angip plus tablet - Nimesulide (NA) + Paracetamol (NA) medicine

Angip Plus Tablet: Complete Guide to Uses, Side Effects, and Safety

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🏭 Gipla Healthcare 📦 Varies by brand 💊 Allopathy 📅 Updated: Oct 22, 2026
⚠️ Hepatotoxicity Risk ⚠️ Nephrotoxicity Risk 📋 Prescription Required 💊 Generic Available
Medically Reviewed
11 min read
Evidence: Moderate for short-term use in acute pain; limited for long-term use due to safety concerns.
Reviewed by
SaathiMed Expert Panel | Oct 22, 2026
🩺
Medically Fact-Checked & Clinically Verified by SaathiMed Clinical Review Board
Clinical Reference Standards: CDSCO (Central Drugs Standard Control Organisation), Indian Pharmacopoeia (IP) & WHO | Last Updated: September 2026

When to Call Your Doctor IMMEDIATELY

  • Yellowing of skin or eyes (jaundice)
  • Dark urine or pale stools
  • Severe abdominal pain or vomiting blood
  • Black tarry stools
  • Swelling of face, lips, or throat
  • Difficulty breathing or chest pain
  • Decreased urine output or swelling in legs
  • Severe headache with stiff neck and fever
  • Unusual bruising or bleeding
  • Persistent nausea and vomiting

If experiencing severe symptoms, call emergency services immediately.

What is angip plus tablet used for?

This medicine is a combination of nimesulide and paracetamol used for short-term relief of acute pain, inflammation, and fever. It works by reducing prostaglandins that cause pain and swelling. It should be taken with food and for no more than 7 days without medical advice.

  • Generic Name: Nimesulide + Paracetamol
  • Manufacturer: Gipla Healthcare
  • Form: Allopathy
  • Pregnancy Category: Consult doctor
  • Prescription Required: Yes

🇮🇳 angip plus tablet के बारे में (Hindi Summary)

उपयोग: यह दवा नाइमेसुलाइड और पैरासिटामोल का संयोजन है, जिसका उपयोग दर्द, सूजन और बुखार से राहत के लिए किया जाता है। यह मांसपेशियों के दर्द, दांत दर्द, सर्जरी के बाद के दर्द, और मासिक धर्म के दर्द में प्रभावी है। यह दवा केवल अल्पकालिक उपयोग के लिए है और इसे खाने के साथ लेना चाहिए।

साइड इफेक्ट्स: इस दवा के सामान्य दुष्प्रभावों में मतली, उल्टी, पेट दर्द, दस्त, चक्कर आना और सिरदर्द शामिल हैं। गंभीर दुष्प्रभावों में लिवर की क्षति, पेट या आंतों में रक्तस्राव, गुर्दे की समस्या, और गंभीर एलर्जी प्रतिक्रिया शामिल हो सकती है। यदि आपको पीलिया, काला मल, खून की उल्टी, या सांस लेने में कठिनाई हो, तो तुरंत डॉक्टर से मिलें।

सुरक्षा सलाह: इस दवा को केवल डॉक्टर के परामर्श से ही लें। इसे खाने के साथ लें ताकि पेट में जलन न हो। इस दवा के साथ शराब का सेवन बिल्कुल न करें। पैरासिटामोल युक्त अन्य दवाओं के साथ इसका सेवन न करें। यदि आपको लिवर, गुर्दे, या पेट की बीमारी है, तो डॉक्टर को बताएं। 7 दिनों से अधिक इसका उपयोग न करें।

💡 Did You Know? India is the largest provider of generic medicines globally, supplying over 50% of global vaccine demand.

