amoril-l tablet - Uses, Price, Side Effects & Substitutes
What is amoril-l tablet used for?
Amlozaar Tablet (Losartan + Amlodipine) is used to treat CARDIAC. It contains Losartan (50mg) + Amlodipine (5mg), which Losartan blocks AT1 receptor, reducing vasoconstriction and aldosterone secretio. Always consult your doctor before use. Take as prescribed.
- Generic Name: Losartan + Amlodipine
- Manufacturer: Clanthis Lifesciences Pvt Ltd
- Form: Allopathy
- Pregnancy Category: A
- Prescription Required: Yes
๐ amoril-l tablet Uses & Benefits
Hypertension, Stable angina (amlodipine component)
Off-label uses: Heart failure (losartan), Migraine prophylaxis (amlodipine)
๐ Drug Information
| Generic Name(s) | Losartan + Amlodipine |
| Brand Name | Amlozaar Tablet |
| Manufacturer | Clanthis Lifesciences Pvt Ltd |
| Packaging / Form | Varies by brand (Allopathy) |
| Therapeutic Class | CARDIAC |
| Action Class | Angiotensin II Receptor Blocker + Calcium Channel Blocker |
| Route of Administration | Oral |
| Storage | Store at 20-25ยฐC (68-77ยฐF), protect from light and moisture. |
| Shelf Life | As per manufacturer |
๐ฌ Pharmacology (PK/PD)
Pharmacokinetics
How It Works
Losartan blocks AT1 receptor, reducing vasoconstriction and aldosterone secretion; Amlodipine inhibits calcium influx into vascular smooth muscle, causing vasodilation.
Mechanism Steps
๐ก How to Take amoril-l tablet
Follow your doctor's prescription exactly.
โ ๏ธ Side Effects of amoril-l tablet
โ Common Side Effects
- Dizziness
- Edema
- Headache
- Fatigue
- Nausea
- Flushing
๐จ Serious Side Effects
- Angioedema
- Hyperkalemia
- Hypotension
- Renal impairment
- Hepatotoxicity
โ ๏ธ Rare Side Effects
- Rhabdomyolysis
- Stevens-Johnson syndrome
- Pancreatitis
- Leukopenia
Consult your doctor if you experience any unusual symptoms.
๐ฌ Drug Interactions
| โ ๏ธ Drug | Severity | Effect |
|---|---|---|
| Aliskiren | Major | Increased risk of hypotension, hyperkalemia, and renal impairment |
| Lithium | Major | Increased lithium toxicity |
| Potassium-sparing diuretics | Major | Increased risk of hyperkalemia |
| CYP3A4 inhibitors | Major | Increased amlodipine levels |
| CYP3A4 inducers | Major | Decreased amlodipine levels |
| NSAIDs | Moderate | Reduced antihypertensive effect |
| ACE inhibitors | Moderate | Additive hypotensive effect |
| Beta-blockers | Moderate | Increased risk of bradycardia |
| Digoxin | Moderate | Possible increased digoxin levels |
| Antacids | Minor | Slight reduction in losartan absorption |
| Cimetidine | Minor | Possible increased amlodipine levels |
| Grapefruit juice | Minor | Increased amlodipine levels |
๐จ Major Interactions
- Aliskiren
- Lithium
- Potassium-sparing diuretics
- CYP3A4 inhibitors (e.g., ketoconazole)
- CYP3A4 inducers (e.g., rifampin)
โก Moderate Interactions
- NSAIDs
- ACE inhibitors
- Beta-blockers
- Digoxin
โน๏ธ Minor Interactions
- Antacids
- Cimetidine
- Grapefruit juice
๐ฝ๏ธ Food Interactions
Grapefruit juice may increase amlodipine levels, High-fat meal may reduce losartan absorption
๐ท Alcohol Interaction
Alcohol may potentiate hypotensive effects.
๐ก๏ธ Safety & Warnings
๐ซ Contraindications
Hypersensitivity to losartan or amlodipine, Pregnancy (2nd and 3rd trimesters), Severe hepatic impairment, Concomitant use with aliskiren in diabetes
๐ Monitoring Parameters
Blood pressure, Heart rate, Serum potassium, Renal function, Liver enzymes
๐คฑ Lactation Safety
Not recommended; excreted in breast milk.
๐ Overdose Management
Symptomatic and supportive; activated charcoal, IV fluids, vasopressors if needed.
โฐ Missed Dose
Take as soon as remembered; skip if almost time for next dose; do not double.