Angip Plus Tablet: Complete Guide to Uses, Side Effects, and Safety
Clinical Reference Standards: CDSCO (Central Drugs Standard Control Organisation), Indian Pharmacopoeia (IP) & WHO | Last Updated: September 2026
When to Call Your Doctor IMMEDIATELY
- Yellowing of skin or eyes (jaundice)
- Dark urine or pale stools
- Severe abdominal pain or vomiting blood
- Black tarry stools
- Swelling of face, lips, or throat
- Difficulty breathing or chest pain
- Decreased urine output or swelling in legs
- Severe headache with stiff neck and fever
- Unusual bruising or bleeding
- Persistent nausea and vomiting
If experiencing severe symptoms, call emergency services immediately.
What is angip plus tablet used for?
This medicine is a combination of nimesulide and paracetamol used for short-term relief of acute pain, inflammation, and fever. It works by reducing prostaglandins that cause pain and swelling. It should be taken with food and for no more than 7 days without medical advice.
- Generic Name: Nimesulide + Paracetamol
- Manufacturer: Gipla Healthcare
- Form: Allopathy
- Pregnancy Category: Consult doctor
- Prescription Required: Yes
🇮🇳 angip plus tablet के बारे में (Hindi Summary)
उपयोग: यह दवा नाइमेसुलाइड और पैरासिटामोल का संयोजन है, जिसका उपयोग दर्द, सूजन और बुखार से राहत के लिए किया जाता है। यह मांसपेशियों के दर्द, दांत दर्द, सर्जरी के बाद के दर्द, और मासिक धर्म के दर्द में प्रभावी है। यह दवा केवल अल्पकालिक उपयोग के लिए है और इसे खाने के साथ लेना चाहिए।
साइड इफेक्ट्स: इस दवा के सामान्य दुष्प्रभावों में मतली, उल्टी, पेट दर्द, दस्त, चक्कर आना और सिरदर्द शामिल हैं। गंभीर दुष्प्रभावों में लिवर की क्षति, पेट या आंतों में रक्तस्राव, गुर्दे की समस्या, और गंभीर एलर्जी प्रतिक्रिया शामिल हो सकती है। यदि आपको पीलिया, काला मल, खून की उल्टी, या सांस लेने में कठिनाई हो, तो तुरंत डॉक्टर से मिलें।
सुरक्षा सलाह: इस दवा को केवल डॉक्टर के परामर्श से ही लें। इसे खाने के साथ लें ताकि पेट में जलन न हो। इस दवा के साथ शराब का सेवन बिल्कुल न करें। पैरासिटामोल युक्त अन्य दवाओं के साथ इसका सेवन न करें। यदि आपको लिवर, गुर्दे, या पेट की बीमारी है, तो डॉक्टर को बताएं। 7 दिनों से अधिक इसका उपयोग न करें।
💊 angip plus tablet Uses & Benefits
[{"condition":"Acute musculoskeletal pain","description":"Relieves pain and inflammation in muscles, joints, and soft tissues due to sprains, strains, or injuries.","evidence":"Well-established"},{"condition":"Dental pain","description":"Provides short-term relief from toothache and pain after dental procedures.","evidence":"Well-established"},{"condition":"Post-operative pain","description":"Used for short-term management of mild to moderate pain after surgery.","evidence":"Moderate"},{"condition":"Fever with inflammation","description":"Reduces fever and associated body aches in conditions like viral infections or post-vaccination.","evidence":"Moderate"},{"condition":"Primary dysmenorrhea","description":"Relieves menstrual cramps and associated pain.","evidence":"Moderate"}]
Off-label uses: [{"condition":"Migraine","description":"Sometimes used for acute migraine attacks, but not a first-line treatment.","evidence":"Limited"},{"condition":"Osteoarthritis flare-ups","description":"May be used short-term for pain relief during flare-ups, but not for long-term management.","evidence":"Limited"}]
Primary treatment for: Acute pain and inflammation
Also treats: Musculoskeletal pain, Dental pain, Post-operative pain, Fever, Dysmenorrhea
📋 Drug Information
| Generic Name(s) | Nimesulide + Paracetamol |
| Brand Name | AP 100mg/325mg Tablet |
| Manufacturer | Gipla Healthcare |
| Packaging / Form | Varies by brand (Allopathy) |
| Therapeutic Class | PAIN ANALGESICS |
| Action Class | Nonsteroidal Anti-inflammatory Drug (NSAID) + Analgesic/Antipyretic |
| Route of Administration | Oral |
| Storage | Store at room temperature between 15°C and 30°C (59°F to 86°F). Keep away from direct sunlight, moisture, and heat. Do not refrigerate unless specified. |
| Shelf Life | 24 months from the date of manufacture, or as printed on the packaging. |
| WHO Guideline | Not established from the available information. The World Health Organization does not recommend nimesulide for children and has raised concerns about its safety profile. |
| ICMR Guideline | Not established from the available information. The Indian Council of Medical Research has not issued specific guidelines for this combination. |
👨⚕️ Doctor's Practical Tips
Evidence-based practical advice from experienced clinicians
🔍 Is This Medicine Right for Your Symptom?
