Ampi-S 1500mg Injection: Complete Medicine Guide
Clinical Reference Standards: CDSCO (Central Drugs Standard Control Organisation), Indian Pharmacopoeia (IP) & WHO | Last Updated: September 2026
When to Call Your Doctor IMMEDIATELY
- Difficulty breathing or swelling of face, lips, or throat
- Severe diarrhea with blood or mucus
- Rash with blistering or peeling skin
- Seizures or convulsions
- Decreased urine output or swelling in legs
- Yellowing of eyes or skin
- Unusual bleeding or bruising
If experiencing severe symptoms, call emergency services immediately.
What is ampi-s 1500mg injection used for?
This medicine is a combination antibiotic injection containing Ampicillin and Sulbactam. It is used to treat serious bacterial infections in hospitals. It works by killing bacteria and preventing their growth. It must be given by a healthcare professional.
- Generic Name: Ampicillin (1000mg) + Sulbactam (500mg)
- Manufacturer: Dote Health Care
- Form: Allopathy
- Pregnancy Category: Consult doctor
- Prescription Required: Yes
🇮🇳 ampi-s 1500mg injection के बारे में (Hindi Summary)
उपयोग: यह दवा एम्पीसिलिन और सल्बैक्टम का संयोजन है, जिसका उपयोग गंभीर जीवाणु संक्रमणों के इलाज के लिए किया जाता है। यह अस्पताल में डॉक्टर द्वारा इंजेक्शन के रूप में दी जाती है। यह पेट, त्वचा, स्त्री रोग और फेफड़ों के संक्रमण में प्रभावी है। यह वायरल संक्रमण जैसे सर्दी-जुकाम के लिए प्रभावी नहीं है।
साइड इफेक्ट्स: आम दुष्प्रभावों में इंजेक्शन स्थल पर दर्द, दस्त, मतली, उल्टी, और त्वचा पर चकत्ते शामिल हैं। गंभीर दुष्प्रभावों में एलर्जी, गंभीर दस्त, और त्वचा की गंभीर प्रतिक्रियाएं शामिल हो सकती हैं। किसी भी असामान्य लक्षण को तुरंत डॉक्टर को बताएं।
सुरक्षा सलाह: यह दवा केवल योग्य स्वास्थ्य पेशेवर द्वारा ही दी जानी चाहिए। उपयोग से पहले अपनी सभी एलर्जी, विशेषकर पेनिसिलिन या सेफलोस्पोरिन से, डॉक्टर को बताएं। गुर्दे या यकृत की समस्या हो तो सूचित करें। कोर्स पूरा करें। दस्त, चकत्ते या सांस लेने में कठिनाई हो तो तुरंत डॉक्टर से मिलें। गर्भावस्था या स्तनपान के दौरान डॉक्टर से सलाह लें।
💊 ampi-s 1500mg injection Uses & Benefits
[{"condition":"Intra-abdominal infections","description":"Used for infections such as peritonitis, appendicitis with rupture, and intra-abdominal abscesses caused by susceptible bacteria.","evidence":"Well-established"},{"condition":"Skin and soft tissue infections","description":"Treats cellulitis, wound infections, and abscesses caused by susceptible organisms.","evidence":"Well-established"},{"condition":"Gynecological infections","description":"Used for pelvic inflammatory disease, endometritis, and other pelvic infections.","evidence":"Well-established"},{"condition":"Pneumonia","description":"Treats community-acquired and hospital-acquired pneumonia caused by susceptible bacteria.","evidence":"Well-established"},{"condition":"Bone and joint infections","description":"May be used for osteomyelitis and septic arthritis caused by susceptible organisms.","evidence":"Moderate"}]
Off-label uses: [{"condition":"Meningitis","description":"Sometimes used for bacterial meningitis when susceptible organisms are confirmed, but not a first-line choice.","evidence":"Limited"},{"condition":"Endocarditis","description":"May be used in combination therapy for certain cases of infective endocarditis.","evidence":"Limited"}]
Primary treatment for: Bacterial infections
Also treats: Intra-abdominal infections, Skin and soft tissue infections, Gynecological infections, Pneumonia
📋 Drug Information
| Generic Name(s) | Ampicillin (1000mg) + Sulbactam (500mg) |
| Brand Name | ampi-s 1500mg injection |
| Manufacturer | Dote Health Care |
| Packaging / Form | Varies by brand (Allopathy) |
| Therapeutic Class | ANTI INFECTIVES |
| Action Class | |
| Route of Administration | Parenteral (intravenous or intramuscular injection) |
| Storage | Store the unreconstituted powder at room temperature (15-30°C) in a dry place, protected from light. After reconstitution, the solution should be used immediately or stored as per the manufacturer's instructions, typically refrigerated and used within 24 hours. |
| Shelf Life | The shelf life of the unreconstituted powder is typically 24 months from the date of manufacture. Check the expiry date on the packaging. |
| WHO Guideline | Not established from the available information. |
| ICMR Guideline | Not established from the available information. |
👨⚕️ Doctor's Practical Tips
Evidence-based practical advice from experienced clinicians
🔍 Is This Medicine Right for Your Symptom?
