally twice daily, preferably after meals. The maximum recommended duration is 5-7 days. Dose must be individualized by a qualified clinician based on indication, age, weight, renal and hepatic function. Do not exceed the recommended dose.
Pediatric DosagePediatric dosing is not established from available information. This medicine is not recommended for children below 12 years of age. Consult a pediatrician for appropriate alternatives.
Elderly DosageElderly patients may be more sensitive to the side effects of this medicine, especially gastrointestinal bleeding and kidney problems. Use with caution and at the lowest effective dose for the shortest duration. Dose must be individualized by a qualified clinician.
Renal ImpairmentUse with caution in patients with kidney disease. Dose reduction may be necessary. Consult a doctor for individualized dosing.
Hepatic ImpairmentContraindicated in severe liver disease. Use with caution in mild to moderate liver impairment. Dose reduction may be necessary. Consult a doctor for individualized dosing.
Maximum Daily DoseMaximum daily dose: Nimesulide 100 mg (two tablets) and paracetamol 1000 mg (two tablets) per day. Do not exceed this dose.

Dosage Timeline

🌅 Morning ❌ ☀️ Afternoon ❌ 🌆 Evening ❌ 🌙 Night ❌

🍽️ Food Timing Guide

With food
Take with meals
Reduces stomach upset and gastrointestinal irritation.
Alcohol
Avoid
Increases risk of liver damage and stomach bleeding.
Grapefruit
Avoid
May increase drug levels and risk of side effects.

⏰ What to Do If You Miss a Dose

📌 Less than half the dosing interval has passed
→ Take the missed dose as soon as you remember.
💡 Continue with the regular schedule.
📌 More than half the dosing interval has passed
→ Skip the missed dose.
💡 Do not double dose to catch up.

⚠️ Side Effects of anmol 50mg/500mg tablet

✅ Common Side Effects

Nausea (Common (5-10%))
Take with food or milk. If persistent, consult your doctor.
Vomiting (Common (5-10%))
Stay hydrated. If severe or persistent, consult your doctor.
Stomach pain (Common (5-10%))
Take with food. Avoid alcohol. If severe, consult your doctor.
Heartburn (Common (5-10%))
Take with food. Avoid spicy foods. If persistent, consult your doctor.
Headache (Common (5-10%))
Usually resolves on its own. If severe, consult your doctor.
Dizziness (Uncommon (1-5%))
Avoid driving or operating machinery until you know how it affects you.

🚨 Serious Side Effects

Gastrointestinal bleeding (Rare (<0.1%))
Seek immediate medical attention if you notice black or bloody stools, vomiting blood, or severe abdominal pain.
Liver damage (Rare (<0.1%))
Seek immediate medical attention if you notice yellowing of skin or eyes, dark urine, or severe fatigue.
Kidney problems (Rare (<0.1%))
Seek immediate medical attention if you notice decreased urine output, swelling, or confusion.
Severe allergic reaction (Rare (<0.1%))
Seek immediate medical attention if you experience swelling of face, lips, or throat, difficulty breathing, or severe rash.

⚠️ Rare Side Effects

Stevens-Johnson syndrome
Seek immediate medical attention if you develop a painful rash with blisters or peeling skin.
Agranulocytosis
Seek immediate medical attention if you develop fever, sore throat, or mouth ulcers.
Aplastic anemia
Seek immediate medical attention if you experience unusual tiredness, pale skin, or frequent infections.

Consult your doctor if you experience any unusual symptoms.

🔬 Drug Interactions

Drug Severity Effect
Warfarin Major
Other NSAIDs Major
Corticosteroids Major
Methotrexate Major
ACE inhibitors Moderate
ARBs Moderate
Diuretics Moderate
Lithium Moderate
SSRIs Moderate
Antacids Minor

🚨 Major Interactions

  • Warfarin
  • Other NSAIDs (e.g., ibuprofen, diclofenac)
  • Corticosteroids
  • Methotrexate

⚡ Moderate Interactions

  • ACE inhibitors and ARBs
  • Diuretics
  • Lithium
  • SSRIs

🍷 Alcohol Interaction

Avoid alcohol while taking this medicine. Alcohol increases the risk of liver damage, especially from paracetamol, and can increase the risk of stomach bleeding from nimesulide.

🔎 Check Your Other Medicines

Educational tool. Always confirm with your doctor or pharmacist.