Educational reference. Always consult a doctor for diagnosis.
🔬 How This Medicine Works (Pharmacology)
Pharmacokinetics
How It Works
This medicine combines two active ingredients with different mechanisms. Nimesulide is a non-steroidal anti-inflammatory drug that selectively inhibits the cyclooxygenase-2 (COX-2) enzyme, reducing the production of prostaglandins, which are chemicals that cause pain, inflammation, and fever. Paracetamol acts primarily in the central nervous system by inhibiting prostaglandin synthesis and possibly activating descending pain pathways, providing analgesic and antipyretic effects. Together, they provide relief from pain and fever through complementary pathways.
Mechanism Steps
💡 How to Take angip plus tablet
Strength: Not established from the available information. The product is a tablet containing nimesulide and paracetamol in fixed proportions. Refer to the package insert for exact strengths.
Dosage Information
| Adult Dosage | The usual adult dose of this medicine is one tablet taken orally every 6 to 8 hours as needed for pain and fever, not exceeding 3 tablets in 24 hours. It should be taken with food or milk to reduce stomach irritation. The dose and duration must be individualized by a qualified clinician based on the indication, age, weight, renal and hepatic function. Do not use for more than 7 days without medical advice. |
| Pediatric Dosage | Pediatric dosing is not established from available information. This medicine is not recommended for children below 12 years of age. Consult a pediatrician for appropriate alternatives. |
| Elderly Dosage | Elderly patients (above 65 years) are more sensitive to the side effects of this medicine, especially gastrointestinal bleeding, kidney problems, and liver toxicity. Use the lowest effective dose for the shortest duration. Dose must be individualized by a qualified clinician based on renal and hepatic function. |
| Renal Impairment | Use with caution in patients with kidney disease. Dose reduction may be necessary. This medicine is contraindicated in severe kidney disease (eGFR <30 mL/min). Consult a doctor for dose adjustment. |
| Hepatic Impairment | Use with caution in patients with liver disease. Dose reduction and close monitoring of liver function are recommended. This medicine is contraindicated in severe liver disease. Consult a doctor for dose adjustment. |
| Maximum Daily Dose | The maximum recommended daily dose is 3 tablets in 24 hours, but the exact limit depends on the strength and clinical judgment. Do not exceed the dose prescribed by your doctor. |
Dosage Timeline
🍽️ Food Timing Guide
⏰ What to Do If You Miss a Dose
⚠️ Side Effects of angip plus tablet
✅ Common Side Effects
🚨 Serious Side Effects
⚠️ Rare Side Effects
Consult your doctor if you experience any unusual symptoms.
