Anafil 600mg Tablet (Quinine): Complete Medicine Guide
Clinical Reference Standards: CDSCO (Central Drugs Standard Control Organisation), Indian Pharmacopoeia (IP) & WHO | Last Updated: September 2026
When to Call Your Doctor IMMEDIATELY
- Blood in stool or vomit
- Severe abdominal pain
- Chest pain or palpitations
- Sudden vision loss or blurred vision
- Severe dizziness or fainting
- Dark red or black urine
- Yellowing of skin or eyes
- Signs of low blood sugar such as shakiness, sweating, confusion
If experiencing severe symptoms, call emergency services immediately.
What is anafil 600mg tablet used for?
This medicine contains quinine 600 mg, an antimalarial used to treat malaria. It works by killing the malaria parasite in the blood. It is also sometimes used for leg cramps but is not recommended for routine use due to side effects.
- Generic Name: Quinine (600mg)
- Manufacturer: Vance Health Pharmaceuticals Ltd
- Form: Allopathy
- Pregnancy Category: Consult doctor
- Prescription Required: Yes
🇮🇳 anafil 600mg tablet के बारे में (Hindi Summary)
उपयोग: यह दवा क्विनाइन 600 मिलीग्राम की गोली है, जिसका उपयोग मलेरिया के इलाज के लिए किया जाता है। यह मलेरिया परजीवी को खून में मारती है। यह पैरों की ऐंठन के लिए भी कभी-कभी दी जाती है, लेकिन इसके दुष्प्रभावों के कारण इसका नियमित उपयोग नहीं किया जाता।
साइड इफेक्ट्स: इस दवा के सामान्य दुष्प्रभावों में जी मिचलाना, सिरदर्द, कान में घंटी बजना, चक्कर आना और धुंधली दृष्टि शामिल हैं। गंभीर दुष्प्रभावों में खून में शर्करा की कमी, दिल की धड़कन में गड़बड़ी, और खून की बीमारियाँ हो सकती हैं। यदि आपको असामान्य रक्तस्राव, पीलिया, या गंभीर चक्कर आए तो तुरंत डॉक्टर से मिलें।
सुरक्षा सलाह: इस दवा को डॉक्टर के बताए अनुसार ही लें। इसे भोजन के साथ लें ताकि पेट की परेशानी कम हो। शराब का सेवन न करें। यदि आपको चक्कर आते हैं या धुंधला दिखता है तो वाहन न चलाएँ। अपने डॉक्टर को अन्य सभी दवाओं के बारे में बताएं। गर्भवती या स्तनपान कराने वाली महिलाएं डॉक्टर से सलाह लें। दवा को बच्चों से दूर रखें।
💊 anafil 600mg tablet Uses & Benefits
- [{"condition":"Uncomplicated malaria due to Plasmodium falciparum","description":"This medicine is used to treat acute malaria infections caused by Plasmodium falciparum, especially in areas where the parasite is resistant to other antimalarials.
- It rapidly reduces fever and parasite load.","evidence":"Well-established"},{"condition":"Malaria due to other Plasmodium species","description":"It is also effective against Plasmodium vivax, Plasmodium ovale, and Plasmodium malariae, although other medicines may be preferred for some species.","evidence":"Well-established"},{"condition":"Nocturnal leg cramps","description":"Sometimes prescribed for severe nocturnal leg cramps when other treatments have failed, but this use is limited due to side effects.","evidence":"Limited"}]
Off-label uses: [{"condition":"Myotonia congenita","description":"Quinine has been used off-label to reduce muscle stiffness in myotonia congenita, but it is not a first-line treatment.","evidence":"Limited"},{"condition":"Babesiosis","description":"In combination with other antimicrobials, quinine has been used off-label to treat babesiosis, a tick-borne parasitic infection.","evidence":"Limited"}]
Primary treatment for: Malaria
Also treats: Nocturnal leg cramps, Babesiosis
📋 Drug Information
| Generic Name(s) | Quinine (600mg) |
| Brand Name | anafil 600mg tablet |
| Manufacturer | Vance Health Pharmaceuticals Ltd |
| Packaging / Form | Varies by brand (Allopathy) |
| Therapeutic Class | ANTI MALARIALS |
| Action Class | Antimalarial- others |
| Route of Administration | Oral |
| Storage | Store at room temperature (15-30°C) in a dry place, away from direct sunlight and moisture. Keep in the original container. |
| Shelf Life | 24 months from the date of manufacture. |
| WHO Guideline | The World Health Organization recommends quinine as an alternative treatment for uncomplicated malaria in specific situations, such as in the first trimester of pregnancy or when artemisinin-based combination therapies are not available. It is also recommended for severe malaria when artesunate is not available. |
| ICMR Guideline | The Indian Council of Medical Research guidelines recommend quinine for the treatment of severe malaria and as an alternative for uncomplicated malaria in certain cases, in line with national malaria treatment protocols. |
👨⚕️ Doctor's Practical Tips
Evidence-based practical advice from experienced clinicians
🔍 Is This Medicine Right for Your Symptom?