Educational reference. Always consult a doctor for diagnosis.
🔬 How This Medicine Works (Pharmacology)
Pharmacokinetics
How It Works
Ampicillin works by binding to penicillin-binding proteins (PBPs) on the bacterial cell wall, inhibiting the cross-linking of peptidoglycan and causing bacterial cell lysis. Sulbactam is a beta-lactamase inhibitor that irreversibly binds to certain beta-lactamase enzymes produced by bacteria, preventing them from hydrolyzing Ampicillin. This combination extends the spectrum of Ampicillin to include beta-lactamase-producing strains of Staphylococcus aureus, Escherichia coli, Klebsiella species, and Bacteroides fragilis.
Mechanism Steps
💡 How to Take ampi-s 1500mg injection
Strength: Each vial contains Ampicillin 1000mg and Sulbactam 500mg as a sterile powder for reconstitution.
Dosage Information
| Adult Dosage | The usual adult dose of this medicine is 1.5 g to 3 g (Ampicillin 1 g to 2 g plus Sulbactam 0.5 g to 1 g) administered intravenously or intramuscularly every 6 to 8 hours. For severe infections, the dose may be increased. The exact dose and duration must be individualized by a qualified clinician based on the type and severity of infection, renal function, and other patient factors. Do not self-administer. |
| Pediatric Dosage | Pediatric dosing is not established from available information. Consult a pediatrician for appropriate dosing in children. |
| Elderly Dosage | Elderly patients may have reduced renal function, which can increase the risk of side effects. Dose adjustment based on renal function is recommended. Monitor renal function closely. |
| Renal Impairment | In patients with renal impairment, the dose and/or dosing interval should be adjusted based on creatinine clearance. For creatinine clearance less than 30 mL/min, the dosing interval may be extended. Consult a clinician for specific adjustments. |
| Hepatic Impairment | No specific dosage adjustment is established for hepatic impairment, but caution is advised. Monitor liver function. |
| Maximum Daily Dose | The maximum recommended daily dose is 12 g (Ampicillin 8 g plus Sulbactam 4 g) for adults with normal renal function. Doses above this are not recommended. |
Dosage Timeline
🍽️ Food Timing Guide
⏰ What to Do If You Miss a Dose
⚠️ Side Effects of ampi-s 1500mg injection
✅ Common Side Effects
🚨 Serious Side Effects
⚠️ Rare Side Effects
Consult your doctor if you experience any unusual symptoms.
🔬 Drug Interactions
| Drug | Severity | Effect |
|---|---|---|
| Warfarin | Major | |
| Methotrexate | Major | |
| Allopurinol | Major | |
| Probenecid | Major | |
| Oral contraceptives | Moderate | |
| Aminoglycosides | Moderate | |
| Tetracyclines | Moderate | |
| Chloramphenicol | Minor | |
| Sulfonamides | Minor | |
| Alcohol | Moderate |
🚨 Major Interactions
- Warfarin
- Methotrexate
- Allopurinol
- Probenecid
⚡ Moderate Interactions
- Oral contraceptives
- Aminoglycosides
- Tetracyclines
🍷 Alcohol Interaction
Alcohol may worsen liver-related side effects and increase the risk of gastrointestinal irritation. It is advisable to avoid alcohol during treatment with this medicine.
🔎 Check Your Other Medicines
Educational tool. Always confirm with your doctor or pharmacist.
🛡️ Safety & Warnings
🚫 Contraindications
["Known severe allergy to penicillins, cephalosporins, or beta-lactam antibiotics","Previous anaphylactic reaction to any beta-lactam antibiotic","Known allergy to Sulbactam or any component of the formulation"]
⚠️ Warnings & Precautions
["Serious and occasionally fatal hypersensitivity reactions can occur. Before therapy, inquire about previous hypersensitivity to penicillins, cephalosporins, or other allergens.","Clostridioides difficile-associated diarrhea may occur. If diarrhea develops, evaluate for this condition.","Use with caution in patients with renal impairment. Dose adjustment may be needed.","Prolonged use may result in overgrowth of non-susceptible organisms, including fungi.","May interfere with certain laboratory tests, such as urine glucose tests and direct Coombs test.","Not effective against viral infections. Do not use for colds or flu."]
🤱 Lactation Safety
Ampicillin and Sulbactam are excreted in small amounts in breast milk. Use with caution in breastfeeding mothers. Monitor the infant for diarrhea or thrush. Consult your doctor.
💊 Overdose Management
Overdose with this medicine is unlikely due to its injectable route. In case of accidental overdose, discontinue the drug and provide supportive care. Monitor renal and hepatic function. Ampicillin and Sulbactam can be removed by hemodialysis in severe cases.
⏰ Missed Dose
Since this medicine is administered by a healthcare professional, missed doses are unlikely. If a dose is missed, contact your healthcare provider for instructions. Do not attempt to self-administer an extra dose.
