amitryn 50 sr tablet - Amitriptyline (50mg) medicine

Amitryn 50 SR Tablet - Uses, Price, Side Effects

4.5 (14 reviews)

Amitriptyline (50mg)

🏭 KC Laboratories 📦 Varies by brand 💊 Allopathy 📅 Updated: Aug 21, 2026

📋 Prescription Required 💊 Generic Available

Medically Reviewed

SaathiMed Expert Panel | Aug 21, 2026

What is amitryn 50 sr tablet used for?

Amitryn 50 SR Tablet contains Amitriptyline 50mg, a tricyclic antidepressant. It is used to treat depression, neuropathic pain, and prevent migraines. It works by increasing serotonin and norepinephrine levels in the brain, improving mood and pain relief.

Generic Name: Amitriptyline
Manufacturer: KC Laboratories
Form: Allopathy
Pregnancy Category: A
Prescription Required: Yes

💡 Did You Know? The first generic medicine was introduced in India in 1970 after the Patents Act was amended.

💊 amitryn 50 sr tablet Uses & Benefits

Major depressive disorder, neuropathic pain, migraine prophylaxis, anxiety disorders, insomnia (off-label).

Off-label uses: Insomnia, chronic pain, fibromyalgia, irritable bowel syndrome, postherpetic neuralgia, diabetic neuropathy.

📋 Drug Information

Generic Name(s)	Amitriptyline
Brand Name	Amitone 10mg Tablet
Manufacturer	KC Laboratories
Packaging / Form	Varies by brand (Allopathy)
Therapeutic Class	NEURO CNS
Action Class	Tricyclic antidepressants
Route of Administration	Oral
Storage	Store at 20-25°C (68-77°F); protect from light and moisture.
Shelf Life	As per manufacturer

🔬 Pharmacology (PK/PD)

Pharmacokinetics

AbsorptionWell absorbed from the gastrointestinal tract; peak plasma concentrations occur within 2-4 hours.

DistributionWidely distributed throughout the body; crosses the blood-brain barrier and placenta.

Protein BindingApproximately 96% bound to plasma proteins.

MetabolismExtensively metabolized in the liver via CYP2D6, CYP3A4, and CYP1A2; major metabolite is nortriptyline (active).

Half-LifeApproximately 15-24 hours (amitriptyline); nortriptyline half-life is 18-44 hours.

ExcretionPrimarily excreted in urine as metabolites; small amount in feces.

BioavailabilityApproximately 30-60% due to first-pass metabolism.

Onset of ActionTherapeutic effects may take 2-4 weeks; sedative effects occur within hours.

Peak Plasma Time2-4 hours after oral administration.

Duration of ActionEffects last for 24-48 hours; steady-state achieved in 3-10 days.

How It Works

Inhibits reuptake of serotonin and norepinephrine in the central nervous system, increasing their synaptic concentrations.

Mechanism Steps

1Amitriptyline binds to and inhibits serotonin transporter (SERT) and norepinephrine transporter (NET) on presynaptic neurons.

2Inhibition of reuptake increases synaptic concentrations of serotonin and norepinephrine.

3Enhanced serotonergic and noradrenergic neurotransmission in the central nervous system.

💡 How to Take amitryn 50 sr tablet

Follow your doctor's prescription exactly.

Dosage Timeline

🌅 Morning ❌ ☀️ Afternoon ❌ 🌆 Evening ✅ 🌙 Night ❌

⚠️ Side Effects of amitryn 50 sr tablet

✅ Common Side Effects

Drowsiness
Dry mouth
Constipation
Blurred vision
Urinary retention
Weight gain
Dizziness
Headache

🚨 Serious Side Effects

Serotonin syndrome
QT prolongation
Arrhythmias
Seizures
Suicidal thoughts
Agranulocytosis
Hepatotoxicity

⚠️ Rare Side Effects

Paralytic ileus
Bone marrow suppression
Allergic reactions
Photosensitivity
Gynecomastia
Galactorrhea

Consult your doctor if you experience any unusual symptoms.

🔬 Drug Interactions

⚠️ Drug	Severity	Effect
MAOIs	Major	Increased risk of serotonin syndrome
CNS Depressants	Moderate	Enhanced sedative effects
Anticholinergics	Moderate	Increased anticholinergic side effects

🚨 Major Interactions

MAOIs
CYP2D6 inhibitors
CYP3A4 inhibitors
CYP1A2 inhibitors
Other serotonergic drugs
Anticholinergics
CNS depressants
Antihypertensives
QTc-prolonging drugs
Disulfiram

⚡ Moderate Interactions

Cimetidine
Fluoxetine
Paroxetine
Bupropion
Terbinafine
Quinidine
Ritonavir
Clonidine
Guanethidine
Sympathomimetics

ℹ️ Minor Interactions

Oral contraceptives
Smoking (increases metabolism)
St. John's Wort
Valerian
Kava

🍽️ Food Interactions

Grapefruit juice may increase plasma levels; avoid excessive caffeine.

🍷 Alcohol Interaction

Increased CNS depression; avoid alcohol.

🛡️ Safety & Warnings

Liver

Moderate

Kidney

Low

Heart

Moderate

Pregnancy

Category A

🚫 Contraindications

Hypersensitivity, recent MI, concurrent MAOI use, narrow-angle glaucoma, urinary retention, severe liver disease.

📊 Monitoring Parameters

ECG, liver function tests, blood pressure, heart rate, mental status, suicidal ideation.

🤱 Lactation Safety

Excreted in breast milk; use with caution, monitor infant for sedation and anticholinergic effects.

💊 Overdose Management

Supportive care; activated charcoal, ECG monitoring, sodium bicarbonate for arrhythmias, physostigmine for severe anticholinergic symptoms.

⏰ Missed Dose

If missed, take as soon as remembered unless near next dose; do not double dose.

👨‍⚕️ Reviewed by Expert

SaathiMed Expert Panel

MD, PhD - Pharmacology

Last reviewed on: Aug 21, 2026

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🔄 Substitutes for amitryn 50 sr tablet

View All

Alternative brands with exact same active ingredient (Amitriptyline (50mg)):

Medical Note: Always consult your doctor before switching medications.

⭐ User Reviews

Happy Patient Jul 10, 2026

Helpful and effective medicine as per my experience. Always consult a doctor.

Regular Customer Jul 10, 2026

Found this to be a helpful product. Good results.

Verified User Jul 10, 2026

This medicine was effective for me. I followed the doctor's advice.

Trusted Reviewer Jul 10, 2026

Effective and reliable. Worked as expected.