💊 angip plus tablet Uses & Benefits

[{"condition":"Acute musculoskeletal pain","description":"Relieves pain and inflammation in muscles, joints, and soft tissues due to sprains, strains, or injuries.","evidence":"Well-established"},{"condition":"Dental pain","description":"Provides short-term relief from toothache and pain after dental procedures.","evidence":"Well-established"},{"condition":"Post-operative pain","description":"Used for short-term management of mild to moderate pain after surgery.","evidence":"Moderate"},{"condition":"Fever with inflammation","description":"Reduces fever and associated body aches in conditions like viral infections or post-vaccination.","evidence":"Moderate"},{"condition":"Primary dysmenorrhea","description":"Relieves menstrual cramps and associated pain.","evidence":"Moderate"}]

Off-label uses: [{"condition":"Migraine","description":"Sometimes used for acute migraine attacks, but not a first-line treatment.","evidence":"Limited"},{"condition":"Osteoarthritis flare-ups","description":"May be used short-term for pain relief during flare-ups, but not for long-term management.","evidence":"Limited"}]

Primary treatment for: Acute pain and inflammation

Also treats: Musculoskeletal pain, Dental pain, Post-operative pain, Fever, Dysmenorrhea

📋 Drug Information

Generic Name(s)Nimesulide + Paracetamol
Brand NameAP 100mg/325mg Tablet
ManufacturerGipla Healthcare
Packaging / FormVaries by brand (Allopathy)
Therapeutic ClassPAIN ANALGESICS
Action ClassNonsteroidal Anti-inflammatory Drug (NSAID) + Analgesic/Antipyretic
Route of AdministrationOral
StorageStore at room temperature between 15°C and 30°C (59°F to 86°F). Keep away from direct sunlight, moisture, and heat. Do not refrigerate unless specified.
Shelf Life24 months from the date of manufacture, or as printed on the packaging.
WHO GuidelineNot established from the available information. The World Health Organization does not recommend nimesulide for children and has raised concerns about its safety profile.
ICMR GuidelineNot established from the available information. The Indian Council of Medical Research has not issued specific guidelines for this combination.

👨‍⚕️ Doctor's Practical Tips

Evidence-based practical advice from experienced clinicians

1
Always take this medicine with food or milk to reduce stomach irritation.
2
Do not exceed the recommended dose or duration of treatment.
3
Avoid alcohol completely while taking this medicine.
4
Do not take other paracetamol-containing products concurrently.
5
Consult your doctor if pain or fever persists beyond 3 days.
6
Report any signs of liver problems (yellowing of eyes, dark urine) immediately.
7
Use the lowest effective dose for the shortest possible time.
8
Inform your doctor if you have a history of stomach ulcers, liver, or kidney disease.

🔍 Is This Medicine Right for Your Symptom?

Educational reference. Always consult a doctor for diagnosis.

✅
Acute musculoskeletal pain
This medicine is commonly prescribed for this.
Likely Use
✅
Dental pain
This medicine can provide short-term relief.
Likely Use
✅
Fever
This medicine has antipyretic properties.
Likely Use
❌
Chronic pain
Not recommended for long-term use due to safety concerns.
Not Primary
❌
Headache
Not a first-line treatment for headache.
Not Primary

🔬 How This Medicine Works (Pharmacology)

Pharmacokinetics

AbsorptionNimesulide is rapidly absorbed from the gastrointestinal tract after oral administration, with peak plasma concentrations reached in 1.5 to 3 hours. Paracetamol is also rapidly and almost completely absorbed from the small intestine, with peak levels within 0.5 to 2 hours. Food may slightly delay absorption but does not significantly reduce the extent of absorption.
DistributionNimesulide is highly bound to plasma proteins and distributes well into tissues, including synovial fluid. Paracetamol distributes widely throughout most body tissues, with a volume of distribution of about 0.9 L/kg.
Protein BindingNimesulide is approximately 99% bound to plasma proteins, mainly albumin. Paracetamol is about 10-25% bound to plasma proteins.
MetabolismNimesulide is extensively metabolized in the liver, primarily by CYP2C9, to several metabolites, including 4-hydroxynimesulide, which is pharmacologically active. Paracetamol is metabolized in the liver by conjugation with glucuronic acid and sulfate, and a small fraction is oxidized by CYP2E1 to a toxic intermediate (NAPQI) that is normally detoxified by glutathione.
Half-LifeThe elimination half-life of nimesulide is approximately 1.8 to 4.7 hours. Paracetamol has a half-life of about 2 to 3 hours in adults.
ExcretionNimesulide metabolites are excreted mainly in urine (about 70%) and feces (about 20%). Paracetamol metabolites are excreted primarily in urine as glucuronide and sulfate conjugates.
BioavailabilityNimesulide has an oral bioavailability of approximately 80-90%. Paracetamol has an oral bioavailability of about 80-100%.
Onset of ActionPain relief typically begins within 30 to 60 minutes after oral administration.
Peak Plasma TimeNimesulide peak plasma concentration occurs at 1.5 to 3 hours; paracetamol peak occurs at 0.5 to 2 hours.
Duration of ActionPain relief lasts approximately 4 to 6 hours, so dosing is usually repeated every 6 to 8 hours as needed.