🔬 Drug Interactions
| Drug | Severity | Effect |
|---|---|---|
| Warfarin | Major | |
| Other NSAIDs | Major | |
| Methotrexate | Major | |
| ACE inhibitors | Moderate | |
| Diuretics | Moderate | |
| Corticosteroids | Moderate | |
| SSRIs | Moderate | |
| Antacids | Minor | |
| Cholestyramine | Minor | |
| Alcohol | Major |
🚨 Major Interactions
- Warfarin
- Other NSAIDs (e.g., ibuprofen, diclofenac)
- Alcohol
- Methotrexate
⚡ Moderate Interactions
- ACE inhibitors and ARBs
- Diuretics (e.g., furosemide)
- Corticosteroids
- SSRIs
🍷 Alcohol Interaction
Avoid alcohol while taking this medicine. Alcohol increases the risk of liver damage from paracetamol and nimesulide, and also raises the risk of stomach bleeding. Even moderate drinking can be harmful.
🔎 Check Your Other Medicines
Educational tool. Always confirm with your doctor or pharmacist.
🛡️ Safety & Warnings
🚫 Contraindications
["Known allergy or hypersensitivity to nimesulide, paracetamol, or any component of the formulation.","Active or history of peptic ulcer or gastrointestinal bleeding.","Severe liver disease or active liver disease.","Severe kidney disease (eGFR
⚠️ Warnings & Precautions
["Do not exceed the recommended dose or duration of treatment.","Take with food to minimize stomach upset.","Avoid alcohol while taking this medicine.","Do not use for more than 7 days without medical advice.","Use with caution in the elderly, who are more prone to side effects.","Inform your doctor if you have a history of liver or kidney disease, stomach ulcers, or asthma.","Stop the medicine and seek medical help if you experience signs of liver injury, bleeding, or allergic reaction.","Do not take other paracetamol-containing products concurrently.","This medicine may cause dizziness; avoid driving or operating machinery until you know how it affects you."]
🤱 Lactation Safety
Not established from the available information. Nimesulide and paracetamol may pass into breast milk. This medicine is not recommended during breastfeeding unless clearly needed and advised by a doctor.
💊 Overdose Management
Overdose of this medicine can cause severe liver damage, especially due to paracetamol. Symptoms of overdose may include nausea, vomiting, abdominal pain, confusion, and yellowing of skin or eyes. If you suspect an overdose, seek emergency medical help immediately. Treatment may include activated charcoal, N-acetylcysteine (for paracetamol toxicity), and supportive care. Do not wait for symptoms to appear.
⏰ Missed Dose
If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and continue with your regular schedule. Do not take a double dose to make up for a missed one.
Additional Safety Advice
Take this medicine only when prescribed by a doctor, and never exceed the recommended dose or duration. Always take it with food or milk to reduce stomach irritation. Avoid drinking alcohol while taking this medicine because it increases the risk of liver damage and stomach bleeding. Do not take other medicines containing paracetamol without checking with your doctor, as this can lead to an overdose. If you have a history of stomach ulcers, liver disease, kidney disease, or asthma, tell your doctor before taking this medicine. Do not use this medicine for more than 7 days without medical advice. Keep out of reach of children. Store in a cool, dry place away from direct sunlight.
👴 Special Considerations for Elderly
💡 For Patients Above 65
Elderly patients are at higher risk of gastrointestinal bleeding, kidney impairment, and liver toxicity from this medicine. Use the lowest effective dose for the shortest duration. Regular monitoring of kidney and liver function is advised. Avoid concurrent use with other NSAIDs or anticoagulants.
🤰 Pregnancy Planning (TTC)
This medicine is not recommended during pregnancy, especially in the third trimester, as it may harm the fetus. If you are planning pregnancy or are pregnant, consult your doctor for safer alternatives for pain and fever relief.
🏥 Post-Surgery Considerations
This medicine may be used for short-term post-operative pain relief, but only under medical supervision. It should be used with caution after surgery due to the risk of bleeding and kidney problems. Follow your surgeon's instructions carefully.
🦷 Dental Procedures
This medicine can be used for short-term relief of dental pain, including after dental procedures. However, inform your dentist if you are taking this medicine, especially if you are scheduled for oral surgery, as it may increase bleeding risk.
💚 Lifestyle Tips for Better Results
🏋️ Exercise Considerations
While taking this medicine, you may feel dizzy or tired. Avoid strenuous exercise or activities that require alertness until you know how the medicine affects you. If you have pain, gentle stretching and low-impact activities are generally safe, but consult your doctor before starting any new exercise routine.