Additional Safety Advice
This medicine must only be given by a qualified healthcare professional in a setting equipped to manage allergic reactions. Before receiving this medicine, inform your doctor about all your allergies, especially to penicillins or cephalosporins, and about any kidney or liver problems. Do not attempt to self-administer this injection. Complete the full course as prescribed, even if you feel better, to prevent resistance. Report persistent diarrhea, rash, or difficulty breathing immediately. Avoid alcohol during treatment as it may worsen side effects and stress the liver. If you are pregnant, planning pregnancy, or breastfeeding, tell your doctor so they can assess the benefits and risks.
👴 Special Considerations for Elderly
💡 For Patients Above 65
Elderly patients are more likely to have reduced kidney function, which can increase the risk of side effects. Dose adjustment based on renal function is recommended. Monitor renal function closely.
🤰 Pregnancy Planning (TTC)
If you are planning pregnancy, consult your doctor before starting this medicine. It is generally considered safe in pregnancy when needed, but the benefits and risks should be weighed.
🏥 Post-Surgery Considerations
This medicine is often used after surgery to prevent or treat infections. It is given intravenously in a hospital setting. Follow your surgeon's instructions for wound care and recovery.
🦷 Dental Procedures
Inform your dentist if you are taking this medicine. It may interact with certain dental procedures or medications. Your dentist may recommend postponing non-urgent procedures until you complete the course.
💚 Lifestyle Tips for Better Results
🏋️ Exercise Considerations
Avoid strenuous exercise during treatment, especially if you are feeling weak or fatigued. Light activity is fine, but listen to your body and rest when needed.
🥗 Diet Recommendations
💼 Impact on Daily Work & Life
This medicine may cause dizziness or fatigue. Avoid driving or operating heavy machinery until you know how it affects you. You may need to take time off work during treatment, especially if you are hospitalized.
🛑 When to Stop This Medicine
Do not stop this medicine without consulting your doctor. Stopping early can lead to incomplete treatment and antibiotic resistance. Your doctor will determine when to stop based on your clinical response.
📅 Long-Term Use Effects
Long-term use of this medicine may lead to antibiotic resistance and overgrowth of non-susceptible organisms. Prolonged use may also increase the risk of liver and kidney problems. Regular monitoring of renal and hepatic function is recommended during extended therapy.
🌿 Non-Medicine Approaches
These can complement medicine but do not replace prescribed treatment.
For milder infections, oral antibiotics may be used instead of injections.
Evidence: Well-establishedDepending on the bacteria, other antibiotics like cephalosporins or carbapenems may be used.
Evidence: Well-established💉 Vaccination Considerations
💉 If You're Getting Vaccinated
This medicine does not interact with vaccines. However, if you are scheduled for a live vaccine, inform your doctor as antibiotics may affect the vaccine's effectiveness.
📦 Storage Guide
✅ DO
Store at room temperature (15-30°C)
❌ DON'T
Do not refrigerate the unreconstituted powder
✅ DO
Keep in original container
❌ DON'T
Do not transfer to unmarked containers
✅ DO
Keep away from direct sunlight
❌ DON'T
Do not store in bathroom cabinet
✈️ Traveling with This Medicine
This medicine is given in a healthcare setting, so travel advice is limited. If you are prescribed this medicine and need to travel, carry it in its original packaging with a copy of your prescription. Keep it at room temperature and protect it from light. Inform security about your medication. If you need to cross time zones, consult your doctor about dosing adjustments.
💰 Cost Analysis & Savings
👥 Real Patient Stories
Educational, anonymized scenarios. Individual results may vary.
💬 Questions Patients Often Ask
A: This medicine starts working within 30 minutes to 1 hour after administration, but you may not feel better for a few days. Complete the full course as prescribed.
A: No, this medicine must be given by a healthcare professional in a clinical setting.
A: Report any side effects to your doctor immediately. Do not ignore severe symptoms.
🤔 Common Patient Concerns
🔄 Substitutes for ampi-s 1500mg injection
View AllAlternative brands with exact same active ingredient:
-
astreak 1000 mg/500 mg injectionChandra Bhagat Pharma Pvt Ltd ₹44.76 90% CHEAPER
-
osocillin-s 1000mg/500mg injectionOsper Formulations Pvt Ltd ₹45.00 90% CHEAPER
-
sulbact 1000 mg/500 mg injectionBiochem Pharmaceutical Industries ₹66.30 85.2% CHEAPER
-
ampitum 1000 mg/500 mg injectionFDC Ltd ₹96.00 78.6% CHEAPER
-
ambact 1.5gm injectionAncalima Lifesciences Ltd ₹110.00 75.5% CHEAPER
Medical Note: Always consult your doctor before switching medications.
🛑 Myths vs. Facts
- Myth: This injection can cure viral infections like the flu.
Fact: This medicine is an antibiotic and is only effective against bacterial infections. It does not treat viral infections. - Myth: You can stop the injection as soon as you feel better.
Fact: You must complete the full course as prescribed to prevent the infection from returning and to avoid antibiotic resistance. - Myth: This medicine is safe for everyone.
Fact: It is not safe for individuals with a known allergy to penicillins or cephalosporins. Always inform your doctor about your allergies.
🔄 Alternative Options
Generic Alternatives
- Ampicillin and Sulbactam injection
Brand Alternatives
- Ampi-S 1500mg injection