Educational reference. Always consult a doctor for diagnosis.
🔬 How This Medicine Works (Pharmacology)
Pharmacokinetics
How It Works
Quinine is a blood schizonticide that accumulates in the acidic food vacuole of the malaria parasite. It interferes with the parasite's ability to polymerize toxic heme into inert hemozoin, leading to the accumulation of free heme which damages the parasite's membranes and kills it. It also has mild analgesic and muscle relaxant properties that may help in leg cramps.
Mechanism Steps
💡 How to Take anafil 600mg tablet
Strength: 600 mg immediate-release tablet.
Dosage Information
| Adult Dosage | The usual adult dose for uncomplicated malaria is 600 mg every 8 hours for 7 days, often combined with doxycycline or clindamycin. For nocturnal leg cramps, a lower dose may be used, but this is rarely recommended. Dose must be individualized by a qualified clinician based on indication, age, weight, renal and hepatic function. |
| Pediatric Dosage | Pediatric dosing is not established from available information. Consult a pediatrician. |
| Elderly Dosage | Elderly patients may be more sensitive to the effects of quinine, especially cardiac and hypoglycemic effects. Dose should be individualized by a clinician, and renal function should be monitored. |
| Renal Impairment | In patients with renal impairment, dose reduction may be necessary. Monitor renal function and adjust dose accordingly under medical supervision. |
| Hepatic Impairment | In patients with hepatic impairment, quinine metabolism may be reduced. Dose adjustment may be required. Consult a clinician. |
| Maximum Daily Dose | The maximum daily dose is typically 1800 mg for adults, but this must be determined by a clinician based on the indication and patient factors. |
Dosage Timeline
🍽️ Food Timing Guide
⏰ What to Do If You Miss a Dose
⚠️ Side Effects of anafil 600mg tablet
✅ Common Side Effects
🚨 Serious Side Effects
⚠️ Rare Side Effects
Consult your doctor if you experience any unusual symptoms.
🔬 Drug Interactions
| Drug | Severity | Effect |
|---|---|---|
| Warfarin | Major | |
| Digoxin | Major | |
| Amiodarone | Major | |
| Mefloquine | Major | |
| Cimetidine | Moderate | |
| Rifampicin | Moderate | |
| Antacids | Moderate | |
| Grapefruit juice | Moderate | |
| Alcohol | Moderate | |
| Paracetamol | Minor |
🚨 Major Interactions
- Warfarin
- Digoxin
- Amiodarone
- Mefloquine
⚡ Moderate Interactions
- Cimetidine
- Rifampicin
- Antacids
🍷 Alcohol Interaction
Alcohol should be avoided while taking this medicine because it can increase the risk of low blood sugar, dizziness, and stomach irritation. It may also worsen liver toxicity.
🔎 Check Your Other Medicines
Educational tool. Always confirm with your doctor or pharmacist.
🛡️ Safety & Warnings
🚫 Contraindications
["Known hypersensitivity to quinine or related compounds.","Glucose-6-phosphate dehydrogenase (G6PD) deficiency.","Optic neuritis.","History of blackwater fever.","Long QT syndrome.","Myasthenia gravis."]
⚠️ Warnings & Precautions
["Use with caution in patients with atrial fibrillation or other cardiac arrhythmias.","May cause hypoglycemia; monitor blood sugar closely, especially in diabetics.","Avoid in patients with a history of thrombocytopenia or hemolytic anemia.","Do not use for nocturnal leg cramps unless other measures have failed.","May impair ability to drive or operate machinery; avoid until you know how it affects you.","Inform your doctor if you are pregnant, planning pregnancy, or breastfeeding."]
🤱 Lactation Safety
Quinine is excreted in breast milk in small amounts. It is generally considered safe during breastfeeding, but consult your doctor as infant monitoring may be needed.
💊 Overdose Management
Overdose of quinine can cause severe cinchonism, cardiac arrhythmias, blindness, and death. Treatment is supportive and symptomatic. Activated charcoal may be given if the patient presents early. For severe cases, hemodialysis or exchange transfusion may be considered. Seek immediate medical attention.
⏰ Missed Dose
If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and continue with your regular schedule. Do not take a double dose to make up for a missed one.
Additional Safety Advice
Take this medicine exactly as prescribed by your doctor. Do not take more or less than the recommended dose. Swallow the tablet whole with a full glass of water, and take it with food to reduce stomach upset. Avoid alcohol while taking this medicine because it can increase the risk of low blood sugar and stomach irritation. Do not drive or operate heavy machinery if you feel dizzy or have blurred vision. Inform your doctor about all other medicines you are taking, especially blood thinners, diabetes medicines, and heart rhythm drugs. If you are pregnant or breastfeeding, consult your doctor before taking this medicine. Keep this medicine out of the reach of children. Store it at room temperature away from moisture and direct sunlight. Do not use it after the expiry date. If you miss a dose, take it as soon as you remember unless it is almost time for the next dose; do not double the dose. Complete the full course even if you feel better, to prevent the infection from returning.