🛡️ Safety & Warnings

🚫 Contraindications

["Known allergy to nimesulide, paracetamol, or any component of the formulation","Active peptic ulcer or history of recurrent ulcers","Severe liver disease","Severe kidney disease","History of asthma, urticaria, or allergic reaction to aspirin or other NSAIDs","Pregnancy (especially third trimester)","Breastfeeding","Children below 12 years of age"]

⚠️ Warnings & Precautions

["Do not exceed the recommended dose or duration of treatment.","Avoid alcohol while taking this medicine.","Take with food to reduce stomach upset.","Consult your doctor if you have a history of stomach ulcers, kidney or liver disease, or asthma.","Do not use this medicine for more than 5-7 days without medical advice.","Stop use and seek medical attention if you experience signs of liver damage, kidney problems, or severe allergic reaction.","Inform your doctor if you are taking blood thinners, other NSAIDs, or corticosteroids."]

🤱 Lactation Safety

Not recommended. Nimesulide is excreted in breast milk and may cause harm to the infant. Paracetamol is considered safe during breastfeeding. Consult your doctor for alternatives.

💊 Overdose Management

Overdose can cause severe liver damage, especially from paracetamol. Symptoms of overdose may include nausea, vomiting, abdominal pain, confusion, and yellowing of the skin or eyes. If you suspect an overdose, seek immediate medical attention. Treatment may include activated charcoal, N-acetylcysteine (for paracetamol toxicity), and supportive care.

⏰ Missed Dose

If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and continue with your regular schedule. Do not take a double dose to make up for a missed one.

Additional Safety Advice

General Safety

Take this medicine exactly as prescribed by your doctor. Do not exceed the recommended dose or duration. Take it with food or milk to reduce stomach upset. Avoid alcohol while taking this medicine because it can increase the risk of liver damage and stomach bleeding. Do not take other medicines containing paracetamol or other NSAIDs without consulting your doctor. If you have a history of stomach ulcers, kidney or liver disease, or asthma, inform your doctor before taking this medicine. Do not use this medicine for more than 5-7 days unless directed by a doctor. Keep out of reach of children. Store at room temperature away from moisture and heat.

👴 Special Considerations for Elderly

💡 For Patients Above 65

Elderly patients are at higher risk of gastrointestinal bleeding, kidney problems, and liver toxicity. Use the lowest effective dose for the shortest duration. Monitor kidney and liver function regularly.

🤰 Pregnancy Planning (TTC)

This medicine is not recommended if you are planning pregnancy or are pregnant. Consult your doctor for safe alternatives for pain and fever management.

🏥 Post-Surgery Considerations

This medicine may be used for short-term post-operative pain relief. However, consult your surgeon before taking it, as it may interact with other medications or affect healing.

🦷 Dental Procedures

This medicine can be used for dental pain, but inform your dentist if you are taking it before any dental procedure. It may increase bleeding risk during dental surgery.

💚 Lifestyle Tips for Better Results

🏃
Maintain a healthy weight to reduce stress on joints.
🥗
Engage in regular low-impact exercise like walking or swimming.
😴
Practice good posture to prevent musculoskeletal pain.
💧
Include anti-inflammatory foods like fruits, vegetables, and omega-3 fatty acids in your diet.
🧘
Get adequate sleep to help your body recover.
🌞
Stay hydrated by drinking plenty of water.

🏋️ Exercise Considerations

Avoid strenuous exercise or activities that may worsen pain while taking this medicine. Gentle stretching and low-impact exercises are generally safe. Consult your doctor before starting any exercise routine.

🥗 Diet Recommendations

Include omega-3 rich foods like fish, flaxseeds, and walnuts.
Reduce intake of processed and fried foods.
Eat plenty of fruits and vegetables.
Stay well hydrated.
Avoid alcohol.

💼 Impact on Daily Work & Life

This medicine may cause dizziness or drowsiness in some people. Avoid driving or operating heavy machinery until you know how it affects you. It is usually safe to continue desk work, but take breaks and avoid prolonged sitting.

🛑 When to Stop This Medicine

Stop taking this medicine if your pain or fever resolves, or after the prescribed duration (usually 5-7 days). If you experience any serious side effects, stop immediately and seek medical attention. Do not stop abruptly if you are on a prescribed course without consulting your doctor.

📅 Long-Term Use Effects

Long-term use of this medicine can increase the risk of liver damage, kidney problems, and gastrointestinal bleeding. It is not recommended for chronic use. Regular monitoring of liver and kidney function may be required if used for more than a few days.