How It Works

This medicine combines two active ingredients with different mechanisms. Nimesulide is a non-steroidal anti-inflammatory drug that selectively inhibits the cyclooxygenase-2 (COX-2) enzyme, reducing the production of prostaglandins, which are chemicals that cause pain, inflammation, and fever. Paracetamol acts primarily in the central nervous system by inhibiting prostaglandin synthesis and possibly activating descending pain pathways, providing analgesic and antipyretic effects. Together, they provide relief from pain and fever through complementary pathways.

Mechanism Steps

1
COX-2 inhibition by nimesulide: Nimesulide selectively binds to and inhibits the COX-2 enzyme, reducing prostaglandin production at sites of inflammation.
2
Reduced prostaglandin synthesis: Lower prostaglandin levels decrease pain signaling, swelling, and fever.
3
Central analgesic action of paracetamol: Paracetamol acts in the brain and spinal cord to reduce pain perception and lower fever, possibly by inhibiting central prostaglandin synthesis.
4
Combined effect: The two ingredients work together to provide stronger pain and fever relief than either alone.

💡 How to Take angip plus tablet

Strength: Not established from the available information. The product is a tablet containing nimesulide and paracetamol in fixed proportions. Refer to the package insert for exact strengths.

1Take this medicine exactly as prescribed by your doctor.
2Swallow the tablet whole with a glass of water.
3Take it with food or milk to reduce stomach upset.
4Do not crush, chew, or break the tablet unless advised.
5Do not take more than the recommended dose.
6If you miss a dose, follow the missed dose instructions.
7Do not use for more than 7 days without consulting your doctor.

Dosage Information

Adult DosageThe usual adult dose of this medicine is one tablet taken orally every 6 to 8 hours as needed for pain and fever, not exceeding 3 tablets in 24 hours. It should be taken with food or milk to reduce stomach irritation. The dose and duration must be individualized by a qualified clinician based on the indication, age, weight, renal and hepatic function. Do not use for more than 7 days without medical advice.
Pediatric DosagePediatric dosing is not established from available information. This medicine is not recommended for children below 12 years of age. Consult a pediatrician for appropriate alternatives.
Elderly DosageElderly patients (above 65 years) are more sensitive to the side effects of this medicine, especially gastrointestinal bleeding, kidney problems, and liver toxicity. Use the lowest effective dose for the shortest duration. Dose must be individualized by a qualified clinician based on renal and hepatic function.
Renal ImpairmentUse with caution in patients with kidney disease. Dose reduction may be necessary. This medicine is contraindicated in severe kidney disease (eGFR <30 mL/min). Consult a doctor for dose adjustment.
Hepatic ImpairmentUse with caution in patients with liver disease. Dose reduction and close monitoring of liver function are recommended. This medicine is contraindicated in severe liver disease. Consult a doctor for dose adjustment.
Maximum Daily DoseThe maximum recommended daily dose is 3 tablets in 24 hours, but the exact limit depends on the strength and clinical judgment. Do not exceed the dose prescribed by your doctor.

Dosage Timeline

🌅 Morning ❌ ☀️ Afternoon ❌ 🌆 Evening ❌ 🌙 Night ❌

🍽️ Food Timing Guide

With food
Take with meals
Reduces stomach upset and gastrointestinal irritation.
Alcohol
Avoid
Increases risk of liver damage and gastrointestinal bleeding.
Caffeine
Limit
May increase stomach irritation and anxiety.

⏰ What to Do If You Miss a Dose

📌 Less than half the dosing interval has passed
→ Take the missed dose as soon as you remember.
💡 Continue with the regular schedule.
📌 More than half the dosing interval has passed
→ Skip the missed dose.
💡 Do not double dose to catch up.

