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amital 25mg tablet - Amitriptyline (25mg) medicine

Amital 25mg Tablet - Uses, Price, Side Effects

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Amitriptyline (25mg)
๐Ÿญ Arwana Pharmaceuticals ๐Ÿ“ฆ Varies by brand ๐Ÿ’Š Allopathy ๐Ÿ“… Updated: Jun 27, 2026
๐Ÿ“‹ Prescription Required ๐Ÿ’Š Generic Available
Medically Reviewed
Dr. SaathiMed Expert Panel | Jun 27, 2026

What is amital 25mg tablet used for?

Amital 25mg tablet contains Amitriptyline, a tricyclic antidepressant used to treat depression and neuropathic pain. It works by increasing serotonin and norepinephrine levels in the brain, improving mood and reducing pain signals. Always take as prescribed by your doctor.

  • Generic Name: Amitriptyline
  • Manufacturer: Arwana Pharmaceuticals
  • Form: Allopathy
  • Pregnancy Category: A
  • Prescription Required: Yes
๐Ÿ’ก Did You Know? Over 80% of the antiretroviral drugs used globally to combat AIDS are supplied by Indian pharmaceutical companies.

๐Ÿ’Š amital 25mg tablet Uses & Benefits

Major depressive disorder, neuropathic pain, migraine prophylaxis, anxiety disorders, insomnia (off-label).

Off-label uses: Insomnia, chronic pain, fibromyalgia, irritable bowel syndrome, postherpetic neuralgia, diabetic neuropathy.

๐Ÿ“‹ Drug Information

Generic Name(s)Amitriptyline
Brand NameAmitone 10mg Tablet
ManufacturerArwana Pharmaceuticals
Packaging / FormVaries by brand (Allopathy)
Therapeutic ClassNEURO CNS
Action ClassTricyclic antidepressants
Route of AdministrationOral
StorageStore at 20-25ยฐC (68-77ยฐF); protect from light and moisture.
Shelf LifeAs per manufacturer

๐Ÿ”ฌ Pharmacology (PK/PD)

Pharmacokinetics

AbsorptionWell absorbed from the gastrointestinal tract; peak plasma concentrations occur within 2-4 hours.
DistributionWidely distributed throughout the body; crosses the blood-brain barrier and placenta.
Protein BindingApproximately 96% bound to plasma proteins.
MetabolismExtensively metabolized in the liver via CYP2D6, CYP3A4, and CYP1A2; major metabolite is nortriptyline (active).
Half-LifeApproximately 15-24 hours (amitriptyline); nortriptyline half-life is 18-44 hours.
ExcretionPrimarily excreted in urine as metabolites; small amount in feces.
BioavailabilityApproximately 30-60% due to first-pass metabolism.
Onset of ActionTherapeutic effects may take 2-4 weeks; sedative effects occur within hours.
Peak Plasma Time2-4 hours after oral administration.
Duration of ActionEffects last for 24-48 hours; steady-state achieved in 3-10 days.

How It Works

Inhibits reuptake of serotonin and norepinephrine in the central nervous system, increasing their synaptic concentrations.

Mechanism Steps

1Amitriptyline binds to and inhibits serotonin transporter (SERT) and norepinephrine transporter (NET) on presynaptic neurons.
2Inhibition of reuptake increases synaptic concentrations of serotonin and norepinephrine.
3Enhanced serotonergic and noradrenergic neurotransmission in the central nervous system.

๐Ÿ’ก How to Take amital 25mg tablet

Follow your doctor's prescription exactly.

Dosage Timeline

๐ŸŒ… Morning โœ… โ˜€๏ธ Afternoon โŒ ๐ŸŒ† Evening โœ… ๐ŸŒ™ Night โŒ

โš ๏ธ Side Effects of amital 25mg tablet

โœ… Common Side Effects

  • Drowsiness
  • Dry mouth
  • Constipation
  • Blurred vision
  • Urinary retention
  • Weight gain
  • Dizziness
  • Headache

๐Ÿšจ Serious Side Effects

  • Serotonin syndrome
  • QT prolongation
  • Arrhythmias
  • Seizures
  • Suicidal thoughts
  • Agranulocytosis
  • Hepatotoxicity

โš ๏ธ Rare Side Effects

  • Paralytic ileus
  • Bone marrow suppression
  • Allergic reactions
  • Photosensitivity
  • Gynecomastia
  • Galactorrhea

Consult your doctor if you experience any unusual symptoms.

๐Ÿ”ฌ Drug Interactions

โš ๏ธ DrugSeverityEffect
MAOIs Major Hypertensive crisis
CNS depressants Moderate Increased sedation
Anticholinergics Moderate Additive anticholinergic effects

๐Ÿšจ Major Interactions

  • MAOIs
  • CYP2D6 inhibitors
  • CYP3A4 inhibitors
  • CYP1A2 inhibitors
  • Other serotonergic drugs
  • Anticholinergics
  • CNS depressants
  • Antihypertensives
  • QTc-prolonging drugs
  • Disulfiram

โšก Moderate Interactions

  • Cimetidine
  • Fluoxetine
  • Paroxetine
  • Bupropion
  • Terbinafine
  • Quinidine
  • Ritonavir
  • Clonidine
  • Guanethidine
  • Sympathomimetics

โ„น๏ธ Minor Interactions

  • Oral contraceptives
  • Smoking (increases metabolism)
  • St. John's Wort
  • Valerian
  • Kava

๐Ÿฝ๏ธ Food Interactions

Grapefruit juice may increase plasma levels; avoid excessive caffeine.

๐Ÿท Alcohol Interaction

Increased CNS depression; avoid alcohol.

๐Ÿ›ก๏ธ Safety & Warnings

Liver
Moderate
Kidney
Low
Heart
Moderate
Pregnancy
Category A

๐Ÿšซ Contraindications

Hypersensitivity, recent MI, concurrent MAOI use, narrow-angle glaucoma, urinary retention, severe liver disease.

๐Ÿ“Š Monitoring Parameters

ECG, liver function tests, blood pressure, heart rate, mental status, suicidal ideation.

๐Ÿคฑ Lactation Safety

Excreted in breast milk; use with caution, monitor infant for sedation and anticholinergic effects.

๐Ÿ’Š Overdose Management

Supportive care; activated charcoal, ECG monitoring, sodium bicarbonate for arrhythmias, physostigmine for severe anticholinergic symptoms.

โฐ Missed Dose

If missed, take as soon as remembered unless near next dose; do not double dose.

๐Ÿ‘จโ€โš•๏ธ Reviewed by Expert

Dr. SaathiMed Expert Panel

MD, PhD - Pharmacology

Reviewed: Jun 27, 2026

๐Ÿ”— View Profile

๐Ÿ”„ Substitutes for amital 25mg tablet

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Alternative brands with exact same active ingredient (Amitriptyline (25mg)):

Medical Note: Always consult your doctor before switching medications.

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