👴 Special Considerations for Elderly
💡 For Patients Above 65
Elderly patients are more prone to side effects such as dizziness, low blood sugar, and heart rhythm problems. Close monitoring is advised.
🤰 Pregnancy Planning (TTC)
If you are planning pregnancy, consult your doctor before taking this medicine. Quinine is generally considered safe for treating malaria in pregnancy when needed, but it should be used under medical supervision.
🏥 Post-Surgery Considerations
Inform your surgeon and anesthesiologist if you are taking this medicine, as it can affect heart rhythm and blood sugar levels during surgery.
🦷 Dental Procedures
Inform your dentist if you are taking this medicine, as it may interact with certain medications used in dental procedures.
💚 Lifestyle Tips for Better Results
🏋️ Exercise Considerations
Avoid strenuous exercise while taking this medicine, especially if you feel dizzy or weak. Light activity is fine if you feel up to it.
🥗 Diet Recommendations
💼 Impact on Daily Work & Life
This medicine may cause dizziness and blurred vision, which can affect your ability to drive or operate machinery. Avoid these activities until you know how the medicine affects you. Take rest as needed.
🛑 When to Stop This Medicine
Do not stop this medicine without consulting your doctor. Complete the full prescribed course. If you experience serious side effects, contact your doctor immediately; they may advise you to stop.
📅 Long-Term Use Effects
Long-term use of this medicine is not recommended unless under strict medical supervision. Prolonged use can increase the risk of blood disorders, heart rhythm problems, and vision changes. Regular monitoring of blood counts, liver and kidney function, and ECG may be required.
🌿 Non-Medicine Approaches
These can complement medicine but do not replace prescribed treatment.
First-line treatment for uncomplicated malaria in many regions.
Evidence: Well-establishedUsing mosquito nets, repellents, and prophylactic medicines can prevent malaria.
Evidence: Well-established💉 Vaccination Considerations
💉 If You're Getting Vaccinated
There is no specific interaction between this medicine and vaccines. However, if you are due for a vaccine, inform your doctor that you are taking this medicine.
📦 Storage Guide
✅ DO
Store at room temperature (15-30°C)
❌ DON'T
Do not refrigerate unless specified
✅ DO
Keep in original container
❌ DON'T
Do not transfer to unmarked containers
✅ DO
Keep away from direct sunlight
❌ DON'T
Do not store in bathroom cabinet
✈️ Traveling with This Medicine
When traveling, carry this medicine in its original packaging with a copy of your prescription. Keep it in your carry-on luggage to avoid loss. Store it at room temperature and protect it from moisture. If crossing time zones, adjust dosing times gradually under medical advice. Check local customs regulations regarding prescription medicines.
💰 Cost Analysis & Savings
👥 Real Patient Stories
Educational, anonymized scenarios. Individual results may vary.
💬 Questions Patients Often Ask
A: Fever usually starts to reduce within 24-48 hours, but you must complete the full course.
A: Yes, take it with food to reduce stomach upset.
A: Take it as soon as you remember, but if it's almost time for the next dose, skip it and continue your schedule.
🤔 Common Patient Concerns
🔄 Substitutes for anafil 600mg tablet
View AllAlternative brands with exact same active ingredient:
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nine 600mg injectionSkymax Laboratories Pvt Ltd ₹15.87 85% CHEAPER
-
Rubiquin 600mg InjectionPCI Pharmaceuticals ₹18.00 83% CHEAPER
-
Falciquin 600mg InjectionTheta Lab Pvt Ltd ₹20.50 80.6% CHEAPER
-
pbquin 600mg injectionP & B Pharmaceuticals Ltd ₹21.16 80% CHEAPER
-
qinet 600mg injectionBennet Pharmaceuticals Limited ₹22.41 78.8% CHEAPER
Medical Note: Always consult your doctor before switching medications.
🛑 Myths vs. Facts
- Myth: Quinine is a safe treatment for leg cramps.
Fact: Quinine is not recommended for routine treatment of leg cramps due to serious side effects. It should only be used when other treatments fail and under medical supervision. - Myth: You can stop taking quinine once you feel better.
Fact: You must complete the full course of treatment to ensure the parasite is completely cleared and to prevent recurrence. - Myth: Quinine can be taken without a prescription.
Fact: Quinine is a prescription medicine and should only be taken under a doctor's supervision.
🔄 Alternative Options
Generic Alternatives
- Quinine sulfate 600 mg tablet
Brand Alternatives
- Anafil 600mg Tablet