amtran 25mg tablet - Uses, Price, Side Effects & Substitutes
What is amtran 25mg tablet used for?
Amitone 10mg Tablet (Amitriptyline) is used to treat NEURO CNS. It contains Amitriptyline (25mg), which Inhibits reuptake of serotonin and norepinephrine in the central nervous system,. Always consult your doctor before use. Take as prescribed.
- Generic Name: Amitriptyline
- Manufacturer: Aan Pharma Pvt Ltd
- Form: Allopathy
- Pregnancy Category: A
- Prescription Required: Yes
๐ amtran 25mg tablet Uses & Benefits
Major depressive disorder, neuropathic pain, migraine prophylaxis, anxiety disorders, insomnia (off-label).
Off-label uses: Insomnia, chronic pain, fibromyalgia, irritable bowel syndrome, postherpetic neuralgia, diabetic neuropathy.
๐ Drug Information
| Generic Name(s) | Amitriptyline |
| Brand Name | Amitone 10mg Tablet |
| Manufacturer | Aan Pharma Pvt Ltd |
| Packaging / Form | Varies by brand (Allopathy) |
| Therapeutic Class | NEURO CNS |
| Action Class | Tricyclic antidepressants |
| Route of Administration | Oral |
| Storage | Store at 20-25ยฐC (68-77ยฐF); protect from light and moisture. |
| Shelf Life | As per manufacturer |
๐ฌ Pharmacology (PK/PD)
Pharmacokinetics
How It Works
Inhibits reuptake of serotonin and norepinephrine in the central nervous system, increasing their synaptic concentrations.
Mechanism Steps
๐ก How to Take amtran 25mg tablet
Follow your doctor's prescription exactly.
โ ๏ธ Side Effects of amtran 25mg tablet
โ Common Side Effects
- Drowsiness
- Dry mouth
- Constipation
- Blurred vision
- Urinary retention
- Weight gain
- Dizziness
- Headache
๐จ Serious Side Effects
- Serotonin syndrome
- QT prolongation
- Arrhythmias
- Seizures
- Suicidal thoughts
- Agranulocytosis
- Hepatotoxicity
โ ๏ธ Rare Side Effects
- Paralytic ileus
- Bone marrow suppression
- Allergic reactions
- Photosensitivity
- Gynecomastia
- Galactorrhea
Consult your doctor if you experience any unusual symptoms.
๐ฌ Drug Interactions
| โ ๏ธ Drug | Severity | Effect |
|---|---|---|
| MAOIs | Major | Risk of serotonin syndrome; hypertensive crisis |
| CYP2D6 inhibitors | Major | Increased amitriptyline levels, toxicity |
| CYP3A4 inhibitors | Major | Increased amitriptyline levels |
| CYP1A2 inhibitors | Major | Increased amitriptyline levels |
| Other serotonergic drugs | Major | Risk of serotonin syndrome |
| Anticholinergics | Major | Additive anticholinergic effects |
| CNS depressants | Major | Enhanced sedation, respiratory depression |
| Antihypertensives | Major | Increased hypotensive effect |
| QTc-prolonging drugs | Major | Increased risk of arrhythmias |
| Disulfiram | Major | Delirium, confusion |
| Cimetidine | Moderate | Increased amitriptyline levels |
| Fluoxetine | Moderate | Increased amitriptyline levels |
| Paroxetine | Moderate | Increased amitriptyline levels |
| Bupropion | Moderate | Increased amitriptyline levels |
| Terbinafine | Moderate | Increased amitriptyline levels |
| Quinidine | Moderate | Increased amitriptyline levels |
| Ritonavir | Moderate | Increased amitriptyline levels |
| Clonidine | Moderate | Decreased antihypertensive effect |
| Guanethidine | Moderate | Decreased antihypertensive effect |
| Sympathomimetics | Moderate | Increased risk of hypertension |
| Oral contraceptives | Minor | Possible decreased amitriptyline efficacy |
| Smoking | Minor | Increased metabolism, decreased levels |
| St. John's Wort | Minor | Possible serotonin syndrome risk |
| Valerian | Minor | Additive sedation |
| Kava | Minor | Additive sedation |
๐จ Major Interactions
- MAOIs
- CYP2D6 inhibitors
- CYP3A4 inhibitors
- CYP1A2 inhibitors
- Other serotonergic drugs
- Anticholinergics
- CNS depressants
- Antihypertensives
- QTc-prolonging drugs
- Disulfiram
โก Moderate Interactions
- Cimetidine
- Fluoxetine
- Paroxetine
- Bupropion
- Terbinafine
- Quinidine
- Ritonavir
- Clonidine
- Guanethidine
- Sympathomimetics
โน๏ธ Minor Interactions
- Oral contraceptives
- Smoking (increases metabolism)
- St. John's Wort
- Valerian
- Kava
๐ฝ๏ธ Food Interactions
Grapefruit juice may increase plasma levels; avoid excessive caffeine.
๐ท Alcohol Interaction
Increased CNS depression; avoid alcohol.
๐ก๏ธ Safety & Warnings
๐ซ Contraindications
Hypersensitivity, recent MI, concurrent MAOI use, narrow-angle glaucoma, urinary retention, severe liver disease.
๐ Monitoring Parameters
ECG, liver function tests, blood pressure, heart rate, mental status, suicidal ideation.
๐คฑ Lactation Safety
Excreted in breast milk; use with caution, monitor infant for sedation and anticholinergic effects.
๐ Overdose Management
Supportive care; activated charcoal, ECG monitoring, sodium bicarbonate for arrhythmias, physostigmine for severe anticholinergic symptoms.
โฐ Missed Dose
If missed, take as soon as remembered unless near next dose; do not double dose.
๐จโโ๏ธ Reviewed by Expert
๐ Substitutes for amtran 25mg tablet
View AllAlternative brands with exact same active ingredient (Amitriptyline (25mg)):
-
calmzee 25 tabletZeelab Pharmacy Pvt Ltd โน6.00 33.3% CHEAPER
-
sereval 25mg tabletOsho Pharma Pvt Ltd โน7.00 22.2% CHEAPER
-
amidep 25mg tabletTriko Pharmaceuticals โน8.50 5.6% CHEAPER
-
amitriptyline hcl 25mg tabletDensa Pharmaceuticals Pvt Ltd โน9.38 4.2% COSTLIER
-
dep 25mg tabletHaryana Formulations Pvt Ltd โน9.38 4.2% COSTLIER
-
triplex 25mg tabletAarpik Pharmaceuticals Pvt Ltd โน13.50 50% COSTLIER
-
depline 25mg tabletRKG Pharma โน13.79 53.2% COSTLIER
-
amilite 25mg tabletElite Pharma Pvt Ltd โน14.00 55.6% COSTLIER
-
mitrip 25mg tabletConcord Biotech Ltd โน14.00 55.6% COSTLIER
-
amypres 25mg tabletPsycormedies โน14.21 57.9% COSTLIER
Medical Note: Always consult your doctor before switching medications.