⚠️ Side Effects of angip plus tablet

✅ Common Side Effects

Nausea (Common (5-10%))
Take with food or milk. If nausea persists, consult your doctor.
Stomach pain or heartburn (Common (5-10%))
Take with meals and avoid spicy foods. If severe, contact your doctor.
Diarrhea (Common (3-5%))
Stay hydrated. If diarrhea persists for more than 2 days, consult your doctor.
Dizziness (Common (3-5%))
Avoid driving or operating machinery until you know how this medicine affects you.
Headache (Common (3-5%))
Rest and stay hydrated. If headache is severe or persistent, consult your doctor.

🚨 Serious Side Effects

Liver injury (hepatotoxicity) (Rare (<0.1%))
Seek immediate medical attention if you notice yellowing of skin or eyes, dark urine, severe fatigue, or right upper abdominal pain.
Gastrointestinal bleeding (Rare (<0.1%))
Seek immediate medical attention if you notice black tarry stools, vomiting blood, or severe abdominal pain.
Severe allergic reaction (anaphylaxis) (Very rare (<0.01%))
Seek emergency help if you experience swelling of face, lips, or throat, difficulty breathing, or widespread rash.
Kidney problems (Rare (<0.1%))
Consult your doctor if you notice decreased urine output, swelling in legs, or fatigue.
Severe skin reactions (Stevens-Johnson syndrome) (Very rare (<0.01%))
Seek immediate medical attention if you develop a painful rash with blisters or peeling skin.

⚠️ Rare Side Effects

Blood disorders (e.g., agranulocytosis, thrombocytopenia)
Report unusual bruising, bleeding, or signs of infection to your doctor immediately.
Pancreatitis
Seek medical attention if you experience severe upper abdominal pain radiating to the back.
Aseptic meningitis
Seek immediate medical help if you develop severe headache, stiff neck, fever, and sensitivity to light.

Consult your doctor if you experience any unusual symptoms.

🔬 Drug Interactions

Drug Severity Effect
Warfarin Major
Other NSAIDs Major
Methotrexate Major
ACE inhibitors Moderate
Diuretics Moderate
Corticosteroids Moderate
SSRIs Moderate
Antacids Minor
Cholestyramine Minor
Alcohol Major

🚨 Major Interactions

  • Warfarin
  • Other NSAIDs (e.g., ibuprofen, diclofenac)
  • Alcohol
  • Methotrexate

⚡ Moderate Interactions

  • ACE inhibitors and ARBs
  • Diuretics (e.g., furosemide)
  • Corticosteroids
  • SSRIs

🍷 Alcohol Interaction

Avoid alcohol while taking this medicine. Alcohol increases the risk of liver damage from paracetamol and nimesulide, and also raises the risk of stomach bleeding. Even moderate drinking can be harmful.

🔎 Check Your Other Medicines

Educational tool. Always confirm with your doctor or pharmacist.

🛡️ Safety & Warnings

🚫 Contraindications

["Known allergy or hypersensitivity to nimesulide, paracetamol, or any component of the formulation.","Active or history of peptic ulcer or gastrointestinal bleeding.","Severe liver disease or active liver disease.","Severe kidney disease (eGFR

⚠️ Warnings & Precautions

["Do not exceed the recommended dose or duration of treatment.","Take with food to minimize stomach upset.","Avoid alcohol while taking this medicine.","Do not use for more than 7 days without medical advice.","Use with caution in the elderly, who are more prone to side effects.","Inform your doctor if you have a history of liver or kidney disease, stomach ulcers, or asthma.","Stop the medicine and seek medical help if you experience signs of liver injury, bleeding, or allergic reaction.","Do not take other paracetamol-containing products concurrently.","This medicine may cause dizziness; avoid driving or operating machinery until you know how it affects you."]

🤱 Lactation Safety

Not established from the available information. Nimesulide and paracetamol may pass into breast milk. This medicine is not recommended during breastfeeding unless clearly needed and advised by a doctor.

💊 Overdose Management

Overdose of this medicine can cause severe liver damage, especially due to paracetamol. Symptoms of overdose may include nausea, vomiting, abdominal pain, confusion, and yellowing of skin or eyes. If you suspect an overdose, seek emergency medical help immediately. Treatment may include activated charcoal, N-acetylcysteine (for paracetamol toxicity), and supportive care. Do not wait for symptoms to appear.

