Libotryp DS 25 mg/10 mg Tablet: Complete Information
Clinical Reference Standards: CDSCO (Central Drugs Standard Control Organisation), Indian Pharmacopoeia (IP) & WHO | Last Updated: September 2026
When to Call Your Doctor IMMEDIATELY
- Severe drowsiness or difficulty staying awake
- Confusion or hallucinations
- Irregular heartbeat or palpitations
- Difficulty breathing or shortness of breath
- Severe allergic reaction (rash, swelling, difficulty swallowing)
- Yellowing of skin or eyes (jaundice)
- Seizures
- Thoughts of self-harm or suicide
If experiencing severe symptoms, call emergency services immediately.
What is amidez forte tablet used for?
This medicine is a combination of Amitriptyline (25 mg) and Chlordiazepoxide (10 mg) used for short-term treatment of anxiety and depression with anxiety. It works by increasing brain chemicals that improve mood and reducing anxiety through GABA enhancement. It is usually taken 1-3 times daily and should not be stopped suddenly.
- Generic Name: Amitriptyline (25mg) + Chlordiazepoxide (10mg)
- Manufacturer: Hamax Pharmaceuticals
- Form: Allopathy
- Pregnancy Category: Consult doctor
- Prescription Required: Yes
🇮🇳 amidez forte tablet के बारे में (Hindi Summary)
उपयोग: यह दवा अमिट्रिप्टिलीन (25 मिलीग्राम) और क्लोरडायजेपॉक्साइड (10 मिलीग्राम) का संयोजन है। इसका उपयोग चिंता और अवसाद के अल्पकालिक उपचार के लिए किया जाता है। यह मस्तिष्क में रसायनों के स्तर को बढ़ाकर मूड को बेहतर बनाती है और चिंता को कम करती है। यह दवा नींद को बेहतर बनाने और मांसपेशियों के तनाव को कम करने में भी मदद करती है। इसका उपयोग केवल डॉक्टर के परामर्श से ही करें।
साइड इफेक्ट्स: आम दुष्प्रभावों में नींद आना, चक्कर आना, मुँह सूखना, धुंधली दृष्टि, कब्ज और पेशाब करने में कठिनाई शामिल हैं। गंभीर दुष्प्रभावों में भ्रम, गंभीर नींद, अनियमित दिल की धड़कन, मतिभ्रम और एलर्जी की प्रतिक्रिया शामिल हो सकती है। यदि कोई असामान्य लक्षण दिखे तो तुरंत डॉक्टर से संपर्क करें।
सुरक्षा सलाह: इस दवा को डॉक्टर के बताए अनुसार ही लें। खुराक को कम या ज्यादा न करें। दवा लेने के बाद गाड़ी चलाने या मशीन चलाने से बचें। शराब का सेवन न करें। दवा को अचानक बंद न करें, इससे withdrawal के लक्षण हो सकते हैं। गर्भवती या स्तनपान कराने वाली महिलाएं डॉक्टर से परामर्श करें।
💊 amidez forte tablet Uses & Benefits
[{"condition":"Anxiety disorders","description":"This medicine is used for short-term management of moderate to severe anxiety, particularly when accompanied by depressive symptoms or muscle tension.","evidence":"Well-established"},{"condition":"Depression with anxiety","description":"The Amitriptyline component helps improve mood, while Chlordiazepoxide provides rapid relief from anxiety symptoms.","evidence":"Well-established"},{"condition":"Chronic tension headache","description":"Amitriptyline is effective in preventing tension-type headaches, and the combination may help when anxiety is a contributing factor.","evidence":"Moderate"},{"condition":"Irritable bowel syndrome (IBS)","description":"Amitriptyline can help reduce abdominal pain and diarrhea in IBS, especially when stress and anxiety are triggers.","evidence":"Moderate"},{"condition":"Neuropathic pain","description":"Amitriptyline is used off-label for nerve pain, and the combination may be prescribed when anxiety coexists.","evidence":"Limited"}]
Off-label uses: [{"condition":"Migraine prophylaxis","description":"Amitriptyline is sometimes prescribed off-label to prevent migraines, but the combination with Chlordiazepoxide is not standard.","evidence":"Limited"},{"condition":"Insomnia","description":"The sedative effects of both components may be used off-label for short-term insomnia, but this is not recommended due to dependence risk.","evidence":"Limited"}]
Primary treatment for: Anxiety disorders
Also treats: Depression with anxiety, Tension headache, Irritable bowel syndrome, Neuropathic pain
📋 Drug Information
| Generic Name(s) | Amitriptyline (25mg) + Chlordiazepoxide (10mg) |
| Brand Name | amidez forte tablet |
| Manufacturer | Hamax Pharmaceuticals |
| Packaging / Form | Varies by brand (Allopathy) |
| Therapeutic Class | NEURO CNS |
| Action Class | |
| Route of Administration | Oral |
| Storage | Store at room temperature between 15°C and 30°C (59°F to 86°F). Protect from light and moisture. Keep in the original container, tightly closed. |
| Shelf Life | 24 months from the date of manufacture. |
| WHO Guideline | Not established from the available information. |
| ICMR Guideline | Not established from the available information. |
👨⚕️ Doctor's Practical Tips
Evidence-based practical advice from experienced clinicians
🔍 Is This Medicine Right for Your Symptom?
