amcil a 100mg injection - Amikacin (100mg) medicine

Amcil A 100mg Injection - Uses, Price, Side Effects

4.4 (14 reviews)

Amikacin (100mg)

🏭 Perk Pharmaceuticals Ltd 📦 Varies by brand 💊 Allopathy 📅 Updated: Aug 21, 2026

📋 Prescription Required 💊 Generic Available

Medically Reviewed

SaathiMed Expert Panel | Aug 21, 2026

What is amcil a 100mg injection used for?

Amcil A 100mg Injection contains Amikacin, an aminoglycoside antibiotic used to treat serious bacterial infections such as septicemia, respiratory tract infections, and complicated urinary tract infections. It works by binding to bacterial ribosomes, inhibiting protein synthesis, and leading to bacterial cell death. It is typically administered intravenously or intramuscularly under medical supervision.

Generic Name: Amikacin
Manufacturer: Perk Pharmaceuticals Ltd
Form: Allopathy
Pregnancy Category: D
Prescription Required: Yes

💡 Did You Know? Over 80% of the antiretroviral drugs used globally to combat AIDS are supplied by Indian pharmaceutical companies.

💊 amcil a 100mg injection Uses & Benefits

Serious Gram-negative infections (sepsis, pneumonia, complicated UTI, intra-abdominal infections); adjunct in tuberculosis; neonatal sepsis.

Off-label uses: Brucellosis, Plague, Tularemia

📋 Drug Information

Generic Name(s)	Amikacin
Brand Name	Amikacin Sulphate 500mg Injection
Manufacturer	Perk Pharmaceuticals Ltd
Packaging / Form	Varies by brand (Allopathy)
Therapeutic Class	OPHTHAL
Action Class	Aminoglycosides
Route of Administration	Intramuscular, Intravenous
Storage	Store at 20-25°C; protect from light; do not freeze.
Shelf Life	As per manufacturer

🔬 Pharmacology (PK/PD)

Pharmacokinetics

AbsorptionRapidly absorbed after intramuscular injection; peak plasma concentrations achieved within 1 hour.

DistributionDistributes widely into extracellular fluids; high concentrations in urine, bile, and synovial fluid; crosses placenta; minimal penetration into cerebrospinal fluid unless meninges inflamed.

Protein Binding0-11%

MetabolismMinimal hepatic metabolism; primarily excreted unchanged.

Half-Life2-3 hours (normal renal function); up to 30-60 hours in renal impairment.

ExcretionRenal excretion (90-98% unchanged) via glomerular filtration.

Bioavailability100% (IM); not absorbed orally.

Onset of ActionRapid (within 1 hour for IM).

Peak Plasma Time1 hour (IM); end of infusion (IV).

Duration of Action8-12 hours (dose-dependent).

How It Works

Binds to 30S ribosomal subunit, causing misreading of mRNA and inhibition of protein synthesis.

Mechanism Steps

1Binds to 30S ribosomal subunit

2Interferes with initiation complex

3Causes misreading of mRNA codons

💡 How to Take amcil a 100mg injection

Follow your doctor's prescription exactly.

Dosage Timeline

🌅 Morning ✅ ☀️ Afternoon ❌ 🌆 Evening ✅ 🌙 Night ❌

⚠️ Side Effects of amcil a 100mg injection

✅ Common Side Effects

Nephrotoxicity
Ototoxicity (vestibular and cochlear)
Nausea
Vomiting
Rash

🚨 Serious Side Effects

Acute renal failure
Irreversible hearing loss
Neuromuscular blockade
Anaphylaxis

⚠️ Rare Side Effects

Superinfection
Clostridium difficile colitis
Hypomagnesemia

Consult your doctor if you experience any unusual symptoms.

🔬 Drug Interactions

⚠️ Drug	Severity	Effect
Warfarin	Moderate	Increased risk of bleeding
Furosemide	Major	Increased nephrotoxicity
Neuromuscular blocking agents	Moderate	Enhanced neuromuscular blockade

🚨 Major Interactions

Neuromuscular blocking agents
Other aminoglycosides
Cisplatin
Loop diuretics
Vancomycin

⚡ Moderate Interactions

Penicillins (synergy)
Cephalosporins
NSAIDs
Methoxyflurane

ℹ️ Minor Interactions

Dimercaprol
Indomethacin

🍽️ Food Interactions

No significant food interactions.

🍷 Alcohol Interaction

No known interaction.

🛡️ Safety & Warnings

Liver

Low

Kidney

Moderate

Heart

Low

Pregnancy

Category D

🚫 Contraindications

Hypersensitivity to amikacin or other aminoglycosides; myasthenia gravis; pre-existing severe renal impairment.

📊 Monitoring Parameters

Renal function (serum creatinine, BUN), urine output, audiometry, serum drug levels (peak and trough).

🤱 Lactation Safety

Caution; small amounts excreted in breast milk; monitor infant for diarrhea, candidiasis.

💊 Overdose Management

Supportive care; hemodialysis may enhance elimination; monitor renal function and hearing.

⏰ Missed Dose

Administer as soon as remembered; if near next dose, skip missed dose; do not double dose.

👨‍⚕️ Reviewed by Expert

SaathiMed Expert Panel

MD, PhD - Pharmacology

Last reviewed on: Aug 21, 2026

🔗 View Profile

🔄 Substitutes for amcil a 100mg injection

View All

Alternative brands with exact same active ingredient (Amikacin (100mg)):

Medical Note: Always consult your doctor before switching medications.

⭐ User Reviews

Certified Buyer Jul 10, 2026

Found this to be a helpful product. Good results.

Verified User Jul 10, 2026

Helpful and effective medicine as per my experience. Always consult a doctor.