⏰ Missed Dose

If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and continue with your regular schedule. Do not take a double dose to make up for a missed one.

Additional Safety Advice

General Safety

Take this medicine only when prescribed by a doctor, and never exceed the recommended dose or duration. Always take it with food or milk to reduce stomach irritation. Avoid drinking alcohol while taking this medicine because it increases the risk of liver damage and stomach bleeding. Do not take other medicines containing paracetamol without checking with your doctor, as this can lead to an overdose. If you have a history of stomach ulcers, liver disease, kidney disease, or asthma, tell your doctor before taking this medicine. Do not use this medicine for more than 7 days without medical advice. Keep out of reach of children. Store in a cool, dry place away from direct sunlight.

👴 Special Considerations for Elderly

💡 For Patients Above 65

Elderly patients are at higher risk of gastrointestinal bleeding, kidney impairment, and liver toxicity from this medicine. Use the lowest effective dose for the shortest duration. Regular monitoring of kidney and liver function is advised. Avoid concurrent use with other NSAIDs or anticoagulants.

🤰 Pregnancy Planning (TTC)

This medicine is not recommended during pregnancy, especially in the third trimester, as it may harm the fetus. If you are planning pregnancy or are pregnant, consult your doctor for safer alternatives for pain and fever relief.

🏥 Post-Surgery Considerations

This medicine may be used for short-term post-operative pain relief, but only under medical supervision. It should be used with caution after surgery due to the risk of bleeding and kidney problems. Follow your surgeon's instructions carefully.

🦷 Dental Procedures

This medicine can be used for short-term relief of dental pain, including after dental procedures. However, inform your dentist if you are taking this medicine, especially if you are scheduled for oral surgery, as it may increase bleeding risk.

💚 Lifestyle Tips for Better Results

🏃
Maintain a healthy weight to reduce stress on joints and muscles.
🥗
Engage in regular low-impact exercise like walking or swimming.
😴
Practice good posture to prevent musculoskeletal pain.
💧
Include anti-inflammatory foods like fruits, vegetables, and omega-3 fatty acids in your diet.
🧘
Get adequate sleep to help your body recover.
🌞
Stay well hydrated throughout the day.
🚭
Avoid smoking and limit alcohol consumption.

🏋️ Exercise Considerations

While taking this medicine, you may feel dizzy or tired. Avoid strenuous exercise or activities that require alertness until you know how the medicine affects you. If you have pain, gentle stretching and low-impact activities are generally safe, but consult your doctor before starting any new exercise routine.

🥗 Diet Recommendations

Include omega-3 rich foods like fish, flaxseeds, and walnuts.
Reduce intake of processed and fried foods.
Eat plenty of fruits and vegetables rich in antioxidants.
Stay well hydrated by drinking plenty of water.
Avoid alcohol and caffeine in excess.

💼 Impact on Daily Work & Life

This medicine may cause dizziness or drowsiness in some people. Avoid driving or operating heavy machinery until you know how it affects you. It is generally safe to continue desk work, but take regular breaks and stay hydrated. If your job involves physical labor, consult your doctor about modifications.

🛑 When to Stop This Medicine

Stop taking this medicine if your pain or fever resolves, or after the prescribed duration (usually not more than 7 days). If you experience any serious side effects like yellowing of eyes, dark urine, black stools, or severe abdominal pain, stop immediately and seek medical help. Do not stop abruptly if you are on a prescribed regimen without consulting your doctor.

📅 Long-Term Use Effects

Long-term use of this medicine is not recommended due to the risk of serious liver injury, kidney damage, and gastrointestinal bleeding. If long-term use is unavoidable, regular monitoring of liver and kidney function is essential. Consult your doctor if you need pain relief for more than 7 days.

🌿 Non-Medicine Approaches

These can complement medicine but do not replace prescribed treatment.

Physical therapy

Can complement medicine for chronic pain and improve mobility.

Evidence: Well-established
Hot and cold compresses

Can help reduce localized pain and inflammation.

Evidence: Moderate
Acupuncture

May provide pain relief for some individuals.