Educational reference. Always consult a doctor for diagnosis.
🔬 How This Medicine Works (Pharmacology)
Pharmacokinetics
How It Works
This medicine combines two active ingredients with distinct mechanisms. Amitriptyline is a tricyclic antidepressant that inhibits the reuptake of serotonin and norepinephrine in the brain, increasing their availability and helping to elevate mood and reduce pain signals. It also blocks histamine H1, muscarinic acetylcholine, and alpha-1 adrenergic receptors, which contributes to its sedative and side effects. Chlordiazepoxide is a benzodiazepine that binds to the GABA-A receptor, enhancing the inhibitory effect of GABA, the brain's main calming neurotransmitter. This leads to reduced anxiety, muscle relaxation, and sedation. Together, they provide rapid relief from anxiety and depressive symptoms, but the combination is intended for short-term use due to the risk of tolerance and dependence with Chlordiazepoxide.
Mechanism Steps
💡 How to Take amidez forte tablet
Strength: Tablet containing Amitriptyline 25 mg and Chlordiazepoxide 10 mg.
Dosage Information
| Adult Dosage | The usual adult dose is one tablet taken one to three times daily, depending on the condition being treated and the patient's response. The dose must be individualized by a qualified clinician based on indication, age, weight, renal and hepatic function. The maximum recommended dose is typically 4 tablets per day, but this should not be exceeded without medical advice. This medicine is intended for short-term use only, usually not exceeding 4-6 weeks. |
| Pediatric Dosage | Pediatric dosing is not established from available information. Consult a pediatrician. |
| Elderly Dosage | Elderly patients are more sensitive to the effects of this medicine, especially drowsiness, dizziness, and confusion. The starting dose should be lower, and the dose should be titrated slowly. Use with caution due to increased risk of falls and cognitive impairment. |
| Renal Impairment | Use with caution in patients with renal impairment. Dose adjustment may be necessary. Consult a doctor for individualized dosing. |
| Hepatic Impairment | Use with caution in patients with hepatic impairment. Dose reduction may be required. Avoid in severe liver disease. |
| Maximum Daily Dose | The maximum daily dose is typically 4 tablets (100 mg amitriptyline and 40 mg chlordiazepoxide), but this should not be exceeded without medical supervision. |
Dosage Timeline
🍽️ Food Timing Guide
⏰ What to Do If You Miss a Dose
⚠️ Side Effects of amidez forte tablet
✅ Common Side Effects
🚨 Serious Side Effects
⚠️ Rare Side Effects
Consult your doctor if you experience any unusual symptoms.
🔬 Drug Interactions
| Drug | Severity | Effect |
|---|---|---|
| MAO inhibitors | Major | |
| Opioids | Major | |
| Alcohol | Major | |
| Fluoxetine | Major | |
| Warfarin | Moderate | |
| Cimetidine | Moderate | |
| Anticholinergics | Moderate | |
| Oral contraceptives | Moderate | |
| Antacids | Minor | |
| Grapefruit juice | Minor |
🚨 Major Interactions
- MAO inhibitors
- CNS depressants (e.g., opioids, alcohol, barbiturates)
- CYP2D6 inhibitors (e.g., fluoxetine, paroxetine, quinidine)
⚡ Moderate Interactions
- Anticholinergics (e.g., benztropine, antihistamines)
- Cimetidine
- Oral contraceptives
🍷 Alcohol Interaction
Alcohol should be completely avoided while taking this medicine. Both amitriptyline and chlordiazepoxide enhance the depressant effects of alcohol on the central nervous system, leading to increased drowsiness, dizziness, impaired judgment, and potentially fatal respiratory depression. Alcohol can also worsen the side effects of this medicine and reduce its effectiveness.