🌿 Non-Medicine Approaches

These can complement medicine but do not replace prescribed treatment.

Physical therapy

Can complement medicine for chronic pain and improve mobility.

Evidence: Well-established
Hot and cold compresses

May help reduce localized pain and inflammation.

Evidence: Moderate
Acupuncture

Some evidence for pain relief in certain conditions.

Evidence: Limited

💉 Vaccination Considerations

💉 If You're Getting Vaccinated

This medicine does not interact with vaccines. However, if you have a fever, consult your doctor before vaccination.

📦 Storage Guide

✅ DO

Store at room temperature (15-30°C)

❌ DON'T

Do not refrigerate unless specified

✅ DO

Keep in original container

❌ DON'T

Do not transfer to unmarked containers

✅ DO

Keep away from direct sunlight

❌ DON'T

Do not store in bathroom cabinet

✈️ Traveling with This Medicine

When traveling, carry this medicine in its original packaging along with a copy of your prescription. Store it at room temperature, away from direct sunlight and moisture. If crossing time zones, continue taking it as prescribed, but adjust timing gradually. Check local customs regulations regarding prescription medicines before travel.

💰 Cost Analysis & Savings

👥 Real Patient Stories

Educational, anonymized scenarios. Individual results may vary.

👤 A 45-year-old office worker with acute lower back pain
Ravi started this medicine as prescribed for his back pain. He took it after meals twice daily. Within two days, his pain reduced significantly, and he was able to return to work. He stopped the medicine after five days as advised by his doctor.
💡 Lesson: Taking this medicine with food and for a short duration helps relieve pain effectively while minimizing side effects.
👤 A 60-year-old woman with knee osteoarthritis
Mrs. Sharma was prescribed this medicine for knee pain. She experienced mild stomach upset initially, but it subsided when she started taking it with food. She used it for a week and then switched to physical therapy for long-term management.
💡 Lesson: This medicine provides short-term relief, but long-term management of osteoarthritis requires lifestyle changes and other therapies.

💬 Questions Patients Often Ask

Q: How long does it take to work?

A: This medicine usually starts relieving pain within 30-60 minutes after taking it.

Q: Can I take it on an empty stomach?

A: It is best to take this medicine with food or milk to reduce stomach upset.

Q: Is it safe to take with other painkillers?

A: Do not take other NSAIDs or paracetamol-containing products without consulting your doctor, as it may increase the risk of side effects.

Q: Can I take it during pregnancy?

A: This medicine is not recommended during pregnancy, especially in the third trimester. Consult your doctor for safe alternatives.

🤔 Common Patient Concerns

💭 These are the concerns patients most commonly raise

  • Can I take this medicine long-term?
  • Will it affect my kidney function?
  • Can I drive after taking this medicine?
  • Does it interact with my blood pressure medicine?
  • What if I miss a dose?
  • Can I drink alcohol while taking this?

🔄 Substitutes for anmol 50mg/500mg tablet

View All

Alternative brands with exact same active ingredient:

Medical Note: Always consult your doctor before switching medications.

🛑 Myths vs. Facts

  • Myth: This medicine can be taken long-term for chronic pain.
    Fact: This medicine is only for short-term use. Long-term use increases the risk of liver, kidney, and stomach problems.
  • Myth: It is safe to take this medicine without a prescription.
    Fact: This medicine is a prescription drug and should only be taken under medical supervision.
  • Myth: Taking this medicine with alcohol is safe.
    Fact: Alcohol increases the risk of liver damage and stomach bleeding. Avoid alcohol while taking this medicine.

🔄 Alternative Options

Generic Alternatives

  • Nimesulide + Paracetamol (generic)

Brand Alternatives

  • Nise-MD
  • Nimulid-MD
  • Nimesulide-P

📊 Comparison with Similar Medicines

[{"medicine":"Ibuprofen + Paracetamol","difference":"Ibuprofen is a non-selective COX inhibitor, while nimesulide is COX-2 selective. Both are effective for pain and fever."},{"medicine":"Diclofenac + Paracetamol","difference":"Diclofenac is a non-selective NSAID with stronger anti-inflammatory effects but higher GI risk."},{"medicine":"Aceclofenac + Paracetamol","difference":"Aceclofenac is a prodrug of diclofenac with similar efficacy but possibly better GI tolerance."}]

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