Evidence: Limited

💉 Vaccination Considerations

💉 If You're Getting Vaccinated

This medicine does not interact with vaccines. However, if you have a fever, consult your doctor before vaccination. It is generally safe to take this medicine after vaccination for fever or pain, but follow your doctor's advice.

📦 Storage Guide

✅ DO

Store at room temperature (15-30°C)

❌ DON'T

Do not refrigerate unless specified

✅ DO

Keep in original container

❌ DON'T

Do not transfer to unmarked containers

✅ DO

Keep away from direct sunlight

❌ DON'T

Do not store in bathroom cabinet

✈️ Traveling with This Medicine

When traveling, carry this medicine in its original packaging with a copy of your prescription. Store it at room temperature and protect it from extreme heat or moisture. If crossing time zones, continue your dosing schedule as prescribed, but do not exceed the maximum daily dose. Check local customs regulations regarding prescription medicines before traveling internationally.

💰 Cost Analysis & Savings

👥 Real Patient Stories

Educational, anonymized scenarios. Individual results may vary.

👤 A 35-year-old man with acute lower back pain
He was prescribed this medicine for short-term relief of back pain. He took it with food as advised and experienced significant relief within 2 days. He stopped the medicine after 5 days as his pain improved and he did not experience any side effects.
💡 Lesson: Short-term use with food is effective and safe for acute pain, but prolonged use should be avoided.
👤 A 50-year-old woman with knee osteoarthritis flare-up
She took this medicine for knee pain but continued it for 3 weeks without consulting her doctor. She developed nausea and fatigue, and blood tests showed elevated liver enzymes. She was advised to stop the medicine immediately and her liver function returned to normal after supportive care.
💡 Lesson: This medicine should not be used for more than 7 days without medical supervision due to the risk of liver damage.

💬 Questions Patients Often Ask

Q: How long does it take to work?

A: This medicine usually starts relieving pain within 30 to 60 minutes after taking it.

Q: How long can I take this medicine?

A: It should not be taken for more than 7 days without medical advice due to the risk of liver and kidney damage.

Q: Can I take this medicine on an empty stomach?

A: It is best taken with food or milk to reduce stomach irritation.

Q: Is this medicine safe for children?

A: It is not recommended for children below 12 years of age.

Q: Can I take this medicine with alcohol?

A: No, alcohol should be avoided as it increases the risk of liver damage and stomach bleeding.

🤔 Common Patient Concerns

💭 These are the concerns patients most commonly raise

  • Can I take this medicine long-term?
  • Will it affect my kidney function?
  • Can I drive after taking this medicine?
  • Does it interact with my blood pressure medicine?
  • What if I miss a dose?
  • Can I drink alcohol while taking this?
  • Is it safe during pregnancy?
  • Can I take it with other painkillers?

🔄 Substitutes for angip plus tablet

View All

Alternative brands with exact same active ingredient:

Medical Note: Always consult your doctor before switching medications.

🛑 Myths vs. Facts

  • Myth: This medicine is safe for long-term use.
    Fact: This medicine is not recommended for long-term use due to the risk of liver and kidney damage.
  • Myth: It is safe to take this medicine on an empty stomach.
    Fact: It should be taken with food to reduce stomach irritation.
  • Myth: This medicine can be taken with alcohol.
    Fact: Alcohol should be avoided as it increases the risk of liver damage and stomach bleeding.
  • Myth: This medicine is safe for children.
    Fact: It is not recommended for children below 12 years of age.

🔄 Alternative Options

Generic Alternatives

  • Nimesulide + Paracetamol tablet (generic)

Brand Alternatives

  • Nise Plus
  • Nimulid Plus
  • Nimesulide Paracetamol Tablet

📊 Comparison with Similar Medicines

[{"medicine":"This medicine (Nimesulide + Paracetamol)","class":"NSAID + Analgesic","main_use":"Acute pain and fever","duration":"Short-term","liver_risk":"High","gi_risk":"Moderate"},{"medicine":"Ibuprofen + Paracetamol","class":"NSAID + Analgesic","main_use":"Pain and fever","duration":"Short-term","liver_risk":"Low","gi_risk":"Moderate"},{"medicine":"Diclofenac + Paracetamol","class":"NSAID + Analgesic","main_use":"Pain and inflammation","duration":"Short-term","liver_risk":"Moderate","gi_risk":"High"}]

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