angizem dp 60mg capsule - Diltiazem (60mg) medicine

angizem dp 60mg capsule - Uses, Price, Side Effects & Substitutes

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๐Ÿญ Sun Pharmaceutical Industries Ltd ๐Ÿ“ฆ Varies by brand ๐Ÿ’Š Allopathy ๐Ÿ“… Updated: Jun 28, 2026
๐Ÿ“‹ Prescription Required ๐Ÿ’Š Generic Available
Medically Reviewed
SaathiMed Expert Panel | Jun 28, 2026

What is angizem dp 60mg capsule used for?

Angizem CD 90 Capsule ER (Diltiazem) is used to treat CARDIAC. It contains Diltiazem (60mg), which Inhibits calcium influx into cardiac and vascular smooth muscle cells via L-type. Always consult your doctor before use. Take as prescribed.

  • Generic Name: Diltiazem
  • Manufacturer: Sun Pharmaceutical Industries Ltd
  • Form: Allopathy
  • Pregnancy Category: C
  • Prescription Required: Yes
๐Ÿ’ก Did You Know? The first generic medicine was introduced in India in 1970 after the Patents Act was amended.

๐Ÿ’Š angizem dp 60mg capsule Uses & Benefits

Hypertension, chronic stable angina, vasospastic angina, atrial fibrillation/flutter (rate control).

Off-label uses: Migraine prophylaxis, Raynaud's phenomenon, anal fissures (topical), hypertrophic cardiomyopathy.

๐Ÿ“‹ Drug Information

Generic Name(s)Diltiazem
Brand NameAngizem CD 90 Capsule ER
ManufacturerSun Pharmaceutical Industries Ltd
Packaging / FormVaries by brand (Allopathy)
Therapeutic ClassCARDIAC
Action ClassCalcium channel blockers- Nondihydropyridines
Route of AdministrationOral (extended-release capsule)
StorageStore at 20-25ยฐC (68-77ยฐF); protect from light and moisture.
Shelf LifeAs per manufacturer

๐Ÿ”ฌ Pharmacology (PK/PD)

Pharmacokinetics

AbsorptionWell absorbed from gastrointestinal tract; undergoes extensive first-pass metabolism.
DistributionDistributed widely; crosses blood-brain barrier and placenta; appears in breast milk.
Protein Binding70-80%
MetabolismHepatic via CYP3A4; major metabolites: desacetyldiltiazem (active), N-monodesmethyldiltiazem.
Half-Life3-4.5 hours (single dose); may increase with repeated dosing.
ExcretionPrimarily renal (2-4% unchanged); biliary/fecal.
Bioavailability40-50% (due to first-pass effect); extended-release formulation provides sustained levels.
Onset of Action30-60 minutes (extended-release)
Peak Plasma Time6-11 hours (extended-release)
Duration of Action12-24 hours (extended-release)

How It Works

Inhibits calcium influx into cardiac and vascular smooth muscle cells via L-type calcium channels, leading to vasodilation and decreased myocardial contractility.

Mechanism Steps

1Binds to L-type calcium channels on cardiac and vascular smooth muscle cells.
2Blocks calcium influx during depolarization.
3Reduces intracellular calcium concentration.

๐Ÿ’ก How to Take angizem dp 60mg capsule

Follow your doctor's prescription exactly.

โš ๏ธ Side Effects of angizem dp 60mg capsule

โœ… Common Side Effects

  • Dizziness
  • Headache
  • Peripheral edema
  • Bradycardia
  • Constipation
  • Nausea
  • Flushing

๐Ÿšจ Serious Side Effects

  • Severe bradycardia
  • Heart block
  • Congestive heart failure
  • Hepatotoxicity
  • Stevens-Johnson syndrome

โš ๏ธ Rare Side Effects

  • Gingival hyperplasia
  • Gynecomastia
  • Parkinsonism
  • Photosensitivity
  • Leukocytoclastic vasculitis

Consult your doctor if you experience any unusual symptoms.

๐Ÿ”ฌ Drug Interactions

โš ๏ธ DrugSeverityEffect
Beta-blockers Major Increased risk of bradycardia, heart block, and hypotension.
Digoxin Major Increased digoxin levels; risk of toxicity.
Cyclosporine Major Increased cyclosporine levels; monitor levels.
Carbamazepine Major Increased carbamazepine levels; risk of toxicity.
Rifampin Major Decreased diltiazem efficacy.
Statins (simvastatin, lovastatin) Major Increased statin levels; risk of myopathy/rhabdomyolysis.
Cimetidine Moderate Increased diltiazem levels.
Phenytoin Moderate Increased phenytoin levels.
Midazolam Moderate Increased midazolam levels; prolonged sedation.
Theophylline Moderate Increased theophylline levels.
Lithium Moderate Increased lithium levels; risk of toxicity.
Grapefruit juice Minor Increased diltiazem levels.
Calcium supplements Minor May reduce antihypertensive effect.
NSAIDs Minor May reduce antihypertensive effect.

๐Ÿšจ Major Interactions

  • Beta-blockers
  • Digoxin
  • Cyclosporine
  • Carbamazepine
  • Rifampin
  • Statins (simvastatin, lovastatin)

โšก Moderate Interactions

  • Cimetidine
  • Anticonvulsants (phenytoin)
  • Benzodiazepines (midazolam)
  • Theophylline
  • Lithium

โ„น๏ธ Minor Interactions

  • Grapefruit juice
  • Calcium supplements
  • NSAIDs

๐Ÿฝ๏ธ Food Interactions

Grapefruit juice may increase diltiazem levels; avoid high-fat meals with extended-release forms.

๐Ÿท Alcohol Interaction

May enhance hypotensive effect; avoid excessive alcohol.

๐Ÿ›ก๏ธ Safety & Warnings

๐Ÿšซ Contraindications

Sick sinus syndrome (without pacemaker), second- or third-degree AV block (without pacemaker), hypotension (systolic <90 mmHg), acute myocardial infarction with pulmonary congestion, hypersensitivity to diltiazem.

๐Ÿ“Š Monitoring Parameters

Blood pressure, heart rate, ECG (PR interval), liver function tests, renal function.

๐Ÿคฑ Lactation Safety

Limited data; use with caution; appears in breast milk.

๐Ÿ’Š Overdose Management

Activated charcoal, gastric lavage; supportive care: atropine for bradycardia, calcium gluconate, vasopressors for hypotension; temporary pacing for heart block.

โฐ Missed Dose

Take as soon as remembered unless near next dose; do not double dose.

๐Ÿ‘จโ€โš•๏ธ Reviewed by Expert

SaathiMed Expert Panel

MD, PhD - Pharmacology

Reviewed: Jun 28, 2026

๐Ÿ”— View Profile

๐Ÿ”„ Substitutes for angizem dp 60mg capsule

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Alternative brands with exact same active ingredient (Diltiazem (60mg)):

Medical Note: Always consult your doctor before switching medications.

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