🔎 Check Your Other Medicines
Educational tool. Always confirm with your doctor or pharmacist.
🛡️ Safety & Warnings
🚫 Contraindications
["Hypersensitivity to amitriptyline, chlordiazepoxide, or other benzodiazepines","Concurrent use of MAO inhibitors","Narrow-angle glaucoma","Severe liver disease","Myasthenia gravis","Acute porphyria","Pregnancy (especially first trimester)","Breastfeeding","Children under 6 years of age","History of substance abuse"]
⚠️ Warnings & Precautions
["This medicine may cause drowsiness and impair ability to drive or operate machinery.","Do not stop this medicine abruptly after prolonged use; taper gradually under medical supervision.","Chlordiazepoxide has a potential for abuse and dependence.","Use with caution in elderly patients due to increased risk of falls and confusion.","May worsen depression and increase suicidal thoughts; monitor closely.","Avoid alcohol and other CNS depressants.","Use with caution in patients with glaucoma, urinary retention, or prostate enlargement.","May cause photosensitivity; avoid excessive sun exposure."]
🤱 Lactation Safety
Both amitriptyline and chlordiazepoxide are excreted in breast milk and may cause sedation and other effects in the nursing infant. Breastfeeding is not recommended while taking this medicine. Consult your doctor for alternative options.
💊 Overdose Management
Overdose of this medicine can be life-threatening. Symptoms include severe drowsiness, confusion, coma, respiratory depression, hypotension, cardiac arrhythmias, and seizures. If overdose is suspected, seek emergency medical attention immediately. Treatment is supportive and may include gastric lavage, activated charcoal, and management of cardiac and respiratory complications. Flumazenil may be used for benzodiazepine toxicity but is contraindicated in mixed overdose with tricyclic antidepressants due to risk of seizures.
⏰ Missed Dose
If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and continue with your regular schedule. Do not take a double dose to make up for a missed one.
Additional Safety Advice
Take this medicine exactly as prescribed. Do not increase or decrease the dose without consulting your doctor. Avoid driving or operating heavy machinery until you know how this medicine affects you. Do not drink alcohol while taking this medicine, as it can increase drowsiness and other side effects. Do not stop this medicine suddenly, especially if you have been taking it for more than a few weeks, as this can cause withdrawal symptoms. Keep this medicine out of reach of children. Inform your doctor about all other medicines you are taking, especially pain relievers, sleeping pills, and blood thinners. Use effective contraception if you are of childbearing age, as this medicine may harm an unborn baby. Do not breastfeed while taking this medicine without consulting your doctor.
👴 Special Considerations for Elderly
💡 For Patients Above 65
Elderly patients are more sensitive to the sedative and anticholinergic effects of this medicine. They are at higher risk of falls, confusion, and cognitive impairment. The dose should be started low and titrated slowly. Regular monitoring is essential.
🤰 Pregnancy Planning (TTC)
If you are planning to become pregnant, consult your doctor before taking this medicine. Both components may harm the fetus. Effective contraception should be used while taking this medicine. Your doctor may switch you to a safer alternative.
🏥 Post-Surgery Considerations
Inform your surgeon and anesthesiologist that you are taking this medicine before any surgery. It can interact with anesthetic agents and increase the risk of complications. Your doctor may advise you to stop the medicine temporarily before surgery.
🦷 Dental Procedures
Inform your dentist that you are taking this medicine before any dental procedure. It can cause dry mouth and increase the risk of dental problems. It may also interact with local anesthetics and sedatives used during dental work.
💚 Lifestyle Tips for Better Results
🏋️ Exercise Considerations
This medicine can cause drowsiness and dizziness, which may affect your coordination. Avoid activities that require mental alertness, such as driving or operating heavy machinery, until you know how the medicine affects you. Light to moderate exercise is generally safe, but listen to your body and avoid overexertion.