🥗 Diet Recommendations
💼 Impact on Daily Work & Life
This medicine may cause dizziness or drowsiness in some people. Avoid driving or operating heavy machinery until you know how it affects you. It is generally safe to continue desk work, but take regular breaks and stay hydrated. If your job involves physical labor, consult your doctor about modifications.
🛑 When to Stop This Medicine
Stop taking this medicine if your pain or fever resolves, or after the prescribed duration (usually not more than 7 days). If you experience any serious side effects like yellowing of eyes, dark urine, black stools, or severe abdominal pain, stop immediately and seek medical help. Do not stop abruptly if you are on a prescribed regimen without consulting your doctor.
📅 Long-Term Use Effects
Long-term use of this medicine is not recommended due to the risk of serious liver injury, kidney damage, and gastrointestinal bleeding. If long-term use is unavoidable, regular monitoring of liver and kidney function is essential. Consult your doctor if you need pain relief for more than 7 days.
🌿 Non-Medicine Approaches
These can complement medicine but do not replace prescribed treatment.
Can complement medicine for chronic pain and improve mobility.
Evidence: Well-establishedCan help reduce localized pain and inflammation.
Evidence: ModerateMay provide pain relief for some individuals.
Evidence: Limited💉 Vaccination Considerations
💉 If You're Getting Vaccinated
This medicine does not interact with vaccines. However, if you have a fever, consult your doctor before vaccination. It is generally safe to take this medicine after vaccination for fever or pain, but follow your doctor's advice.
📦 Storage Guide
✅ DO
Store at room temperature (15-30°C)
❌ DON'T
Do not refrigerate unless specified
✅ DO
Keep in original container
❌ DON'T
Do not transfer to unmarked containers
✅ DO
Keep away from direct sunlight
❌ DON'T
Do not store in bathroom cabinet
✈️ Traveling with This Medicine
When traveling, carry this medicine in its original packaging with a copy of your prescription. Store it at room temperature and protect it from extreme heat or moisture. If crossing time zones, continue your dosing schedule as prescribed, but do not exceed the maximum daily dose. Check local customs regulations regarding prescription medicines before traveling internationally.
💰 Cost Analysis & Savings
👥 Real Patient Stories
Educational, anonymized scenarios. Individual results may vary.
💬 Questions Patients Often Ask
A: This medicine usually starts relieving pain within 30 to 60 minutes after taking it.
A: It should not be taken for more than 7 days without medical advice due to the risk of liver and kidney damage.
A: It is best taken with food or milk to reduce stomach irritation.
A: It is not recommended for children below 12 years of age.
A: No, alcohol should be avoided as it increases the risk of liver damage and stomach bleeding.
🤔 Common Patient Concerns
🔄 Substitutes for angip plus tablet
View AllAlternative brands with exact same active ingredient:
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numic plus tabletSymbiotic Drugs ₹3.49 89.6% CHEAPER
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ransulide plus tabletSun Pharmaceutical Industries Ltd ₹5.13 84.7% CHEAPER
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Ransulide Plus SyrupSun Pharmaceutical Industries Ltd ₹9.47 71.8% CHEAPER
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nimisun plus suspensionBaksun Healthcare Pvt Ltd ₹26.34 21.7% CHEAPER
-
i nid p tabletIatros Pharmaceuticals Pvt Ltd ₹26.78 20.3% CHEAPER
Medical Note: Always consult your doctor before switching medications.
🛑 Myths vs. Facts
- Myth: This medicine is safe for long-term use.
Fact: This medicine is not recommended for long-term use due to the risk of liver and kidney damage. - Myth: It is safe to take this medicine on an empty stomach.
Fact: It should be taken with food to reduce stomach irritation. - Myth: This medicine can be taken with alcohol.
Fact: Alcohol should be avoided as it increases the risk of liver damage and stomach bleeding. - Myth: This medicine is safe for children.
Fact: It is not recommended for children below 12 years of age.
🔄 Alternative Options
Generic Alternatives
- Nimesulide + Paracetamol tablet (generic)
Brand Alternatives
- Nise Plus
- Nimulid Plus
- Nimesulide Paracetamol Tablet