🥗 Diet Recommendations
💼 Impact on Daily Work & Life
This medicine can cause drowsiness and impair your ability to drive or operate machinery. It may affect your concentration and reaction time. Avoid driving or operating heavy machinery until you know how it affects you. Inform your employer if your job requires alertness. Take sick leave if needed during the initial adjustment period.
🛑 When to Stop This Medicine
Do not stop this medicine without consulting your doctor. If you have been taking it for more than a few weeks, your doctor will gradually reduce the dose to prevent withdrawal symptoms. If you experience severe side effects or allergic reactions, seek immediate medical attention.
📅 Long-Term Use Effects
Long-term use of this medicine can lead to tolerance, dependence, and withdrawal symptoms upon discontinuation. It may also cause cognitive impairment, memory problems, and increased risk of falls, especially in the elderly. Regular monitoring by a doctor is essential. This medicine is not recommended for long-term use beyond 4-6 weeks without careful evaluation.
🌿 Non-Medicine Approaches
These can complement medicine but do not replace prescribed treatment.
CBT is effective for anxiety and depression and can complement or reduce the need for medication.
Evidence: Well-establishedThese practices can help reduce anxiety and improve mood.
Evidence: ModerateExercise has been shown to reduce symptoms of anxiety and depression.
Evidence: Well-established💉 Vaccination Considerations
💉 If You're Getting Vaccinated
Not established from the available information. Consult your doctor regarding vaccinations while taking this medicine.
📦 Storage Guide
✅ DO
Store at room temperature (15-30°C)
❌ DON'T
Do not refrigerate unless specified
✅ DO
Keep in original container
❌ DON'T
Do not transfer to unmarked containers
✅ DO
Keep away from direct sunlight
❌ DON'T
Do not store in bathroom cabinet
✈️ Traveling with This Medicine
When traveling, carry this medicine in its original packaging with a copy of your prescription. Keep it in your carry-on luggage to avoid loss. Store at room temperature and protect from extreme heat or cold. If crossing time zones, adjust dosing times gradually in consultation with your doctor. Do not pack it in checked baggage. Check local customs regulations for controlled substances, as Chlordiazepoxide may be regulated.
💰 Cost Analysis & Savings
👥 Real Patient Stories
Educational, anonymized scenarios. Individual results may vary.
💬 Questions Patients Often Ask
A: The anti-anxiety effect may be felt within 30-60 minutes, but the antidepressant effect may take 1-2 weeks to become noticeable.
A: No, you should not stop this medicine suddenly as it can cause withdrawal symptoms. Your doctor will gradually reduce the dose.
A: Yes, the Chlordiazepoxide component can cause dependence if used for a long time. It is intended for short-term use only.
A: You should inform your doctor about all other medicines you are taking, as this medicine can interact with many drugs.
🤔 Common Patient Concerns
🔄 Substitutes for amidez forte tablet
View AllAlternative brands with exact same active ingredient:
-
calmzee-c forte tabletZeelab Pharmacy Pvt Ltd ₹8.00 33.3% CHEAPER
-
amipox 25 mg/10 mg tabletParasol Laboratories ₹14.63 21.9% COSTLIER
-
amilite plus 25mg/10mg tabletElite Pharma Pvt Ltd ₹16.88 40.7% COSTLIER
-
amypres c 25mg/10mg tabletPsycormedies ₹16.88 40.7% COSTLIER
-
depline forte 25 mg/10 mg tabletRKG Pharma ₹17.35 44.6% COSTLIER
Medical Note: Always consult your doctor before switching medications.
🛑 Myths vs. Facts
- Myth: This medicine is a sleeping pill.
Fact: It is not a sleeping pill but a combination of an antidepressant and an anti-anxiety medicine that can cause drowsiness as a side effect. - Myth: I can stop this medicine whenever I want.
Fact: Stopping suddenly can cause withdrawal symptoms. Always taper under medical supervision. - Myth: This medicine is safe for long-term use.
Fact: It is intended for short-term use only due to the risk of dependence on the chlordiazepoxide component.
🔄 Alternative Options
Generic Alternatives
- Amitriptyline 25 mg + Chlordiazepoxide 10 mg tablet (generic)
Brand Alternatives
- Libotryp DS 25 mg/10 mg tablet